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Browse our IL21 Proteins (IL21)

Full name:
Interleukin 21 Proteins (IL21)
On www.antibodies-online.com are 71 Interleukin 21 (IL21) Proteins from 17 different suppliers available. Additionally we are shipping IL21 Antibodies (210) and IL21 Kits (82) and many more products for this protein. A total of 376 IL21 products are currently listed.
Synonyms:
IL-21, Za11
list all proteins Gene Name GeneID UniProt
IL21 59067 Q9HBE4
IL21 60505 Q9ES17
IL21 365769 A3QPB9

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IL21 Proteins (IL21) by Origin

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Top referenced IL21 Proteins

  1. Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2666654 : Eto, Lao, DiToro, Barnett, Escobar, Kageyama, Yusuf, Crotty: IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. in PLoS ONE 2011 (PubMed)
    Show all 7 references for ABIN2666654

  2. Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2667504 : Coquet, Chakravarti, Smyth, Godfrey: Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 7 references for ABIN2667504

  3. Mouse (Murine) IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2666656 : Kaplan, Glosson, Stritesky, Yeh, Kinzfogl, Rohrabaugh, Goswami, Pham, Levy, Brutkiewicz, Blum, Cooper, Hangoc, Broxmeyer: STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis. in Blood 2011 (PubMed)
    Show all 6 references for ABIN2666656

  4. Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2003099 : Sivakumar, Foster, Clegg: Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. in Immunology 2004 (PubMed)
    Show all 3 references for ABIN2003099

  5. Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN413500 : Yoon, Zhang, Berner, Blom, Choi: Notch ligands expressed by follicular dendritic cells protect germinal center B cells from apoptosis. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 2 references for ABIN413500

More Proteins for IL21 Interaction Partners

Human Interleukin 21 (IL21) interaction partners

  1. IL-21 (show IL17C Proteins) exerts major effects on B-cell activation (show BLNK Proteins) and differentiation or apoptosis during humoral immune responses, and also affects different subtypes of T cells. (Review)

  2. The results suggest that IL-21 (show IL17C Proteins) promotes migration and invasion of Rheumatoid arthritis-Fibroblast-like synoviocytes. Therefore, therapeutic strategies targeting IL-21 (show IL17C Proteins) might be effective for the treatment of Rheumatoid arthritis.

  3. IL-12 (show IL12A Proteins) induced the generation of IL-21 (show IL17C Proteins)- and IFN-gamma (show IFNG Proteins)-co-expressing poly-functional CD4 (show CD4 Proteins)+ T cells from human naive CD4 (show CD4 Proteins)+ T cells.

  4. IL-21 (show IL17C Proteins) expression is promoted by MEKK4 (show MAP3K4 Proteins) in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma

  5. Human IL-21 (show IL17C Proteins)+IFN-gamma (show IFNG Proteins)+CD4 (show CD4 Proteins)+ T cells in nasal polyps are regulated by IL-12 (show IL12A Proteins).

  6. CD3(+)TCRvbeta11(+) NKT cells from a local site of M. tuberculosis infection produce IL-21, express CXCR5 and CD40L, help B cells to secrete IgG and IgA, and may participate in local immune responses against M. tuberculosis infection.

  7. IL-21 (show IL17C Proteins) protein was higher in serum and mRNA and protein were higher in disc tissue of patients with lumbar disc herniation compared to controls.

  8. both IL-21 (show IL17C Proteins) rs907715 and rs2221903 polymorphisms may be associated with systemic lupus erythematosus susceptibility (meta-analysis)

  9. all Ifng (show IFNG Proteins)+ T cells produced IL-21 (show IL17C Proteins), but only a small percentage of highly proliferative Ifng (show IFNG Proteins)+ T cells maintained a T-bethi phenotype

  10. The high levels of memory and activated B cells and follicular helper T cells were positively associated with the progression of immunoglobulin A nephropathy. This may be mediated by the overexpression of AID, which is potentially regulated by IL21 (show IL17C Proteins).

Mouse (Murine) Interleukin 21 (IL21) interaction partners

  1. this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 (show CD8A Proteins) T cells and influencing their migratory properties, accumulation, and functions.

  2. Dysregulated development of IL-17 (show IL17A Proteins)- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.

  3. results demonstrate that, in the setting of lupus-like CD4 (show CD4 Proteins) T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 (show CD8A Proteins) T cells is critical for CTL effector maturation whereas a lack of IL-21R (show IL21R Proteins) downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production

  4. Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R (show IL21R Proteins), and a series of genes associated with TFH cell development and function.

  5. IL-21 from microbiota-specific Th17 and/or Tfh cells contributes to robust intestinal IgA levels by enhancing IgA(+) CSR, IgA production and B-cell trafficking into the intestine.

  6. this report demonstrates a critical role for IL-21 in the generation of a primary effector CD8 (show CD8A Proteins) T cell response to an infectious disease model.

  7. IL-21 drives the activation and expansion of a novel population of IL-13 (show IL13 Proteins)-producing Tc2 (show TCN2 Proteins) cells, which serve as a critical link between inflammation and fibrosis.

  8. these findings underscore the important collaboration between IL-4 (show IL4 Proteins) and IL-21 in shaping T-dependent B cells antibody responses.

  9. IL-21-mediated signaling supports generation and stabilization of pathogenic Th17 cells and development of spontaneous autoimmunity.

  10. In vivo treatment with IL-21 results in complete mantle cell lymphoma regression in syngeneic mice via natural killer - and T-cell-dependent mechanisms.

Cow (Bovine) Interleukin 21 (IL21) interaction partners

  1. The results revealed that the peak expression of IL6 (show IL6 Proteins) and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.

IL21 Protein Profile

Protein Summary

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with IL21

  • interleukin 21 (IL21)
  • interleukin 21 (Il21)
  • interleukin 21-like (LOC100344172)
  • IL-21 protein
  • Za11 protein

Protein level used designations for Interleukin 21 Proteins (IL21)

interleukin-21 , interleukin-21 isoform , IL-21

GENE ID SPECIES
59067 Homo sapiens
60505 Mus musculus
365769 Rattus norvegicus
378475 Bos taurus
100726049 Cavia porcellus
442935 Canis lupus familiaris
403123 Sus scrofa
100861248 Capra hircus
554218 Gallus gallus
100862657 Ovis aries
100344172 Oryctolagus cuniculus
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