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Human NPPB Protein expressed in Wheat germ - ABIN1312892
Shaw, Fildes, Pucha?ka, Basith, Yonan, Williams: BNP directly immunoregulates the innate immune system of cardiac transplant recipients in vitro. in Transplant immunology 2008
CNP and BNP serve as oocyte maturation inhibitor to inhibit oocyte maturation in mammals
ANP and BNP gene expression differs considerably between cardiac chambers in the first 72 hours of life in healthy piglets, resembling the transition from fetal to neonate circulation. The cardiac gene expression does not explain plasma concentrations.
Up-regulation of BNP and a reduction in a ratio of sarcoplasmic reticulum calcium ATPase 2a in failing myocardium are observed in a porcine model of tachycardia.
Data show that all five molecules, BNP, ICAM-1 (show ICAM1 Proteins), TNF-alpha (show TNF Proteins), VCAM-1 (show VCAM1 Proteins) and IL-6 (show IL6 Proteins), quickly and reliably signaled adverse interactions.
identification and characterization of a novel alternatively spliced variant of porcine and human NPPB (show BNP Proteins) resulting from exon 2 skipping
Arial natriuretic factor (ANF (show HESX1 Proteins)) and N-terminal proANF may be better suited than brain natriuretic peptide (show BNP Proteins) as markers of cardiac preload during the development and treatment of acute heart failure.
Regional differences in BNP and CNP (show NPPC Proteins) expression were observed in myocardium with sustained left ventricular dyssynchronous contraction.
BNP gene body hypermethylation is associated with the risk of rheumatic heart disease (RHD), and also influenced by the warfarin anticoagulant therapy of RHD patients after surgery, which could represent novel and promising targets for therapeutic development.
IL-6 receptor blockade has an effect on high-sensitivity troponin T and NT-proBNP in rheumatoid arthritis
An exercise-associated increase in hs-cTnT and NT-proBNP occurred in response to a 60-minute maximal swimming test that was independent of pubertal status/adolescent vs adults. The present data also suggests that baseline and postexercise hs-cTnT values are higher in male compared with female, with no sex differences in NT-proBNP values.
Brain Natriuretic Peptide (show BNP Proteins) levels increased as heart failure duration increased.
NT-proBNP and BNP levels were statistically higher in patients with heart failure and anemia compared to patients with heart failure and without anemia.
The rs198389 G allele in the NPPB (show BNP Proteins) promoter is associated with elevated levels of NT-proBNP throughout adult life, reduced blood pressure, hypertension and cardiovascular mortality, and increased lifespan.
Combination of high serum BNP levels, along with high soluble AXL had greater predictive value for heart failure than BNP alone.
Acute treatment of type 2 diabetics with a DPP-4 inhibitor exerts no clinically-meaningful effects on BNP and NT-proBNP levels.
Review of reference values of BNP in infants and children and values found in various heart diseases, including the role of BNP levels in diagnosing pediatric heart diseases.
In cancer patients, as well as colon cancer model mice, the plasma BNP levels were elevated, possibly due to cancer-related inflammation. The effect of cancer on the BNP levels should be considered when using BNP as an indicator of heart failure in cancer patients
Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A (show NPR1 Proteins) pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.
we have validated a novel gene, Myh14, as a negative regulator of ISO-induced left ventricular mass hypertrophy in an in vivo mouse model and demonstrated the up-regulation of immediate early gene Myc, fetal gene Nppb, and fibrosis gene Lgals3 in ISO-treated Myh14 deficient hearts compared to controls.
P2X3 (show P2RX3 Proteins) receptors on mouse trigeminal ganglion neurons are subjected to contrasting modulation by inhibitory brain natriuretic peptide (show BNP Proteins) and facilitatory calcitonin gene-related peptide (show CALCA Proteins) that both operate via complex intracellular signaling.
mouse trigeminal neurons endogenous BNP acts on NPR-A (show NPR1 Proteins) receptors to determine constitutive depression of P2X3 (show P2RX3 Proteins) receptor function. Tonic inhibition of P2X3 (show P2RX3 Proteins) receptor activity by BNP/NPR-A (show NPR1 Proteins)/PKG (show PRKG1 Proteins) pathways occurs via two distinct mechanisms: P2X3 (show P2RX3 Proteins) serine phosphorylation and receptor redistribution to non-raft membrane compartments
The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP.
Data (including data from studies in knockout mice) suggest expression of ANP (show NPPA Proteins)/BNP/GC-A (show GUCA1A Proteins) (atrial natriuretic peptide (show NPPA Proteins), brain natriuretic peptide (show BNP Proteins), and guanylyl cyclase-A (show NPR1 Proteins)) is important in embryonic neovascularization and organogenesis.
Goalpha plays a role in ANF sorting during intracellular vectorial transport and with the presence of a mechanism that preserves the molar relationship between cellular ANF and BNP.
The RNA-Seq demonstrates that NPPB (show BNP Proteins) which well activates natriuretic peptide receptor 1 (NPR1 (show NPR1 Proteins)), is well expressed in mouse dorsal root ganglian.
a slow modulatory action by BNP on TRPV1 (show TRPV1 Proteins) and P2X3 (show P2RX3 Proteins) receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli
Natriuretic peptides buffer renin (show REN Proteins)-dependent hypertension.
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
gamma-brain natriuretic peptide
, natriuretic peptides B
, brain type natriuretic peptide
, natriuretic peptide precursor B
, natriuretic protein
, brain natriuretic peptide
, Brain natriuretic factor
, natriuretic peptide precursor type B
, Gamma-brain natriuretic peptide