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Human ERCC1 Protein expressed in Escherichia coli (E. coli) - ABIN1098618
van Duin, de Wit, Odijk, Westerveld, Yasui, Koken, Hoeijmakers, Bootsma: Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10. in Cell 1986
Show all 2 references for ABIN1098618
ERCC1 and XPF protect short telomeres from homologous recombination.
these results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair
ERCC1 is critical for protecting chondrocytes from catabolic stress and is associated with the pathophysiology of osteoarthritis.
SLX4 is a tumor suppressor, which activates XPF-ERCC1 nuclease (show DCLRE1C Proteins) specificity in DNA crosslink repair.
ERCC1 is essential for melanoma growth and resistance to cisplatin.
Smad4 (show SMAD4 Proteins) loss-associated Snail (show SNAI1 Proteins) reduction compromises Ercc1-mediated DNA repair, contributing to increased UV-induced skin carcinogenesis.
analysis of accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(delta/-) mouse
This study demonistrated that the ERCC1 deficiency-associated downregulation of the cholesterol biosynthesis pathway is at least in part due to lowered expression of its master transcription factor SREBF2 (show SREBF2 Proteins)
we have identified a novel skin-specific Ercc1 transcript in mice that originates from a promoter approximately 400 bp upstream of the normal promoter, rather than from more distant potential transcriptional start sites.
Ercc1(Delta/-) mice develop widespread astrocytosis and microgliosis, and motor neuron loss and denervation of skeletal muscle fibers.
Performed metabolic profiling of serum and urine of the ERCC1(d/-) mouse, which has a modified ERCC1 gene, in comparison to wild type ERCC1 mice and in relation to aging by (1)H NMR spectroscopy.
there is a significant difference in biological behavior between ERCC1 rs3212986 gene polymorphism and treatment outcome of gastric cancer.
Logistic regression analysis was taken to analyze the association between ERCC1 and ERCC2 (show ERCC2 Proteins) genetic polymorphisms and response to chemotherapy.
Patients with negative expression of ERCC1 in tumor tissues had a significantly longer median DFS (show FST Proteins) and median OS compared to patients with positive expression of ERCC1
oxaliplatin-based chemotherapy increases ERCC1 and DPYD (show DPYD Proteins) expression levels; bevacizumab induces VEGFA (show VEGFA Proteins) expression in metastatic colorectal cancer
Inhibition of DNA-repair genes Ercc1 and Mgmt (show MGMT Proteins) enhances temozolomide efficacy in glioma treatment.
this study showed that ERCC1 rs2298881C>A could predict the survival outcomes of patients with surgically resected early stage Non-Small Cell Lung Cancer.
Upon UVC radiation, Nlp interacts with XPA (show XPA Proteins) and ERCC1, and enhances their association
ERCC1 rs11615 polymorphism might influence the response to cisplatin-based chemotherapy and affect the clinical outcome for osteosarcoma patients.
ERCC1 rs11615 and ERCC1 rs2298881 genetic polymorphisms are significantly associated with poor response to chemotherapy and unfavourable survival of osteosarcoma.
The results show that the ERCC1 118 CC genotype confers better efficacy of NB-UVB therapy in patients with active vitiligo (show MITF Proteins).
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
DNA excision repair protein ERCC-1
, excision repair cross-complementing 1
, excision repair 1