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Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305081
Gray, Glaister, Chen, Goeddel, Pennica: Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. in Journal of immunology (Baltimore, Md. : 1950) 1986
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Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1589581
Hollborn, Vogler, Reichenbach, Wiedemann, Bringmann, Kohen: Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. in Molecular vision 2015
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Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN413480
Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011
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Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN988112
Zhang, Bennett, Verkman: Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms. in Annals of neurology 2011
Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN804033
Tiwari, Wang, Brochetta, Ke, Vita, Qi, Rivera, Soranzo, Zabucchi, Hong, Blank: VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways. in Blood 2008
Rat (Rattus) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN809718
Yang, Poon, Luo, Cheung, Ho, Lo, Fan: Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway. in Journal of immunology (Baltimore, Md. : 1950) 2004
Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305079
Kitamura, Tange, Terasawa, Chiba, Kuwaki, Miyagawa, Piao, Miyazono, Urabe, Takaku: Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. in Journal of cellular physiology 1989
Leukocyte expression of IL-1beta was detectable only following injury, which activated leukocytes throughout zebrafish embryos in a caspase (show CASP3 Proteins) dependent manner.
Embryo and larva leukocytes upregulate IL-1beta expression proportional to the dose of ultraviolet radiation exposure in an immune response at the organismal level.
findings reveal that the Il-1beta-Myd88 (show MYD88 Proteins) axis and NADPH oxidase (show NOX1 Proteins)-mediated ROS (show ROS1 Proteins) signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation.
the expression levels of IL-1beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae
These results represent the first demonstration of processing and secretion of zebrafish IL-1beta in response to a pathogen.
Data show that injury stimulates IL-1beta secretion by fibroblasts, which activates NF-kappaB (show NFKB1 Proteins) and ATF-4 (show ATF4 Proteins) and stimulates interaction with the PDGF-R alpha (show PDGFRA Proteins) promoter, which is regulated also by HDAC1 (show HDAC1 Proteins) and 2.
These studies elucidate an important role for neutrophils and IL-1beta in lung carcinogenesis.
PLCd1 (show PLCD1 Proteins) negatively regulates lipopolysaccharide-induced production of IL-1b and Fc gamma receptor (show FCGR1A Proteins)-mediated phagocytosis in macrophages.
these data are the first to show dramatic posttranscriptional control of inflammatory cytokine production by a relevant tissue-derived macrophage population and proteasomal degradation of proIL-1beta and NLRP3 (show NLRP3 Proteins) as a mechanism to control inflammasome activation
data provide evidence that the NLRC4 (show NLRC4 Proteins) inflammasome contributes to resistance through regulation of caspase-1 (show CASP1 Proteins), IL-1beta and IL-18 (show IL18 Proteins) in a CD11blowLy6Glow population of cells
Caspase (show CASP3 Proteins)-l, Caspase-11 (show CASP4 Proteins) and Dectin-1 (show CLEC7A Proteins)/syk (show SYK Proteins) pathway are involved in the IL-1beta generation in fungal keratosis.
An increase in IL-1beta expression after the irradiation of stromal cells may be related to both the induction of inflammation due to massive cell death and to a profound stimulation of the expression of this proinflammatory cytokine expression
Since neither IL-1alpha nor IL-1beta depletions completely rescued the phenotype, we believe that IL-1alpha and IL-1beta have a similar and probably complementary role in FHF progression
findings suggest that neutrophil-macrophage interaction is a therapeutic target for hepatic I/R injury and may also provide new insights into the inflammasome-independent mechanism of IL-1beta maturation in the liver.
investigated the function of Card9 (show CARD9 Proteins)-mediated innate immunity in inflammation-associated colon carcinogenesis; report that Card9 (show CARD9 Proteins)-signaling drives the production of IL-1beta within the damaged intestine and regulates the subsequent generation of IL-22 (show IL22 Proteins) by group3 innate lymphoid cells, which promotes tumorigenesis via STAT3 (show STAT3 Proteins) activation within the transformed epithelium
IL-1beta gene polymorphisms appear to confer susceptibility to the disease in Indian systemic lupus erythematosus patients.
The results of this study reveal that mutant allele (T) of IL1B-511 promoter Single Nucleotide Polymorphism tends to be associated with elevated Anti-cyclic citrullinated peptide antibody and IL-1beta levels as observed in rheumatoid arthritis patients and hence disease susceptibility.
Data show that HDAC-1 (show HDAC1 Proteins) is enriched at the PDGF-D (show PDGFD Proteins) promoter in cells exposed to IL-1beta and forms a cytokine-inducible gene-silencing complex with p65 (show GORASP1 Proteins) and IRF-1 (show IRF1 Proteins).
the pro-inflammatory cytokine interleukin-1 (IL-1 (show IL1A Proteins)) elicited profound expansion of myeloid progenitors in approximately 67% of acute myeloid leukemia (show BCL11A Proteins) patients while suppressing the growth of normal progenitors.
