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POLI Antibodies

(Polymerase (DNA Directed) iota (POLI))
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity).
POLI antibody  (AA 616-715) POLI antibody  (AA 616-715) POLI antibody (AA 616-715) (ABIN564869)

POLI Reactivity: Human ELISA, WB Host: Mouse Monoclonal 8G9 unconjugated

POLI antibody  (N-Term) POLI antibody  (N-Term) POLI antibody (N-Term) (ABIN6264338)

POLI Reactivity: Human, Mouse, Rat ELISA, ICC, IF, IHC, WB Host: Rabbit Polyclonal unconjugated

POLI antibody  (AA 458-711) POLI antibody  (AA 458-711) POLI antibody (AA 458-711) (ABIN7150251)

POLI Reactivity: Human ELISA, IF, IHC Host: Rabbit Polyclonal unconjugated

POLI Antibodies by Reactivity

Find POLI Antibodies for a variety of species such as anti-Human POLI, anti-Rat POLI, anti-Mouse POLI. The species listed below are among those available. Click on a link to go to the corresponding products.

POLI Antibodies by Application

Find POLI Antibodies validated for a specific application such as WB, ELISA, IHC, IF (cc). Some of the available applications are listed below. Click on a link to go to the corresponding products.

POLI Antibodies by Host

Find POLI Antibodies with a specific Host. The Host listed below are among those available. Click on a link to go to the corresponding products.

POLI Antibodies by Binding Specificity

Find POLI Antibodies with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

POLI Antibodies by Clonality

Find available monoclonal or polyclonal POLI Antibodies. Click on a link to go to the corresponding products.

POLI Antibodies by Clone

Find POLI Antibodies with a specific Clone. The Clone listed below are among those available. Click on a link to go to the corresponding products.

POLI Antibodies by Conjugate

Find POLI Antibodies with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular POLI Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (3)
  • (5)
Cat. No. ABIN564869
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, ICC, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN6264338
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (2)
Cat. No. ABIN7150251
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, ICC, IF, WB
Validations
  • (2)
Cat. No. ABIN6257132
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, IHC (p), WB
Validations
  • (2)
Cat. No. ABIN1491524
Quantity 100 μL
Datasheet Datasheet

Application WB
Validations
  • (2)
Cat. No. ABIN2784869
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC (p), WB
Validations
  • (2)
Cat. No. ABIN5531016
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN7184828
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Application ELISA, ICC, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
  • (1)
Cat. No. ABIN1714435
Quantity 100 μL
Datasheet Datasheet

Application WB
Validations
  • (1)
Cat. No. ABIN6744961
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN1534839
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN1107000
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7150254
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN7150253
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7150252
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our POLI Antibodies

McIntyre, Sobolewska, Fedorowicz, McLenigan, Macias, Woodgate, Sledziewska-Gojska: "DNA polymerase ι is acetylated in response to SN2 alkylating agents." in: Scientific reports, Vol. 9, Issue 1, pp. 4789, (2019) (PubMed).

Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).

Sekimoto, Oda, Kurashima, Hanaoka, Yamashita: "Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication." in: Molecular and cellular biology, Vol. 35, Issue 4, pp. 699-715, (2015) (PubMed).

Ziv, Zeisel, Mirlas-Neisberg, Swain, Nevo, Ben-Chetrit, Martelli, Rossi, Schiesser, Canman, Carell, Geacintov, Falini, Domany, Livneh: "Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin." in: Nature communications, Vol. 5, pp. 5437, (2014) (PubMed).

Diamant, Hendel, Vered, Carell, Reissner, de Wind, Geacinov, Livneh: "DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity." in: Nucleic acids research, Vol. 40, Issue 1, pp. 170-80, (2011) (PubMed).

Takezawa, Ishimi, Aiba, Yamada: "Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation." in: Journal of nucleic acids, Vol. 2010, pp. 750296, (2010) (PubMed).

Ziv, Geacintov, Nakajima, Yasui, Livneh: "DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 28, pp. 11552-7, (2009) (PubMed).

Wang, Woodgate, McManus, Mead, McCormick, Maher: "Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations." in: Cancer research, Vol. 67, Issue 7, pp. 3018-26, (2007) (PubMed).

Choi, Besaratinia, Lee, Lee, Pfeifer: "The role of DNA polymerase iota in UV mutational spectra." in: Mutation research, Vol. 599, Issue 1-2, pp. 58-65, (2006) (PubMed).

Frank, Tissier, McDonald, Rapi?-Otrin, Zeng, Gearhart, Woodgate: "Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template." in: The EMBO journal, Vol. 20, Issue 11, pp. 2914-22, (2001) (PubMed).

Aliases for POLI Antibodies

DNA polymerase iota (POLI) Antibodies
polymerase (DNA directed) iota (poli) Antibodies
DNA polymerase iota (LOC551219) Antibodies
DNA polymerase iota (AFUA_4G11140) Antibodies
DNA polymerase iota (LOC5568276) Antibodies
polymerase (DNA directed) iota (Pol-iota) Antibodies
polymerase (DNA directed), iota (Poli) Antibodies
DNA polymerase iota (Poli) Antibodies
GB12093 Antibodies
NV16187 Antibodies
poli Antibodies
RAD3OB Antibodies
RAD30B Antibodies
Rad30b Antibodies
wu:fc27h11 Antibodies
zgc:110185 Antibodies
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