Browse our IL21 Proteins (IL21)

Full name:
Interleukin 21 Proteins (IL21)
On are 69 Interleukin 21 (IL21) Proteins from 17 different suppliers available. Additionally we are shipping IL21 Antibodies (292) and IL21 Kits (81) and many more products for this protein. A total of 455 IL21 products are currently listed.
IL-21, Za11
list all proteins Gene Name GeneID UniProt
IL21 59067 Q9HBE4
IL21 60505 Q9ES17
IL21 365769 A3QPB9

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IL21 Proteins (IL21) by Origin

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Top referenced IL21 Proteins

  1. Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2667504 : Coquet, Chakravarti, Smyth, Godfrey: Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 7 references for 2667504

  2. Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2666654 : Eto, Lao, DiToro, Barnett, Escobar, Kageyama, Yusuf, Crotty: IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. in PLoS ONE 2011 (PubMed)
    Show all 7 references for 2666654

  3. Mouse (Murine) IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2666656 : Kaplan, Glosson, Stritesky, Yeh, Kinzfogl, Rohrabaugh, Goswami, Pham, Levy, Brutkiewicz, Blum, Cooper, Hangoc, Broxmeyer: STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis. in Blood 2011 (PubMed)
    Show all 6 references for 2666656

  4. Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2003099 : Sivakumar, Foster, Clegg: Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. in Immunology 2004 (PubMed)
    Show all 3 references for 2003099

  5. Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN413500 : Yoon, Zhang, Berner, Blom, Choi: Notch ligands expressed by follicular dendritic cells protect germinal center B cells from apoptosis. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 2 references for 413500

More Proteins for IL21 Interaction Partners

Human Interleukin 21 (IL21) interaction partners

  1. this study shows that induction of IL-21 (show IL17C Proteins) in T follicular helper cells is an indicator of influenza vaccine response in a HIV-infected pediatric cohort

  2. IL-21 (show IL17C Proteins) levels in rheumatoid arthritis synovial fluid were associated with matrix metalloproteinase (show MMP20 Proteins) (MMP)-1 (show MMP1 Proteins) and MMP-3 (show MMP3 Proteins).

  3. the elevated level of IL-2 (show IL2 Proteins)+ and IL-21 (show IL17C Proteins)+ T cells and a positive correlation between IL-21 (show IL17C Proteins)+ cells with clinical activity index in ulcerative colitis patients may contribute to the pathogenesis of disease.

  4. these results demonstrate a novel function for IL-21 (show IL17C Proteins) in tuning NK and CD4 (show CD4 Proteins)+ T cell interactions promoting a specific expansion of central memory lymphocytes

  5. Combined IL-21 (show IL17C Proteins)-primed polyclonal CTL plus CTLA4 (show CTLA4 Proteins) blockade controls refractory metastatic melanoma in a patient

  6. Our work suggests that IL-21 (show IL17C Proteins) regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 (show IL17C Proteins) may link immune responses to physiological or pathological platelet-dependent processes.

  7. this study shows that Th17/Treg imbalance and increased IL-21 (show IL17C Proteins) are associated with liver injury in patients with chronic HBV infection

  8. The findings of the current study indicate an association between IL-21 (show IL17C Proteins)+TFH cells and disease activity. IL-21 (show IL17C Proteins)+TFH levels may prove to be a useful marker of disease activity in OA patients.

  9. IL-21 (show IL17C Proteins) is involved in the pathological development of Intervertebral Disc Degeneration and IL-21 (show IL17C Proteins) could aggravate IVD (show IVD Proteins) degeneration by stimulating TNF-alpha (show TNF Proteins) through the STAT (show STAT1 Proteins) signaling pathway

  10. Our findings suggest that the rs12508721T/C and rs2221903A/G polymorphisms of IL-21 (show IL17C Proteins) gene are associated with the susceptibility of HBV-related hepatocellular carcinoma (HCC (show FAM126A Proteins)) and chronic HBV infection. The genetic variant may in fact cause protection against the HBV-related HCC (show FAM126A Proteins).

Mouse (Murine) Interleukin 21 (IL21) interaction partners

  1. IL-6 (show IL6 Proteins) is identified as a master regulator of IL-21 in effector CD8 (show CD8A Proteins)(+) T cells.

  2. Our work suggests that IL-21 regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 may link immune responses to physiological or pathological platelet-dependent processes.

  3. we identify novel distal regulatory elements in the mouse Il21 locus and demonstrate a dynamic long-range chromatin interaction between the Il21 promoter and these regulatory elements, which contributes to the regulated expression of IL-21

  4. this study shows that IL-21 acts as a potent inhibitor of a IL-17A (show IL17A Proteins)-producing T-cell subset during Mycobacterium bovis Bacillus infection

  5. IL-21 may play an important role in the pathogenesis of SSc (show CYP11A1 Proteins) as a Th17 effector cytokine, and IL-21 may induce the differentiation of Th17 cells in the BLM-induced systemic sclerosis mouse model via Il21R (show IL21R Proteins).

  6. The data of this study suggested that an increase in astrocyte-derived IL-21 expression in hippocampal subregions following KA-induced seizures may have potent regulatory effects on epileptogenesis.

  7. this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 (show CD8A Proteins) T cells and influencing their migratory properties, accumulation, and functions.

  8. Dysregulated development of IL-17 (show IL17A Proteins)- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.

  9. results demonstrate that, in the setting of lupus-like CD4 (show CD4 Proteins) T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 (show CD8A Proteins) T cells is critical for CTL effector maturation whereas a lack of IL-21R (show IL21R Proteins) downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production

  10. Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R (show IL21R Proteins), and a series of genes associated with TFH cell development and function.

Cow (Bovine) Interleukin 21 (IL21) interaction partners

  1. The results revealed that the peak expression of IL6 (show IL6 Proteins) and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.

IL21 Protein Profile

Protein Summary

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with IL21

  • interleukin 21 (IL21)
  • interleukin 21 (Il21)
  • interleukin 21-like (LOC100344172)
  • IL-21 protein
  • Za11 protein

Protein level used designations for Interleukin 21 Proteins (IL21)

interleukin-21 , interleukin-21 isoform , IL-21

59067 Homo sapiens
60505 Mus musculus
365769 Rattus norvegicus
378475 Bos taurus
100726049 Cavia porcellus
442935 Canis lupus familiaris
403123 Sus scrofa
100861248 Capra hircus
554218 Gallus gallus
100862657 Ovis aries
100344172 Oryctolagus cuniculus
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