Browse our SOCS3 Proteins (SOCS3)

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Suppressor of Cytokine Signaling 3 Proteins (SOCS3)
On are 24 Suppressor of Cytokine Signaling 3 (SOCS3) Proteins from 9 different suppliers available. Additionally we are shipping SOCS3 Antibodies (223) and SOCS3 Kits (51) and many more products for this protein. A total of 305 SOCS3 products are currently listed.
ATOD4, Cis3, Cish3, EF-10, Ef10, fj09e12, MGC64393, MGC75749, MGC81248, Socs-3, SOCS3, Ssi-3, Ssi3, wu:fj09e12, xsocs3, zgc:56537
list all proteins Gene Name GeneID UniProt
SOCS3 9021 O14543
SOCS3 12702 O35718
SOCS3 89829 O88583

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SOCS3 Proteins (SOCS3) by Origin

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Top referenced SOCS3 Proteins

  1. Human SOCS3 Protein expressed in Escherichia coli (E. coli) - ABIN2004222 : Okamura, Iwata, Nagata, Tamekane, Shimoyama, Gomyo, Yakushijin, Urahama, Hamaguchi, Fukui, Chihara, Ito, Matsui: Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. in Blood 2004 (PubMed)
    Show all 5 references for 2004222

  2. Human SOCS3 Protein expressed in Wheat germ - ABIN1320930 : Jiang, Biswas, Steinle: Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-? signaling in the rMC-1 cell line. in Molecular vision 2014 (PubMed)

More Proteins for SOCS3 Interaction Partners

Zebrafish Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a

  2. stat3 (show STAT3 Proteins)/socs3 pathway is a key response in all tissue regeneration in zebrafish.

  3. Trpm7 (show TRPM7 Proteins) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Proteins)+)-sensitive Socs3a pathway.

  4. SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 Proteins) pathway by chemical inhibitors

  5. The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.

  6. in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 Proteins) and SOCS3 proteins.

Human Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. Studies indicate that suppressors of cytokine signaling (SOCS (show CISH Proteins)) proteins CIS (show CISH Proteins), SOCS1 (show SOCS1 Proteins), and SOCS3 can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4 (show CD4 Proteins)(+) T cells and the maturation of CD8 (show CD8A Proteins)(+) T cells.

  2. In M1-activated human monocyte-derived macrophages, SOCS3 silencing decreased expression of proinflammatory markers and increased M2 macrophage markers. SOCS3 knockdown radically affects the temporal dynamics of M1 macrophages' particle engulfment through increased PI3K and Ras-related C3 botulinum toxin substrate 1 (Rac1) activity. SOCS3 drives macrophage inflammatory responses and modulates key phagocytosis signaling.

  3. The results of this study demonstrated that HBx of hepatitis B virus impairs interferon (show IFNA Proteins) signaling via increased expression of SOCS3 and PP2A (show PPP2R4 Proteins).

  4. Overexpression of SOCS3 inhibited proliferation, migration, invasion and tumorigenic ability of colorectal cancer cells while increased cell apoptosis. Reduced expression of SOCS3 promoted the growth and metastasis of colorectal cancer.

  5. SOCS3, which is a critical negative regulator of cytokine response to tuberculosis infection and its nearby lncRNA XLOC_012582, were highly expressed in active tuberculosis B cells.

  6. Data show that the suppressor of cytokine signaling-3 (SOCS3) promoter hypermethylation was associated with relatively low mRNA expression in tumor tissues.

  7. Data show that ELOVL7, SOCS3, ACSL4 (show ACSL4 Proteins) and CLU (show CLU Proteins) were upregulated while PRKAR1A (show PRKAR1A Proteins) and ABCG1 (show ABCG1 Proteins) were downregulated in the phlegm-dampness group.

  8. There are pronounced changes in the expression of SOCS3 only in Non-allergic Asthma.

  9. epigenetic signatures at AQP3 (show AQP3 Proteins) and SOCS3 engage in low-grade inflammation across different tissues, possible via JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) mediated pathways

  10. SHP2 (show PTPN11 Proteins), SOCS3 and PIAS3 (show PIAS3 Proteins) levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 (show PIAS3 Proteins) downregulation is more reversely correlated with STAT3 (show STAT3 Proteins) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (show STAT3 Proteins) downregulation and decreased incidence of STAT3 (show STAT3 Proteins) nuclear translocation, PIAS3 (show PIAS3 Proteins) is upregulated, the SHP2 (show PTPN11 Proteins) level remains unchanged and SOCS3 is downregulated.

Pig (Porcine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. SOCS3 is an important negative regulator of insulin (show INS Proteins) signaling in porcine adipocytes.

Cow (Bovine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.

