Browse our anti-Smooth Muscle Actin (ACTA2) Antibodies

Full name:
anti-Actin, alpha 2, Smooth Muscle, Aorta Antibodies (ACTA2)
On www.antibodies-online.com are 259 Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) Antibodies from 31 different suppliers available. Additionally we are shipping Smooth Muscle Actin Kits (25) and Smooth Muscle Actin Proteins (11) and many more products for this protein. A total of 302 Smooth Muscle Actin products are currently listed.
Synonyms:
0610041G09Rik, a-SMA, AAT6, ACT-4, ACTA2, actc1, ACTSA, Actvs, alphaSMA, asma, MYMY5, sm-actin, SMactin, SMalphaA, wu:fb63d03
list all antibodies Gene Name GeneID UniProt
ACTA2 59 P62736
ACTA2 11475 P62737
ACTA2 81633 P62738

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Most Popular Reactivities for anti-Smooth Muscle Actin (ACTA2) Antibodies

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anti-Human Smooth Muscle Actin Antibodies:

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Top referenced anti-Smooth Muscle Actin Antibodies

  1. Human Monoclonal Smooth Muscle Actin Primary Antibody for WB - ABIN396199 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 6 references for 396199

  2. Human Monoclonal Smooth Muscle Actin Primary Antibody for FACS - ABIN4897983 : Asosingh, Aldred, Vasanji, Drazba, Sharp, Farver, Comhair, Xu, Licina, Huang, Anand-Apte, Yoder, Tuder, Erzurum: Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. in The American journal of pathology 2008 (PubMed)
    Show all 5 references for 4897983

  3. Human Polyclonal Smooth Muscle Actin Primary Antibody for IHC, ELISA - ABIN185271 : Reddy, Ozgur, Lu, Chang, Mohan, Kumar, Ruley: Structure of the human smooth muscle alpha-actin gene. Analysis of a cDNA and 5' upstream region. in The Journal of biological chemistry 1990 (PubMed)
    Show all 4 references for 185271

  4. Human Monoclonal Smooth Muscle Actin Primary Antibody for FACS - ABIN4897981 : Morris, Khan, Ahmad, Weston, Nofchissey, Pinchuk, Beswick: G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. in British journal of cancer 2014 (PubMed)
    Show all 3 references for 4897981

  5. Human Monoclonal Smooth Muscle Actin Primary Antibody for IHC, ELISA - ABIN968946 : Guo, Pannu, Tran-Fadulu, Papke, Yu, Avidan, Bourgeois, Estrera, Safi, Sparks, Amor, Ades, McConnell, Willoughby, Abuelo, Willing, Lewis, Kim, Scherer, Tung, Ahn, Buja, Raman, Shete, Milewicz: Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections. in Nature genetics 2007 (PubMed)
    Show all 2 references for 968946

  6. Human Monoclonal Smooth Muscle Actin Primary Antibody for ICC, FACS - ABIN968945 : Salas, Bartoli, Deville, Gaudart, Fina, Calisti, Bollini, Curvale, Gentet, Duffaud, Figarella-Branger, Bouvier: Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas. in Virchows Archiv : an international journal of pathology 2007 (PubMed)
    Show all 2 references for 968945

  7. Chicken Monoclonal Smooth Muscle Actin Primary Antibody for IHC (p) - ABIN114405 : Skalli, Pelte, Peclet, Gabbiani, Gugliotta, Bussolati, Ravazzola, Orci: Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989 (PubMed)
    Show all 2 references for 114405

  8. Human Monoclonal Smooth Muscle Actin Primary Antibody for ICC, FACS - ABIN968947 : Shimojima, Yamamoto: ACTA2 is not a major disease-causing gene for moyamoya disease. in Journal of human genetics 2009 (PubMed)
    Show all 2 references for 968947

  9. Chicken Monoclonal Smooth Muscle Actin Primary Antibody for IHC (fro), IF - ABIN356280 : Miwa, Manabe, Kurokawa, Kamada, Kanda, Bruns, Ueyama, Kakunaga: Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes. in Molecular and cellular biology 1991 (PubMed)
    Show all 2 references for 356280

More Antibodies against Smooth Muscle Actin Interaction Partners

Xenopus laevis Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.

