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Browse our DUSP4 Proteins (DUSP4)

Full name:
Dual Specificity Phosphatase 4 Proteins (DUSP4)
On www.antibodies-online.com are 6 Dual Specificity Phosphatase 4 (DUSP4) Proteins from 4 different suppliers available. Additionally we are shipping DUSP4 Antibodies (102) and DUSP4 Kits (6) and many more products for this protein. A total of 122 DUSP4 products are currently listed.
Synonyms:
2700078F24Rik, AI844617, BB104621, DUSP4, E130306H24Rik, HVH2, MGC131045, Mkp-2, Mkp2, TYP, zgc:55423
list all proteins Gene Name GeneID UniProt
DUSP4 1846 Q13115
DUSP4 319520 Q8BFV3
Rat DUSP4 DUSP4 60587 Q62767

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DUSP4 Proteins (DUSP4) by Origin

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More Proteins for DUSP4 Interaction Partners

Zebrafish Dual Specificity Phosphatase 4 (DUSP4) interaction partners

  1. our results indicate that Nodal regulated dusp4 plays a repressive role in mesendoderm induction.

  2. dusp4 is essential for early development; knockout of dusp4 revealed a specific loss of sox17 (show SOX17 Proteins), establishing a new class of endoderm specification defect.

Human Dual Specificity Phosphatase 4 (DUSP4) interaction partners

  1. Data indicate that normalization of dual-specific phosphatase 4 (DUSP4) expression using a specific siRNA improved CD4(+) T-cell activity in idiopathic CD4 lymphopenia (ICL).

  2. Ectopic expression of wild-type DUSP4, but not of a phosphatase-deficient mutant, dephosphorylates c-JUN N-terminal kinase (JNK) and induces apoptosis in DLBCL cells.

  3. Low DUSP4 expression levels predict recurrence and mortality in triple-negative breast cancer patients

  4. Data suggest that MKP-2 rather than MKP-1 is tamoxifen-regulated and that the elevated expression of MKP-2 in MCF7-TAMR cells potentially functions to restore tamoxifen sensitivity.

  5. MKP-1 (show DUSP1 Proteins) and MKP-2 stability is regulated by ERK (show EPHB2 Proteins)-mediated phosphorylation through a degradation pathway independent of polyubiquitination

  6. Instead, autophagic cell death was the major consequence, and our investigation of mechanisms suggested it is mediated via the dual specificity phosphatase-4 (DUSP4) dependent ERK (show EPHB2 Proteins) inactivation pathway

  7. DUSP4 attenuates ERK (show EPHB2 Proteins) signaling and reduces cell viability, suggesting that the novel crosstalk between NFkappaB (show NFKB1 Proteins) and mitogen activated protein kinase (show MAPK1 Proteins) pathways contributes to cell survival.

  8. DUSP1 (show DUSP1 Proteins), DUSP4, and DUSP5 (show DUSP5 Proteins) differentially modulate endothelial MAPK (show MAPK1 Proteins) signaling pathways downstream of Tie-2 (show TEK Proteins) receptors.

  9. Enforced expression of DUSP4 reduced the CD44 (show CD44 Proteins)(+)/CD24 (show CD24 Proteins)(-) population in multiple BLBC cell lines in a MEK (show MAP2K1 Proteins)-dependent manner, limiting tumor formation of claudin-low SUM159PT cells in mice.

  10. high DUSP4 expression was associated with a worse overall survival and with clinical characteristics typical for BRAF (show BRAF Proteins) mutant patients

Mouse (Murine) Dual Specificity Phosphatase 4 (DUSP4) interaction partners

  1. domain-mapping results showed that both the substrate-interacting and the phosphatase domains of DUSP4 (show DUSP9 Proteins) were required for its optimal interaction with STAT5 (show STAT5A Proteins), while the coiled-coil domain of STAT5 (show STAT5A Proteins) appeared to hinder this interaction

  2. MKP-2 knock-out mice show deficits in working memory and spatial reference.

  3. DUSP4 (show DUSP9 Proteins) is crucial for neuronal differentiation and functions in the neurogenesis of embryonic stem cells.

  4. MKP-1 (show DUSP1 Proteins) and MKP-2 stability is regulated by ERK (show EPHB2 Proteins)-mediated phosphorylation through a degradation pathway independent of polyubiquitination

  5. Loss of MKP-2 expression is associated with enhanced susceptibility to parasite infection.

  6. LH/hCG (show CGA Proteins) tightly regulates MKP-2 expression, which modulates the induction of CYP11A1 (show CYP11A1 Proteins) by 8Br-cAMP.

  7. Dusp1 (show DUSP1 Proteins) and Dusp4 (show DUSP9 Proteins) are cardioprotective genes that play a critical role in the heart by dampening p38 MAPK (show MAPK14 Proteins) signaling that would otherwise reduce contractility and induce cardiomyopathy.

  8. Loss of MKP-2 regulates early inflammation in acute lung injury.

  9. Increased DUSP4 (show DUSP9 Proteins) expression in activated T cells in the elderly in part accounts for defective adaptive immune responses.

  10. protein deficiency enhances CD25 (show IL2RA Proteins) expression and CD4 (show CD4 Proteins)+ T-cell proliferation without impeding T-cell development

DUSP4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

Alternative names and synonyms associated with DUSP4

  • dual specificity phosphatase 4 (dusp4)
  • dual specificity phosphatase 4 (DUSP4)
  • dual specificity phosphatase 4 (Dusp4)
  • 2700078F24Rik protein
  • AI844617 protein
  • BB104621 protein
  • DUSP4 protein
  • E130306H24Rik protein
  • HVH2 protein
  • MGC131045 protein
  • Mkp-2 protein
  • Mkp2 protein
  • TYP protein
  • zgc:55423 protein

Protein level used designations for DUSP4

dual specificity protein phosphatase 4 , dual specificity phosphatase 4 , MAP kinase phosphatase 2 , VH1 homologous phosphatase 2 , dual specificity protein phosphatase hVH2 , mitogen-activated protein kinase phosphatase 2 , serine/threonine specific protein phosphatase

GENE ID SPECIES
394146 Danio rerio
464497 Pan troglodytes
540380 Bos taurus
548863 Xenopus (Silurana) tropicalis
734786 Xenopus laevis
100223600 Taeniopygia guttata
1846 Homo sapiens
319520 Mus musculus
60587 Rattus norvegicus
395642 Gallus gallus
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