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Browse our IL1B Proteins (IL1B)

Full name:
Interleukin 1, beta Proteins (IL1B)
On www.antibodies-online.com are 210 Interleukin 1, beta (IL1B) Proteins from 25 different suppliers available. Additionally we are shipping IL1B Antibodies (808) and IL1B Kits (229) and many more products for this protein. A total of 1279 IL1B products are currently listed.
Synonyms:
IL-1, IL-1B, IL-1BETA, il1-b, IL1-BETA, IL1B, IL1beta, IL1F2, zgc:111873
list all proteins Gene Name GeneID UniProt
IL1B 16176 P10749
IL1B 24494  
IL1B 3553 P01584

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IL1B Proteins (IL1B) by Origin

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Top referenced IL1B Proteins

  1. Rabbit IL1B Protein expressed in Escherichia coli (E. coli) - ABIN2008815 : March, Mosley, Larsen, Cerretti, Braedt, Price, Gillis, Henney, Kronheim, Grabstein: Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. in Nature 1985 (PubMed)
    Show all 5 references for ABIN2008815

  2. Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305081 : Gray, Glaister, Chen, Goeddel, Pennica: Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. in Journal of immunology (Baltimore, Md. : 1950) 1986 (PubMed)
    Show all 4 references for ABIN1305081

  3. Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN413480 : Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011 (PubMed)
    Show all 2 references for ABIN413480

  4. Rat (Rattus) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN809718 : Yang, Poon, Luo, Cheung, Ho, Lo, Fan: Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway. in Journal of immunology (Baltimore, Md. : 1950) 2004 (PubMed)

  5. Dog (Canine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN2008853 : Kim, Mok, Kim, Joo: Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. in Molecular vision 2008 (PubMed)

  6. Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305079 : Kitamura, Tange, Terasawa, Chiba, Kuwaki, Miyagawa, Piao, Miyazono, Urabe, Takaku: Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. in Journal of cellular physiology 1989 (PubMed)

More Proteins for IL1B Interaction Partners

Zebrafish Interleukin 1, beta (IL1B) interaction partners

  1. Leukocyte expression of IL-1beta was detectable only following injury, which activated leukocytes throughout zebrafish embryos in a caspase (show CASP3 Proteins) dependent manner.

  2. Embryo and larva leukocytes upregulate IL-1beta expression proportional to the dose of ultraviolet radiation exposure in an immune response at the organismal level.

  3. findings reveal that the Il-1beta-Myd88 (show MYD88 Proteins) axis and NADPH oxidase (show NOX1 Proteins)-mediated ROS (show ROS1 Proteins) signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation.

  4. the expression levels of IL-1beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae

  5. These results represent the first demonstration of processing and secretion of zebrafish IL-1beta in response to a pathogen.

Mouse (Murine) Interleukin 1, beta (IL1B) interaction partners

  1. It has been demonstrated that beta-endorphin (show POMC Proteins) stimulates the zymosan-induced secretion of reactive oxygen species and suppresses the spontaneous production of IL-1beta and IL-10 (show IL10 Proteins) by murine peritoneal macrophages in vivo.

  2. ARTD1 (show PARP1 Proteins) controls osteoclast development and bone remodelling via its enzymatic activity by modulating the epigenetic marks surrounding the IL-1beta promoter and expression of IL-1beta and subsequently also Nfatc1 (show NFATC1 Proteins)/A.

  3. The work identifies a pathogenic role of postnatal IL1b/IL-1R1 pathway and subsequent prolonged prominent increase of endocannabinoid signaling in adult seizure susceptibility following prolonged febrile seizures.

  4. This study establishes IL-1beta and IFN-I levels as key homeostatic variables of protective, yet tuned, immune responses against severe invasive bacterial infection.

  5. JNK1 (show MAPK8 Proteins) mediates pancreatic beta apoptotic cell death associated with increased Myc (show MYC Proteins) expression in IL1-beta treated cells.

  6. SER140 treatment postpones the onset of diabetes in female NOD mice by interfering with IL-1beta/Il1 (show IL1A Proteins) receptor signaling.

