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Browse our anti-LCK (LCK) Antibodies

Full name:
anti-Lymphocyte-Specific Protein tyrosine Kinase Antibodies (LCK)
On are 341 Lymphocyte-Specific Protein tyrosine Kinase (LCK) Antibodies from 29 different suppliers available. Additionally we are shipping LCK Kits (18) and LCK Proteins (11) and many more products for this protein. A total of 392 LCK products are currently listed.
Hck-3, LCK, Lck1, Lcktkr, LSK, Lskt, p56, P56LCK, pp58lck, tkl, YT16, zgc:136695

All available anti-LCK Antibodies

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Top referenced anti-LCK Antibodies

  1. Human Polyclonal LCK Primary Antibody for FACS, IF - ABIN392101 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 4 references for ABIN392101

  2. Human Polyclonal LCK Primary Antibody for FACS, IHC (p) - ABIN650741 : Paster, Paar, Eckerstorfer, Jakober, Drbal, Schütz, Sonnleitner, Stockinger: Genetically encoded Förster resonance energy transfer sensors for the conformation of the Src family kinase Lck. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 3 references for ABIN650741

  3. Human Polyclonal LCK Primary Antibody for EIA, IHC (p) - ABIN359986 : Harris, Yang, Stein, Lucy, Brusten, Herath, Parekh, Waterfield, OHare, Neville, Page, Zvelebil: Cluster analysis of an extensive human breast cancer cell line protein expression map database. in Proteomics 2002 (PubMed)
    Show all 2 references for ABIN359986

  4. Human Polyclonal LCK Primary Antibody for WB - ABIN196860 : Heck, Friedrich, Gack, Lengenfelder, Schmidt, Müller-Fleckenstein, Fleckenstein, Ensser, Biesinger: Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs. in Journal of virology 2006 (PubMed)
    Show all 2 references for ABIN196860

  5. Human Polyclonal LCK Primary Antibody for ELISA, WB - ABIN1533129 : Rouer, Van Huynh, Lavareda de Souza, Lang, Fischer, Benarous: Structure of the human lck gene: differences in genomic organisation within src-related genes affect only N-terminal exons. in Gene 1990 (PubMed)

  6. Human Polyclonal LCK Primary Antibody for IP, IHC - ABIN223217 : Feng, Lucchinetti, Enkavi, Wang, Gehrig, Roschitzki, Schaub, Tajkhorshid, Zaugg, Zaugg: Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria. in American journal of physiology. Cell physiology 2010 (PubMed)

  7. Cow (Bovine) Polyclonal LCK Primary Antibody for WB - ABIN2785755 : Merino, Avila-Flores, Shirai, Moraga, Saito, Mérida: Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)

More Antibodies against LCK Interaction Partners

Mouse (Murine) Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

  1. essential for thymic development in presence or absence of Cbl, ensuring MHC restriction of T cells

  2. Lck-Dlx5 (show DLX5 Antibodies) mice develop T-ALLs that consistently acquire overexpression of Myc (show MYC Antibodies) and activation of Akt (show AKT1 Antibodies).

  3. Lck-CD8 (show CD8A Antibodies) interaction is required for initial CD8 (show CD8A Antibodies) recruitment.

  4. The kinase Itk (show ITK Antibodies) and the adaptor TSAd (show SH2D2A Antibodies) change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.

  5. CD4 (show CD4 Antibodies) is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase (show YES1 Antibodies) p56lck

  6. Study concludes that the intracellular state of Lck Study conclude that the intracellular state of Lck determines the specificity of thymic selection and that Lck association with coreceptor proteins during thymic selection is the mechanism by which MHC restriction is imposed on a randomly generated alphabetaTCR repertoire.

  7. LCK could be considered a target attenuated by the anti-aging effects of CR. Integrative analysis of cDNA microarray and interactome data are powerful tools for identifying target molecules that are involved in the aging process and modulated by CR.

  8. Mechanistically, poly-G oligonucleotides directly induce the phosphorylation of Lck (an essential element of the T cell-signaling pathway), thereby enhancing production of IL-2 (show IL2 Antibodies) and CD8 (show CD8A Antibodies) T cell proliferation.

