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Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2666654
Eto, Lao, DiToro, Barnett, Escobar, Kageyama, Yusuf, Crotty: IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. in PLoS ONE 2011
Show all 7 references for ABIN2666654
Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2667504
Coquet, Chakravarti, Smyth, Godfrey: Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 7 references for ABIN2667504
Mouse (Murine) IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2666656
Kaplan, Glosson, Stritesky, Yeh, Kinzfogl, Rohrabaugh, Goswami, Pham, Levy, Brutkiewicz, Blum, Cooper, Hangoc, Broxmeyer: STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis. in Blood 2011
Show all 6 references for ABIN2666656
Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2003099
Sivakumar, Foster, Clegg: Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. in Immunology 2004
Show all 3 references for ABIN2003099
Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN413500
Yoon, Zhang, Berner, Blom, Choi: Notch ligands expressed by follicular dendritic cells protect germinal center B cells from apoptosis. in Journal of immunology (Baltimore, Md. : 1950) 2009
Show all 2 references for ABIN413500
The findings of the current study indicate an association between IL-21 (show IL17C Proteins)+TFH cells and disease activity. IL-21 (show IL17C Proteins)+TFH levels may prove to be a useful marker of disease activity in OA patients.
IL-21 (show IL17C Proteins) is involved in the pathological development of Intervertebral Disc Degeneration and IL-21 (show IL17C Proteins) could aggravate IVD (show IVD Proteins) degeneration by stimulating TNF-alpha (show TNF Proteins) through the STAT (show STAT1 Proteins) signaling pathway
Our findings suggest that the rs12508721T/C and rs2221903A/G polymorphisms of IL-21 (show IL17C Proteins) gene are associated with the susceptibility of HBV-related hepatocellular carcinoma (HCC (show FAM126A Proteins)) and chronic HBV infection. The genetic variant may in fact cause protection against the HBV-related HCC (show FAM126A Proteins).
Hepatitis C virus specific IL-21 (show IL17C Proteins) producing T cells but not IL-17A (show IL17A Proteins) producing T Cells are associated with hepatitis C viral control in HIV/ hepatitis C virus coinfection.
this study shows that the serum levels of IL-21 (show IL17C Proteins) are higher in Iranian diabetes type I patients compared to the healthy individuals
We characterized the expressed IL-21 (show IL17C Proteins) gene from immune tissues of two macropod species, the tammar wallaby (Macropus eugenii), a model macropod, and the closely related endangered bridled nailtail wallaby (Onychogalea fraenata). The open reading frame of macropod IL-21 (show IL17C Proteins) is 462 nucleotides in length and encodes a 153-mer (show MERTK Proteins) putative protein that has 46% identity with human IL-21 (show IL17C Proteins).
The rs2055979 C>A polymorphism of the IL-21 gene is associated with cryptorchidism susceptibility, and the C allele increases the risk of cryptorchidism in a Chinese Han population.
Polymorphisms in IL21 (show IL17C Proteins) may be associated with sepsis risk
review on IL-21 (show IL17C Proteins) as is a crucial cytokine associated with pemphigus
There is a strong association between IL2 (show IL2 Proteins)/IL21 (show IL17C Proteins) rs6822844 variant and susceptibility to rheumatoid arthritis (RA) in the Algerian population; this association is independent from the autoantibodies status of RA patients.
IL-21 may play an important role in the pathogenesis of SSc (show CYP11A1 Proteins) as a Th17 effector cytokine, and IL-21 may induce the differentiation of Th17 cells in the BLM-induced systemic sclerosis mouse model via Il21R (show IL21R Proteins).
The data of this study suggested that an increase in astrocyte-derived IL-21 expression in hippocampal subregions following KA-induced seizures may have potent regulatory effects on epileptogenesis.
this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 (show CD8A Proteins) T cells and influencing their migratory properties, accumulation, and functions.
Dysregulated development of IL-17 (show IL17A Proteins)- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.
results demonstrate that, in the setting of lupus-like CD4 (show CD4 Proteins) T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 (show CD8A Proteins) T cells is critical for CTL effector maturation whereas a lack of IL-21R (show IL21R Proteins) downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production
Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R (show IL21R Proteins), and a series of genes associated with TFH cell development and function.
IL-21 from microbiota-specific Th17 and/or Tfh cells contributes to robust intestinal IgA levels by enhancing IgA(+) CSR, IgA production and B-cell trafficking into the intestine.
this report demonstrates a critical role for IL-21 in the generation of a primary effector CD8 (show CD8A Proteins) T cell response to an infectious disease model.
IL-21 drives the activation and expansion of a novel population of IL-13 (show IL13 Proteins)-producing Tc2 (show TCN2 Proteins) cells, which serve as a critical link between inflammation and fibrosis.
these findings underscore the important collaboration between IL-4 (show IL4 Proteins) and IL-21 in shaping T-dependent B cells antibody responses.
The results revealed that the peak expression of IL6 (show IL6 Proteins) and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, interleukin-21 isoform