  7. Sertoli cells have a functional NALP3 (show NLRP3 Proteins) inflammasome that modulates NOD1 (show NOD1 Proteins) and pro-IL-1beta expression, while NOD2 inversely promoted IL-1beta expression.

  8. IL-1beta has the potential to induce bladder remodeling and deteriorate urodynamic parameters in partial bladder outlet obstruction.

  9. Macrophage autophagy functions to limit acute toxin-induced liver injury and death by inhibiting the generation of inflammasome-dependent IL-1beta

  10. this study demonstrates a novel role of HDAC8 (show HDAC8 Proteins) in LeTx immunotoxicity and regulation of pro-IL-1beta production likely through eRNAs.

Human Interleukin 1, beta (IL1B) interaction partners

  1. In the Chinese population, IL-1beta C+3953T has significant genetic association with an increased risk of spontaneous preterm birth.

  2. The changes observed in the expression of IL-1 (show IL1A Proteins) and IL-6 (show IL6 Proteins) seem to exclude their immediate involvement in the progress of B-cell chronic lymphocytic leukaemia.

  3. These results suggest that ROCK may be important in IL-1 (show IL1A Proteins)-induced signaling through MKK4 (show MAP2K4 Proteins) to JNK (show MAPK8 Proteins) and the activation of p38 MAPK (show MAPK14 Proteins).

  4. This study demonstrated that dysregulated expression of NLRP3 (show NLRP3 Proteins)-caspase-1 (show CASP1 Proteins)-IL-1beta axis was observed in patients with MM, suggesting they might be involved in the pathogenesis of MM.

  5. Serum IL-1beta and IL-6 (show IL6 Proteins) concentrations in the infants who developed perinatal asphyxia were significantly higher compared to values in the normal infants.

  6. The NLRP3 (show NLRP3 Proteins)/caspase-1 (show CASP1 Proteins)/IL-1beta axis is active in cartilaginous endplates of patients with Modic changes and inflammatory cascades can exacerbate the cartilaginous endplate degeneration which may act as a trigger for intervertebral disc degeneration and low back pain.

  7. the single nucleotide polymorphisms (SNPs) in IL-1beta-31 might be associated with the gastritis risk, especially in the Caucasian population, while SNPs in the IL-1beta-511 might not be.

  8. Secretion of IL-1beta in the course of Fusobacterium nucleatum infection of gingival epithelial cells.

  9. Taking into account the effects of race, further subgroup analyses were performed and our results showed no association between the IL1B gene -511C/T polymorphism and ischemic stroke (IS) in either Asians or Caucasians. No publication bias was found in our study. In conclusion, the IL1B gene -511C/T polymorphism might not be associated with IS risk.

  10. Data suggest IL1b regulates expression of extracellular matrix proteins (such as MMP1 (show MMP1 Proteins) and MMP3 (show MMP3 Proteins)) and proteins involved in cell adhesion (such as ICAM1 (show ICAM1 Proteins) and VCAM1 (show VCAM1 Proteins)) in white adipocytes; studies were conducted using differentiated adipocytes (in primary culture) that were obtained from subcutaneous adipose tissue of an obese woman.

Pig (Porcine) Interleukin 1, beta (IL1B) interaction partners

  1. This study showed that classical swine fever virus and p7 protein induced IL-1beta secretion and that p7 protein was a short-lived protein degraded by the proteasome.

  2. local expression of IL-1beta and IL-8 (show IL8 Proteins) in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls

  3. IL1B regulates expression of IL1R1 (show IL1RN Proteins) and IL1RAP (show IL1RAP Proteins) and stimulates expression of PTGS1 (show PTGS1 Proteins) and PTGS2 (show PTGS2 Proteins) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (show PLIN1 Proteins)-implantation period of pregnancy in pigs.

  4. the results presented here strongly suggest IL-1beta as a key molecule guiding tissue remodelling events after myocardial infarction.

Cow (Bovine) Interleukin 1, beta (IL1B) interaction partners

  1. The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 (show IL1RN Proteins) protein and IL1B and IL1R1 (show IL1RN Proteins) mRNA were detected.

