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Browse our MAPK3 Proteins (MAPK3)

Full name:
Mitogen-Activated Protein Kinase 3 Proteins (MAPK3)
On www.antibodies-online.com are 33 Mitogen-Activated Protein Kinase 3 (MAPK3) Proteins from 11 different suppliers available. Additionally we are shipping MAPK3 Antibodies (487) and MAPK3 Kits (41) and many more products for this protein. A total of 591 MAPK3 products are currently listed.
Synonyms:
ATMAPK3, ATMPK3, Erk-1, Erk1, Ert2, Esrk1, fi06b09, HS44KDAP, HUMKER1A, MAPK1, mitogen-activated protein kinase 3, MNK1, Mtap2k, p44, p44-ERK1, p44-MAPK, p44erk1, p44mapk, Prkm3, T6D9.4, Tb08.10J17.940, wu:fi06b09, zERK1
list all proteins Gene Name GeneID UniProt
MAPK3 5595 P27361
MAPK3 26417 Q63844
MAPK3 50689 P21708

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MAPK3 Proteins (MAPK3) by Origin

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Top referenced MAPK3 Proteins

  1. Human MAPK3 Protein expressed in Escherichia coli (E. coli) - ABIN667192 : Kim, Cochran: Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter. in Molecular and cellular biology 2000 (PubMed)

More Proteins for MAPK3 Interaction Partners

Arabidopsis thaliana Mitogen-Activated Protein Kinase 3 (MAPK3) interaction partners

  1. MKK4 (show MAP2K4 Proteins), MKK5 (show MAP2K5 Proteins), MKK7 (show MAP2K7 Proteins), and MKK9, are responsible for the activation of MPK3 and MPK6 (show MAPK6 Proteins) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (show MAPK1 Proteins) signaling through MKK4 (show MAP2K4 Proteins)/5/7/9-MPK3/6 cascades.

  2. Phosphatase AP2C1, as well as AP2C1-targeted MPK3 and MPK6 (show MAPK6 Proteins), are important regulators of plant-nematode interaction, where the co-ordinated action of these signalling components ensures the timely activation of plant defence.

  3. Results demonstrated the contribution of MPK3 and MPK6 (show MAPK6 Proteins) to riboflavin-induced resistance.

  4. These results indicate that the MVB pathway is positively regulated by pathogen-responsive MPK3/6 through LIP5 phosphorylation and plays a critical role in plant immune system

  5. MKK3-MPK6 is activated by blue light in a MYC2-dependent manner.

  6. MPK3 and MPK6 (show MAPK6 Proteins) target a subclass of 'VQ-motif'-containing proteins to regulate immune responses.

  7. MicroRNA biogenesis factor DRB1 (show EPHX1 Proteins) is a phosphorylation target of mitogen activated protein kinase (show MAPK1 Proteins) MPK3 in both rice and Arabidopsis

  8. MPK3 represses the constitutive and flg22-induced expression of defence genes in Arabidopsis thaliana.

  9. These results suggest that the MKK9-MPK3/MPK6 (show MAPK6 Proteins) cascade is part of the phosphate signaling pathway in plants.

  10. AZI1 overexpression in the mpk3 genetic background partially alleviates the salt-hypersensitive phenotype of this mutant, but functional MPK3 appears to be required for the full extent of AZI1-conferred robustness.

Cow (Bovine) Mitogen-Activated Protein Kinase 3 (MAPK3) interaction partners

  1. MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide (show NPPC Proteins) and this process is related to the EGFR (show EGFR Proteins) and MAPK3/1 signal pathways

  2. Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.

  3. ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.

  4. Thrombospondin 1 (show THBS1 Proteins), fibronectin (show FN1 Proteins), and vitronectin (show VTN Proteins) are differentially dependent upon RAS, ERK1/2, and p38 (show MAPK14 Proteins) for induction of vascular smooth muscle cell chemotaxis.

  5. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

  6. These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (show EGR1 Proteins) nuclear accumulation.

  7. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

  8. This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (show MAPK1 Proteins).

  9. findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 dependent.

  10. Results suggest that estrogen receptors and the ERK1/2 signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.

Candida albicans Mitogen-Activated Protein Kinase 3 (MAPK3) interaction partners

  1. Cek2 (show FGFR3 Proteins) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.

  2. knockdown of SUV420H1 (show SUV420H1 Proteins) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level

  3. Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (show MAPK1 Proteins) pathway in response to environmental cues.

