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TDG Products

(Thymine-DNA Glycosylase (TDG))

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The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008].

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Featured TDG Categories

TDG Antibodies

High quality antibodies with extensive validation data.

TDG ELISA Kits

Reliable ELISA kits for a wide range of species.

TDG Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TDG Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN7153379
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, ICC, IF, WB
Validations
  • (2)
Cat. No. ABIN6258811
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Human, Mouse, Rat
Application IC, IF, WB
Validations
  • (2)
Cat. No. ABIN7299484
Quantity 100 μL
Datasheet Datasheet

Recommended TDG ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959949
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1134027
Quantity 96 tests
Datasheet Datasheet

Recommended TDG Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095891
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134519
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1322425
Quantity 2 μg
Datasheet Datasheet

Latest Publications for our TDG products

Galanos, Pappas, Polyzos, Kotsinas, Svolaki, Giakoumakis, Glytsou, Pateras, Swain, Souliotis, Georgakilas, Geacintov, Scorrano, Lukas, Lukas, Livneh, Lygerou, Chowdhury, Sørensen, Bartek, Gorgoulis: "Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability." in: Genome biology, Vol. 19, Issue 1, pp. 37, (2018) (PubMed).

Lin, Kang, Lu, Wang, Ma, Leung: "A G-quadruplex-selective luminescent probe with an anchor tail for the switch-on detection of thymine DNA glycosylase activity." in: Biosensors & bioelectronics, Vol. 86, pp. 849-57, (2016) (PubMed).

Huang, Lu, Ding, Chu, Hsu, Chen, Tsao, Chen, Lee, Shan, Chen: "TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1." in: Oncogene, Vol. 36, Issue 16, pp. 2202-2214, (2016) (PubMed).

Sassa, Çağlayan, Dyrkheeva, Beard, Wilson: "Base excision repair of tandem modifications in a methylated CpG dinucleotide." in: The Journal of biological chemistry, Vol. 289, Issue 20, pp. 13996-4008, (2014) (PubMed).

Baba, Maita, Jee, Uchimura, Saitoh, Sugasawa, Hanaoka, Tochio, Hiroaki, Shirakawa: "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1." in: Nature, Vol. 435, Issue 7044, pp. 979-82, (2005) (PubMed).

Hardeland, Steinacher, Jiricny, Schär: "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover." in: The EMBO journal, Vol. 21, Issue 6, pp. 1456-64, (2002) (PubMed).

Neddermann, Gallinari, Lettieri, Schmid, Truong, Hsuan, Wiebauer, Jiricny: "Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12767-74, (1996) (PubMed).

Neddermann, Jiricny: "Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1642-6, (1994) (PubMed).

Synonyms and alternative names related to TDG

thymine DNA glycosylase (TDG), thymine DNA glycosylase, tandem duplicate 1 (tdg.1), putative g/t mismatch-specific thymine DNA glycosylase (Smp_149220), G/T mismatch-specific thymine DNA glycosylase (Tsp_05734), thymine DNA glycosylase S homeolog (tdg.S), thymine DNA glycosylase (tdg), thymine DNA glycosylase (Tdg), thymine-DNA glycosylase (Tdg), 5-MCDG, E130317C12Rik, hTDG, JZA-3, Jza1, MGC82456, MGC89441, wu:fb44b11, zgc:110622

Protein level used designations for TDG

  • G/T mismatch-specific thymine DNA glycosylase
  • G/T mismatch DNA glycosylase
  • G/t mismatch-specific thymine DNA glycosylase
  • thymine-DNA glycosylase
  • G/T mismatch-specific thymine DNA glycosylase-like
  • g/T mismatch-specific thymine DNA glycosylase-like
  • C-JUN leucine zipper interactive protein JZA-3
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