  2. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 Proteins) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Mouse (Murine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. Data suggest that, in B cell lymphoma, expression of MIRN30 is up-regulated in both granulocytic myeloid-derived suppressor cells and monocytic myeloid-derived suppressor cells; in B cell lymphoma, 3prime untranslated region of Socs3 appears to be direct target of MIRN30 in myeloid-derived suppressor cell differentiation. (MIRN30 = microRNA 30; Socs3 = suppressor of cytokine signaling 3 protein)

  2. Cell type-specific, different roles for viral immediate early (show JUN Proteins) or early gene expression and/or viral tegument proteins in the early stimulation of SOCS1 (show SOCS1 Proteins) and SOCS3 during murine cytomegalovirus infection.

  3. oncostatin M (show OSM Proteins) mitigated the proliferation of Th17 cells and decreased the expression of IL-17 (show IL17A Proteins) and IL-21 (show IL21 Proteins); it promoted the activation of suppressor of cytokine signaling 3 (SOCS3), STAT3 (show STAT3 Proteins), and STAT5 (show STAT5A Proteins); observations suggest that OSM (show OSM Proteins) can inhibit Th17 differentiation by reciprocally controlling SOCS3, STAT3 (show STAT3 Proteins), and STAT5 (show STAT5A Proteins)

  4. Results demonstrate a novel tunable form of cross-talk in which alveolar epithelial cells use Prostaglandin E2 (PGE2) as a signal to request SOCS3 from alveolar macrophages to dampen their endogenous inflammatory responses during infection.

  5. Loss of SOCS3 significantly accelerated the pathology and inflammatory disease characteristic of SOCS1 (show SOCS1 Proteins) deficiency. We propose a model in which SOCS1 (show SOCS1 Proteins) and SOCS3 operate independently to control specific cytokine responses and together modulate the proliferation and activation of lymphoid and myeloid cells to prevent rapid inflammatory disease

  6. This study showed that leptin (show LEP Proteins) resistant infertility is caused in part by the leptin (show LEP Proteins) signaling molecule SOCS3. Deletion of SOCS3 from brain neurons delays the onset of diet-induced infertility.

  7. SOCS3 plays a divergent role in relation to local vs. systemic effects of Ang II (show AGT Proteins) on the vasculature.

  8. These results indicate that Platelet-activating Factor -mediated endotoxin tolerance is initiated via IDO (show IDO1 Proteins)- and JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins)-dependent expression of SOCS3.

  9. expression in leptin receptor (show LEPR Proteins)-positive cells contributes to fasting-induced (show C10orf10 Proteins) hyperphagia and weight regain

  10. a novel negative feedback loop mediated by STAT3 (show STAT3 Proteins)-SOCS3, which is tightly controlled by SENP1 (show SENP1 Proteins) via de-SUMOylation of protein tyrosine phosphatase 1B (PTP1B (show PTPN1 Proteins)), in IFN-gamma (show IFNG Proteins) signaling, is reported.

SOCS3 Protein Profile

Protein Summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

Alternative names and synonyms associated with SOCS3

  • suppressor of cytokine signaling 3a (socs3a)
  • suppressor of cytokine signaling 3 (socs3)
  • suppressor of cytokine signaling 3 (SOCS3)
  • suppressor of cytokine signaling 3a (socs3)
  • suppressor of cytokine signaling 3 (LOC100227853)
  • suppressor of cytokine signaling 3 (Socs3)
  • ATOD4 protein
  • Cis3 protein
  • Cish3 protein
  • EF-10 protein
  • Ef10 protein
  • fj09e12 protein
  • MGC64393 protein
  • MGC75749 protein
  • MGC81248 protein
  • Socs-3 protein
  • SOCS3 protein
  • Ssi-3 protein
  • Ssi3 protein
  • wu:fj09e12 protein
  • xsocs3 protein
  • zgc:56537 protein

Protein level used designations for SOCS3

suppressor of cytokine signaling 3 , suppressor of cytokine signaling 3a , STAT-induced STAT inhibitor 3 , cytokine-inducible SH2 protein 3 , cytokine signaling suppressor , SOCS-3 , CIS-3 , E2a-Pbx1 target gene in fibroblasts 10 , cytokine inducible SH2-containing protein 3 , suppressors of cytokine signaling 3

335409 Danio rerio
380467 Xenopus laevis
394588 Xenopus (Silurana) tropicalis
414533 Xenopus laevis
448204 Xenopus (Silurana) tropicalis
454921 Pan troglodytes
100050730 Equus caballus
100192332 Gasterosteus aculeatus
100272212 Oncorhynchus mykiss
100294595 Ovis aries
100528984 Ictalurus punctatus
100227853 Taeniopygia guttata
9021 Homo sapiens
442949 Canis lupus familiaris
493186 Sus scrofa
282081 Bos taurus
12702 Mus musculus
89829 Rattus norvegicus
395299 Gallus gallus
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