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Browse our IL1B Proteins (IL1B)

Full name:
Interleukin 1, beta Proteins (IL1B)
On are 199 Interleukin 1, beta (IL1B) Proteins from 24 different suppliers available. Additionally we are shipping IL1B Antibodies (787) and IL1B Kits (243) and many more products for this protein. A total of 1261 IL1B products are currently listed.
IL-1, IL-1B, IL-1BETA, il1-b, IL1-BETA, IL1B, IL1beta, IL1F2, zgc:111873
list all proteins Gene Name GeneID UniProt
IL1B 16176 P10749
IL1B 24494  
IL1B 3553 P01584

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IL1B Proteins (IL1B) by Origin

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Top referenced IL1B Proteins

  1. Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN2667492 : Nazarenko, Marhaba, Reich, Voronov, Vitacolonna, Hildebrand, Elter, Rajasagi, Apte, Zöller: Tumorigenicity of IL-1alpha- and IL-1beta-deficient fibrosarcoma cells. in Neoplasia (New York, N.Y.) 2008 (PubMed)
    Show all 5 references for ABIN2667492

  2. Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305081 : Gray, Glaister, Chen, Goeddel, Pennica: Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. in Journal of immunology (Baltimore, Md. : 1950) 1986 (PubMed)
    Show all 4 references for ABIN1305081

  3. Dog (Canine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN2008853 : Kim, Mok, Kim, Joo: Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. in Molecular vision 2008 (PubMed)

  4. Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305079 : Kitamura, Tange, Terasawa, Chiba, Kuwaki, Miyagawa, Piao, Miyazono, Urabe, Takaku: Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. in Journal of cellular physiology 1989 (PubMed)

More Proteins for IL1B Interaction Partners

Zebrafish Interleukin 1, beta (IL1B) interaction partners

  1. Leukocyte expression of IL-1beta was detectable only following injury, which activated leukocytes throughout zebrafish embryos in a caspase (show CASP3 Proteins) dependent manner.

  2. Embryo and larva leukocytes upregulate IL-1beta expression proportional to the dose of ultraviolet radiation exposure in an immune response at the organismal level.

  3. findings reveal that the Il-1beta-Myd88 (show MYD88 Proteins) axis and NADPH oxidase (show NOX1 Proteins)-mediated ROS (show ROS1 Proteins) signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation.

  4. the expression levels of IL-1beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae

  5. These results represent the first demonstration of processing and secretion of zebrafish IL-1beta in response to a pathogen.

Mouse (Murine) Interleukin 1, beta (IL1B) interaction partners

  1. Pyridoxal 5'-phosphate and pyridoxal reduced IL-1beta production induced by LPS (show TLR4 Proteins) and ATP, or by LPS (show TLR4 Proteins) alone, in mice.

  2. Gal-3 (show LGALS3 Proteins) expression promotes acute colitis and plays an important pro-inflammatory role in the induction phase of colitis by promoting the activation of NLRP3 (show NLRP3 Proteins) inflammasome and production of IL-1beta in macrophages.

  3. our studies have uncovered a specific role for caspase-1 (show CASP1 Proteins)-mediated IL-1beta release in the manifestation of Familial Mediterranean Fever (show MEFV Proteins)

  4. TNFalpha (show TNF Proteins) and IL-1beta produced by inflammatory monocytes play a key role in the loss of the intestinal barrier function during Cryptosporidium parvum infection.

  5. the suppressed early innate/inflammatory responses instigated by the imbalance between IL-1beta and IL-1Ra (show IL1RN Proteins) is an underlying cause for delayed wound healing in the diabetic corneas

  6. The antiinflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and its main constituent (-)-alpha-bisabolol in pleurisy model is related to a significant reduction of the pro-inflammatory cytokines TNf-alpha (show TNF Proteins) and Il1beta.

  7. In silico analyses and experimental validation demonstrated that the kinase activity of p38(MAPK (show MAPK14 Proteins)) determines signal amplitude, whereas phosphatase activity affects both signal amplitude and duration. p38(MAPK (show MAPK14 Proteins)) and MK2 (show KCNA2 Proteins) concentrations and responsiveness toward IL-1beta were quantitatively compared between hepatocytes and macrophages

  8. telmisartan can reduce traumatic cerebral edema by inhibiting the NLRP3 (show NLRP3 Proteins) inflammasome-regulated IL-1beta and IL-18 (show IL18 Proteins) accumulation.

