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Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN413500
Yoon, Zhang, Berner, Blom, Choi: Notch ligands expressed by follicular dendritic cells protect germinal center B cells from apoptosis. in Journal of immunology (Baltimore, Md. : 1950) 2009
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Report efficient retroviral vector transduction of primary human natural killer cells that were stimulated by a combination of IL-2 (show IL2 Proteins) and engineered K562 cells expressing membrane-bound IL-21 (show IL17C Proteins) for cancer immunotherapy.
IL21 (show IL17C Proteins) reduction in osteosarcoma patients due to PD-1 (show PDCD1 Proteins) and pd-L1 (show CD274 Proteins) mediated follicular helper T cells suppression.
this study shows that induction of IL-21 (show IL17C Proteins) in T follicular helper cells is an indicator of influenza vaccine response in a HIV-infected pediatric cohort
IL-21 (show IL17C Proteins) levels in rheumatoid arthritis synovial fluid were associated with matrix metalloproteinase (MMP)-1 (show MMP1 Proteins) and MMP-3 (show MMP3 Proteins).
the elevated level of IL-2 (show IL2 Proteins)+ and IL-21 (show IL17C Proteins)+ T cells and a positive correlation between IL-21 (show IL17C Proteins)+ cells with clinical activity index in ulcerative colitis patients may contribute to the pathogenesis of disease.
these results demonstrate a novel function for IL-21 (show IL17C Proteins) in tuning NK and CD4 (show CD4 Proteins)+ T cell interactions promoting a specific expansion of central memory lymphocytes
Combined IL-21 (show IL17C Proteins)-primed polyclonal CTL plus CTLA4 (show CTLA4 Proteins) blockade controls refractory metastatic melanoma in a patient
Our work suggests that IL-21 (show IL17C Proteins) regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 (show IL17C Proteins) may link immune responses to physiological or pathological platelet-dependent processes.
this study shows that Th17/Treg imbalance and increased IL-21 (show IL17C Proteins) are associated with liver injury in patients with chronic HBV infection
The findings of the current study indicate an association between IL-21 (show IL17C Proteins)+TFH cells and disease activity. IL-21 (show IL17C Proteins)+TFH levels may prove to be a useful marker of disease activity in OA patients.
IL-6 (show IL6 Proteins) is identified as a master regulator of IL-21 in effector CD8 (show CD8A Proteins)(+) T cells.
Our work suggests that IL-21 regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 may link immune responses to physiological or pathological platelet-dependent processes.
we identify novel distal regulatory elements in the mouse Il21 locus and demonstrate a dynamic long-range chromatin interaction between the Il21 promoter and these regulatory elements, which contributes to the regulated expression of IL-21
this study shows that IL-21 acts as a potent inhibitor of a IL-17A (show IL17A Proteins)-producing T-cell subset during Mycobacterium bovis Bacillus infection
IL-21 may play an important role in the pathogenesis of SSc (show CYP11A1 Proteins) as a Th17 effector cytokine, and IL-21 may induce the differentiation of Th17 cells in the BLM-induced systemic sclerosis mouse model via Il21R (show IL21R Proteins).
The data of this study suggested that an increase in astrocyte-derived IL-21 expression in hippocampal subregions following KA-induced seizures may have potent regulatory effects on epileptogenesis.
this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 (show CD8A Proteins) T cells and influencing their migratory properties, accumulation, and functions.
Dysregulated development of IL-17 (show IL17A Proteins)- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.
results demonstrate that, in the setting of lupus-like CD4 (show CD4 Proteins) T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 (show CD8A Proteins) T cells is critical for CTL effector maturation whereas a lack of IL-21R (show IL21R Proteins) downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production
Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R (show IL21R Proteins), and a series of genes associated with TFH cell development and function.
The results revealed that the peak expression of IL6 (show IL6 Proteins) and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, interleukin-21 isoform