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anti-Human Hepcidin Antibodies:
anti-Mouse (Murine) Hepcidin Antibodies:
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Human Polyclonal Hepcidin Primary Antibody for WB - ABIN4892228
Bose, Megyesi, Shah, Hiatt, Hall, Karaduta, Swaminathan: Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis. in PLoS ONE 2015
Human Polyclonal Hepcidin Primary Antibody for ELISA - ABIN450057
Ward, Roberts, Brookes, Joy, Martin, Ismail, Spychal, Iqbal, Tselepis: Increased hepcidin expression in colorectal carcinogenesis. in World journal of gastroenterology 2008
Human Polyclonal Hepcidin Primary Antibody for WB - ABIN2776909
Theurl, Theurl, Seifert, Mair, Nairz, Rumpold, Zoller, Bellmann-Weiler, Niederegger, Talasz, Weiss: Autocrine formation of hepcidin induces iron retention in human monocytes. in Blood 2008
This study shows that hepcidin knockdown in zebrafish using morpholinos leads to iron overload.
The data also show that the antibacterial activity of hepcidin-2 depends upon the disulfide bridges.
data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hemojuvelin (show HFE2 Antibodies).
Hepcidin expression is regulated by a transferrin-a (show Tf Antibodies)-dependent pathway in the zebrafish embryo.
During regulation of hepcidin synthesis, multiple promoter elements in the HAMP gene respond to variable signaling pathways corresponding to different extracellular situations.
Our findings indicate that the HAMP-P -582A>G polymorphism (rs10421768) is associated with susceptibility to extrapulmonary TB, but not pulmonary TB. CD14 (show NDUFA2 Antibodies)+ monocytes from individuals with the rs10421768 GG genotype secreted significantly less hepcidin in response to M. tuberculosis lipoarabinomannan compared with cells from individuals with either the AA or AG genotypes.
Expression of Hepcidin and Ferroportin (show SLC40A1 Antibodies) in the Placenta, and Ferritin (show FTL Antibodies) and Transferrin Receptor 1 (show TFR Antibodies) Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes
this study shows that hepcidin is involved in the pathogenesis of sepsis-induced acute kidney injury
The hepcidin plays a role in the pathogenesis and progression of kidney injury via modulation of iron-mediated oxidant injury.
The levels of hepcidin were higher, while those of iron, transferrin (show Tf Antibodies), and sTfR (show TFRC Antibodies) were lower in children with cardiometabolic risk factors.
Main pathways of systemic and genetic regulation of hepcidin, as well as its influence on the disorders related to iron metabolism. Review.
Data suggest hepcidin is the master regulator of systemic iron homeostasis; hepcidin levels are suppressed when erythropoiesis is stimulated; the erythroid-derived hormone erythroferrone appears to be a convincing candidate for link between increased erythropoiesis and hepcidin suppression. [REVIEW]
Data suggest that proinflammatory cytokine interleukin-1beta (IL1B (show IL1B Antibodies)) up-regulates hepcidin expression in hepatocytes; inflammation induces IL1B (show IL1B Antibodies) production in Kupffer cells and hepatocytes; IL1B (show IL1B Antibodies) up-regulates CEBPD (CCAAT/enhancer binding protein delta (show CEBPD Antibodies)) expression in hepatocytes; up-regulation of CEBPD (show CEBPD Antibodies) expression up-regulates hepcidin transcription.
modification of HS structure mediated by heparanase (show HPSE Antibodies) overexpression affects hepcidin expression and iron homeostasis
these results characterise a new model of rapidly inducible hepcidin disruption, and demonstrate the critical contribution of hepcidin to the hypoferraemia of inflammation
Hepatic gene expression of hepcidin is regulated in beta-thalassemia by ATOH8 (show ATOH8 Antibodies).
Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin (show Tf Antibodies)-bound iron.
The data demonstrate that endothelial cells are the predominant source of BMP6 (show BMP6 Antibodies) in the liver and support a model in which endothelial cells BMP6 (show BMP6 Antibodies) has paracrine actions on hepatocyte hemojuvelin (show HFE2 Antibodies) to regulate hepcidin transcription and maintain systemic iron homeostasis.
Smad1 (show SMAD1 Antibodies) and Smad5 (show SMAD5 Antibodies) have overlapping functions to govern hepcidin transcription. Moreover, erythropoietin (show EPO Antibodies) and erythroferrone target Smad1 (show SMAD1 Antibodies)/5 signaling and require Smad1 (show SMAD1 Antibodies)/5 to suppress hepcidin expression.
Genetic inactivation of hepatic angiocrine Bmp2 (show BMP2 Antibodies) signaling in Stab2 (show STAB2 Antibodies)-Cre mice caused massive iron overload in the liver and increased serum iron levels and iron deposition in several organs similar to classic hereditary hemochromatosis (show HFE Antibodies); these changes were mediated by decreased hepatic expression of hepcidin, a key regulator of iron homeostasis.
These studies indicate that drug-like minihepcidins have a potential as future therapeutics for untransfused beta-thalassemia and polycythemia vera (show IGF2BP3 Antibodies).
the function of matriptase-2 (show TMPRSS6 Antibodies) is dominant over that of ERFE and is essential in facilitating hepcidin suppression by attenuating the BMP-SMAD (show SMAD1 Antibodies) signaling.
hepcidin induction by endoplasmic reticulum stress involves the central SMAD1 (show SMAD1 Antibodies)/5/8 pathway
Increased hepcidin in transferrin (show Tf Antibodies)-treated thalassemic mice correlates with increased liver BMP2 (show BMP2 Antibodies) expression and decreased hepatocyte ERK (show EPHB2 Antibodies) activation.
this study demonstrates that urine hepcidin-25 concentrations strongly correlate with hepatic hepcidin mRNA abundance, plasma hepcidin-25 levels, iron transferrin (show Tf Antibodies) saturation and non-heme liver iron levels.
Data suugest that hepcidin might had antiinflammatory function and is a candidate regulator of the cross-talk between iron regulation and inflammation.
report the full-length cDNA sequences of porcine hepcidin and liver-expressed antimicrobial peptide-2 (LEAP-2 (show LEAP2 Antibodies))
Hepcidin peptide is up-regulated by iron and bacterial components in the trout liver.
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
hepcidin antimicrobial peptide
, antimicrobial peptide
, iron regulatory peptide
, preprohepcidin 1
, liver-expressed antimicrobial peptide 1
, putative liver tumor regressor
, hepcidin antimicrobial peptide 1
, antimicrobial peptide hepcidin
, putative hepcidin antibacterial peptide