DUSP4 Products
(Dual Specificity Phosphatase 4 (DUSP4))
Categories
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008].
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Featured DUSP4 Categories
DUSP4 Antibodies
High quality antibodies with extensive validation data.
DUSP4 ELISA Kits
Reliable ELISA kits for a wide range of species.
DUSP4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DUSP4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN6263269
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN515105
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN392861
Quantity
400 μL
Datasheet
Datasheet
Recommended DUSP4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966428
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648052
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1130804
Quantity
96 tests
Datasheet
Datasheet
Recommended DUSP4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352136
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3079077
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3124597
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our DUSP4 products
: "Statins affect ETS1-overexpressing triple-negative breast cancer cells by restoring DUSP4 deficiency." in: Scientific reports, Vol. 6, pp. 33035, (2016) (PubMed).: "Modulation of p38 kinase by DUSP4 is important in regulating cardiovascular function under oxidative stress." in: Free radical biology & medicine, Vol. 89, pp. 170-81, (2015) (PubMed).
: "Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancers." in: International journal of oncology, Vol. 45, Issue 6, pp. 2250-66, (2014) (PubMed).
: "Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²?-induced apoptosis." in: Free radical biology & medicine, Vol. 74, pp. 188-99, (2014) (PubMed).
: "Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 167, Issue 1, pp. 93-101, (2012) (PubMed).
: "Dual-specificity MAP kinase phosphatases (MKPs) and cancer." in: Cancer metastasis reviews, Vol. 27, Issue 2, pp. 253-61, (2008) (PubMed).
: "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress." in: The Journal of biological chemistry, Vol. 282, Issue 39, pp. 28395-407, (2007) (PubMed).
: "Mitogen-activated protein kinase phosphatase 2: a novel transcription target of p53 in apoptosis." in: Cancer research, Vol. 66, Issue 12, pp. 6033-9, (2006) (PubMed).
: "Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase." in: The Journal of biological chemistry, Vol. 281, Issue 37, pp. 27167-77, (2006) (PubMed).
: "Cell transformation by v-Jun deactivates ERK MAP kinase signalling." in: Oncogene, Vol. 21, Issue 42, pp. 6540-8, (2002) (PubMed).
Synonyms and alternative names related to DUSP4
dual specificity phosphatase 4 (dusp4), dual specificity phosphatase 4 (DUSP4), dual specificity phosphatase 4 S homeolog (dusp4.S), dual specificity phosphatase 4 (Dusp4), 2700078F24Rik, AI844617, BB104621, DUSP4, E130306H24Rik, hvh2, HVH2, MGC131045, mkp-2, MKP-2, Mkp-2, mkp2, MKP2, Mkp2, typ, TYP, zgc:55423Protein level used designations for DUSP4
- dual specificity protein phosphatase 4
- dual specificity phosphatase 4
- MAP kinase phosphatase 2
- VH1 homologous phosphatase 2
- dual specificity protein phosphatase hVH2
- mitogen-activated protein kinase phosphatase 2
- serine/threonine specific protein phosphatase
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