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Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2667504
Coquet, Chakravarti, Smyth, Godfrey: Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 7 references for ABIN2667504
Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2666654
Eto, Lao, DiToro, Barnett, Escobar, Kageyama, Yusuf, Crotty: IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. in PLoS ONE 2011
Show all 7 references for ABIN2666654
Mouse (Murine) IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2666656
Kaplan, Glosson, Stritesky, Yeh, Kinzfogl, Rohrabaugh, Goswami, Pham, Levy, Brutkiewicz, Blum, Cooper, Hangoc, Broxmeyer: STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis. in Blood 2011
Show all 6 references for ABIN2666656
Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN2003099
Sivakumar, Foster, Clegg: Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. in Immunology 2004
Show all 3 references for ABIN2003099
Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN413500
Yoon, Zhang, Berner, Blom, Choi: Notch ligands expressed by follicular dendritic cells protect germinal center B cells from apoptosis. in Journal of immunology (Baltimore, Md. : 1950) 2009
Show all 2 references for ABIN413500
Polymorphisms in IL21 (show IL17C Proteins) may be associated with sepsis risk
review on IL-21 (show IL17C Proteins) as is a crucial cytokine associated with pemphigus
There is a strong association between IL2 (show IL2 Proteins)/IL21 (show IL17C Proteins) rs6822844 variant and susceptibility to rheumatoid arthritis (RA) in the Algerian population; this association is independent from the autoantibodies status of RA patients.
HCV infection increased the frequency of CD4 (show CD4 Proteins)+CXCR5 (show CXCR5 Proteins)+ T cells and decreased the frequency of CD27 (show CD27 Proteins)+IgG+ B cells. CD4 (show CD4 Proteins)+CXCR5 (show CXCR5 Proteins)+ T cells activated CD27 (show CD27 Proteins)+IgG+ B cells via the secretion of IL-21 (show IL17C Proteins).
IL-21 (show IL17C Proteins) exerts major effects on B-cell activation (show BLNK Proteins) and differentiation or apoptosis during humoral immune responses, and also affects different subtypes of T cells. (Review)
The results suggest that IL-21 (show IL17C Proteins) promotes migration and invasion of Rheumatoid arthritis-Fibroblast-like synoviocytes. Therefore, therapeutic strategies targeting IL-21 (show IL17C Proteins) might be effective for the treatment of Rheumatoid arthritis.
IL-12 (show IL12A Proteins) induced the generation of IL-21 (show IL17C Proteins)- and IFN-gamma (show IFNG Proteins)-co-expressing poly-functional CD4 (show CD4 Proteins)+ T cells from human naive CD4 (show CD4 Proteins)+ T cells.
IL-21 (show IL17C Proteins) expression is promoted by MEKK4 (show MAP3K4 Proteins) in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma
Human IL-21 (show IL17C Proteins)+IFN-gamma (show IFNG Proteins)+CD4 (show CD4 Proteins)+ T cells in nasal polyps are regulated by IL-12 (show IL12A Proteins).
CD3(+)TCRvbeta11(+) NKT cells from a local site of M. tuberculosis infection produce IL-21, express CXCR5 and CD40L, help B cells to secrete IgG and IgA, and may participate in local immune responses against M. tuberculosis infection.
The data of this study suggested that an increase in astrocyte-derived IL-21 expression in hippocampal subregions following KA-induced seizures may have potent regulatory effects on epileptogenesis.
this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 (show CD8A Proteins) T cells and influencing their migratory properties, accumulation, and functions.
Dysregulated development of IL-17 (show IL17A Proteins)- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.
results demonstrate that, in the setting of lupus-like CD4 (show CD4 Proteins) T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 (show CD8A Proteins) T cells is critical for CTL effector maturation whereas a lack of IL-21R (show IL21R Proteins) downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production
Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R (show IL21R Proteins), and a series of genes associated with TFH cell development and function.
IL-21 from microbiota-specific Th17 and/or Tfh cells contributes to robust intestinal IgA levels by enhancing IgA(+) CSR, IgA production and B-cell trafficking into the intestine.
this report demonstrates a critical role for IL-21 in the generation of a primary effector CD8 (show CD8A Proteins) T cell response to an infectious disease model.
IL-21 drives the activation and expansion of a novel population of IL-13 (show IL13 Proteins)-producing Tc2 (show TCN2 Proteins) cells, which serve as a critical link between inflammation and fibrosis.
these findings underscore the important collaboration between IL-4 (show IL4 Proteins) and IL-21 in shaping T-dependent B cells antibody responses.
IL-21-mediated signaling supports generation and stabilization of pathogenic Th17 cells and development of spontaneous autoimmunity.
The results revealed that the peak expression of IL6 (show IL6 Proteins) and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, interleukin-21 isoform