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Children carrying the T allele of the MBOAT7 polymorphism had higher plasma alanine aminotransferase than the noncarriers; children with the MBOAT7, PNPLA3, and TM6SF2 variants had the highest plasma ALT
MBOAT7 polymorphism contributes to hepatic inflammation and liver fibrosis in patients with chronic hepatitis B.
Fibrosis stages were affected by the PNPLA3 (show PNPLA3 Proteins) (P = 0.042) and MBOAT7 (P = 0.021) but not by the TM6SF2 polymorphism (P > 0.05). The PNPLA3 (show PNPLA3 Proteins), TM6SF2, and MBOAT7 variants are associated with increased liver injury. The TM6SF2 variant seems to modulate predominantly hepatic fat accumulation, whereas the MBOAT7 polymorphism is linked to fibrosis. The PNPLA3 (show PNPLA3 Proteins) polymorphism confers risk of both increased steatosis and fibrosis
identification of six consanguineous families harboring homozygous inactivating variants in MBOAT7, encoding lysophosphatidylinositol acyltransferase (LPIAT1); subjects presented with intellectual disability frequently accompanied by epilepsy and autistic features
Report an association between the MBOAT7 rs641738 variant and the development and severity of NAFLD in individuals of European descent.
Variants in the MBOAT7 gene is associated with alcohol-related cirrhosis.
ssSPTa is identified as an LPIAT1-interacting protein.
MBOAT5 (show LPCAT3 Proteins) and MBOAT7 in arachidonate recycling, thus regulating free arachidonic acid levels and leukotriene synthesis in neutrophils
LENG4 is located in the leukocyte receptor cluster on chromosome 19.
describes the cloning of human MBOAT7
These results suggest that LPEAT1/MBOAT1 (show MBOAT1 Proteins) plays an important role in neurite outgrowth and function.
Data show that lysophosphatidylinositol acyltransferase 1 (LPIAT1, also known as MBOAT7) plays a crucial role in brain development in mice.
Congenital hydrocephalus (show FOXC1 Proteins) in Mboat 7 null mice
Knockdown of class III PI 3 (show PI3 Proteins)-kinase causes growth defects in mboa-7 mutants.
mboa-7 encodes a member of the membrane-bound O-acyltransferase family, suggesting that mboa-7 is lysoPI acyltransferase.
This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants.
, LPLAT 7
, bladder and breast carcinoma-overexpressed gene 1 protein
, leukocyte receptor cluster (LRC) member 4
, lyso-PI acyltransferase
, lysophosphatidylinositol acyltransferase
, lysophospholipid acyltransferase 7
, malignant cell expression-enhanced gene/tumor progression-enhanced
, O-acyltransferase domain-containing protein 7
, leukocyte receptor cluster member 4
, membrane-bound O-acyltransferase domain-containing protein 7