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Human PDGFRB ELISA Kit for Sandwich ELISA - ABIN417446
Feng, He, Song, Wang, Simpson, Zhang, Luo, Wu, Huang: Platelet-derived growth factor receptor beta: a novel urinary biomarker for recurrence of non-muscle-invasive bladder cancer. in PLoS ONE 2014
Rat (Rattus) PDGFRB ELISA Kit for Sandwich ELISA - ABIN432487
Salva, Turan, Akbuğa: Inhibition of Glomerular Mesangial Cell Proliferation by siPDGF-B- and siPDGFR-β-Containing Chitosan Nanoplexes. in AAPS PharmSciTech 2016
The data of this study revealed an acute accumulation of PDGFRbeta+ BBB (show ALMS1 ELISA Kits)-related cells in degenerating brain areas, which can be long lasting, suggesting an active role for PDGFRbeta-signaling in blood vessel and post-injury tissue recovery.
Ltbp4 (show LTBP4 ELISA Kits) regulates Pdgfrb expression via TGFbeta (show TGFB1 ELISA Kits)-dependent modulation of Nrf2 (show NFE2L2 ELISA Kits) transcription factor function.
The results provide functional evidence that elevated PDGFRbeta signaling causes tissue wasting or overgrowth reminiscent of human genetic syndromes and that the STAT1 (show STAT1 ELISA Kits) pathway is a crucial modulator of this phenotypic spectrum.
Identify PDGFRbeta as a driver in activating Akt (show AKT1 ELISA Kits)/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.
Data show that three platelet-derived growth factor receptor beta (PDGFRB) mutants (R561C, P660T and N666K) were able to transform NIH3T3 and Ba/F3 cells to different extents.
data therefore collectively suggest that upon TGFbeta (show TGFB1 ELISA Kits) stimulation, SP1 (show SP1 ELISA Kits) recruits SMAD2 (show SMAD2 ELISA Kits) to the promoter of Pdgfrb to up-regulate its expression and thus Pdgfrb is a direct downstream target of the TGFbeta (show TGFB1 ELISA Kits)/SMAD2 (show SMAD2 ELISA Kits) signaling
PdgfrbetaF7/F7 mice between 4-6 and 36-48 weeks of age developed a region-dependent loss in pericyte coverage (22-46, 24-44 and 4-31%) and cell numbers (36-49, 34-64 and 11-36%), reduction in capillary length (20-39, 13-46 and 1-30%), and an increase in extravascular fibrinogen-derived deposits (3.4-5.2, 2.8-4.1 and 0-3.6-fold) demonstrating BBB (show ALMS1 ELISA Kits) breakdown in the cortex, hippocampus and thalamus, respectively.
PDGF-B (show PDGFB ELISA Kits)-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.
there is great possibility that EPCs overexpressing PDGFR-beta enhanc VSMC apoptosis and suppress VSMC migration by competitive consumption of PDGF (show PDGFA ELISA Kits)-BB in the early phase after carotid artery injury in mice.
PDGFRalpha and PDGFRbeta are coexpressed in the craniofacial mesenchyme of mid-gestation mouse embryos and that ablation of Pdgfrb in the neural crest lineage results in increased nasal septum width, delayed palatal shelf development, and subepidermal blebbing.
Perivascular PDGFR-alpha (show PDGFRA ELISA Kits) and -beta were identified as independent markers predicting survival in metastatic colorectal cancer (mCRC).
Genetic analyses indicated a platelet derived growth factor receptor beta (PDGFRB) gene missense heterozygous germline mutation in a newborn boy, and his sister suffered from skull base tumor with same genotype and histology.
Here we report on a special case of a Ph-like acute lymphoblastic leukemia patient who had a variant ATF7IP (show ATF7IP ELISA Kits)/PDGFRB fusion. In this case, a variant fusion was created between ATF7IP (show ATF7IP ELISA Kits) exon 9 (instead of exon 13) and PDGFRB exon 11, resulting in the loss of 411 nucleotides and 137 amino acids in the ATF7IP (show ATF7IP ELISA Kits)/PDGFRB fusion cDNA and its encoded chimeric protein, respectively.
Data show that MLLT11/AF1q (show MLLT11 ELISA Kits)-induced PDGFR signaling enhanced STAT3 (show STAT3 ELISA Kits) activity through Src kinase (show CSK ELISA Kits) activation.
In conclusion, a specific class of mutations in PDGFRB causes a clinically recognizable syndromic form of skeletal overgrowth.
Suggest the association of activation of Akt (show AKT1 ELISA Kits)-mTOR (show FRAP1 ELISA Kits) pathway proteins and PDGFR-beta in fibrosarcomatous transformation of dermatofibrosarcoma protuberans.
High PDGFRB expression is associated with gastric cancer.
Authors identified gain-of-function PDGFRB mutations in the majority of multifocal infantile myofibromatosis cases, shedding light on the mechanism of disease development, which is reminiscent of multifocal venous malformations induced by TIE2 (show TEK ELISA Kits) mutations.
findings not only confirm the important role of R853 in establishing the resistant phenotype of the mutant NDEL1 (show NDEL1 ELISA Kits)-PDGFRB, but also underline the potential of protein modelling for prediction of sensitivity and resistance to TKI treatment.
A novel mutation in PDGFRB [NM_002609.3:c.1699A > G, p.Lys567Glu] was identified in infantile myofibromatosis patients.
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor\; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
CD140 antigen-like family member B
, PDGF beta chain
, beta platelet-derived growth factor receptor
, beta-type platelet-derived growth factor receptor
, platelet-derived growth factor receptor 1
, platelet-derived growth factor receptor beta
, platelet-derived growth factor receptor beta variant 1
, Platelet-derived growth factor receptor, beta
, protein tyrosin kinase