Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG ELISA Kits) signal.
Alterated IQGAP1 (show IQGAP1 ELISA Kits)/Rho GTPase (show RACGAP1 ELISA Kits) signaling in myeloproliferative neoplasm erythrocytes is dependent on JAK2/CALR (show CALR ELISA Kits) mutational status.
primary cells from a patient with KRAS-mutant juvenile myelomonocytic leukemia displayed reduced colony formation in response to JAK2 inhibition
The results showed that AG490 inhibited (p)-JAK2 and RANKL (show TNFSF11 ELISA Kits) expression.
the accumulation of reactive oxygen species (ROS (show ROS1 ELISA Kits)) in cells expressing JAK2V617F compromises the NHE-1 (show SLC9A1 ELISA Kits)/Bcl-xL (show BCL2L1 ELISA Kits) deamidation pathway by repressing NHE-1 (show SLC9A1 ELISA Kits) upregulation in response to DNA damage. hematopoietic stem cells (HSCs), FOXO3A (show FOXO3 ELISA Kits) is largely localized within the nuclei despite the presence of JAK2V617F mutation, suggesting that JAK2-FOXO (show FOXO3 ELISA Kits) signaling has a different effect on progenitors compared with stem cells.
Overexpression of Msi2 (show MSI2 ELISA Kits) significantly increased and silencing of Msi2 (show MSI2 ELISA Kits) reduced the phosphorylation of JAK2 and its downstream effecter STAT3 (show STAT3 ELISA Kits).
our data elucidate that knockdown of HOXD-AS1 (show PTGDR ELISA Kits) dramatically suppresses gastric cancer cell growth by inactivating the Janus kinase 2/signal transducer and activator of transcription 3 (show STAT3 ELISA Kits) pathway in vitro and in vivo, contributing to a better understanding of gastric cancer pathogenesis and providing a possible theoretical foundation for long non-coding RNA-directed diagnosis and therapy against this disease.
Germline variation in the JAK2 gene was associated with survival in patients with castration-resistant prostate cancer
TERT (show TERT ELISA Kits) rs2736100 A>C SNP and JAK2 46/1 haplotype significantly contribute to the occurrence of JAK2 V617F and CALR (show CALR ELISA Kits) mutated myeloproliferative neoplasms
this study shows that Korean patients with psoriasis show a strong association for JAK2 single nucleotide polymorphism
JAK2 is a direct BCL6 (show BCL6 ELISA Kits) target gene; BCL6 (show BCL6 ELISA Kits) bound to the JAK2 promoter
Data show that CUZD1 (show CUZD1 ELISA Kits) interacts with a complex containing JAK1 (show JAK1 ELISA Kits)/JAK2 and STAT5 (show STAT5A ELISA Kits), downstream transducers of prolactin (show PRL ELISA Kits) signaling in the mammary gland.
these results have revealed that phosphorylation of Tyr (show TYR ELISA Kits)-343, Tyr (show TYR ELISA Kits)-460, and Tyr (show TYR ELISA Kits)-464 in EpoR (show EPOR ELISA Kits) underlies JAK2 V617F mutant-induced tumorigenesis.
this study shows that ampelopsin reduces inflammatory response of microglial cells through inhibition of JAK2-STAT3 (show STAT3 ELISA Kits) signaling
At the molecular level, administration of liraglutide induced the expression of PDX-1 (show PDX1 ELISA Kits), MafA (show MAFA ELISA Kits), p-JAK2 and p-Stat3 (show STAT3 ELISA Kits) in high-fat diet-induced diabetes model to relatively normal levels.
this study shows that resokaempferol inhibits the inflammatory response in activated macrophages by blocking the activation of the JAK2 pathway
Data show that protein tyrosine phosphatase 1B (PTP1B (show PTPN1 ELISA Kits))-deficiency enhanced JAK2-STAT3 (show STAT3 ELISA Kits) signaling in hypothalamic microglia and attenuated inflammation.
JAK1 (show JAK1 ELISA Kits), JAK2, and JAK3 (show JAK3 ELISA Kits) are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor.
JAK (show JAK3 ELISA Kits) mediated signaling is involved in the differentiation and proliferation of mesenchymal progenitor cells.
IL-3 (show IL-3 ELISA Kits) signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis.
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 ELISA Kits)-STAT (show STAT1 ELISA Kits)-AKT (show AKT1 ELISA Kits) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A ELISA Kits) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A ELISA Kits) and mTOR (show FRAP1 ELISA Kits) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B ELISA Kits) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase