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anti-Mouse (Murine) ROCK1 Antibodies:
anti-Rat (Rattus) ROCK1 Antibodies:
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Human Monoclonal ROCK1 Primary Antibody for IF, WB - ABIN968386
Ishizaki, Maekawa, Fujisawa, Okawa, Iwamatsu, Fujita, Watanabe, Saito, Kakizuka, Morii, Narumiya: The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. in The EMBO journal 1996
Show all 5 Pubmed References
Human Monoclonal ROCK1 Primary Antibody for IF, WB - ABIN968387
Nakagawa, Fujisawa, Ishizaki, Saito, Nakao, Narumiya: ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. in FEBS letters 1996
Show all 5 Pubmed References
Dog (Canine) Monoclonal ROCK1 Primary Antibody for ICC, IF - ABIN252549
Zhao, Miller, Pfeiffer, Buras, Stahl: Anoxia and reoxygenation of human endothelial cells decrease ceramide glucosyltransferase expression and activates caspases. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003
Show all 4 Pubmed References
Human Polyclonal ROCK1 Primary Antibody for ICC, IF - ABIN152055
Chang, Xie, Shah, Schneider, Entman, Wei, Schwartz: Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 3 Pubmed References
Human Polyclonal ROCK1 Primary Antibody for IF (p), IHC (p) - ABIN707771
Wang, Zhang, Wang, Zhang, Mao, Zhuang, Tang, Luo, Zhou, Zhang: Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway. in The international journal of biochemistry & cell biology 2013
Show all 2 Pubmed References
Human Monoclonal ROCK1 Primary Antibody for IF, ELISA - ABIN562671
Gong, Fang, Peng, Liu, Du: Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors. in Journal of biotechnology 2010
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Human Monoclonal ROCK1 Primary Antibody for ELISA, WB - ABIN969563
Kroll, Epting, Kern, Dietz, Feng, Hammes, Wieland, Augustin: Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. in American journal of physiology. Heart and circulatory physiology 2009
Show all 2 Pubmed References
Human Monoclonal ROCK1 Primary Antibody for WB - ABIN223244
Dasgupta, Argaiz, Mercado, Maul, Garza, Enriquez, Abdel-Monem, Prakasam, Andreeff, Thiagarajan: Platelet senescence and phosphatidylserine exposure. in Transfusion 2010
polarity-induced spatiotemporal control of Rok and Pkn (show PKN1 Antibodies) is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.
Loss of DRok function in tendon cells results in mis (show AMH Antibodies)-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous (show TNC Antibodies) junction formation and muscle morphogenesis.
model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (show FHOD1 Antibodies) homolog Knittrig in controlling macrophage migration
Atonal and EGFR (show EGFR Antibodies) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
The structure of Shrm (show SHROOM3 Antibodies) domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm (show SHROOM3 Antibodies) function, is reported.
Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.
CD44 (show CD44 Antibodies) interaction with p115RhoGEF (show ARHGEF1 Antibodies) and ROK plays a pivotal role in promoting Gab-1 (show GAB1 Antibodies) phosphorylation leading to Gab-1 (show GAB1 Antibodies).PI 3 (show PI3 Antibodies)-kinase membrane localization, AKT (show AKT1 Antibodies) signaling, and cytokine (M-CSF (show CSF1R Antibodies)) production during HA-mediated breast cancer progression
Drok and Drosophila Lim (show ZYX Antibodies)-kinase interact in the developing nervous system
DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis
activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
Data indicate that oxidative stress in diabetes causes a decrease in miR (show MLXIP Antibodies)-133a expression leading to an increase in RhoA (show RHOA Antibodies)/Rho kinase (show ROCK2 Antibodies) pathway and muscle contraction.
that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation
ANXA1 (show ANXA1 Antibodies) restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA (show RHOA Antibodies)-ROCK signaling pathway
the cross-talk between canonical and non-canonical signaling pathways of Wnt3A (show WNT3A Antibodies), which induces GSK-3beta (show GSK3b Antibodies) phosphorylation and beta-catenin (show CTNNB1 Antibodies) accumulation through RhoA (show RHOA Antibodies) and ROCK activation.
Inhibition of ROCK1 largely blocked Endothelial-to-mesenchymal transition and the increase in endothelial permeability under this high-glucose condition, but overexpression of ROCK1 induced these changes.