  9. Adrenomedullin (show ADM Proteins) expression was also significantly increased in synovial fibroblasts and macrophages in response to IL-1beta treatment. Adrenomedullin (show ADM Proteins) (AM) was produced by synovial fibroblasts and macrophages in inflamed synovial tissue and that increased levels of AM may exert anti-inflammatory effects on synovial macrophages.

  10. Ellagic acid treatment augmented specific IL-10 (show IL10 Proteins) production in response to S. mansoni antigenic stimulation. However, specific IL-1beta, IL-4 (show IL4 Proteins), IL-12 (show IL12A Proteins), IL-13 (show IL13 Proteins), IL-17A (show IL17A Proteins), TNF-alpha (show TNF Proteins) and IFN-gamma (show IFNG Proteins) production were significantly reduced with ex vivo and in vivo ellagic acid treatment.

Human Interleukin 1, beta (IL1B) interaction partners

  1. present findings suggest that IL-1b T-31C and IL-4 (show IL4 Proteins) VNTR polymorphisms but not IL-1b C-511T polymorphism may contribute in systemic lupus erythematosus (SLE) pathogenesis. In addition, CT and TT genotypes of IL-1b C-511T polymorphism were associated with SLE.

  2. IL-1beta plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection

  3. Interleukin-1beta promoter (-511 C/T) polymorphism was not found to be associated with type-II diabetes, the elevated levels of Interleukin-1beta transcripts observed in patients could confer risk towards type-II diabetes.

  4. The findings indicate that IL-1b and bFGF (show FGF2 Proteins) contribute to HHV-6B growth and the onset of encephalitis.

  5. this study identifies a previously unknown role for IL-1beta in facilitating group 2 innate lymphoid cells maturation and plasticity

  6. this study shows that interleukin 1beta directly activated group 2 innate lymphoid cells and that IL-12 (show IL12A Proteins) induced the conversion of these activated cells into interferon-gamma (show IFNG Proteins)-producing group 1 innate lymphoid cells, which was reversed by IL-4 (show IL4 Proteins)

  7. The frequency of postoperative septic shock was higher in patients with IL-1B rs16944 AA genotype than in patients with IL-1B rs16944 GG/AG genotype.

  8. Data show that the synthetic liver X receptors (LXRs) agonist T0901317 promoted cytokines IL-1beta, IL-6 (show IL6 Proteins) and TNFalpha (show TNF Proteins) mRNA degradation, destabilized TNFalpha (show TNF Proteins) mRNA through its 3'-untranslated region, and increased the expression of tristetraprolin (TTP (show ZFP36 Proteins)).

  9. Macrophage-derived IL-1beta enhances monosodium urate crystal-induced neutrophil extracellular trap release in neutrophils. We identified a new mechanism by which macrophages and IL-1beta affect neutrophil functions, and could contribute to the inflammatory conditions present in gout

  10. TAp73beta upregulates pro-IL-1beta mRNA and processed IL-1beta protein. In addition, analysis of breast and lung cancer patient cohorts demonstrated that interaction between p73 (show TP73 Proteins) and IL-1beta predicts a negative survival outcome in these cancers.

Pig (Porcine) Interleukin 1, beta (IL1B) interaction partners

  1. This study showed that classical swine fever virus and p7 protein induced IL-1beta secretion and that p7 protein was a short-lived protein degraded by the proteasome.

  2. local expression of IL-1beta and IL-8 (show IL8 Proteins) in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls

  3. IL1B regulates expression of IL1R1 (show IL1RN Proteins) and IL1RAP (show IL1RAP Proteins) and stimulates expression of PTGS1 (show PTGS1 Proteins) and PTGS2 (show PTGS2 Proteins) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (show PLIN1 Proteins)-implantation period of pregnancy in pigs.

  4. the results presented here strongly suggest IL-1beta as a key molecule guiding tissue remodelling events after myocardial infarction.

Cow (Bovine) Interleukin 1, beta (IL1B) interaction partners

  1. The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 (show IL1RN Proteins) protein and IL1B and IL1R1 (show IL1RN Proteins) mRNA were detected.

