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anti-Human POLB Antibodies:
anti-Mouse (Murine) POLB Antibodies:
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Cow (Bovine) Monoclonal POLB Primary Antibody for IHC (p), IP - ABIN153073
Fotiadou, Henegariu, Sweasy: DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line. in Cancer research 2004
Show all 6 references for 153073
Human Polyclonal POLB Primary Antibody for IHC (p), IHC - ABIN407651
Dutto, Sukhanova, Tillhon, Cazzalini, Stivala, Scovassi, Lavrik, Prosperi: p21CDKN1A Regulates the Binding of Poly(ADP-Ribose) Polymerase-1 to DNA Repair Intermediates. in PLoS ONE 2016
Show all 4 references for 407651
Human Monoclonal POLB Primary Antibody for IHC (p), WB - ABIN115052
Husain, Morton, Beard, Singhal, Prasad, Wilson, Besterman: Specific inhibition of DNA polymerase beta by its 14 kDa domain: role of single- and double-stranded DNA binding and 5'-phosphate recognition. in Nucleic acids research 1995
Show all 2 references for 115052
Mouse (Murine) Polyclonal POLB Primary Antibody for IHC, WB - ABIN3022385
Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. in Cell cycle (Georgetown, Tex.) 2015
Cow (Bovine) Polyclonal POLB Primary Antibody for IHC, WB - ABIN2786683
Batra, Beard, Shock, Pedersen, Wilson: Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. in Molecular cell 2008
DNA polymerase beta is sensitive to Mn2+ and Mg2 (show MCOLN1 Antibodies)+ and its optimumal pH is 9.
In brief, the major differences in BER performed by early stage embryos and adults are the absence of DNA polymerase-beta, leading to predominance of replicative polymerases, in early stage embryos.
High DNA polymerase beta mRNA expression is associated with Graves' thyroid tissue.
Polbeta was shown to inhibit the 3'->5' exonuclease (show EXOSC10 Antibodies) activity of APE1 (show APEX1 Antibodies) when both enzymes were added simultaneously and to insert the correct nucleotide into the gap arising after hydrolysis of AP site clustered with the benzo[a]pyrene adducts.
Remote mutations induce functional changes in active site residues of human DNA polymerase beta.
It has been concluded based on calculations and the experimental pH profile that the most likely path for the wild-type (WT) and the D256E and D256A mutants is a proton transfer (PT) to the bulk, although the WT may also use a PT to Asp (show ASIP Antibodies) 256.
The homozygous/heterozygous genotypes containing the African allele showed higher POLB expression than the homozygous white allele genotype (P < .001). A replication study using a GEO data set validated all 5 eQTLs and also showed a statistically significant difference in POLB expression based on genetic ancestry (P = .002).
HMGB1 (show HMGB1 Antibodies) stimulates activity of DNA polymerase beta on nucleosome substrates in the process of base excision repair.
The results help to define the tolerance of DNA Pol beta to subtle local structural and functional alterations derived from lysine 72.
PolB is ubiquitylated on amino-acid residues K206 and K244 when not in a complex with XRCC1 (show XRCC1 Antibodies).
Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.
a substitution mutation, R152C, impairs Pol beta polymerase activity and DNA base excision repair efficiency.
pol beta plays an important role in bypassing a 5',8-cyclo-dA during DNA replication and repair.
we show here that heterozygosity for a Y265C mutation in Polbeta, a key polymerase in the BER pathway, is enough to significantly reduce both the number of expansions seen in paternal gametes and the extent of somatic expansion in some tissues
The aberrant DNA replication mediated by the PCNA (show PCNA Antibodies)-DNA pol-b complex induces p53 (show TP53 Antibodies)-dependent neuronal cell death
Y265C POLB mutation leads to several pathologies associated with SLE and short CDR3 regions during VDJ recombination in B cells.
Pol beta deficiency could enable ROS (show ROS1 Antibodies) accumulation.
Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM (show CNTNAP1 Antibodies)) with no effect on mutation specificity, suggesting no direct role in SHM (show CNTNAP1 Antibodies).
Transient OGG1 (show OGG1 Antibodies), APE1 (show APEX1 Antibodies), PARP1 (show PARP1 Antibodies) and Polbeta expression in an Alzheimer's disease mouse model.
Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (show APEX1 Antibodies) and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 (show MBD3 Antibodies) in individual morula embryos.
Overexpression of Pol beta could reduce oxidative damage and protect cells from hydroquinone genotoxicity.
Polbeta could protect cells from apoptosis induced by hydroquinone through decrease of ROS (show ROS1 Antibodies) level and depolarization of mitochondria.
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date.
DNA-directed DNA polymerase beta
, DNA polymerase beta
, polymerase (DNA directed), beta
, DNA polymerase beta-like
, DNA pol beta
, DNA polymerase beta subunit
, mutant DNA polymerase beta
, Pol beta