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Browse our ERCC1 Proteins (ERCC1)

Full name:
Excision Repair Cross Complementing Polypeptide-1 Proteins (ERCC1)
On are 11 Excision Repair Cross Complementing Polypeptide-1 (ERCC1) Proteins from 6 different suppliers available. Additionally we are shipping ERCC1 Antibodies (245) and ERCC1 Kits (12) and many more products for this protein. A total of 278 ERCC1 products are currently listed.
COFS4, Ercc-1, RAD10, T12H1.18, T12H1_18, UV20, UVR7, UV REPAIR DEFICIENT 7
list all proteins Gene Name GeneID UniProt
Rat ERCC1 ERCC1 292673  
ERCC1 13870 P07903
ERCC1 2067 P07992

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ERCC1 Proteins (ERCC1) by Origin

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Top referenced ERCC1 Proteins

  1. Human ERCC1 Protein expressed in Escherichia coli (E. coli) - ABIN1098618 : van Duin, de Wit, Odijk, Westerveld, Yasui, Koken, Hoeijmakers, Bootsma: Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10. in Cell 1986 (PubMed)
    Show all 2 references for ABIN1098618

More Proteins for ERCC1 Interaction Partners

Arabidopsis thaliana Excision Repair Cross Complementing Polypeptide-1 (ERCC1) interaction partners

  1. ERCC1 and XPF protect short telomeres from homologous recombination.

Mouse (Murine) Excision Repair Cross Complementing Polypeptide-1 (ERCC1) interaction partners

  1. we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b (show BUB1B Proteins)(H/H) mice, which have a faulty mitotic checkpoint (show BUB3 Proteins), and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand crosslink repair. we found that Bub1b (show BUB1B Proteins)(H/H), but not Ercc1(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...

  2. these results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair

  3. ERCC1 is critical for protecting chondrocytes from catabolic stress and is associated with the pathophysiology of osteoarthritis.

  4. SLX4 is a tumor suppressor, which activates XPF-ERCC1 nuclease (show DCLRE1C Proteins) specificity in DNA crosslink repair.

  5. ERCC1 is essential for melanoma growth and resistance to cisplatin.

  6. Smad4 (show SMAD4 Proteins) loss-associated Snail (show SNAI1 Proteins) reduction compromises Ercc1-mediated DNA repair, contributing to increased UV-induced skin carcinogenesis.

  7. analysis of accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(delta/-) mouse

  8. This study demonistrated that the ERCC1 deficiency-associated downregulation of the cholesterol biosynthesis pathway is at least in part due to lowered expression of its master transcription factor SREBF2 (show SREBF2 Proteins)

  9. we have identified a novel skin-specific Ercc1 transcript in mice that originates from a promoter approximately 400 bp upstream of the normal promoter, rather than from more distant potential transcriptional start sites.

  10. Ercc1(Delta/-) mice develop widespread astrocytosis and microgliosis, and motor neuron loss and denervation of skeletal muscle fibers.

Human Excision Repair Cross Complementing Polypeptide-1 (ERCC1) interaction partners

  1. The prognostic index comprising XRCC1 (show XRCC1 Proteins) rs25487, ERCC2 (show ERCC2 Proteins) rs13181, and rs1799793 polymorphisms may be a useful predictor of clinical outcomes in MGC treated with EOF.

  2. It was concluded that patients with stage I NSCLC with high ERCC1 expression had superior survival rates relative to those with low ERCC1 expression. Tumors with an irregular edge and signs of spiculation on CT were significantly correlated with low expression of ERCC1.

  3. Stratified analyses revealed that A/A + G/A genotypes of XRCC1 (show XRCC1 Proteins) rs25487 are associated with significantly reduced risk of death compared with the G/G genotype in patients grouped by tumor size, portal vein tumor thrombus (PVTT), alpha-fetoprotein (AFP (show AFP Proteins)) and TNM (show ODZ1 Proteins) stage (all p < 0.05). The ERCC1 rs13181 and XPD (show ERCC2 Proteins) rs11615 polymorphisms were not predictive of clinical outcome for HCC (show FAM126A Proteins) patients

  4. ERCC1 Gene C8092A Polymorphism is associated with response to Platinum-based Chemotherapy in Advanced Gastric Cancer.

  5. The purpose of this study was to assess the previously reported inconsistent association of polymorphisms in ERCC1 (rs11615, rs3212986), ERCC2 (show ERCC2 Proteins) (rs13181, rs1799793, rs238406), and ERCC5 (show ERCC5 Proteins) (rs17655) with the development of brain tumors.

  6. The ERCC1 rs3212986 gene polymorphism was associated with increased risk of pancreatic cancer in the dominant and recessive models.

  7. ERCC1 rs11615 and ERCC2 (show ERCC2 Proteins) rs50871 polymorphisms could influence the risk of larynx cancer in Chinese population, particularly among smokers.

  8. Study found that the ERCC1 rs3212986 polymorphism was associated with the development of breast cancer in Chinese population.

  9. Identification of ERCC1 expression level of tumor tissues in non-small cell lung cancer patients before treatment was not useful in prediction of treatment response and prognosis.

  10. The ERCC1 level at diagnosis is predictive for the outcome of patients with non-metastatic, high-grade osteosarcoma (OS) treated with neoadjuvant chemotherapy, and co-evaluation with ABCB1 (show ABCB1 Proteins) can identify high-risk groups of OS patients who are refractory to standard regimens.

ERCC1 Protein Profile

Protein Summary

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

Alternative names and synonyms associated with ERCC1

  • DNA excision repair protein ERCC-1 (ERCC1)
  • excision repair cross-complementing rodent repair deficiency, complementation group 1 (Ercc1)
  • excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1)
  • COFS4 protein
  • Ercc-1 protein
  • RAD10 protein
  • T12H1.18 protein
  • T12H1_18 protein
  • UV20 protein
  • UVR7 protein

Protein level used designations for ERCC1

DNA excision repair protein ERCC-1 , excision repair cross-complementing 1 , excision repair 1

819685 Arabidopsis thaliana
292673 Rattus norvegicus
13870 Mus musculus
2067 Homo sapiens
612282 Canis lupus familiaris
100286808 Sus scrofa
615637 Bos taurus
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