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Browse our anti-ROCK1 (ROCK1) Antibodies

Full name:
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 1 Antibodies (ROCK1)
On www.antibodies-online.com are 148 rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Antibodies from 26 different suppliers available. Additionally we are shipping ROCK1 Proteins (6) and ROCK1 Kits (2) and many more products for this protein. A total of 161 ROCK1 products are currently listed.
Synonyms:
1110055K06Rik, CG9774, Dmel\\CG9774, DRhk, drok, LOC100229794, p160ROCK, Rhk, RhoK, Rock, ROCK-1, ROCK-I, ROCK1, Rok, ROKalpha/beta
list all antibodies Gene Name GeneID UniProt
ROCK1 19877 P70335
ROCK1 81762 Q63644
ROCK1 6093 Q13464

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Most Popular Reactivities for anti-ROCK1 (ROCK1) Antibodies

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anti-Mouse (Murine) ROCK1 Antibodies:

anti-Rat (Rattus) ROCK1 Antibodies:

anti-Human ROCK1 Antibodies:

All available anti-ROCK1 Antibodies

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Top referenced anti-ROCK1 Antibodies

  1. Human Monoclonal ROCK1 Primary Antibody for IF, WB - ABIN968386 : Ishizaki, Maekawa, Fujisawa, Okawa, Iwamatsu, Fujita, Watanabe, Saito, Kakizuka, Morii, Narumiya: The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. in The EMBO journal 1996 (PubMed)
    Show all 5 references for ABIN968386

  2. Dog (Canine) Monoclonal ROCK1 Primary Antibody for ICC, IF - ABIN252549 : Zhao, Miller, Pfeiffer, Buras, Stahl: Anoxia and reoxygenation of human endothelial cells decrease ceramide glucosyltransferase expression and activates caspases. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 (PubMed)
    Show all 4 references for ABIN252549

  3. Human Polyclonal ROCK1 Primary Antibody for IF (p), IHC (p) - ABIN707771 : Wang, Zhang, Wang, Zhang, Mao, Zhuang, Tang, Luo, Zhou, Zhang: Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway. in The international journal of biochemistry & cell biology 2013 (PubMed)
    Show all 2 references for ABIN707771

  4. Human Polyclonal ROCK1 Primary Antibody for EIA, WB - ABIN783446 : Takahashi, Tuiki, Saya, Kaibuchi: Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24. in Genomics 1999 (PubMed)
    Show all 2 references for ABIN783446

  5. Human Monoclonal ROCK1 Primary Antibody for ELISA, WB - ABIN969563 : Kroll, Epting, Kern, Dietz, Feng, Hammes, Wieland, Augustin: Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. in American journal of physiology. Heart and circulatory physiology 2009 (PubMed)
    Show all 2 references for ABIN969563

  6. Human Polyclonal ROCK1 Primary Antibody for ICC, IF - ABIN152055 : Chang, Xie, Shah, Schneider, Entman, Wei, Schwartz: Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 2 references for ABIN152055

  7. Human Monoclonal ROCK1 Primary Antibody for IF, ELISA - ABIN562671 : Gong, Fang, Peng, Liu, Du: Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors. in Journal of biotechnology 2010 (PubMed)
    Show all 2 references for ABIN562671

  8. Human Monoclonal ROCK1 Primary Antibody for WB - ABIN223244 : Dasgupta, Argaiz, Mercado, Maul, Garza, Enriquez, Abdel-Monem, Prakasam, Andreeff, Thiagarajan: Platelet senescence and phosphatidylserine exposure. in Transfusion 2010 (PubMed)

More Antibodies against ROCK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (show FHOD1 Antibodies) homolog Knittrig in controlling macrophage migration

  2. Atonal and EGFR (show EGFR Antibodies) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.

  3. The structure of Shrm (show SHROOM3 Antibodies) domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm (show SHROOM3 Antibodies) function, is reported.

  4. Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.

  5. CD44 (show CD44 Antibodies) interaction with p115RhoGEF (show ARHGEF1 Antibodies) and ROK plays a pivotal role in promoting Gab-1 (show GAB1 Antibodies) phosphorylation leading to Gab-1 (show GAB1 Antibodies).PI 3 (show PI3 Antibodies)-kinase membrane localization, AKT (show AKT1 Antibodies) signaling, and cytokine (M-CSF (show CSF1R Antibodies)) production during HA-mediated breast cancer progression

  6. Drok and Drosophila Lim (show ZYX Antibodies)-kinase interact in the developing nervous system

  7. DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis

  8. activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics

  9. In parallel to regulation of crb RNA and protein, Rho1 activity also signals through Rho-kinase (Rok) to induce apical constriction and cell shape change during invagination of salivary gland.

Mouse (Murine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. Inhibition of ROCK1 largely blocked Endothelial-to-mesenchymal transition and the increase in endothelial permeability under this high-glucose condition, but overexpression of ROCK1 induced these changes.

  2. While the loss of either Rock1 or Rock2 (show ROCK2 Antibodies) had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 (show ROCK2 Antibodies) have been genetically deleted.

  3. Fyn (show FYN Antibodies) mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin (show PXN Antibodies) phosphorylation

  4. YQFM ameliorates the OGD-induced brain microvascular endothelial cell barrier disruption associated with the NF-kappaB/p65 and ROCK1/MLC signaling pathways.

  5. Extracellular vesicle-encapsulated caspase-3 (show CASP3 Antibodies) was largely responsible for the alveolar macrophage activation via the ROCK1 pathway.

