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anti-Human Hepcidin Antibodies:
anti-Mouse (Murine) Hepcidin Antibodies:
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Human Polyclonal Hepcidin Primary Antibody for ELISA - ABIN450057
Ward, Roberts, Brookes, Joy, Martin, Ismail, Spychal, Iqbal, Tselepis: Increased hepcidin expression in colorectal carcinogenesis. in World journal of gastroenterology 2008
Human Polyclonal Hepcidin Primary Antibody for WB - ABIN4892228
Bose, Megyesi, Shah, Hiatt, Hall, Karaduta, Swaminathan: Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis. in PLoS ONE 2015
Human Polyclonal Hepcidin Primary Antibody for WB - ABIN2776909
Theurl, Theurl, Seifert, Mair, Nairz, Rumpold, Zoller, Bellmann-Weiler, Niederegger, Talasz, Weiss: Autocrine formation of hepcidin induces iron retention in human monocytes. in Blood 2008
The bone morphogenetic protein (BMP) pathway regulates expression of hepcidin through transcriptional activation via BMP-responsive elements (REs) 1 and 2 on the promoter. A search for GC-rich sequences on the hepcidin promoter indicated 13 regions across the distal (A to F), middle (G to I), and proximal (J to M) areas.
Of the non-HFE (show HFE Antibodies) forms of iron overload, TFR2 (show TFR2 Antibodies)-, HFE2 (show HFE2 Antibodies)-, and HAMP-related forms are predicted to be rare, with pathogenic allele frequencies in the range of 0.00007 to 0.0005. Significantly, SLC40A1 (show SLC40A1 Antibodies) variants that have been previously associated with autosomal-dominant ferroportin (show SLC40A1 Antibodies) disease were identified in several populations (pathogenic allele frequency 0.0004), being most prevalent among Africans
Data (including data from studies using knockout mice) suggest that MT2 (show MT2 Antibodies)/TMPRSS6 (show TMPRSS6 Antibodies) suppresses hepcidin expression in hepatocytes independently of HJV (show HFE2 Antibodies); MT2 (show MT2 Antibodies)/TMPRSS6 (show TMPRSS6 Antibodies) cleaves ALK2 (show ACRV1 Antibodies), ALK3 (show BMPR1A Antibodies), ACTRIIA (show ACVR2A Antibodies), BMPR2 (show BMPR2 Antibodies), HFE (show HFE Antibodies), and, to a lesser extent, HJV (show HFE2 Antibodies) and TFR2 (show TFR2 Antibodies); thus, MT2 (show MT2 Antibodies)/TMPRSS6 (show TMPRSS6 Antibodies) suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway. (MT2 (show MT2 Antibodies)/TMPRSS6 (show TMPRSS6 Antibodies) = matriptase-2 (show TMPRSS6 Antibodies); HJV (show HFE2 Antibodies) = hemojuvelin (show HFE2 Antibodies))
two unrelated hepatocellular carcinoma patients bore the HAMP:c.-153C>T mutation at the heterozygous state, which is associated with increased risk of iron overload and severe hemochromatosis (show HFE Antibodies)
Hepcidin-25 released from plaque macrophages and other cell surfaces contributed to the plaque instability by inducing endothelial cell death.
Hepcidin plasma levels were increased in patients with early rheumatoid arthritis compared with healthy volunteers.
study followed the dynamics of hepcidin-mediated ferroportin (show SLC40A1 Antibodies) internalization; also showed that the novel p.D84E mutation, associated with the classical form of ferroportin (show SLC40A1 Antibodies) disease, is both iron transport defective and hepcidin insensitive
During regulation of hepcidin synthesis, multiple promoter elements in the HAMP gene respond to variable signaling pathways corresponding to different extracellular situations.
Our findings indicate that the HAMP-P -582A>G polymorphism (rs10421768) is associated with susceptibility to extrapulmonary TB, but not pulmonary TB. CD14 (show NDUFA2 Antibodies)+ monocytes from individuals with the rs10421768 GG genotype secreted significantly less hepcidin in response to M. tuberculosis lipoarabinomannan compared with cells from individuals with either the AA or AG genotypes.
Expression of Hepcidin and Ferroportin (show SLC40A1 Antibodies) in the Placenta, and Ferritin (show FTL Antibodies) and Transferrin Receptor 1 (show TFR Antibodies) Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes
downregulation of hepcidin by siRNA increased iron uptake in bone and liver, which aggravated unloading-induced bone loss.
These data suggest that, in Hjv (show HFE2 Antibodies)(-/-) females, Bmp6 (show BMP6 Antibodies) can provide a signal adequate to maintain hepcidin to a level sufficient to avoid extrahepatic iron loading.
The authors generated mice with cardiomyocyte-specific deletion of hepcidin, or knock-in of hepcidin-resistant ferroportin (show SLC40A1 Antibodies). They find that while both models maintain normal systemic iron homeostasis, the mice nonetheless develop fatal contractile and metabolic dysfunction as a consequence of cardiomyocyte iron deficiency.
Erythroferrone and matriptase-2 (show TMPRSS6 Antibodies) independently regulate hepcidin expression.
Acute tacrolimus treatment transiently increases hepcidin in wild-type mice. FKBP12 (show FKBP1A Antibodies) preferentially targets the BMP receptor (show BMPR1A Antibodies) ALK2 (show ACRV1 Antibodies). ALK2 (show ACRV1 Antibodies) mutants defective in binding FKBP12 (show FKBP1A Antibodies) increase hepcidin expression in a ligand-independent manner, through BMP-SMAD (show SMAD1 Antibodies) signaling.
Hamp1 mRNA and plasma hepcidin levels are not good predictors of tissue iron levels, at least in males
The lack of effect of erythropoietin (show EPO Antibodies) on hepcidin expression in mask mice can not be explained by changes in erythroferrone synthesis, as splenic erythroferrone content increased after erythropoietin (show EPO Antibodies) administration in both C57BL/6 and mask mice.
these results characterise a new model of rapidly inducible hepcidin disruption, and demonstrate the critical contribution of hepcidin to the hypoferraemia of inflammation
Hepatic gene expression of hepcidin is regulated in beta-thalassemia by ATOH8 (show ATOH8 Antibodies).
Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin (show Tf Antibodies)-bound iron.
This study shows that hepcidin knockdown in zebrafish using morpholinos leads to iron overload.
The data also show that the antibacterial activity of hepcidin-2 depends upon the disulfide bridges.
data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hemojuvelin (show HFE2 Antibodies).
Hepcidin expression is regulated by a transferrin-a (show Tf Antibodies)-dependent pathway in the zebrafish embryo.
this study demonstrates that urine hepcidin-25 concentrations strongly correlate with hepatic hepcidin mRNA abundance, plasma hepcidin-25 levels, iron transferrin (show Tf Antibodies) saturation and non-heme liver iron levels.
Data suugest that hepcidin might had antiinflammatory function and is a candidate regulator of the cross-talk between iron regulation and inflammation.
report the full-length cDNA sequences of porcine hepcidin and liver-expressed antimicrobial peptide-2 (LEAP-2 (show LEAP2 Antibodies))
Hepcidin peptide is up-regulated by iron and bacterial components in the trout liver.
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
, liver-expressed antimicrobial peptide 1
, putative liver tumor regressor
, hepcidin antimicrobial peptide 1
, hepcidin antimicrobial peptide
, antimicrobial peptide
, iron regulatory peptide
, preprohepcidin 1
, antimicrobial peptide hepcidin
, putative hepcidin antibacterial peptide