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Browse our anti-MEN1 (MEN1) Antibodies

Full name:
anti-Multiple Endocrine Neoplasia I Antibodies (MEN1)
On www.antibodies-online.com are 109 Multiple Endocrine Neoplasia I (MEN1) Antibodies from 13 different suppliers available. Additionally we are shipping MEN1 Proteins (3) and MEN1 Kits (1) and many more products for this protein. A total of 116 MEN1 products are currently listed.
Synonyms:
AW045611, MEAI, menin, SCG2

Most Popular Reactivities for anti-MEN1 (MEN1) Antibodies

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anti-Mouse (Murine) MEN1 Antibodies:

anti-Human MEN1 Antibodies:

anti-Rat (Rattus) MEN1 Antibodies:

All available anti-MEN1 Antibodies

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Top referenced anti-MEN1 Antibodies

  1. Human Polyclonal MEN1 Primary Antibody for ChIP, ICC - ABIN151584 : Hughes, Rozenblatt-Rosen, Milne, Copeland, Levine, Lee, Hayes, Shanmugam, Bhattacharjee, Biondi, Kay, Hayward, Hess, Meyerson: Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. in Molecular cell 2004 (PubMed)
    Show all 26 references for ABIN151584

More Antibodies against MEN1 Interaction Partners

Mouse (Murine) Multiple Endocrine Neoplasia I (MEN1) interaction partners

  1. The inactivation of menin in the thyroid gland of young mice does not seem to change the histological pattern, but it influences the proliferation of follicular cells. Further molecular studies especially in aged mice are needed to better understand the correlation between certain oncogenes and the inactive status of menin.

  2. Data show that progranulin (show GRN Antibodies) is upregulated in neuroendocrine tumors (NETs) and islets of the multiple endocrine neoplasia 1 protein (MEN1) mouse as well as in the serum of patients with pancreatic NETs associated with glucagonoma syndrome.

  3. Although mice lacking Men1 developed insulinomas as expected, elimination of ARC (show NOL3 Antibodies) in this context did not significantly alter tumor load. Cellular rates of proliferation and death in these tumors were also not perturbed in the absence of ARC (show NOL3 Antibodies).

  4. The study characterized the binding position of Ezh2 (show EZH2 Antibodies) and menin at all annotated genes in embryonic stem cells and B and T lymphocytes.

  5. Data demonstrate that loss of Men1 in pancreatic islet cells alters the epigenetic landscape of its target genes during early stages of pancreatic neuroendocrine tumor formation.

  6. Data show that menin, encoded by the MEN1 gene, inhibits the transcriptional activity of nuclear receptor liver X receptor alpha (LXRalpha (show NR1H3 Antibodies)).

  7. Conditional knockout of beta-catenin (show CTNNB1 Antibodies) suppresses the tumorigenesis and growth of Men1-deficient pancreatic neuroendocrine tumors.

  8. miR (show MLXIP Antibodies)-802 expression levels are increased in lung carcinoma tissues and targets the tumor suppressor menin and downregulates its expression.

  9. CDK4 (show CDK4 Antibodies) is a critical downstream target of MEN1-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 (show CDK2 Antibodies) is dispensable for tumorigenesis in these neuroendocrine cell types.

  10. This work shows that Men1 ablation in the pancreatic beta-cells leads to the inactivation of specific transcription factors, resulting in glucagon (show GCG Antibodies)-expressing tumor development, which sheds light on the mechanisms of islet tumorigenesis.

Human Multiple Endocrine Neoplasia I (MEN1) interaction partners

  1. rs2959656, a nonsynonymous variant in MEN1, is associated with the development of clinically active pituitary adenoma.

  2. Study acts as a further supplement of the genetic features of neuroendocrine tumors. Somatic mutations of three potential tumor-related genes (HRAS (show HRAS Antibodies), PAK1 (show PAK1 Antibodies) and MEN1) might contribute to the tumorigenesis of thymic neuroendocrine tumors with EAS.

  3. The results and clinical course of disease in this case indicate the potential role of menin in the development of non-endocrine or atypical-endocrine tumors in MEN1 patients.

  4. cellular staining for menin also reveals the distribution of menin in the cell membrane and the punctate-like cell organelles

  5. study to evaluate frequency of Multiple Endocrine Neoplasia type 1 (MEN1) in patients with pituitary adenoma and to perform genetic analysis and familial screening of those with MEN1; genetic analysis showed MEN1 mutations in 4 index cases: IVS4+1 G>A, IVS3-6 C>T, c.1547insC and a new D180A mutation

  6. Study reports the coexistence of a germline intronic heterozygote variation at the MEN1 gene (IVS4+1G>T) and a germline mutation of exon 11 of RET proto-oncogene (show RET Antibodies) (K666M) in a large Italian family and describes clinical manifestations in the carriers.

  7. novel MEN1 c.8251G>A mutation in a family with multiple endocrine neoplasia type 1

  8. progenitors. Our findings define SON as a fine-tuner of the MLL (show MLL Antibodies)-menin interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia.

  9. interaction between menin and Dnmt1 (show DNMT1 Antibodies) reversibly regulates pancreatic cancer cell growth downstream of Hedgehog (show SHH Antibodies) pathways with complex mutual modulation networks.

  10. Molecular analysis of sporadic insulinoma (show RPS15 Antibodies) revealed presence of three novel exonic mutations, two novel intronic variations, three reported exon SNPs, and one intronic SNP (rs669976).

MEN1 Antigen Profile

Antigen Summary

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with MEN1

  • multiple endocrine neoplasia I (men1) antibody
  • multiple endocrine neoplasia I (MEN1) antibody
  • multiple endocrine neoplasia 1 (Men1) antibody
  • multiple endocrine neoplasia I (Men1) antibody
  • AW045611 antibody
  • MEAI antibody
  • menin antibody
  • SCG2 antibody

Protein level used designations for MEN1

multiple endocrine neoplasia 1 , menin , multiple endocrine neoplasia I , menin-like , multiple endocrine neoplasia protein

GENE ID SPECIES
549115 Xenopus (Silurana) tropicalis
692344 Felis catus
743979 Pan troglodytes
100158320 Xenopus laevis
100411101 Callithrix jacchus
100441476 Pongo abelii
100472417 Ailuropoda melanoleuca
100538227 Danio rerio
17283 Mus musculus
4221 Homo sapiens
29417 Rattus norvegicus
483758 Canis lupus familiaris
100523533 Sus scrofa
539431 Bos taurus
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