Browse our anti-ROCK1 (ROCK1) Antibodies

Full name:
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 1 Antibodies (ROCK1)
On are 152 rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Antibodies from 29 different suppliers available. Additionally we are shipping ROCK1 Proteins (9) and ROCK1 Kits (4) and many more products for this protein. A total of 170 ROCK1 products are currently listed.
1110055K06Rik, CG9774, Dmel\\CG9774, DRhk, drok, LOC100229794, p160ROCK, Rhk, RhoK, Rock, ROCK-1, ROCK-I, ROCK1, Rok, ROKalpha/beta
list all antibodies Gene Name GeneID UniProt
ROCK1 19877 P70335
ROCK1 81762 Q63644
ROCK1 6093 Q13464

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Most Popular Reactivities for anti-ROCK1 (ROCK1) Antibodies

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anti-Mouse (Murine) ROCK1 Antibodies:

anti-Rat (Rattus) ROCK1 Antibodies:

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Top referenced anti-ROCK1 Antibodies

  1. Human Monoclonal ROCK1 Primary Antibody for IF, WB - ABIN968386 : Ishizaki, Maekawa, Fujisawa, Okawa, Iwamatsu, Fujita, Watanabe, Saito, Kakizuka, Morii, Narumiya: The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. in The EMBO journal 1996 (PubMed)
    Show all 5 references for 968386

  2. Dog (Canine) Monoclonal ROCK1 Primary Antibody for ICC, IF - ABIN252549 : Zhao, Miller, Pfeiffer, Buras, Stahl: Anoxia and reoxygenation of human endothelial cells decrease ceramide glucosyltransferase expression and activates caspases. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 (PubMed)
    Show all 4 references for 252549

  3. Human Polyclonal ROCK1 Primary Antibody for ICC, IF - ABIN152055 : Chang, Xie, Shah, Schneider, Entman, Wei, Schwartz: Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 3 references for 152055

  4. Human Monoclonal ROCK1 Primary Antibody for IF, ELISA - ABIN562671 : Gong, Fang, Peng, Liu, Du: Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors. in Journal of biotechnology 2010 (PubMed)
    Show all 2 references for 562671

  5. Human Polyclonal ROCK1 Primary Antibody for IF (p), IHC (p) - ABIN707771 : Wang, Zhang, Wang, Zhang, Mao, Zhuang, Tang, Luo, Zhou, Zhang: Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway. in The international journal of biochemistry & cell biology 2013 (PubMed)
    Show all 2 references for 707771

  6. Human Monoclonal ROCK1 Primary Antibody for ELISA, WB - ABIN969563 : Kroll, Epting, Kern, Dietz, Feng, Hammes, Wieland, Augustin: Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. in American journal of physiology. Heart and circulatory physiology 2009 (PubMed)
    Show all 2 references for 969563

  7. Human Monoclonal ROCK1 Primary Antibody for WB - ABIN223244 : Dasgupta, Argaiz, Mercado, Maul, Garza, Enriquez, Abdel-Monem, Prakasam, Andreeff, Thiagarajan: Platelet senescence and phosphatidylserine exposure. in Transfusion 2010 (PubMed)

More Antibodies against ROCK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. Loss of DRok function in tendon cells results in mis (show AMH Antibodies)-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous (show TNC Antibodies) junction formation and muscle morphogenesis.

  2. model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (show FHOD1 Antibodies) homolog Knittrig in controlling macrophage migration

  3. Atonal and EGFR (show EGFR Antibodies) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.

  4. The structure of Shrm (show SHROOM3 Antibodies) domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm (show SHROOM3 Antibodies) function, is reported.

  5. Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.

  6. CD44 (show CD44 Antibodies) interaction with p115RhoGEF (show ARHGEF1 Antibodies) and ROK plays a pivotal role in promoting Gab-1 (show GAB1 Antibodies) phosphorylation leading to Gab-1 (show GAB1 Antibodies).PI 3 (show PI3 Antibodies)-kinase membrane localization, AKT (show AKT1 Antibodies) signaling, and cytokine (M-CSF (show CSF1R Antibodies)) production during HA-mediated breast cancer progression

  7. Drok and Drosophila Lim (show ZYX Antibodies)-kinase interact in the developing nervous system

  8. DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis

  9. activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics

  10. In parallel to regulation of crb RNA and protein, Rho1 activity also signals through Rho-kinase (Rok) to induce apical constriction and cell shape change during invagination of salivary gland.

Mouse (Murine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation

  2. ANXA1 (show ANXA1 Antibodies) restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA (show RHOA Antibodies)-ROCK signaling pathway

  3. the cross-talk between canonical and non-canonical signaling pathways of Wnt3A (show WNT3A Antibodies), which induces GSK-3beta (show GSK3b Antibodies) phosphorylation and beta-catenin (show CTNNB1 Antibodies) accumulation through RhoA (show RHOA Antibodies) and ROCK activation.

  4. Inhibition of ROCK1 largely blocked Endothelial-to-mesenchymal transition and the increase in endothelial permeability under this high-glucose condition, but overexpression of ROCK1 induced these changes.

  5. While the loss of either Rock1 or Rock2 (show ROCK2 Antibodies) had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 (show ROCK2 Antibodies) have been genetically deleted.

  6. Fyn (show FYN Antibodies) mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin (show PXN Antibodies) phosphorylation

  7. YQFM ameliorates the OGD-induced brain microvascular endothelial cell barrier disruption associated with the NF-kappaB/p65 and ROCK1/MLC signaling pathways.