The levels of IL-1 (show IL1A Proteins), IL-6 (show IL6 Proteins) and TNF-alpha (show TNF Proteins) in GCF (show GUCY2F Proteins) were higher in patients with ischemic stroke but the difference was not significant. In conclusion, ischemic stroke was found to be associated with higher levels of IL-1beta and IL-6 (show IL6 Proteins) in serum
The expression of IL-1beta and IL-6 (show IL6 Proteins) during leprosy reactions did not differ significantly between tissues obtained from leprosy patients with and without HIV coinfection.
This study demonstrated that In Indian subjects, IL1B rs1143634 was associated with higher and lower morphine use.
IL-1beta induced apoptosis and the expression of catabolic mediators by inducing autophagy, and the autophagy in part was mediated through the activation of AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins)/P70S6K (show RPS6KB1 Proteins) signaling pathway in human osteoarthritis chondrocytes.
The use of Piezosurgery for ORS seems to promote more favorable wound healing compared with rotary instruments, as the lower pain and the low levels of IL-1beta mRNA at the surgical sites suggest a milder underlying inflammatory response.
This study showed that classical swine fever virus and p7 protein induced IL-1beta secretion and that p7 protein was a short-lived protein degraded by the proteasome.
local expression of IL-1beta and IL-8 (show IL8 Proteins) in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls
IL1B regulates expression of IL1R1 (show IL1RN Proteins) and IL1RAP (show IL1RAP Proteins) and stimulates expression of PTGS1 (show PTGS1 Proteins) and PTGS2 (show PTGS2 Proteins) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (show PLIN1 Proteins)-implantation period of pregnancy in pigs.
the results presented here strongly suggest IL-1beta as a key molecule guiding tissue remodelling events after myocardial infarction.
The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 (show IL1RN Proteins) protein and IL1B and IL1R1 (show IL1RN Proteins) mRNA were detected.
For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor (show P2RX7 Proteins).
Role of TGF-beta1 (show TGFB1 Proteins) and TNF-alpha (show TNF Proteins) in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Testicular IL-1 alpha (show IL1A Proteins) and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Proteins) bioactivity and IL-6 (show IL6 Proteins) concentrations were greatest in the immediate pre-pubertal period.
Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.
Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF (show PGF Proteins)(2alpha) and PGE (show LIPF Proteins)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1 (show IL1A Proteins)-induced matrix degradation and loss of tissue material properties
dynamic compression stimulates cell proliferation and proteoglycan (show Vcan Proteins) synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 (show JUN Proteins) signalling pathways
These results indicate that activation of the intrinsic antistaphylococcal response in bovine endothelial cells (BEC), enhanced by TNF-alpha (show TNF Proteins) and IL-1beta, is effective to eliminate S. aureus and S. epidermidis.
the low friction of articular cartilage can be modified by TGF-beta1 (show TGFB1 Proteins) and IL-1beta treatment and that the friction coefficient depends on multiple factors, including superficial zone protein localization and surface roughness
Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 (show IL6 Proteins) in rabbit cornea cells.
IL-1beta and TNF-alpha (show TNF Proteins) expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha (show TNF Proteins).
IL-1beta induced a significant reduction in the relative intrinsic activity of GLUT5 and in this decrease are involved NO signal pathways; blockage of D-fructose intestinal uptake by IL-1beta may play an essential role in the pathophysiology of septic shock.
The inhibitory effect of IL-1beta on D-galactose absorption across mucosal side of enterocyte could be mediated by the activation of several kinases and nuclear factor kappa B.
Glucosamine hydrochloride treatment can can partially decrease the expression levels of IL-1 beta and increase the expression levels of TGF-beta 1 (show TGFB1 Proteins), which delays the development of osteoarthritis.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of IL1B transcripts depending on luteal stage.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta,COX-2, and TGFbeta1 (show TGFB1 Proteins)
Increased PGE2 production led to reduction in 5-LO (show ALOX5 Proteins) products in LPS (show IRF6 Proteins)-treated equine whole blood via IL-1b.
Results suggested that chemokine (show CCL1 Proteins) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.
IL-1beta-induced up-regulation of matrix metalloproteinase 13 (show MMP13 Proteins) mRNA was blocked by all concentrations of geldanamycin tested
This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Proteins) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
, IL-1 beta
, interleukin-1 beta
, preinterleukin 1 beta
, prointerleukin-1 beta
, Interleukin-1 beta
, precursor interleukin-1beta
, interleukin-1 beta proprotein
, interleukin 1 beta
, lymphocyte proliferation-potentiating factor