IL-21 Protein (AA 30-162)
-
- Target See all IL-21 (IL21) Proteins
- IL-21 (IL21) (Interleukin 21 (IL21))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 30-162
-
Origin
- Human
-
Source
- HEK-293 Cells
- Purpose
- Human IL-21 Protein, Tag Free, low endotoxin (HPLC verified)
- Purity
- >98 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 0.01 EU per μg by the LAL method.
- Top Product
- Discover our top product IL21 Protein
-
Interleukin 21 (IL21) protein
IL21 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95% as determined by Tris-Bis PAGE
Interleukin 21 (IL21) (AA 32-162) protein (His-Avi Tag,Biotin)IL21 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 21 (IL21) (AA 63-162) protein (GST tag)IL21 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 21 (IL21) (AA 18-146) protein (His-IF2DI Tag)IL21 Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 21 (IL21) (AA 25-155) protein (His-IF2DI Tag)IL21 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 21 (IL21) (AA 1-162) protein (GST tag)IL21 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 21 (IL21) (AA 18-146) protein (His-Avi Tag,Biotin)IL21 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 21 (IL21) proteinIL21 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Interleukin 21 (IL21) protein (His tag)IL21 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Interleukin 21 (IL21) (AA 30-162) (Active) protein (Fc Tag)IL21 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
-
- Target
- IL-21 (IL21) (Interleukin 21 (IL21))
- Alternative Name
- IL-21 (IL21 Products)
- Synonyms
- IL-21 Protein, Za11 Protein, interleukin 21 Protein, IL21 Protein, Il21 Protein
- Background
- Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
- Molecular Weight
- 15.5 kDa
- NCBI Accession
- NP_068575
- Pathways
- JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
-
