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this work provides evidence that the sushi-IL-15Ralpha/IL-15 (show IL15 Proteins) fusion protein RLI (show ABCE1 Proteins) enhances antitumor activity of anti-PD-1 (show PDCD1 Proteins) treatment and is a promising approach to stimulate host immunity
this study describes variants of splicing of IL-15Ra expressed in intestinal epithelial cells, and identifies those variants with the ability of binding IL-15 (show IL15 Proteins) and following the secretory pathway, as well as determines if any of these variants are regulated by methylation of DNA
Report improved antitumoral NK-cell activity in DC-based vaccine strategies through the use of IL-15 (show IL15 Proteins)/IL-15Ralpha mRNA-engineered designer DC.
The novel mechanism of IL-15 (show IL15 Proteins) transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15 (show IL15 Proteins):IL-15Ralpha-coated nanoparticles for antigen delivery.
significant association of rs2228059 with ossification of the posterior longitudinal ligament of the spine in Chinese Han population
NK cell activation in human hantavirus infection explained by virus-induced IL-15 (show IL15 Proteins)/IL15Ralpha expression
IRF-1 (show IRF1 Proteins) promotes LTx I/R injury via hepatocyte IL-15 (show IL15 Proteins)/IL-15Ralpha production and suggest that targeting IRF-1 (show IRF1 Proteins) and IL-15 (show IL15 Proteins)/IL-15Ralpha may be effective in reducing I/R injury associated with LTx.
Coexpression of IL15RA and IL15 (show IL15 Proteins) was also sufficient to activate peripheral blood mononuclear cells.
Circulating levels of IL-15 (show IL15 Proteins) and IL-15Ralpha seem to reflect visceral distribution of adipose tissue; epicardial fat may be a potential source of both IL-15 (show IL15 Proteins) and IL-15Ralpha.
our study provides strong evidence that the functional IL-15RA rs2228059 A>C polymorphism may contribute to the risk of ESCC.
this study shows that synergistic enhancement of adaptive immunity by the combination of epigallo catechin gallate and vitamin A or E is dependent on both IL-15 (show IL15 Proteins) and its receptor
Spontaneous cage activity was not different and IL-15 (show IL15 Proteins) protein levels were lower in male and female mIl15ra(fl/fl (show FLT3LG Proteins))/Cre(+) mice.
Despite being protected against diet induced obesity, IL-15R alpha knockout mice are hyperglycemic and insulin (show INS Proteins)-resistant.
IL-15 (show IL15 Proteins) directly induces pro-oxidative gene expression in primary myogenic cultures. Primary myogenic cultures require IL-15RA to respond to IL-15 (show IL15 Proteins).
we found that aging-related functional NK cell deficiency was completely reversed by injecting soluble IL-15 (show IL15 Proteins)/IL-15Ralpha complexes.
a greater mitochondrial density and mitochondrial DNA content was found in fast muscles from IL-15-Receptor-alpha KO mice that was not due to the presence of smaller muscle fibers.
IL-15 (show IL15 Proteins) is produced and secreted only as a heterodimer with IL-15Ralpha.
IL-15 (show IL15 Proteins) can signal via IL-15Ralpha, JNK (show MAPK8 Proteins), and NF-kappaB (show NFKB1 Proteins) to drive RANTES (show CCL5 Proteins) production by myeloid cells.
Stage 3 thymic invariant natural killer NKT (show CTSL1 Proteins) cells are specifically reduced in IL-15Ralpha-deficient mice, whereas the acquisition of natural killer (NK) receptors occurs at stage 3 IL15 (show IL15 Proteins)-dependent thymic cell development.
Different levels of IL-15 (show IL15 Proteins) trans-presentation are required for different natural killer (NK) cell developmental events to reach full maturation status
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.
interleukin-15 receptor subunit alpha
, interleukin 15 receptor alpha
, interleukin 15 receptor, alpha
, interleukin 15 receptor, alpha chain
, IL-15 receptor subunit alpha