Human Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. Cells in high glucose for 7 days showed a significant decrease in mRNA expression of CD31 (show HBA1 Antibodies) and VE-cadherin (show CDH5 Antibodies), and a significant increase in that of alpha-SMA (show SMN1 Antibodies) and collagen I.

  2. ACTA2 is the isoform of contractile protein (show TNNT2 Antibodies) alpha-actin present in vascular smooth muscle cells (SMCs) throughout the arterial tree.4 Pathologic conditions in individuals with ACTA2 mutations show increased deposition of SMCs in the intimal arterial layer, leading to a decreased intraluminal diameter.4

  3. Two novel actin alpha 2 mutations (N117I and L348R) were identified in each familial non-syndromatic thoracic aortic aneurysm proband separately, and an additional novel actin alpha 2 mutation (Y168N) was identified in one patient with sporadic non-syndromatic thoracic aortic aneurysm.

  4. The R179H mutation has the potential to affect actin structure and function in both the contractile domain of the cell and the more dynamic cytoskeletal pool of actin, both of which are required for contraction.

  5. site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 (show KRT82 Antibodies) and R159) subdomains that are essential for Purbeta (show PURB Antibodies) transcriptional repressor function in Acta2 promoter-reporter assays. In keeping with their diminished Acta2 repressor activity in fibroblasts, purified Purbeta (show PURB Antibodies) variants containing an R267A mutation exhibited reduced binding affinity for purine-ric (show FXYD5 Antibodies)...

  6. Data show that the expression profiles of three proteins: E-cadherin (show CDH1 Antibodies), Snail (show SNAI1 Antibodies), and alpha-smooth muscle actin (show ACTG2 Antibodies) were significantly different in extraprostatic extension prostate cancer (PCa (show FLVCR1 Antibodies)) compared with intra-prostatic tumour.

  7. ACTA2 mutations are associated with structural disruption and functional impairment of contractile proteins, and predispose to a variety of diffuse vascular diseases including TAAD, CAD (show CAD Antibodies), ischemic strokes, and Moyamoya disease. Vascular SMCs are also implicated in vascular remodeling in both physiological and pathological conditions.

  8. Parenchymal alphaSMA expression in hepatic tissue appeared to increase only among hepatitis C subjects with fibrosis 3-4.

  9. Multisystemic smooth muscle dysfunction syndrome secondary to an ACTA2 mutation.

  10. alpha-SMA expression, and MLC phosphorylation, whereas butaprost inhibited TGF-beta2-induced CPCG contraction, actin polymerization, and MLC phosphorylation.

Mouse (Murine) Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. Disruption of smooth muscle Acta2 increases reactive oxygen species levels, activates NF-kappaB (show NFKB1 Antibodies) signaling and increases AngII receptor type I a expression.

  2. The expression levels of alpha-smooth muscle actin (show ACTG2 Antibodies) (alpha-SMA (show SMN1 Antibodies), a marker of fibroblast activation) in fibrotic livers were significantly higher than those in control livers.

  3. this study identifies Rac1 as a downstream target for SMA (show SMN1 Antibodies) to inhibit smooth muscle cell proliferation and migration.

  4. the coordinated up-regulations of desmin (show DES Antibodies) and alpha- actinin (show ACTN1 Antibodies) specifically in the early stage of diastolic heart failure mouse models indicate a novel myocardial response.

  5. site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 (show KRT82 Antibodies) and R159) subdomains that are essential for Purbeta (show PURB Antibodies) transcriptional repressor function in Acta2 promoter-reporter assays. In keeping with their diminished Acta2 repressor activity in fibroblasts, purified Purbeta (show PURB Antibodies) variants containing an R267A mutation exhibited reduced binding affinity for purine-ric (show FXYD5 Antibodies)...

