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Human Monoclonal POLB Primary Antibody for IHC (p), WB - ABIN115052
Husain, Morton, Beard, Singhal, Prasad, Wilson, Besterman: Specific inhibition of DNA polymerase beta by its 14 kDa domain: role of single- and double-stranded DNA binding and 5'-phosphate recognition. in Nucleic acids research 1995
Show all 2 references for ABIN115052
Human Polyclonal POLB Primary Antibody for WB - ABIN2786683
Batra, Beard, Shock, Pedersen, Wilson: Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. in Molecular cell 2008
Mouse (Murine) Polyclonal POLB Primary Antibody for IHC, WB - ABIN3022385
Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. in Cell cycle (Georgetown, Tex.) 2015
DNA polymerase beta is sensitive to Mn2+ and Mg2 (show MCOLN1 Antibodies)+ and its optimumal pH is 9.
In brief, the major differences in BER performed by early stage embryos and adults are the absence of DNA polymerase-beta, leading to predominance of replicative polymerases, in early stage embryos.
Pol lambda (show POLL Antibodies) can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases.
POLB was pinpointed as a target gene of miR (show MLXIP Antibodies)- 499. Additionally, we identified that miR (show MLXIP Antibodies)-499 can enhance cisplatin's function of inhibiting proliferation and of promoting apoptosis in EC9706 and KYSE30 cell lines.
Since APE1 (show APEX1 Antibodies), XRCC1 (show XRCC1 Antibodies) and POLB proteins operate downstream the same DNA repair pathway to eliminate DNA oxidative damage, their expression above basal levels found in our study could reveal excessive oxidative stress in high-grade bladder tumors.
findings indicate that the IKBKB and POLB SNPs confer no genetic predisposition to SLE risk in this Chinese Han population
The structure of pol beta in binary complex with template 8-oxoG in a base excision repair substrate, is reported.[Dna polymerase beta]
Fen1 (show FEN1 Antibodies) significantly stimulated trinucleotide repeats expansion by Pol beta, but not by the related enzyme Pol lambda (show POLL Antibodies).
Data show that tongue cancer resistance-associated protein 1 (TCRP1) contributes to cisplatin (DDP (show TIMM8A Antibodies)) resistance via the increased expression of DNA polymerase beta subunit (Pol beta) in lung cancer cells.
DNA polymerase beta catalyzes lesion bypass across benzo[a]pyrene-derived DNA adduct in an error prone manner.
HSP90 (show HSP90 Antibodies) regulates DNA repair by interaction between XRCC1 (show XRCC1 Antibodies) and DNA polymerase beta.
The results suggest that POLB gene with T889C mutation in surgically resected primary gastric tissues may be clinically useful for predicting responsiveness to chemotherapy in patients with GC.
pol beta plays an important role in bypassing a 5',8-cyclo-dA during DNA replication and repair.
we show here that heterozygosity for a Y265C mutation in Polbeta, a key polymerase in the BER pathway, is enough to significantly reduce both the number of expansions seen in paternal gametes and the extent of somatic expansion in some tissues
The aberrant DNA replication mediated by the PCNA (show PCNA Antibodies)-DNA pol-b complex induces p53 (show TP53 Antibodies)-dependent neuronal cell death
Y265C POLB mutation leads to several pathologies associated with SLE and short CDR3 regions during VDJ recombination in B cells.
Pol beta deficiency could enable ROS (show ROS1 Antibodies) accumulation.
Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM (show CNTNAP1 Antibodies)) with no effect on mutation specificity, suggesting no direct role in SHM (show CNTNAP1 Antibodies).
Transient OGG1 (show OGG1 Antibodies), APE1 (show APEX1 Antibodies), PARP1 (show PARP1 Antibodies) and Polbeta expression in an Alzheimer's disease mouse model.
Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (show APEX1 Antibodies) and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 (show MBD3 Antibodies) in individual morula embryos.
Overexpression of Pol beta could reduce oxidative damage and protect cells from hydroquinone genotoxicity.
Polbeta could protect cells from apoptosis induced by hydroquinone through decrease of ROS (show ROS1 Antibodies) level and depolarization of mitochondria.
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date.
DNA-directed DNA polymerase beta
, DNA polymerase beta
, polymerase (DNA directed), beta
, DNA polymerase beta-like
, DNA pol beta
, DNA polymerase beta subunit
, mutant DNA polymerase beta
, Pol beta