  6. indicates that the up-regulation of ROCK1 activity in RhoA (show RHOA Antibodies)-deleted macrophages and macrophage phenotype/polarity are dependent on non-apoptotic Caspase-3 (show CASP3 Antibodies)

  7. Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

  8. Results suggest that Rho-associated, coiled-coil containing protein kinase (ROCK) inhibitors fasudil may be an emerging therapeutic option for targeting cancer vasculogenic mimicry (VM).

  9. doxorubicin induces caspase (show CASP3 Antibodies) activation, necrosis, and actin cytoskeleton alterations largely through ROCK1-dependent and oxidative stress-independent pathways

  10. Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR (show PTPRF Antibodies) and RPTPsigma (show PTPRS Antibodies) and Modulation of the Rho/ROCK Pathway.

Human rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. vThese results suggest that ROCK may be important in IL-1 (show IL1A Antibodies)-induced signaling through MKK4 (show MAP2K4 Antibodies) to JNK (show MAPK8 Antibodies) and the activation of p38 MAPK (show MAPK14 Antibodies).

  2. There are 2 isoforms: ROCK1 and ROCK2 (show ROCK2 Antibodies). They have different functions in different types of cells and tissues. There is growing evidence that ROCKs contribute to the development of cardiovascular diseases, including cardiac fibrosis, hypertrophy, and subsequent heart failure.

  3. the results suggested that miR335 directly targets Rhoassociated protein kinase (show CDK7 Antibodies) 1 (ROCK1) in bladder cancer.

  4. Data suggest that Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor Y-27632 may be therapeutically useful in tongue squamous cell carcinoma (TSCC).

  5. these findings indicate that miR (show MLXIP Antibodies)-145 acts as a tumor suppressor and its downregulation in tumor tissues may contribute to the progression and metastasis of hepatocellular carcinoma (HCC (show FAM126A Antibodies))through a mechanism involving ROCK1, suggesting miR (show MLXIP Antibodies)-145 as a potential new diagnostic and therapeutic target for the treatment of HCC (show FAM126A Antibodies)

  6. Increased ROCK1 expression is associated with breast cancer.

  7. The level of ROCK1 increases in junctional zone smooth muscle cells in patients with adenomyosis.

  8. Significant associations between ROCK1, ROCK2 (show ROCK2 Antibodies), RhoA (show RHOA Antibodies) and RhoC (show RHOC Antibodies) gene polymorphisms and systemic sclerosis were demonstrated.

  9. Data show tht Rho kinase (ROCK) activity was increased by inhibiting integrin alpha4 with human umbilical vein endothelial cells (HUVECs) and hypoxia.

  10. Melatonin has shown to be effective in controlling metastatic breast cancer in vitro and in vivo, not only via inhibition of the proliferation of tumor cells but also through direct antagonism of metastatic mechanism of cells rendered by ROCK-1 inhibition.

Rabbit rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

Pig (Porcine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. Results indicate that ROCK1 and ROCK2 (show ROCK2 Antibodies) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.

  2. It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.

Cow (Bovine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (show LIMK1 Antibodies)/cofilin (show CFL1 Antibodies) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.

  2. In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.

  3. p38 (show MAPK14 Antibodies) phosphorylation and MMP13 (show MMP13 Antibodies) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  4. The RhoA (show RHOA Antibodies)/ROCK signaling pathway is an important negative regulator of vascular calcification.

  5. caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A (show HTR2A Antibodies)) receptors through their Rho/ROCK signaling.

  6. A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (show DDX4 Antibodies) vasorum endothelial cells, is reported.

ROCK1 Antigen Profile

Antigen Summary

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

Alternative names and synonyms associated with ROCK1

  • Rho-associated, coiled-coil containing protein kinase 1 (ROCK1) antibody
  • Rho-associated, coiled-coil containing protein kinase 1 (LOC100229794) antibody
  • Rho-kinase (rok) antibody
  • Rho-associated coiled-coil containing protein kinase 1 (Rock1) antibody
  • Rho-associated, coiled-coil containing protein kinase 1 (rock1) antibody
  • 1110055K06Rik antibody
  • CG9774 antibody
  • Dmel\\CG9774 antibody
  • DRhk antibody
  • drok antibody
  • LOC100229794 antibody
  • p160ROCK antibody
  • Rhk antibody
  • RhoK antibody
  • Rock antibody
  • ROCK-1 antibody
  • ROCK-I antibody
  • ROCK1 antibody
  • Rok antibody
  • ROKalpha/beta antibody

Protein level used designations for ROCK1

Rho-associated coiled coil containing protein kinase 1 , rho-associated protein kinase 1 , Rho-associated, coiled-coil containing protein kinase 1 , CG9774-PA , DRho-kinase , ROCK , Rho-associated kinase , RhoA kinase , drosophila rho-associated kinase , rho kinase , rok-PA , Rho-associated coiled-coil forming kinase 1 , p160 ROCK-1 , p160ROCK , rho-associated, coiled-coil-containing protein kinase 1 , rho-associated, coiled-coil-containing protein kinase I , Rho-associated kinase beta , liver regeneration-related protein LRRG199 , p150 RhoA-binding kinase ROK beta , Rho kinase , p160-ROCK , renal carcinoma antigen NY-REN-35 , HEBM1 , cAMP-dependent protein kinase ROCK-I , cePKA , corneal epithelial Rho-associated-Ser/Thr kinase 1 , Rho-kinase beta , Rho-associated protein kinase 1 , rho-associated coiled-coil domain-containing protein kinase 1

GENE ID SPECIES
100034056 Equus caballus
100229794 Taeniopygia guttata
43916 Drosophila melanogaster
19877 Mus musculus
81762 Rattus norvegicus
6093 Homo sapiens
480181 Canis lupus familiaris
100009220 Oryctolagus cuniculus
397447 Sus scrofa
785911 Bos taurus
455326 Pan troglodytes
100329779 Danio rerio
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