  8. Extracellular vesicle-encapsulated caspase-3 (show CASP3 Antibodies) was largely responsible for the alveolar macrophage activation via the ROCK1 pathway.

  9. In experimental autoimmune encephalomyelitis (EAE), ROCK activity was also increased in serum, spleen, brain and spinal cord. Neuron injury with scratch and TNF-alpha (show TNF Antibodies) stimulation induced the up-regulation of ROCK activity.

  10. indicates that the up-regulation of ROCK1 activity in RhoA (show RHOA Antibodies)-deleted macrophages and macrophage phenotype/polarity are dependent on non-apoptotic Caspase-3 (show CASP3 Antibodies)

Human rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. Despite sharing the catalytic domain with ROCK2 (show ROCK2 Antibodies), ROCK1 appears to be the dominant kinase essential for junctional integrity and contractile tension at epithelial ZA.

  2. RhoA (show RHOA Antibodies)/ROCK and Raf-1 (show RAF1 Antibodies)/CK2 (show CSNK2A1 Antibodies) pathway are responsible for TNF-alpha (show TNF Antibodies)-mediated endothelial cytotoxicity via regulation of the vimentin (show VIM Antibodies) cytoskeleton.

  3. High ROCK1 expression is associated with Clear cell renal cell carcinoma (show MOK Antibodies).

  4. Studies showed that ROCK isoforms, ROCK1 and ROCK2 (show ROCK2 Antibodies), have been found in various types of neuron-like cell lines and neurons, and function as different regulators in axon outgrowth, neurite retraction, cell survival, autophagy, energy balance, and generation of endogenous beta amyloid. [review]

  5. BCR-ABL-dependent ROCK, but not TK, is involved in CD1d downregulation. We propose that ROCK, which is most likely activated by the DH/PH domain of BCR-ABL, mediates iNKT-cell immune subversion in chronic myeloid leukaemia (CML) patients by downregulating CD1d expression on CML mDCs.

  6. that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation

  7. Silencing Drp1 (show CRMP1 Antibodies) inhibits glioma cells proliferation and invasion by RHOA (show RHOA Antibodies)/ ROCK1 pathway.

  8. RhoB and ROCK play a key role in preeclampsia.

  9. We successfully identified a novel pathway via which SIN (show EFS Antibodies) exerted antioxidative and renal protective functions, and provided a molecular basis for potential SIN (show EFS Antibodies) applications in treating DN vascular disorders.

  10. The results of the present study indicate that miR126 inhibits RCC (show XRCC1 Antibodies) cell proliferation, migration and invasion by downregulating ROCK1.

Rabbit rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

Pig (Porcine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. Results indicate that ROCK1 and ROCK2 (show ROCK2 Antibodies) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.

  2. It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.

Cow (Bovine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (show LIMK1 Antibodies)/cofilin (show CFL1 Antibodies) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.

  2. In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.

  3. p38 (show MAPK14 Antibodies) phosphorylation and MMP13 (show MMP13 Antibodies) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  4. The RhoA (show RHOA Antibodies)/ROCK signaling pathway is an important negative regulator of vascular calcification.

  5. caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A (show HTR2A PLURAL_@19334@)) receptors through their Rho/ROCK signaling.

  6. A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (show DDX4 Antibodies) vasorum endothelial cells, is reported.

ROCK1 Antigen Profile

Antigen Summary

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

Alternative names and synonyms associated with ROCK1

  • Rho-associated, coiled-coil containing protein kinase 1 (ROCK1) antibody
  • Rho-associated, coiled-coil containing protein kinase 1 (LOC100229794) antibody
  • Rho-kinase (rok) antibody
  • Rho-associated coiled-coil containing protein kinase 1 (Rock1) antibody
  • Rho-associated, coiled-coil containing protein kinase 1 (rock1) antibody
  • 1110055K06Rik antibody
  • CG9774 antibody
  • Dmel\\CG9774 antibody
  • DRhk antibody
  • drok antibody
  • LOC100229794 antibody
  • p160ROCK antibody
  • Rhk antibody
  • RhoK antibody
  • Rock antibody
  • ROCK-1 antibody
  • ROCK-I antibody
  • ROCK1 antibody
  • Rok antibody
  • ROKalpha/beta antibody

Protein level used designations for ROCK1

Rho-associated coiled coil containing protein kinase 1 , rho-associated protein kinase 1 , Rho-associated, coiled-coil containing protein kinase 1 , CG9774-PA , DRho-kinase , ROCK , Rho-associated kinase , RhoA kinase , drosophila rho-associated kinase , rho kinase , rok-PA , Rho-associated coiled-coil forming kinase 1 , p160 ROCK-1 , p160ROCK , rho-associated, coiled-coil-containing protein kinase 1 , rho-associated, coiled-coil-containing protein kinase I , Rho-associated kinase beta , liver regeneration-related protein LRRG199 , p150 RhoA-binding kinase ROK beta , Rho kinase , p160-ROCK , renal carcinoma antigen NY-REN-35 , HEBM1 , cAMP-dependent protein kinase ROCK-I , cePKA , corneal epithelial Rho-associated-Ser/Thr kinase 1 , Rho-kinase beta , Rho-associated protein kinase 1 , rho-associated coiled-coil domain-containing protein kinase 1

100034056 Equus caballus
100229794 Taeniopygia guttata
43916 Drosophila melanogaster
19877 Mus musculus
81762 Rattus norvegicus
6093 Homo sapiens
480181 Canis lupus familiaris
100009220 Oryctolagus cuniculus
397447 Sus scrofa
785911 Bos taurus
455326 Pan troglodytes
100329779 Danio rerio
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