  2. For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor (show P2RX7 Proteins).

  3. Role of TGF-beta1 (show TGFB1 Proteins) and TNF-alpha (show TNF Proteins) in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

  4. Testicular IL-1 alpha (show IL1A Proteins) and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Proteins) bioactivity and IL-6 (show IL6 Proteins) concentrations were greatest in the immediate pre-pubertal period.

  5. Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.

  6. Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF (show PGF Proteins)(2alpha) and PGE (show LIPF Proteins)(2) production during luteal phase.

  7. non-metalloproteinase mechanisms participate in IL-1 (show IL1A Proteins)-induced matrix degradation and loss of tissue material properties

  8. dynamic compression stimulates cell proliferation and proteoglycan (show Vcan Proteins) synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 (show JUN Proteins) signalling pathways

  9. These results indicate that activation of the intrinsic antistaphylococcal response in bovine endothelial cells (BEC), enhanced by TNF-alpha (show TNF Proteins) and IL-1beta, is effective to eliminate S. aureus and S. epidermidis.

  10. the low friction of articular cartilage can be modified by TGF-beta1 (show TGFB1 Proteins) and IL-1beta treatment and that the friction coefficient depends on multiple factors, including superficial zone protein localization and surface roughness

Rabbit Interleukin 1, beta (IL1B) interaction partners

  1. Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 (show IL6 Proteins) in rabbit cornea cells.

  2. IL-1beta and TNF-alpha (show TNF Proteins) expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha (show TNF Proteins).

  3. IL-1beta induced a significant reduction in the relative intrinsic activity of GLUT5 and in this decrease are involved NO signal pathways; blockage of D-fructose intestinal uptake by IL-1beta may play an essential role in the pathophysiology of septic shock.

  4. The inhibitory effect of IL-1beta on D-galactose absorption across mucosal side of enterocyte could be mediated by the activation of several kinases and nuclear factor kappa B.

  5. Glucosamine hydrochloride treatment can can partially decrease the expression levels of IL-1 beta and increase the expression levels of TGF-beta 1 (show TGFB1 Proteins), which delays the development of osteoarthritis.

  6. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of IL1B transcripts depending on luteal stage.

  7. results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta,COX-2, and TGFbeta1 (show TGFB1 Proteins)

Horse (Equine) Interleukin 1, beta (IL1B) interaction partners

  1. Increased PGE2 production led to reduction in 5-LO (show ALOX5 Proteins) products in LPS (show IRF6 Proteins)-treated equine whole blood via IL-1b.

  2. Results suggested that chemokine (show CCL1 Proteins) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.

  3. IL-1beta-induced up-regulation of matrix metalloproteinase 13 (show MMP13 Proteins) mRNA was blocked by all concentrations of geldanamycin tested

  4. This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Proteins) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

IL1B Protein Profile

Protein Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Alternative names and synonyms associated with IL1B

  • interleukin 1, beta (il1b)
  • interleukin 1 beta (Il1b)
  • interleukin 1 beta (IL-1B)
  • interleukin 1, beta (IL1B)
  • IL-1 protein
  • IL-1B protein
  • IL-1BETA protein
  • il1-b protein
  • IL1-BETA protein
  • IL1B protein
  • IL1beta protein
  • IL1F2 protein
  • zgc:111873 protein

Protein level used designations for Interleukin 1, beta Proteins (IL1B)

interlukin-1 beta , IL-1 beta , interleukin-1 beta , catabolin , preinterleukin 1 beta , pro-interleukin-1-beta , prointerleukin-1 beta , Interleukin-1 beta , precursor interleukin-1beta , interleukin-1 beta proprotein , interleukin 1 beta , lymphocyte proliferation-potentiating factor , interleukin-beta

405770 Danio rerio
16176 Mus musculus
24494 Rattus norvegicus
443539 Ovis aries
100135556 Cavia porcellus
3553 Homo sapiens
397122 Sus scrofa
281251 Bos taurus
100860816 Capra hircus
395196 Gallus gallus
403974 Canis lupus familiaris
100008990 Oryctolagus cuniculus
100034237 Equus caballus
768274 Felis catus
704701 Macaca mulatta
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