Browse our Thymine-DNA Glycosylase Proteins (TDG)

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Thymine-DNA Glycosylase Proteins (TDG)
On are 6 Thymine-DNA Glycosylase (TDG) Proteins from 3 different suppliers available. Additionally we are shipping Thymine-DNA Glycosylase Antibodies (64) and Thymine-DNA Glycosylase Kits (6) and many more products for this protein. A total of 84 Thymine-DNA Glycosylase products are currently listed.
5-MCDG, E130317C12Rik, hTDG, JZA-3, Jza1, MGC82456, MGC89441, wu:fb44b11, zgc:110622
list all proteins Gene Name GeneID UniProt
TDG 21665 P56581
TDG 6996 Q13569
Rat TDG TDG 114521  

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Thymine-DNA Glycosylase Proteins (TDG) by Origin

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Top referenced Thymine-DNA Glycosylase Proteins

  1. Human TDG Protein expressed in Escherichia coli (E. coli) - ABIN1098673 : Um, Harbers, Benecke, Pierrat, Losson, Chambon: Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase. in The Journal of biological chemistry 1998 (PubMed)
    Show all 2 references for 1098673

More Proteins for Thymine-DNA Glycosylase Interaction Partners

Cow (Bovine) Thymine-DNA Glycosylase (TDG) interaction partners

  1. miR (show MYLIP Proteins)-29b targets LPL (show LPL Proteins) and TDG genes and regulates apoptosis and triglyceride production in mammary epithelial cells.

Xenopus laevis Thymine-DNA Glycosylase (TDG) interaction partners

  1. CRL4(Cdt2) targets thymine DNA glycosylase (TDG), a base excision repair enzyme that is involved in DNA demethylation

Pig (Porcine) Thymine-DNA Glycosylase (TDG) interaction partners

  1. TDG gene knockdown could inhibit the differentiation of pig pre-adipocytes and affect the DNA methylation (show HELLS Proteins) levels of certain transcription factors.

Mouse (Murine) Thymine-DNA Glycosylase (TDG) interaction partners

  1. The DNA demethylation marks are dynamically regulated in both in vivo and in vitro aging conditions, which are associated with Tet3 over-expression and Tdg repression.

  2. TDG, as a new coactivator, promotes beta-catenin (show CTNNB1 Proteins)/TCFs transactivation and functionally cooperates with CBP (show CREBBP Proteins) in canonical Wnt (show WNT2 Proteins) signaling.

  3. Embryonic lethality in Tdg (-/-) embryos is due, in part, to the reduction of noradrenaline levels.

  4. data suggest that oxidation of 5-methylcytosine by Tet proteins followed by TDG-mediated base excision of 5-carboxylcytosine constitutes a pathway for active DNA demethylation

  5. Results demonstrate that TDG is required for normal mammalian development and the establishment of proper promoter/enhancer DNA methylation (show HELLS Proteins) patterns that are conducive to transcription during embryogenesis

  6. TDG-dependent DNA repair has evolved to provide epigenetic stability in lineage committed cells

  7. Association of CBP/p300 (show CREBBP Proteins) acetylase and TDG links DNA repair and transcription.

  8. binds SUM0-1; TDGb was also shown to interact with the promyelocytic leukemia protein (PML (show PML Proteins)) in vitro as well as to colocalize with this protein to nuclear bodies in transfected cells

  9. TDG sumoylation promotes intramolecular interactions with amino- and carboxy-terminal SUMO-1 (show SUMO1 Proteins) binding motifs that dramatically alter the biochemical properties and subcellular localization of TDG

  10. Data report the characterization of interactions between Dnmt3b (show DNMT3B Proteins) and both thymine-DNA glycosylase (Tdg) and methyl-CpG binding domain protein 4 (show MBD4 Proteins).

Human Thymine-DNA Glycosylase (TDG) interaction partners

  1. Results indicate how Thymine DNA glycosylase (TDG) employs an adaptable active site to excise a broad variety of nucleobases from DNA.

  2. Results indicate the presence of base excision repair -dependent and base excision repair-independent functions of TDG, which are involved in regulation of cellular DNA damage responses and gene expression patterns.

  3. findings indicate that sumoylation and SUMO binding are not essential for TDG-mediated excision and repair of 5-carboxylcytosine bases.

  4. Data show that Ras protein regulates inhibitor of growth protein 4 (ING4 (show ING4 Proteins))-thymine-DNA glycosylase (TDG)-Fas (show FAS Proteins) protein axis to promote apoptosis resistance in pancreatic cancer.

  5. A long TA repeat in the promoter region of IL28B (show IL28B Proteins) was associated with spontaneous HCV clearance.

  6. NEIL1 (show NEIL1 Proteins) and NEIL2 (show NEIL2 Proteins) cooperate with TDG during base excision: TDG occupies the abasic site and is displaced by NEILs, which further process the baseless sugar, thereby stimulating TDG-substrate turnover.

  7. Computational modeling study investigated the glycosidic bond cleavage reaction in human thymine DNA glycosylase

  8. levels of TET3 and TDG mRNAs were independent prognostic factors for early breast cancer patients who received anthracycline chemotherapy

  9. TDG releases the excised base from its tight product complex with abasic DNA, contrary to previous reports. Moreover, DNA-free TDG exhibits no significant binding to free nucleobases (uracil, thymine, 5-hydroxymethyluracil)

  10. these results suggest that individuals harboring the G199S in Thymine DNA glycosylase variant may have increased risk for developing cancer.

Thymine-DNA Glycosylase (TDG) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.

Alternative names and synonyms associated with Thymine-DNA Glycosylase (TDG)

  • thymine-DNA glycosylase (TDG)
  • thymine-DNA glycosylase (tdg)
  • G/t mismatch-specific thymine DNA glycosylase (Smp_149220)
  • G/T mismatch-specific thymine DNA glycosylase (Tsp_05734)
  • thymine DNA glycosylase (Tdg)
  • thymine-DNA glycosylase (Tdg)
  • 5-MCDG protein
  • E130317C12Rik protein
  • hTDG protein
  • JZA-3 protein
  • Jza1 protein
  • MGC82456 protein
  • MGC89441 protein
  • wu:fb44b11 protein
  • zgc:110622 protein

Protein level used designations for Thymine-DNA Glycosylase Proteins (TDG)

G/T mismatch-specific thymine DNA glycosylase , G/T mismatch DNA glycosylase , G/t mismatch-specific thymine DNA glycosylase , thymine-DNA glycosylase , G/T mismatch-specific thymine DNA glycosylase-like , g/T mismatch-specific thymine DNA glycosylase-like , C-JUN leucine zipper interactive protein JZA-3

395510 Gallus gallus
517825 Bos taurus
553789 Danio rerio
8343678 Schistosoma mansoni
10910381 Trichinella spiralis
399413 Xenopus laevis
448432 Xenopus (Silurana) tropicalis
452188 Pan troglodytes
475448 Canis lupus familiaris
700061 Macaca mulatta
100155184 Sus scrofa
100398863 Callithrix jacchus
100452129 Pongo abelii
100598008 Nomascus leucogenys
21665 Mus musculus
6996 Homo sapiens
114521 Rattus norvegicus
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