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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG ELISA Kits) signal.
we demonstrate that like other kinases JAK2 is prone to develop resistant mutations against ATP site inhibitors, but targeting the substrate-binding site prevents the selection of resistant mutations.
by molecular docking analysis and tumor sphere assay we discover that curcumin was able to inhibit JAK2 activity and reduce tumor spheres via inhibiting the JAK2/STAT3 (show STAT3 ELISA Kits) signaling pathway
we conclude that the JAK2-STAT3 (show STAT3 ELISA Kits) pathway promotes the development of paclitaxel resistance via upregulating the expression of prosurvival and antiapoptotic genes.
Our results reveal JAK2 as critical component of chemokine (show CCL1 ELISA Kits) signaling in B-cell chronic lymphocytic leukemia B-lymphocytes
Data suggest that stathmin 1 (show STMN1 ELISA Kits) silencing or paclitaxel treatment, combined with ruxolitinib could be an effective strategy for promoting apoptosis in Janus kinase 2 (JAK2 V617F) cells.
Genomic amplification of 9p24.1 targeting JAK2, PD-L1 (show CD274 ELISA Kits), and PD-L2 (show PDCD1LG2 ELISA Kits) is enriched in high-risk triple negative breast cancer.
Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (show STAT3 ELISA Kits) (JAK2/STAT3 (show STAT3 ELISA Kits)) inhibitor AG490 significantly inhibited the migration, invasion and MMP-2 (show MMP2 ELISA Kits) expression induced by leptin (show LEP ELISA Kits) in endometriotic cells.
a novel role for JAK2/STAT1 (show STAT1 ELISA Kits) in EGFR (show EGFR ELISA Kits)-mediated immune evasion, and therapies targeting this signaling axis may be beneficial to block PD-L1 (show CD274 ELISA Kits) upregulation found in a large subset of head and neck cancer tumors.
study provided evidence that the presence of the JAK2V617F mutation is associated with quantitative changes in monocyte and lymphocyte populations, namely marked reduction in the percentage of monocytes, CD8 (show CD8A ELISA Kits)+ T and B cells and concurrent increase in NK cells
Suggest JAK2/STAT1 (show STAT1 ELISA Kits) signaling has key role in transducing endothelial transcriptomic changes induced by oxLDL.
The critical role of Jak2 in mediating prolactin (show PRL ELISA Kits)-induced luminal maturation of mammary epithelial cells.
JAK1 (show JAK1 ELISA Kits)/JAK2 inhibition of graft-versus-host disease was associated with the modulation of chemokine receptor (show CCR1 ELISA Kits) expression, which may have been one factor in the reduced infiltration of donor T cells in graft-versus-host disease target organs.
Findings indicate that CD24(+) antigen (show CD24 ELISA Kits) cells play a role in tumor migration and metastasis and support Janus kinase 2 protein (JAK2) as a therapeutic target in ovarian cancer.
JAK2(V617I) resulted in cytokine hyperresponsiveness without constitutive activation in the absence of ligand, whereas JAK2(V617F) resulted in constitutive activation
The pro-inflammatory cytokine, interferon-gamma (show IFNG ELISA Kits) may contribute to diarrhea associated with intestinal inflammation in part through regulation of the epithelial aquaporin-1 (show AQP1 ELISA Kits) water channel (show AQP4 ELISA Kits) via a non-classical JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) receptor signalling pathway.
JAK2 participates in the signalling, regulating the voltage-gated K(+) channel (show KCND3 ELISA Kits) KCNA3 (show KCNA3 ELISA Kits).
PRDX6 (show PRDX6 ELISA Kits) promotes lung tumor development via its mediated and CCL5 (show CCL5 ELISA Kits)-associated activation of the JAK2/STAT3 (show STAT3 ELISA Kits) pathway.
The data support an important role of LIF (show LIF ELISA Kits)-JAK2-STAT3 (show STAT3 ELISA Kits) regulation in the development of colonic adenocarcinoma-related cachexia.
Studied the liver-specific role of PTP1B (show PTPN1 ELISA Kits) in GH signaling; found under 48-hour fasting GH-resistant conditions, GH stimulation in vivo led to a robust stimulation of the JAK (show JAK3 ELISA Kits)-STAT (show STAT1 ELISA Kits) signalling pathway.
HDAC2 (show HDAC2 ELISA Kits) might be a downstream effector of Jak2 to mediate cardiac hypertrophic response by pressure overload or Ang-II (show AGT ELISA Kits).
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 ELISA Kits)-STAT (show STAT1 ELISA Kits)-AKT (show AKT1 ELISA Kits) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A ELISA Kits) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A ELISA Kits) and mTOR (show FRAP1 ELISA Kits) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B ELISA Kits) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase