Browse our anti-POLB (POLB) Antibodies

Full name:
anti-Polymerase (DNA Directed), beta Antibodies (POLB)
On are 105 Polymerase (DNA Directed), beta (POLB) Antibodies from 22 different suppliers available. Additionally we are shipping POLB Proteins (14) and POLB Kits (5) and many more products for this protein. A total of 132 POLB products are currently listed.
A430088C08Rik, DDBDRAFT_0186152, DDBDRAFT_0215784, DDBDRAFT_0232376, DDB_0186152, DDB_0215784, DDB_0232376, POLB, wu:fa97a05, zgc:109924

Most Popular Reactivities for anti-POLB (POLB) Antibodies

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anti-Human POLB Antibodies:

anti-Mouse (Murine) POLB Antibodies:

anti-Rat (Rattus) POLB Antibodies:

All available anti-POLB Antibodies

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Top referenced anti-POLB Antibodies

  1. Cow (Bovine) Monoclonal POLB Primary Antibody for IHC (p), IP - ABIN153073 : Fotiadou, Henegariu, Sweasy: DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line. in Cancer research 2004 (PubMed)
    Show all 6 references for 153073

  2. Human Polyclonal POLB Primary Antibody for IHC (p), IHC - ABIN407651 : Dutto, Sukhanova, Tillhon, Cazzalini, Stivala, Scovassi, Lavrik, Prosperi: p21CDKN1A Regulates the Binding of Poly(ADP-Ribose) Polymerase-1 to DNA Repair Intermediates. in PLoS ONE 2016 (PubMed)
    Show all 4 references for 407651

  3. Human Monoclonal POLB Primary Antibody for IHC (p), WB - ABIN115052 : Husain, Morton, Beard, Singhal, Prasad, Wilson, Besterman: Specific inhibition of DNA polymerase beta by its 14 kDa domain: role of single- and double-stranded DNA binding and 5'-phosphate recognition. in Nucleic acids research 1995 (PubMed)
    Show all 2 references for 115052

  4. Human Monoclonal POLB Primary Antibody for IHC (fro), IHC (p) - ABIN153074 : Sykora, Kanno, Akbari, Kulikowicz, Baptiste, Leandro, Lu, Tian, May, Becker, Croteau, Wilson, Sobol, Yasui, Bohr: DNA polymerase beta participates in mitochondrial DNA repair. in Molecular and cellular biology 2017 (PubMed)
    Show all 2 references for 153074

  5. Mouse (Murine) Polyclonal POLB Primary Antibody for IHC, WB - ABIN3022385 : Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. in Cell cycle (Georgetown, Tex.) 2015 (PubMed)

  6. Cow (Bovine) Polyclonal POLB Primary Antibody for IHC, WB - ABIN2786683 : Batra, Beard, Shock, Pedersen, Wilson: Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. in Molecular cell 2008 (PubMed)

More Antibodies against POLB Interaction Partners

Zebrafish Polymerase (DNA Directed), beta (POLB) interaction partners

  1. DNA polymerase beta is sensitive to Mn2+ and Mg2 (show MCOLN1 Antibodies)+ and its optimumal pH is 9.

  2. In brief, the major differences in BER performed by early stage embryos and adults are the absence of DNA polymerase-beta, leading to predominance of replicative polymerases, in early stage embryos.

Human Polymerase (DNA Directed), beta (POLB) interaction partners

  1. Data suggest that POLB activity is not essential for HIV-1 integration into human macrophages and other cells; limited cellular dNTP pools, but not POLB expression, are primary factor for HIV-1 DNA gap repair, particularly in non-dividing cells.

  2. High DNA polymerase beta mRNA expression is associated with Graves' thyroid tissue.

  3. Polbeta was shown to inhibit the 3'->5' exonuclease (show EXOSC10 Antibodies) activity of APE1 (show APEX1 Antibodies) when both enzymes were added simultaneously and to insert the correct nucleotide into the gap arising after hydrolysis of AP site clustered with the benzo[a]pyrene adducts.

