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anti-Human SMAD7 Antibodies:
anti-Mouse (Murine) SMAD7 Antibodies:
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Human Polyclonal SMAD7 Primary Antibody for IHC, IHC (p) - ABIN4354717
Roman-Blas, Stokes, Jimenez: Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes. in Osteoarthritis and cartilage 2007
Show all 9 Pubmed References
Human Polyclonal SMAD7 Primary Antibody for WB - ABIN4354712
Kleiter, Pedré, Mueller, Poeschl, Couillard-Despres, Spruss, Bogdahn, Giegerich, Steinbrecher: Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis. in Journal of neuroimmunology 2007
Show all 4 Pubmed References
Human Polyclonal SMAD7 Primary Antibody for IHC (p), WB - ABIN3044025
Tao, Hu, Li, Liu, Wu, Li, Fu, Wei, Luo: Tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor ?/Smad pathways. in Transplantation proceedings 2011
Show all 3 Pubmed References
Human Monoclonal SMAD7 Primary Antibody for IHC (p), ELISA - ABIN517666
Chen, Yang, Huang, Hsue, Lin et al.: Aberrant expression in multiple components of the transforming growth factor-?1-induced Smad signaling pathway during 7,12-dimethylbenz[a]anthracene-induced hamster buccal-pouch squamous-cell ... in Oral oncology 2011
Show all 2 Pubmed References
Cow (Bovine) Polyclonal SMAD7 Primary Antibody for WB - ABIN2779418
Briones-Orta, Sosa-Garrocho, Moreno-Alvarez, Fonseca-Sánchez, Macías-Silva: SnoN co-repressor binds and represses smad7 gene promoter. in Biochemical and biophysical research communications 2006
Smad7 regulates TGF-beta1 (show TGFB1 Antibodies) signaling via a negative feedback loop and mediates the interaction between TGF-beta1 (show TGFB1 Antibodies) and other signaling pathways; suggesting that Smad7 over expression may have therapeutic potential in ALL.
Missense variant in smad7 gene is associated with colorectal cancer.
ASPP2 (show TP53BP2 Antibodies) suppresses invasion, peritoneal dissemination and TGF-beta1 (show TGFB1 Antibodies)-induced EMT (show ITK Antibodies) by inhibiting Smad7 degradation mediated by ITCH in gastric cancer cells.
Transforming Growth Factor beta inhibitor peptide P144 (show TCERG1 Antibodies) downregulates SKI (show SKI Antibodies) and an upregulates SMAD7 at both transcriptional and translational levels in glioblastoma cell lines.
The inverse correlation between Smad7 and AhR (show AHR Antibodies) expression helps to propagate inflammatory signals in the gut (show GUSB Antibodies) in Crohn's disease.
RNF11 (show RNF11 Antibodies) sequestration of the E3 ligase SMURF2 (show SMURF2 Antibodies) on membranes antagonizes SMAD7 down-regulation of transforming growth factor beta signaling
NR2F2 (show NR2F1 Antibodies) could promote TGF-beta (show TGFB1 Antibodies)-induced epithelial-mesenchymal transition of colorectal carcinoma cells and inhibit Smad7 expression via transactivation of miR (show MLXIP Antibodies)-21.
this study shows that in refractory celiac disease, high Smad7 associates with defective TGF-beta1 (show TGFB1 Antibodies) signaling and sustains inflammatory cytokine production
miR (show MLXIP Antibodies)-590-5p promotes osteoblast differentiation by indirectly protecting and stabilizing the Runx2 (show RUNX2 Antibodies) protein by targeting Smad7 gene expression.
the findings show that TIEG1 (show KLF10 Antibodies) is highly expressed in human keloids and that it directly binds and represses Smad7 promoter-mediated activation of TGF-beta (show TGFB1 Antibodies)/Smad2 (show SMAD2 Antibodies) signaling
Smad7 plays a protective role in acute kidney injury by preventing tubular epithelial cells from the G1 cell cycle arrest.
study reports an alternately-spliced form of Smad7, Smad7Delta, that is induced by TGF-beta (show TGFB1 Antibodies) and CLIC4 (show CLIC4 Antibodies), is a dominant inhibitor of Smad7 and enhances TGF-beta (show TGFB1 Antibodies) signaling
Pancreatic depletion of SMAD7 resulted in age-dependent increases in beta cell dysfunction with accelerated glucose intolerance, followed by overt diabetes.
results indicate that miR (show MLXIP Antibodies)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) and Wnt (show WNT2 Antibodies) signaling pathway by directly targeting Smad7 and Tcf7l2 (show TCF7L2 Antibodies)
microRNA-497 modulates breast cancer cell proliferation, invasion, and survival by targeting SMAD7.
results indicate that miR (show MLXIP Antibodies)-195a-5p inhibits MTEC1 proliferation, at least in part, via down-regulation of Smad7
Data indicate that, in irritable bowel disease, high Smad7 contributes to sustain detrimental immune responses and knockdown of this molecule can help attenuate the ongoing mucosal inflammation in patients with such disorders
Hic-5 (show TGFB1I1 Antibodies) deficiency attenuates the activation of hepatic stellate cells and liver fibrosis though reducing the TGF-beta (show TGFB1 Antibodies)/Smad2 (show SMAD2 Antibodies) signaling by upregulation of Smad7
Data show that microRNA miR (show MLXIP Antibodies)-21 was significantly upregulated by bone morphogenetic protein 9 (BMP9 (show GDF2 Antibodies)) during the osteogenesis the multilineage cells (MMCs) by suppressing Smad7 protein.
Tril (show TRIL Antibodies) is a novel component of a Bmp-Gata2 (show GATA2 Antibodies) positive-feedback loop that plays an essential role in hematopoietic specification, by targeting Smad7 for degradation.
cTid1 can bind to other members of the Smad (show SMAD1 Antibodies) family and that highest binding activity occurs with the negative regulatory Smad7, through the conserved MH2 (show SCN4A Antibodies) domain
Smad7 has a role in Xenopus mesodermal and neural induction
SMAD7 plays a potentially important role in mammalian prenatal skeletal muscle development and is a candidate gene for promoting greater weaning weight in pig breeding.
MiR (show MYLIP Antibodies)-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene
a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7.
Results suggest that myostatin (show MSTN Antibodies) auto-regulates its gene expression through a Smad7 dependent mechanism in myogenic cells.
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
MAD (mothers against decapentaplegic, Drosophila) homolog 7
, MAD homolog 8
, Mothers against decapentaplegic, drosophila, homolog of, 7
, SMAD, mothers against DPP homolog 7
, mothers against DPP homolog 8
, mothers against decapentaplegic homolog 7
, MAD homolog 7
, SMAD 7
, mothers against DPP homolog 7
, mothers against decapentaplegic homolog 8
, MAD, mothers against decapentaplegic homolog 7
, mothers against DPP 7
, mothers against decapentaplegic-like protein 7
, SMAD family member 7