  4. The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.

  5. Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (show CDC42 Proteins) GTPase (show RACGAP1 Proteins).

Zebrafish Mitogen-Activated Protein Kinase 3 (MAPK3) interaction partners

  1. ERK1/2-Akt1 (show AKT1 Proteins) crosstalk regulates arteriogenesis in mice and zebrafish.

  2. eena (show SH3GL1 Proteins) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (show MAPK1 Proteins) pathway

  3. ERK1 and ERK2 (show MAPK1 Proteins) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.

  4. These results demonstrate that induction of Hsp70 (show HSPA1A Proteins) in response to heat stress is dependent on ERK (show MAPK1 Proteins) activation in Pac2 (show PSMG2 Proteins) cells.

  5. Data define distinct roles for ERK1 and ERK2 (show MAPK1 Proteins) in developmental cell migration processes during zebrafish embryogenesis.

Human Mitogen-Activated Protein Kinase 3 (MAPK3) interaction partners

  1. Inhibiting miR (show MLXIP Proteins)-21 attenuates hepatic fibrosis by suppressing both the ERK1 in hepatic stellate cells and epithelial-mesenchymal transition of hepatocyte.

  2. ERK1 and ERK2 interact with Gab2 via a novel docking motif, which is required for subsequent Gab2 phosphorylation in response to ERK1/2 activation.

  3. By simulating therapeutic strategies that target multiple nodes of the pathway such as Raf and SphK1, we conclude that combination therapy should be much more effective in blocking VEGF signaling to EKR1/2. The model has important implications for interventions that target signaling pathways in angiogenesis relevant to cancer, vascular diseases, and wound healing.

  4. Taken together we show that FBXO25 functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation.

  5. IQ domain of IQGAP1 is both necessary and sufficient for binding to ERK1 and ERK2 (show MAPK1 Proteins), as well as to the MAPK (show MAPK1 Proteins) kinases MEK1 (show MAP2K1 Proteins) and MEK2 (show MAP2K2 Proteins).

  6. The level of ERK1/2 phosphorylation was significantly increased by tunicamycin treatment in control cells, not in SLC30A3 (show Slc30a3 Proteins) knockdown cells. The ERK1/2 pathway is thought to have an association with defensive effects of SLC30A3 (show Slc30a3 Proteins) on cellular stress such as ER stress.

  7. VEGF-A (show VEGFA Proteins) driven Mdm2 (show MDM2 Proteins) phosphorylation on Ser166 is dependent on the ERK1/2/p90RSK (show RPS6KA1 Proteins) signaling pathway in primary human endothelial cells.

  8. Deregulated ERK1/2 MAP kinase (show MAPK1 Proteins) signaling promotes aneuploidy by a Fbxw7beta-Aurora A (show AURKA Proteins) pathway.

  9. CCL2 (show CCL2 Proteins) suppressed HDL (show HSD11B1 Proteins) internalization and cholesterol efflux via CCR2 (show CCR2 Proteins) induction and p42 (show EPB42 Proteins)/44 MAPK (show MAPK1 Proteins) activation in ECs. CCL2 (show CCL2 Proteins) induction may contribute to impair HDL (show HSD11B1 Proteins) function and form atherosclerosis in coronary artery disease.

  10. This implies a pleiotropic effect of ERK1/2 in cellular senescence induced by excess thymidine.

Mouse (Murine) Mitogen-Activated Protein Kinase 3 (MAPK3) interaction partners

  1. We also demonstrated that ERK1 deletion potentiates DC vaccination and provides a survival advantage in high-grade gliomas.

  2. Low frequency pulsed electromagnetic field (PEMF) induced the activation of extracellular signal-regulated kinases ERK1/2, and the phosphorylation level of ERK1/2 increased after 15 min when exposed to PEMF.

  3. A- and B-Raf ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF protein stability.

  4. RKIP (show PEBP1 Proteins) knockdown promotes ERK1 and PPAR gamma (show PPARG Proteins) activation during adipogenesis.

  5. Results indicate that methanol extract of Thunbergia alata (MTA (show DNMT1 Proteins)) selectively inhibits the excessive production of inflammatory mediators in macrophages by reducing phosphorylation of extracellular signalregulated kinase (ERK (show EPHB2 Proteins)) and signal transducer and activator of transcription 3 (STAT3 (show STAT3 Proteins)).