  4. Remote mutations induce functional changes in active site residues of human DNA polymerase beta.

  5. It has been concluded based on calculations and the experimental pH profile that the most likely path for the wild-type (WT) and the D256E and D256A mutants is a proton transfer (PT) to the bulk, although the WT may also use a PT to Asp (show ASIP Antibodies) 256.

  6. The homozygous/heterozygous genotypes containing the African allele showed higher POLB expression than the homozygous white allele genotype (P < .001). A replication study using a GEO data set validated all 5 eQTLs and also showed a statistically significant difference in POLB expression based on genetic ancestry (P = .002).

  7. HMGB1 (show HMGB1 Antibodies) stimulates activity of DNA polymerase beta on nucleosome substrates in the process of base excision repair.

  8. The results help to define the tolerance of DNA Pol beta to subtle local structural and functional alterations derived from lysine 72.

  9. PolB is ubiquitylated on amino-acid residues K206 and K244 when not in a complex with XRCC1 (show XRCC1 Antibodies).

  10. Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.

Mouse (Murine) Polymerase (DNA Directed), beta (POLB) interaction partners

  1. pol beta plays an important role in bypassing a 5',8-cyclo-dA during DNA replication and repair.

  2. we show here that heterozygosity for a Y265C mutation in Polbeta, a key polymerase in the BER pathway, is enough to significantly reduce both the number of expansions seen in paternal gametes and the extent of somatic expansion in some tissues

  3. The aberrant DNA replication mediated by the PCNA (show PCNA Antibodies)-DNA pol-b complex induces p53 (show TP53 Antibodies)-dependent neuronal cell death

  4. Y265C POLB mutation leads to several pathologies associated with SLE and short CDR3 regions during VDJ recombination in B cells.

  5. Pol beta deficiency could enable ROS (show ROS1 Antibodies) accumulation.

  6. Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM (show CNTNAP1 Antibodies)) with no effect on mutation specificity, suggesting no direct role in SHM (show CNTNAP1 Antibodies).

  7. Transient OGG1 (show OGG1 Antibodies), APE1 (show APEX1 Antibodies), PARP1 (show PARP1 Antibodies) and Polbeta expression in an Alzheimer's disease mouse model.

  8. Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (show APEX1 Antibodies) and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 (show MBD3 Antibodies) in individual morula embryos.

  9. Overexpression of Pol beta could reduce oxidative damage and protect cells from hydroquinone genotoxicity.

  10. Polbeta could protect cells from apoptosis induced by hydroquinone through decrease of ROS (show ROS1 Antibodies) level and depolarization of mitochondria.

POLB Antigen Profile

Antigen Summary

The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date.

Alternative names and synonyms associated with POLB

  • polymerase (DNA directed), beta (polb) antibody
  • polymerase (DNA directed), beta (POLB) antibody
  • DNA polymerase X family protein (polB) antibody
  • DNA polymerase beta-like (LOC100526021) antibody
  • polymerase (DNA directed), beta (Polb) antibody
  • A430088C08Rik antibody
  • DDBDRAFT_0186152 antibody
  • DDBDRAFT_0215784 antibody
  • DDBDRAFT_0232376 antibody
  • DDB_0186152 antibody
  • DDB_0215784 antibody
  • DDB_0232376 antibody
  • POLB antibody
  • wu:fa97a05 antibody
  • zgc:109924 antibody

Protein level used designations for POLB

DNA-directed DNA polymerase beta , DNA polymerase beta , polymerase (DNA directed), beta , DNA polymerase beta-like , DNA pol beta , DNA polymerase beta subunit , mutant DNA polymerase beta , Pol beta , polymerase-beta

448741 Xenopus (Silurana) tropicalis
554204 Danio rerio
704801 Macaca mulatta
737210 Pan troglodytes
8624738 Dictyostelium discoideum AX4
100348691 Oryctolagus cuniculus
100393825 Callithrix jacchus
100441812 Pongo abelii
100526021 Sus scrofa
5423 Homo sapiens
614688 Bos taurus
397973 Xenopus laevis
18970 Mus musculus
29240 Rattus norvegicus
426794 Gallus gallus
494001 Canis lupus familiaris
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