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Browse our SOCS3 Proteins (SOCS3)

Full name:
Suppressor of Cytokine Signaling 3 Proteins (SOCS3)
On are 24 Suppressor of Cytokine Signaling 3 (SOCS3) Proteins from 9 different suppliers available. Additionally we are shipping SOCS3 Antibodies (219) and SOCS3 Kits (48) and many more products for this protein. A total of 298 SOCS3 products are currently listed.
ATOD4, Cis3, Cish3, EF-10, Ef10, fj09e12, MGC64393, MGC75749, MGC81248, Socs-3, SOCS3, Ssi-3, Ssi3, wu:fj09e12, xsocs3, zgc:56537
list all proteins Gene Name GeneID UniProt
SOCS3 9021 O14543
SOCS3 12702 O35718
SOCS3 89829 O88583

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SOCS3 Proteins (SOCS3) by Origin

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Top referenced SOCS3 Proteins

  1. Human SOCS3 Protein expressed in Escherichia coli (E. coli) - ABIN2004222 : Okamura, Iwata, Nagata, Tamekane, Shimoyama, Gomyo, Yakushijin, Urahama, Hamaguchi, Fukui, Chihara, Ito, Matsui: Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. in Blood 2004 (PubMed)
    Show all 5 references for ABIN2004222

  2. Human SOCS3 Protein expressed in Wheat germ - ABIN1320930 : Jiang, Biswas, Steinle: Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-? signaling in the rMC-1 cell line. in Molecular vision 2014 (PubMed)

More Proteins for SOCS3 Interaction Partners

Zebrafish Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a

  2. stat3 (show STAT3 Proteins)/socs3 pathway is a key response in all tissue regeneration in zebrafish.

  3. Trpm7 (show TRPM7 Proteins) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Proteins)+)-sensitive Socs3a pathway.

  4. SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 Proteins) pathway by chemical inhibitors

  5. The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.

  6. in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 Proteins) and SOCS3 proteins.

Human Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. epigenetic signatures at AQP3 (show AQP3 Proteins) and SOCS3 engage in low-grade inflammation across different tissues, possible via JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) mediated pathways

  2. SHP2 (show PTPN11 Proteins), SOCS3 and PIAS3 (show PIAS3 Proteins) levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 (show PIAS3 Proteins) downregulation is more reversely correlated with STAT3 (show STAT3 Proteins) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (show STAT3 Proteins) downregulation and decreased incidence of STAT3 (show STAT3 Proteins) nuclear translocation, PIAS3 (show PIAS3 Proteins) is upregulated, the SHP2 (show PTPN11 Proteins) level remains unchanged and SOCS3 is downregulated.

  3. SOCS3 methylation status was associated with multiple metabolic syndrome traits, including central obesity, fat depots, insulin (show INS Proteins) responsiveness, and plasma lipids.

  4. The results revealed that although the expression levels of SOCS1 (show SOCS1 Proteins), SOCS3 and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 (show PIAS3 Proteins) downregulation is more negatively correlated with STAT3 (show STAT3 Proteins) activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.

  5. reduced type I interferon (show IFNA Proteins) production in obesity is caused by SOCS3 overexpression as well as tolerance induced by leptin (show LEP Proteins)

  6. Data suggest that single nucleotide polymorphisms (SNPs) in suppressor of cytokine signaling 3 (SOCS3) may play a role in the pathogenesis of metabolic syndrome (MS).

  7. that siRNA-mediated SOCS3 knock-down in human osteoarthritic chondrocytes increased production of IL-1beta (show IL1B Proteins)-induced prostaglandin E2

  8. SOCS3 promoter was methylated in H2228 cells as well as in three cases of seven EML4-ALK-positive lung cancer tissues.

  9. Data suggest that microRNA miR19a3p plays an important role in beta cell function, and that the miR (show MLXIP Proteins)-19a-3p/suppressor of cytokine signaling 3 (SOCS3) axis may become a potential therapeutic target for diabetes.

  10. Significantly higher levels of suppressor of cytokine signalling (show SOCS1 Proteins) proteins SOCS3 and SOCS4 (show SOCS6 Proteins) in non-healing chronic wounds compared to the healing/healed chronic wounds were observed at the transcript level.

Pig (Porcine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. SOCS3 is an important negative regulator of insulin (show INS Proteins) signaling in porcine adipocytes.

