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anti-Human RYR2 Antibodies:
anti-Rat (Rattus) RYR2 Antibodies:
anti-Mouse (Murine) RYR2 Antibodies:
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Two regions of the ryanodine receptor (show RYR3 Antibodies) calcium channel are involved in Ca(2 (show CA2 Antibodies)+)-dependent inactivation
[REVIEW] The efficacy of divalent calcium ion (Ca2 (show CA2 Antibodies)+) release in the myocardium depends on the amount of Ca2 (show CA2 Antibodies)+ loaded into the Ca2 (show CA2 Antibodies)+ store and the way in which this Ca2 (show CA2 Antibodies)* load influences the activity of the ryanodine receptor (show RYR3 Antibodies) Ca2+ release channel (RyR2).
There were substantial transmural gradients in Cav1.2 (show CACNA1C Antibodies), KChIP2 (show KCNIP2 Antibodies), ERG (show KCNH2 Antibodies), KvLQT1 (show KCNQ1 Antibodies), Kir2.1 (show KCNJ2 Antibodies), NCX1 (show SLC8A1 Antibodies), SERCA2a (show ATP2A2 Antibodies) and RyR2 at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.
phosphorylation and K201 acted similarly to change the conformation of RyR1/2 and regulate FKBP12/12.6 binding.
Common variants rs790899 and rs1891246 of RYR2 were significantly associated with HG and weight loss.
The left atrium / right atrium expression ratio was significantly increased in Atrial fibrillation for ryanodine receptor 2 - gene related to calcium uptake and release, and located on the sarcoplasmic reticulum membrane.
a direct interaction exists between RyR2 and CSQ2, is reported.
In a national cohort of RyR2 mutation-positive CPVT patients, SCD (show SCD Antibodies), ASCD and syncope were presenting events in the majority of probands and also occurred in 36% of relatives identified through family screening.
We identified a variant in the RYR2 gene (NM_001035) which involved a change of a glycine to an arginine in position155 of the gene product (c.463G > A, p.Gly155Arg, p.G155R). This RYR2 gene mutation is a novel rare genetic variant as it was not present in any of the international databases consulted.
Data suggest that post-translational modifications (phosphorylation, oxidation, and nitrosylation) of RyR2 (ryanodine receptor 2) occur downstream of production of amyloid beta-peptides through ADRB2 (beta2-adrenergic receptor (show ADRB2 Antibodies)) Ca2 (show CA2 Antibodies)+ signaling cascade that activates PKA (protein kinase A).
The unique properties of the CaM-F142L mutation may provide novel clues on how to suppress excessive RyR2 Ca(2 (show CA2 Antibodies)+) release by manipulating the CaM-RyR2 interaction.
Cardiac adrenergic response and progression towards HF proceed unaltered in mice harboring the RyR2-S2808A mutation. Preventing RyR2-S2808 phosphorylation does not preclude a normal sympathetic response nor mitigates the pathophysiological consequences of MI.
These results also suggest that altered cytosolic Ca(2 (show CA2 Antibodies)+) activation of RyR2 represents a common defect of RyR2 mutations associated with catecholaminergic polymorphic ventricular tachycardia and atrial fibrillation, which could potentially be suppressed by carvedilol or (R)-carvedilol.
CaM and S100A1 can concurrently bind to and functionally modulate RyR1 and RyR2, but this does not involve direct competition at the RyR CaM binding site.
K4750Q mutation causes three RyR2 defects: hypersensitization to activation by cytosolic Ca2 (show CA2 Antibodies)+, loss of cytosolic Ca2 (show CA2 Antibodies)+/Mg2 (show MCOLN1 Antibodies)+-mediated inactivation, and hypersensitization to luminal Ca2 (show CA2 Antibodies)+ activation.
InsP3 dependent sarcoplasmic reticulum-Ca2 (show CA2 Antibodies)+ flux constitute the main mechanism of functional crosstalk between InsP3R2 (show ITPR2 Antibodies) and RyR2 resulting in more Ca2 (show CA2 Antibodies)+ sensitized RyRs to trigger subsequent Ca2 (show CA2 Antibodies)+-induced Ca2 (show CA2 Antibodies)+ release activation.
The heart contraction is controlled by the Ca2 (show CA2 Antibodies)+-induced Ca2 (show CA2 Antibodies)+ release between L-type Ca2 (show CA2 Antibodies)+ channels and ryanodine receptors. RyRs became more sensitive to Ca2 (show CA2 Antibodies)+ triggers without FKBP12.6 (show FKBP1B Antibodies), leading to ventricular arrthymias.
Allele-specific silencing of RYR2 prevents life-threatening arrhythmias in genetic carriers.
Redox modification of RyR2 synergistically with CaMKII (show CAMK2G Antibodies) phosphorylation modulates reperfusion arrhythmias.
These results demonstrate that Ryr2 controls mitochondrial Ca(2 (show CA2 Antibodies)+) dynamics and plays a specific, critical role in promoting glucose oxidation in cardiomyocytes. These findings indicate that partial RYR2 loss is sufficient to cause metabolic abnormalities seen in heart disease.
data suggest that interactions between the cytoplasmic region of S6 and the U motif of RyR2 are important for stabilizing the closed state of the channel. Mutations in the S6/U motif domain interface likely destabilize the closed state of RyR2
these results suggest that neuronal RyR2 Ca(2 (show CA2 Antibodies)+) leak due to Calstabin2 (show FKBP1B Antibodies) deletion contributes to learning deficiency and memory impairment.
Nav1.5 (show SCN5A Antibodies) is downregulated and INa (show INA Antibodies) is reduced in RyR2-P2328S ventricles.
The minimal KEKE motif of TRN (show TNPO1 Antibodies) involved in the interactions with CSQ2, HRC (show HRC Antibodies) and RyR2 within the Ca2 (show CA2 Antibodies)+ release units of cardiac sarcoplasmic reticulum has been defined.
This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.
cardiac muscle ryanodine receptor
, ryanodine receptor 2 (cardiac)
, ryanodine receptor 2-like
, Ca2+ release channel
, cardiac muscle ryanodine receptor-calcium release channel
, cardiac muscle-type ryanodine receptor
, ryanodine receptor 2
, type 2 ryanodine receptor
, cardiac ryanodine receptor 2
, cardiac-type ryanodine receptor
, islet-type ryanodine receptor
, kidney-type ryanodine receptor
, ryanodine receptor type II
, calcium release channel
, ryanodine receptor type 2