  6. Alpha-smooth muscle actin (show ACTG2 Antibodies) protein (show ACTR3 Antibodies) and mRNA are enhanced from brain blood vessels in an Alzheimer's disease animal model.

  7. Astragaloside can delay the renal fibrosis process in diabetic mice by influencing the TGF-beta (show TGFB1 Antibodies)/SMADS signaling pathway and down-regulating TGF-beta1 (show TGFB1 Antibodies), SMAD2 (show SMAD2 Antibodies)/3, and alpha-SMA (show SMN1 Antibodies) expression.

  8. The increased expressions of the cartilage-associated proteins Collagen2 and alpha-SMA (show SMN1 Antibodies) during scleral chondrogenesis accompany myopia development.

  9. Results suggest that the atypical motif asparaging-cysteine-systeine Asn(17)-Cys(18)-Cys(19) is crucial for the normal surface trafficking and function of hydroxycarboxylic acid receptor 2 protein hGPR109A.

  10. Results suggest that the atypical motif asparaging-cysteine-systeine Asn(17)-Cys(18)-Cys(19) is crucial for the normal surface trafficking and function of hydroxycarboxylic acid receptor 2 protein hGPR109A.

Rabbit Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. TnT has a previously unrecognized role in forming the inactive state of regulated actin.

  2. The terminal pointed end subunit is tilted (show OTOP1 Antibodies) towards the penultimate subunit, allowing specific and extra loop-to-loop inter-strand contacts between the two end subunits, which is not possible in other parts of the filament.

  3. There was no significant change in the expression of TGF-beta(2 (show TGFB2 Antibodies)) and alpha-SMA (show SMN1 Antibodies) after laser-assisted intrastromal scanning.

  4. The arrangement of actin subunits in an actin dimer assembled by tandem W domains resembles that of a long-pitch helix of the actin filament.

  5. The distribution of laminin and alphaSMA in the testis and epididymis might point out to their roles in the male reproduction.

Smooth Muscle Actin (ACTA2) Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Alternative names and synonyms associated with Smooth Muscle Actin (ACTA2)

  • actin, alpha 2, smooth muscle, aorta (acta2) antibody
  • actin, alpha 2, smooth muscle, aorta (ACTA2) antibody
  • actin, alpha 2, smooth muscle, aorta (Acta2) antibody
  • 0610041G09Rik antibody
  • a-SMA antibody
  • AAT6 antibody
  • ACT-4 antibody
  • ACTA2 antibody
  • actc1 antibody
  • ACTSA antibody
  • Actvs antibody
  • alphaSMA antibody
  • asma antibody
  • MYMY5 antibody
  • sm-actin antibody
  • SMactin antibody
  • SMalphaA antibody
  • wu:fb63d03 antibody

Protein level used designations for ACTA2

SM actin , alpha smooth muscle actin , alpha-SM-actin , actin, alpha 2, smooth muscle, aorta , actin alpha cardiac 1 , actin, aortic smooth muscle , vascular smooth muscle alpha-actin , alpha-smooth muscle actin , actin, aortic smooth muscle-like , alpha-cardiac actin , cell growth-inhibiting gene 46 protein , actin, alpha, vascular smooth muscle , alpha-actin-2 , alpha actin 2 , alpha-actin , smooth muscle alpha-actin , alpha actin

GENE ID SPECIES
431847 Xenopus laevis
477587 Canis lupus familiaris
496696 Xenopus (Silurana) tropicalis
733615 Sus scrofa
100074413 Ornithorhynchus anatinus
100173819 Pongo abelii
466148 Pan troglodytes
100062175 Equus caballus
100396597 Callithrix jacchus
100427024 Macaca mulatta
100579983 Nomascus leucogenys
59 Homo sapiens
11475 Mus musculus
322509 Danio rerio
515610 Bos taurus
423787 Gallus gallus
100009271 Oryctolagus cuniculus
81633 Rattus norvegicus
100722917 Cavia porcellus
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