While the loss of either Rock1 or Rock2 (show ROCK2 Antibodies) had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 (show ROCK2 Antibodies) have been genetically deleted.
Fyn (show FYN Antibodies) mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin (show PXN Antibodies) phosphorylation
YQFM ameliorates the OGD-induced brain microvascular endothelial cell barrier disruption associated with the NF-kappaB/p65 and ROCK1/MLC signaling pathways.
Extracellular vesicle-encapsulated caspase-3 (show CASP3 Antibodies) was largely responsible for the alveolar macrophage activation via the ROCK1 pathway.
In experimental autoimmune encephalomyelitis (EAE), ROCK activity was also increased in serum, spleen, brain and spinal cord. Neuron injury with scratch and TNF-alpha (show TNF Antibodies) stimulation induced the up-regulation of ROCK activity.
Genetic variant in ROCK1 gene is associated with progression of prostate cancer.
Results showed that ROCK1 gene rs2271255 (Lys222Glu), rs35996865, and ROCK2 (show ROCK2 Antibodies) gene rs726843, rs2290156, rs10178332, rs35768389 (Asp601Val) polymorphisms were significantly associated with respiratory distress syndrome (RDS (show PRPH2 Antibodies)), and that they could be a risk factor for development of neonatal RDS (show PRPH2 Antibodies).
Despite sharing the catalytic domain with ROCK2 (show ROCK2 Antibodies), ROCK1 appears to be the dominant kinase essential for junctional integrity and contractile tension at epithelial ZA.
RhoA (show RHOA Antibodies)/ROCK and Raf-1 (show RAF1 Antibodies)/CK2 (show CSNK2A1 Antibodies) pathway are responsible for TNF-alpha (show TNF Antibodies)-mediated endothelial cytotoxicity via regulation of the vimentin (show VIM Antibodies) cytoskeleton.
High ROCK1 expression is associated with Clear cell renal cell carcinoma (show MOK Antibodies).
Studies showed that ROCK isoforms, ROCK1 and ROCK2 (show ROCK2 Antibodies), have been found in various types of neuron-like cell lines and neurons, and function as different regulators in axon outgrowth, neurite retraction, cell survival, autophagy, energy balance, and generation of endogenous beta amyloid. [review]
BCR-ABL-dependent ROCK, but not TK, is involved in CD1d downregulation. We propose that ROCK, which is most likely activated by the DH/PH domain of BCR-ABL, mediates iNKT-cell immune subversion in chronic myeloid leukaemia (CML) patients by downregulating CD1d expression on CML mDCs.
Silencing Drp1 (show CRMP1 Antibodies) inhibits glioma cells proliferation and invasion by RHOA (show RHOA Antibodies)/ ROCK1 pathway.
RhoB and ROCK play a key role in preeclampsia.
Results indicate that ROCK1 and ROCK2 (show ROCK2 Antibodies) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.
results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (show LIMK1 Antibodies)/cofilin (show CFL1 Antibodies) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.
In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.
p38 (show MAPK14 Antibodies) phosphorylation and MMP13 (show MMP13 Antibodies) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
The RhoA (show RHOA Antibodies)/ROCK signaling pathway is an important negative regulator of vascular calcification.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (show DDX4 Antibodies) vasorum endothelial cells, is reported.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Rho-associated coiled coil containing protein kinase 1
, rho-associated protein kinase 1
, Rho-associated, coiled-coil containing protein kinase 1
, Rho-associated kinase
, RhoA kinase
, drosophila rho-associated kinase
, rho kinase
, Rho-associated coiled-coil forming kinase 1
, p160 ROCK-1
, rho-associated, coiled-coil-containing protein kinase 1
, rho-associated, coiled-coil-containing protein kinase I
, Rho-associated kinase beta
, liver regeneration-related protein LRRG199
, p150 RhoA-binding kinase ROK beta
, Rho kinase
, renal carcinoma antigen NY-REN-35
, cAMP-dependent protein kinase ROCK-I
, corneal epithelial Rho-associated-Ser/Thr kinase 1
, Rho-kinase beta
, Rho-associated protein kinase 1
, rho-associated coiled-coil domain-containing protein kinase 1