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Browse our SOCS3 Proteins (SOCS3)

Full name:
Suppressor of Cytokine Signaling 3 Proteins (SOCS3)
On www.antibodies-online.com are 19 Suppressor of Cytokine Signaling 3 (SOCS3) Proteins from 9 different suppliers available. Additionally we are shipping SOCS3 Antibodies (178) and SOCS3 Kits (50) and many more products for this protein. A total of 256 SOCS3 products are currently listed.
Synonyms:
ATOD4, Cis3, Cish3, EF-10, Ef10, fj09e12, MGC64393, MGC75749, MGC81248, Socs-3, SOCS3, Ssi-3, Ssi3, wu:fj09e12, xsocs3, zgc:56537
list all proteins Gene Name GeneID UniProt
SOCS3 9021 O14543
SOCS3 12702 O35718
SOCS3 89829 O88583

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SOCS3 Proteins (SOCS3) by Origin

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Top referenced SOCS3 Proteins

  1. Human SOCS3 Protein expressed in Escherichia coli (E. coli) - ABIN2004222 : Okamura, Iwata, Nagata, Tamekane, Shimoyama, Gomyo, Yakushijin, Urahama, Hamaguchi, Fukui, Chihara, Ito, Matsui: Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. in Blood 2004 (PubMed)
    Show all 5 references for ABIN2004222

  2. Human SOCS3 Protein expressed in Wheat germ - ABIN1320930 : Jiang, Biswas, Steinle: Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-? signaling in the rMC-1 cell line. in Molecular vision 2014 (PubMed)

More Proteins for SOCS3 Interaction Partners

Zebrafish Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a

  2. stat3 (show STAT3 Proteins)/socs3 pathway is a key response in all tissue regeneration in zebrafish.

  3. Trpm7 (show TRPM7 Proteins) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Proteins)+)-sensitive Socs3a pathway.

  4. SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 Proteins) pathway by chemical inhibitors

  5. The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.

  6. in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 Proteins) and SOCS3 proteins.

Human Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. miR (show MLXIP Proteins)-203 and miR (show MLXIP Proteins)-221 regulate SOCS1 (show SOCS1 Proteins) and SOCS3 in essential thrombocythemia

  2. Dysregulation of SOCS3 functions can cause a variety of diseases, including allergy, autoimmune diseases, inflammation and cancer. (Review)

  3. induction of SOCS3 may be a novel mechanism by which FXR (show NR1H4 Proteins) exerts its anti-hepatocellular carcinoma effects

  4. H. pylori infection induced hepatic insulin (show INS Proteins) resistance by the c-Jun (show JUN Proteins)/miR (show MLXIP Proteins)-203/SOCS3 signaling pathway and provide possible implications with regard to resolving insulin (show INS Proteins) resistance.

  5. A significant relevance involved in SOCS3 gene polymorphisms and infantile asthma development based on a Chinese Han population.

  6. In hepatocellular carcinoma tumor tissues, SOCS3 showed an increased methylation frequency and intensity compared with that in the adjacent non-tumor tissues.

  7. Data suggest that PCSK9 (show PCSK9 Proteins) is involved in regulation of lipid metabolism in hepatocytes by proinflammatory cytokine TNFalpha (show TNF Proteins); induction of lipogenesis and insulin (show INS Proteins) resistance in liver (as seen in obesity) involves up-regulation of both PCSK9 (show PCSK9 Proteins) and SOCS3.

  8. Epigenetic inhibition of SOCS3 is regulated by miR1264 which specifically targets DNMT1 (show DNMT1 Proteins) transcript.

  9. Decreased SOCS3 expression is associated with cholangiocarcinoma.

  10. SOCS3 down-expression induces lineage commitment towards erythroid progenitor cell fate by activation of erythroid-specific gene in HSCs

Pig (Porcine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. SOCS3 is an important negative regulator of insulin (show INS Proteins) signaling in porcine adipocytes.

Cow (Bovine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.

  2. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 Proteins) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Mouse (Murine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. CCR5 blockade suppresses B16 melanoma growth by inhibiting of IL-6 (show IL6 Proteins)-Stat3 (show STAT3 Proteins) signaling pathway via upregulation of SOCS3.

  2. AHR (show AHR Proteins) plays protective roles against high-fat diet-induced hepatic steatosis and the subsequent lipotoxicity via direct transcriptional regulation of Socs3 gene expression.

  3. The liver regenerative effects of HCM appear to be mediated by persistent and uninhibited expression of STAT3 (show STAT3 Proteins) in the liver, which results from decreased expression of SOCS3

  4. SOCS3 gene expression attenuates contact hypersensitivity by suppressing MMP12 (show MMP12 Proteins) production.

  5. These results suggest that neuronal and glial cell SOCS3 limits pathological retinal angiogenesis by suppressing VEGF signaling.

  6. Socs3 deletion in cortical neurons promotes sprouting of corticospinal axons after unilateral pyramidotomy, restoring skilled locomotion.

  7. SOCS3-deficient and sufficient B-lineage cell migration towards CXCL12 (show CXCL12 Proteins) in vitro was undistinguishable, and B-lineage cell amoeboid motility within BM parenchyma was also unaffected by SOCS3-deficiency

  8. RORalpha regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation

  9. findings suggest that SOCS3 may represent a key factor that exacerbates the development of myocardial IRI.

  10. The critical function of SOCS3 is as a negative regulator of MDSC development and function via inhibition of STAT3 (show STAT3 Proteins) activation.

SOCS3 Protein Profile

Protein Summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

Alternative names and synonyms associated with SOCS3

  • suppressor of cytokine signaling 3a (socs3a)
  • suppressor of cytokine signaling 3 (socs3)
  • suppressor of cytokine signaling 3 (SOCS3)
  • suppressor of cytokine signaling 3a (socs3)
  • suppressor of cytokine signaling 3 (LOC100227853)
  • suppressor of cytokine signaling 3 (Socs3)
  • ATOD4 protein
  • Cis3 protein
  • Cish3 protein
  • EF-10 protein
  • Ef10 protein
  • fj09e12 protein
  • MGC64393 protein
  • MGC75749 protein
  • MGC81248 protein
  • Socs-3 protein
  • SOCS3 protein
  • Ssi-3 protein
  • Ssi3 protein
  • wu:fj09e12 protein
  • xsocs3 protein
  • zgc:56537 protein

Protein level used designations for SOCS3

suppressor of cytokine signaling 3 , suppressor of cytokine signaling 3a , STAT-induced STAT inhibitor 3 , cytokine-inducible SH2 protein 3 , cytokine signaling suppressor , SOCS-3 , CIS-3 , E2a-Pbx1 target gene in fibroblasts 10 , cytokine inducible SH2-containing protein 3 , suppressors of cytokine signaling 3

GENE ID SPECIES
335409 Danio rerio
380467 Xenopus laevis
394588 Xenopus (Silurana) tropicalis
414533 Xenopus laevis
448204 Xenopus (Silurana) tropicalis
454921 Pan troglodytes
100050730 Equus caballus
100192332 Gasterosteus aculeatus
100272212 Oncorhynchus mykiss
100294595 Ovis aries
100528984 Ictalurus punctatus
100227853 Taeniopygia guttata
9021 Homo sapiens
442949 Canis lupus familiaris
493186 Sus scrofa
282081 Bos taurus
12702 Mus musculus
89829 Rattus norvegicus
395299 Gallus gallus
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