  6. Neuroprotective effects of oleoylethanolamide on cerebral ischemia may be attributed to its antiapoptotic property achieved, at least in part, through the PPARalpha signaling and inhibition of both TLR4/NF-kappaB and ERK1/2 signaling pathways.

  7. These results indicated that the activation of the ERK1/2 signal transduction pathway may have an important role in glucosestimulated insulin (show INS Proteins) secretion in betaTC6 cells.

  8. PI3K, MAPK/ERK (show MAPK1 Proteins) 1/2, and p38 (show CRK Proteins)-signaling proteins are not the main regulators of local production of erythropoietin (show EPO Proteins) after 30% loss of circulating blood volume.

  9. Lipopolysaccharides significantly up-regulated RANKL (show TNFSF11 Proteins) expression and activated the ERK1/2 pathway to induce IL-6 (show IL6 Proteins) mRNA expression and protein synthesis in MLO-Y4 cells.

  10. RACK1 (show GNB2L1 Proteins) plays an important role in the maintenance of morphine conditioned place preference, likely via activation of ERK (show EPHB2 Proteins)-CREB (show CREB1 Proteins) pathway in hippocampus.

Pig (Porcine) Mitogen-Activated Protein Kinase 3 (MAPK3) interaction partners

  1. Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (show BCL2L11 Proteins).

  2. Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.

  3. This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.

  4. CSF2 (show CSF2 Proteins) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (show MAPK1 Proteins)-dependent MTOR (show FRAP1 Proteins) signal transduction cascades.

  5. PGRN (show GRN Proteins) inhibits adipogenesis in porcine preadipocytes partially through ERK (show MAPK1 Proteins) activation mediated PPARgamma (show PPARG Proteins) phosphorylation.

  6. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Proteins)/ERK (show MAPK1 Proteins)/TSC2/mTOR (show FRAP1 Proteins) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  7. Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (show MAPK8 Proteins)/2 dependent.

  8. Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 and p38 MAPK (show MAPK14 Proteins) phosphorylation

  9. ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (show IGF1 Proteins) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (show IGF1R Proteins)

  10. Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.

MAPK3 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.

Alternative names and synonyms associated with MAPK3

  • mitogen-activated protein kinase 3 (MPK3)
  • mitogen-activated protein kinase 3 (MAPK3)
  • MAP kinase-like orf; aka CEK1; one of two protein kinase genes similar to S. cerevisiae MAP kinases FUS3 (YBL016W) and KSS1 (YGR040W) involved in pheromone signal transduction (ERK1)
  • mitogen-activated protein kinase 3 (Mapk3)
  • mitogen-activated protein kinase 3 (mapk3)
  • mitogen activated protein kinase 3 (Mapk3)
  • mitogen-activated protein kinase 3 (Tb927.8.3550)
  • mitogen-activated protein kinase 3 (Tc00.1047053509475.10)
  • ATMAPK3 protein
  • ATMPK3 protein
  • Erk-1 protein
  • Erk1 protein
  • Ert2 protein
  • Esrk1 protein
  • fi06b09 protein
  • HS44KDAP protein
  • HUMKER1A protein
  • MAPK1 protein
  • mitogen-activated protein kinase 3 protein
  • MNK1 protein
  • Mtap2k protein
  • p44 protein
  • p44-ERK1 protein
  • p44-MAPK protein
  • p44erk1 protein
  • p44mapk protein
  • Prkm3 protein
  • T6D9.4 protein
  • Tb08.10J17.940 protein
  • wu:fi06b09 protein
  • zERK1 protein

Protein level used designations for MAPK3

extracellular signal-regulated kinase 1 , likely protein kinase , MAP kinase isoform p44 , MAPK 1 , extracellular signal-related kinase 1 , insulin-stimulated MAP2 kinase , microtubule-associated protein 2 kinase , MAP kinase 3 , p44 MAP kinase , pp42/MAP kinase , MAP kinase 1 , MAPK 3 , mitogen-activated 3 , mitogen-activated protein kinase 1 , mitogen-activated protein kinase 3 , extracellular signal-regulated kinase-1

GENE ID SPECIES
823706 Arabidopsis thaliana
531391 Bos taurus
3642789 Candida albicans SC5314
479790 Canis lupus familiaris
100725692 Cavia porcellus
399480 Danio rerio
100066173 Equus caballus
5595 Homo sapiens
26417 Mus musculus
50689 Rattus norvegicus
445013 Sus scrofa
3659358 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3531528 Trypanosoma cruzi strain CL Brener
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