DUSP4 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2719838

Product Details

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 2

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This DUSP4 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human DUSP4 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Alternative Name: Dusp4 (DUSP4 Products)

Synonyms: zgc:55423 Protein, DUSP4 Protein, typ Protein, hvh2 Protein, mkp2 Protein, mkp-2 Protein, MGC131045 Protein, HVH2 Protein, MKP-2 Protein, MKP2 Protein, TYP Protein, 2700078F24Rik Protein, AI844617 Protein, BB104621 Protein, E130306H24Rik Protein, Mkp-2 Protein, Mkp2 Protein, dual specificity phosphatase 4 Protein, dual specificity phosphatase 4 S homeolog Protein, dusp4 Protein, DUSP4 Protein, dusp4.S Protein, Dusp4 Protein

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

Molecular Weight: 32.8 kDa

NCBI Accession: NP_476499

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades