SOCS3 Protein (AA 1-225, full length) (His-SUMO Tag)
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- Target See all SOCS3 Proteins
- SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))
- Protein Type
- Recombinant
- Protein Characteristics
- full length, AA 1-225
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Origin
- Rat
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This SOCS3 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL SAEPAGTFLI RDSSDQRHFF TLSVETQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV LKLVHHYMPP PGAPSFSLPP TEPSFEVQEQ PPAQALPGGT PKRAYYIYSG GEKIPLVLSR PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product SOCS3 Protein
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Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) protein (GST tag)
SOCS3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) protein (His-IF2DI Tag)SOCS3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) protein (Strep Tag)Crystallography grade SOCS3 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) protein (Strep Tag)Crystallography grade SOCS3 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) (Active) protein (His tag)SOCS3 Origin: Mouse Host: Escherichia coli (E. coli) > 97 % AcA, CC Active
Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225), (full length) protein (His tag)SOCS3 Origin: Rat Host: Yeast Recombinant > 90 % SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))
- Alternative Name
- SOCS3 (SOCS3 Products)
- Synonyms
- socs3 Protein, fj09e12 Protein, zgc:56537 Protein, wu:fj09e12 Protein, MGC64393 Protein, MGC75749 Protein, xsocs3 Protein, MGC81248 Protein, atod4 Protein, cis3 Protein, cish3 Protein, socs-3 Protein, ssi-3 Protein, ssi3 Protein, SOCS3 Protein, ATOD4 Protein, CIS3 Protein, Cish3 Protein, SOCS-3 Protein, SSI-3 Protein, SSI3 Protein, Cis3 Protein, EF-10 Protein, Ef10 Protein, Ssi3 Protein, Socs-3 Protein, Ssi-3 Protein, suppressor of cytokine signaling 3a Protein, suppressor of cytokine signaling 3 S homeolog Protein, suppressor of cytokine signaling 3 Protein, suppressor of cytokine signaling 3 L homeolog Protein, socs3a Protein, socs3.S Protein, socs3 Protein, socs3.L Protein, SOCS3 Protein, Socs3 Protein
- Background
- SOCS family proteins form part of a classical negative feedback syst that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize IL6ST .
- Molecular Weight
- 40.79 kDa
- UniProt
- O88583
- Pathways
- JAK-STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C
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