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Human SOCS3 Protein expressed in Escherichia coli (E. coli) - ABIN2004222
Okamura, Iwata, Nagata, Tamekane, Shimoyama, Gomyo, Yakushijin, Urahama, Hamaguchi, Fukui, Chihara, Ito, Matsui: Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. in Blood 2004
Show all 5 references for ABIN2004222
Human SOCS3 Protein expressed in Wheat germ - ABIN1320930
Jiang, Biswas, Steinle: Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-? signaling in the rMC-1 cell line. in Molecular vision 2014
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a
stat3 (show STAT3 Proteins)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (show TRPM7 Proteins) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Proteins)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 Proteins) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 Proteins) and SOCS3 proteins.
The rs115785973 could be regulated by miR (show MLXIP Proteins)-4308 which caused an up-regulation ofsuppressor of cytokine signaling 3 in patients with GA and AA genotype.
Our data offer the convincing evidence for the first time that the aberrant expressions of ZFP36 (show ZFP36 Proteins) and SOCS3 may be involved into the progression and patients' prognosis of prostate cancer
SOCS3 along with STAT3 (show STAT3 Proteins) participates in regulatory mechanisms in ccRCC.
None of the clinicopathological parameters were associated with the expressions of FIH-1 and SOCS3 at mRNA level.
Micronome revealed miR (show MLXIP Proteins)-19a/b as key regulator of SOCS3 during cancer related inflammation of oral squamous cell carcinoma.
IGFBP2 and SOCS3 were up-regulated in Kashin-Beck disease chondrocytes and decreased with increasing selenium concentrations. IGFBP2 expressed highest in the middle zone of KBD cartilage, SOCS3 expressed higher in the middle and deep zone. IGFBP2 and SOCS3 may be the biomarkers for KBD diagnosis and evaluating the effect of selenium supplement.
Results show that IFN-alpha (show IFNA Proteins) antagonizes STAT3 (show STAT3 Proteins) and SOCS3 signaling triggered by hepatitis C virus (HCV )and that STAT3 (show STAT3 Proteins) regulation correlates inversely with SOCS3 induction by IFN-alpha (show IFNA Proteins), which may be important in better understanding the complex interplay between IFN-alpha (show IFNA Proteins) and signal molecules during HCV infection.
data show that HBV-induced mitochondrial ROS (show ROS1 Proteins) production represses SOCS3 expression through Snail (show SNAI1 Proteins)-mediated epigenetic silencing, leading to the sustained activation of IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) pathway and ultimately contributing to hepatocarcinogenesis.
These data thus suggest that overexpression of SOCS1 (show SOCS1 Proteins) and SOCS3 induced by denguevirus infection leads to impairment of antiviral response through the inhibition of STAT (show STAT1 Proteins) functionality.
demonstrate an epigenetic mechanism of SOCS3 up-regulation in steroid resistant children with the nephrotic syndrome. The assessment of methylation/unmethylation of SOCS3 promoter might be an early marker for steroid responsiveness in NS patients
SOCS3 is an important negative regulator of insulin (show INS Proteins) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 Proteins) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
Study indicated that SOCS3 suppresses complete polarization to M1 phenotype through blocking IL6 (show IL6 Proteins) production, and Abeta (show APP Proteins)-challenged primary-cultured microglia replicate the in vivo gene expression pattern of microglia in APPswe/PS1dE9 mice
Results identify unrecognized functions of Yes-associated protein (YAP (show YAP1 Proteins)) in preventing reactive astrogliosis and reveal a pathway of YAP (show YAP1 Proteins)- suppressor of cytokine signaling 3 (SOCS (show CISH Proteins)) for the negatively control of neuroinflammation.
SOCS3 serves as an immune modulator interfering with T cells and B cells, and SOCS3 may act as a predictive marker for immune modulation of mesenchymal stromal cells.
Signal transducer and activator of transcription 3 (show STAT3 Proteins) and suppressor of cytokine signaling 3 play important, yet unexpected, roles in NG2 (show Vcan Proteins) cell proliferation and differentiation after spinal cord injury.
The results of this study showed that the role of SOCS3 in mediating pregnancy-induced metabolic adaptations.
Concentration of SOCS-3 protein and coimmunoprecipitation of SOCS-3 protein with both the IR-beta subunit (show POLG Proteins) as well as IRS-1 (show IRS1 Proteins) was found to be decreased by 4-HIL
CCR5 blockade suppresses B16 melanoma growth by inhibiting of IL-6 (show IL6 Proteins)-Stat3 (show STAT3 Proteins) signaling pathway via upregulation of SOCS3.
AHR (show AHR Proteins) plays protective roles against high-fat diet-induced hepatic steatosis and the subsequent lipotoxicity via direct transcriptional regulation of Socs3 gene expression.
The liver regenerative effects of HCM appear to be mediated by persistent and uninhibited expression of STAT3 (show STAT3 Proteins) in the liver, which results from decreased expression of SOCS3
SOCS3 gene expression attenuates contact hypersensitivity by suppressing MMP12 (show MMP12 Proteins) production.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3