  2. For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor (show P2RX7 Proteins).

  3. Role of TGF-beta1 (show TGFB1 Proteins) and TNF-alpha (show TNF Proteins) in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

  4. Testicular IL-1 alpha (show IL1A Proteins) and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Proteins) bioactivity and IL-6 (show IL6 Proteins) concentrations were greatest in the immediate pre-pubertal period.

  5. Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.

  6. Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF (show PGF Proteins)(2alpha) and PGE (show LIPF Proteins)(2) production during luteal phase.

  7. non-metalloproteinase mechanisms participate in IL-1 (show IL1A Proteins)-induced matrix degradation and loss of tissue material properties

  8. dynamic compression stimulates cell proliferation and proteoglycan (show Vcan Proteins) synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 (show JUN Proteins) signalling pathways

  9. These results indicate that activation of the intrinsic antistaphylococcal response in bovine endothelial cells (BEC), enhanced by TNF-alpha (show TNF Proteins) and IL-1beta, is effective to eliminate S. aureus and S. epidermidis.

  10. the low friction of articular cartilage can be modified by TGF-beta1 (show TGFB1 Proteins) and IL-1beta treatment and that the friction coefficient depends on multiple factors, including superficial zone protein localization and surface roughness

Rabbit Interleukin 1, beta (IL1B) interaction partners

  1. Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 (show IL6 Proteins) in rabbit cornea cells.

  2. IL-1beta and TNF-alpha (show TNF Proteins) expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha (show TNF Proteins).

  3. IL-1beta induced a significant reduction in the relative intrinsic activity of GLUT5 and in this decrease are involved NO signal pathways; blockage of D-fructose intestinal uptake by IL-1beta may play an essential role in the pathophysiology of septic shock.

  4. The inhibitory effect of IL-1beta on D-galactose absorption across mucosal side of enterocyte could be mediated by the activation of several kinases and nuclear factor kappa B.

  5. Glucosamine hydrochloride treatment can can partially decrease the expression levels of IL-1 beta and increase the expression levels of TGF-beta 1 (show TGFB1 Proteins), which delays the development of osteoarthritis.

  6. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of IL1B transcripts depending on luteal stage.

  7. results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta,COX-2, and TGFbeta1 (show TGFB1 Proteins)

Horse (Equine) Interleukin 1, beta (IL1B) interaction partners

  1. Increased PGE2 production led to reduction in 5-LO (show ALOX5 Proteins) products in LPS (show IRF6 Proteins)-treated equine whole blood via IL-1b.

  2. Results suggested that chemokine (show CCL1 Proteins) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.

  3. IL-1beta-induced up-regulation of matrix metalloproteinase 13 (show MMP13 Proteins) mRNA was blocked by all concentrations of geldanamycin tested

  4. This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Proteins) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

IL1B Protein Profile

Protein Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Alternative names and synonyms associated with IL1B

  • interleukin 1, beta (il1b)
  • interleukin 1 beta (Il1b)
  • interleukin 1 beta (IL-1B)
  • interleukin 1, beta (IL1B)
  • IL-1 protein
  • IL-1B protein
  • IL-1BETA protein
  • il1-b protein
  • IL1-BETA protein
  • IL1B protein
  • IL1beta protein
  • IL1F2 protein
  • zgc:111873 protein

Protein level used designations for Interleukin 1, beta Proteins (IL1B)

interlukin-1 beta , IL-1 beta , interleukin-1 beta , catabolin , preinterleukin 1 beta , pro-interleukin-1-beta , prointerleukin-1 beta , Interleukin-1 beta , precursor interleukin-1beta , interleukin-1 beta proprotein , interleukin 1 beta , lymphocyte proliferation-potentiating factor , interleukin-beta

GENE ID SPECIES
405770 Danio rerio
16176 Mus musculus
24494 Rattus norvegicus
443539 Ovis aries
100135556 Cavia porcellus
3553 Homo sapiens
397122 Sus scrofa
281251 Bos taurus
100860816 Capra hircus
395196 Gallus gallus
403974 Canis lupus familiaris
100008990 Oryctolagus cuniculus
100034237 Equus caballus
768274 Felis catus
704701 Macaca mulatta
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