  9. Specific pharmacological inhibition and genetic silencing indicated the involvement of Lck in the regulation of neuritic outgrowth.

  10. Data show that activation of both tuned and untuned CD4 (show CD4 Antibodies) single-positive (SP) thymocytes is Lck-dependent.

Human Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

  1. Results demonstrate that Lck represses oxidative phosphorylation through competitive binding with mitochondrial CRIF1 (show GADD45GIP1 Antibodies) in a kinase-independent manner.

  2. introducing bulky side-chains into this patch (GGxxG to GVxxL) impairs the Lck-independent role of CD4 in T cell activation upon TCR engagement of agonist and weak agonist stimulation.

  3. our results support a novel function of nuclear Lck in promoting human leukemic T cell survival through interaction with a tumor suppressor, CRIF1 (show GADD45GIP1 Antibodies)

  4. TSAD (show SH2D2A Antibodies) binds to and co-localizes with Nck (show NCK1 Antibodies). Expression of TSAD (show SH2D2A Antibodies) increases both Nck (show NCK1 Antibodies)-Lck and Nck (show NCK1 Antibodies)-SLP-76 (show LCP2 Antibodies) interaction in T cells.

  5. These findings demonstrate highly dynamic Lck palmitoylation kinetics that are essential for signaling downstream of the Fas receptor (show FAS Antibodies).

  6. Cells from PAX5 (show PAX5 Antibodies) translocated patients show LCK up-regulation and over-activation, as well as STAT5 (show STAT5A Antibodies) hyper-phosphorylation, compared to PAX5 (show PAX5 Antibodies) wt and PAX5 (show PAX5 Antibodies) deleted cases.

  7. T cell receptor (TCR)-CD3 (show CD3 Antibodies) complex and the Lck kinase were required for Ca(2 (show CA2 Antibodies)+) mobilization but not for apoptosis induction in Jurkat cells.

  8. In T-cells, cholesterol-dependent domains function in the regulation of the Src (show SRC Antibodies) family kinase Lck (p56lck) by sequestering Lck from its activator CD45 (show PTPRC Antibodies). (Review)

  9. The kinase Itk (show ITK Antibodies) and the adaptor TSAd (show SH2D2A Antibodies) change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.

  10. Phosphatase CD45 (show PTPRC Antibodies) both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters, depending on LCK activity.

Pig (Porcine) Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

  1. LCK gene could be an useful candidate gene in selection for increasing litter size in pigs.

LCK Antigen Profile

Antigen Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.

Alternative names and synonyms associated with LCK

  • lymphocyte-specific protein tyrosine kinase (lck) antibody
  • lymphocyte-specific protein tyrosine kinase (LCK) antibody
  • lymphocyte-specific protein tyrosine kinase (LOC100349102) antibody
  • lymphocyte protein tyrosine kinase (Lck) antibody
  • lymphocyte-specific protein tyrosine kinase (Lck) antibody
  • Hck-3 antibody
  • LCK antibody
  • Lck1 antibody
  • Lcktkr antibody
  • LSK antibody
  • Lskt antibody
  • p56 antibody
  • P56LCK antibody
  • pp58lck antibody
  • tkl antibody
  • YT16 antibody
  • zgc:136695 antibody

Protein level used designations for LCK

lymphocyte protein tyrosine kinase , lymphocyte-specific protein tyrosine kinase , tyrosine-protein kinase Lck-like , leukocyte C-terminal Src kinase , lymphocyte cell-specific protein-tyrosine kinase , proto-oncogene tyrosine-protein kinase LCK , T-lymphocyte specific protein tyrosine kinase p56lck , p56(LSTRA) protein-tyrosine kinase , t cell-specific protein-tyrosine kinase , tyrosine-protein kinase Lck , tyrosine protein kinase , tyrosine-protein kinase LCK , p56-LCK

414333 Danio rerio
456715 Pan troglodytes
100216439 Ovis aries
100349102 Oryctolagus cuniculus
100436326 Pongo abelii
100477981 Ailuropoda melanoleuca
16818 Mus musculus
3932 Homo sapiens
396460 Gallus gallus
313050 Rattus norvegicus
478151 Canis lupus familiaris
100233188 Sus scrofa
508890 Bos taurus
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