Cow (Bovine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.

  2. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 Proteins) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Mouse (Murine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. SOCS3 plays a divergent role in relation to local vs. systemic effects of Ang II (show AGT Proteins) on the vasculature.

  2. These results indicate that Platelet-activating Factor -mediated endotoxin tolerance is initiated via IDO (show IDO1 Proteins)- and JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins)-dependent expression of SOCS3.

  3. expression in leptin receptor (show LEPR Proteins)-positive cells contributes to fasting-induced (show C10orf10 Proteins) hyperphagia and weight regain

  4. a novel negative feedback loop mediated by STAT3 (show STAT3 Proteins)-SOCS3, which is tightly controlled by SENP1 (show SENP1 Proteins) via de-SUMOylation of protein tyrosine phosphatase 1B (PTP1B (show PTPN1 Proteins)), in IFN-gamma (show IFNG Proteins) signaling, is reported.

  5. Vasoproliferative retinopathies may benefit from a CNTF (show CNTF Proteins)-dependent and SOCS3-mediated angiomodulatory effect.

  6. this study shows that fungal pattern receptors share with other ITAM-coupled receptors the capacity to produce cross-inhibition through a mechanism involving STAT3 (show STAT3 Proteins) and induction of SOCS3 and IL-10 (show IL10 Proteins), but that cannot be explained through type I IFN signaling

  7. this study shows that suppression of IL-6 (show IL6 Proteins)/Stat3 (show STAT3 Proteins) pathway in dendritic cells by paeoniflorin is mediated via upregulation of Socs3

  8. Study indicated that SOCS3 suppresses complete polarization to M1 phenotype through blocking IL6 (show IL6 Proteins) production, and Abeta (show APP Proteins)-challenged primary-cultured microglia replicate the in vivo gene expression pattern of microglia in APPswe/PS1dE9 mice

  9. Results identify unrecognized functions of Yes-associated protein (YAP (show YAP1 Proteins)) in preventing reactive astrogliosis and reveal a pathway of YAP (show YAP1 Proteins)- suppressor of cytokine signaling 3 (SOCS (show CISH Proteins)) for the negatively control of neuroinflammation.

  10. SOCS3 serves as an immune modulator interfering with T cells and B cells, and SOCS3 may act as a predictive marker for immune modulation of mesenchymal stromal cells.

SOCS3 Protein Profile

Protein Summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

Alternative names and synonyms associated with SOCS3

  • suppressor of cytokine signaling 3a (socs3a)
  • suppressor of cytokine signaling 3 (socs3)
  • suppressor of cytokine signaling 3 (SOCS3)
  • suppressor of cytokine signaling 3a (socs3)
  • suppressor of cytokine signaling 3 (LOC100227853)
  • suppressor of cytokine signaling 3 (Socs3)
  • ATOD4 protein
  • Cis3 protein
  • Cish3 protein
  • EF-10 protein
  • Ef10 protein
  • fj09e12 protein
  • MGC64393 protein
  • MGC75749 protein
  • MGC81248 protein
  • Socs-3 protein
  • SOCS3 protein
  • Ssi-3 protein
  • Ssi3 protein
  • wu:fj09e12 protein
  • xsocs3 protein
  • zgc:56537 protein

Protein level used designations for SOCS3

suppressor of cytokine signaling 3 , suppressor of cytokine signaling 3a , STAT-induced STAT inhibitor 3 , cytokine-inducible SH2 protein 3 , cytokine signaling suppressor , SOCS-3 , CIS-3 , E2a-Pbx1 target gene in fibroblasts 10 , cytokine inducible SH2-containing protein 3 , suppressors of cytokine signaling 3

335409 Danio rerio
380467 Xenopus laevis
394588 Xenopus (Silurana) tropicalis
414533 Xenopus laevis
448204 Xenopus (Silurana) tropicalis
454921 Pan troglodytes
100050730 Equus caballus
100192332 Gasterosteus aculeatus
100272212 Oncorhynchus mykiss
100294595 Ovis aries
100528984 Ictalurus punctatus
100227853 Taeniopygia guttata
9021 Homo sapiens
442949 Canis lupus familiaris
493186 Sus scrofa
282081 Bos taurus
12702 Mus musculus
89829 Rattus norvegicus
395299 Gallus gallus
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