Browse our IL1B Proteins (IL1B)

Full name:
Interleukin 1, beta Proteins (IL1B)
On www.antibodies-online.com are 205 Interleukin 1, beta (IL1B) Proteins from 25 different suppliers available. Additionally we are shipping IL1B Antibodies (818) and IL1B Kits (272) and many more products for this protein. A total of 1328 IL1B products are currently listed.
Synonyms:
IL-1, IL-1B, IL-1BETA, il1-b, IL1-BETA, IL1B, IL1beta, IL1F2, zgc:111873
list all proteins Gene Name GeneID UniProt
IL1B 16176 P10749
IL1B 24494  
IL1B 3553 P01584

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IL1B Proteins (IL1B) by Origin

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Top referenced IL1B Proteins

  1. Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305081 : Gray, Glaister, Chen, Goeddel, Pennica: Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. in Journal of immunology (Baltimore, Md. : 1950) 1986 (PubMed)
    Show all 4 references for 1305081

  2. Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN413480 : Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011 (PubMed)
    Show all 2 references for 413480

  3. Dog (Canine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN2008853 : Kim, Mok, Kim, Joo: Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. in Molecular vision 2008 (PubMed)

  4. Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305079 : Kitamura, Tange, Terasawa, Chiba, Kuwaki, Miyagawa, Piao, Miyazono, Urabe, Takaku: Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. in Journal of cellular physiology 1989 (PubMed)

More Proteins for IL1B Interaction Partners

Zebrafish Interleukin 1, beta (IL1B) interaction partners

  1. Leukocyte expression of IL-1beta was detectable only following injury, which activated leukocytes throughout zebrafish embryos in a caspase (show CASP3 Proteins) dependent manner.

  2. Embryo and larva leukocytes upregulate IL-1beta expression proportional to the dose of ultraviolet radiation exposure in an immune response at the organismal level.

  3. findings reveal that the Il-1beta-Myd88 (show MYD88 Proteins) axis and NADPH oxidase (show NOX1 Proteins)-mediated ROS (show ROS1 Proteins) signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation.

  4. the expression levels of IL-1beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae

  5. These results represent the first demonstration of processing and secretion of zebrafish IL-1beta in response to a pathogen.

Mouse (Murine) Interleukin 1, beta (IL1B) interaction partners

  1. these results implicate IL-1 beta as an important driver of neonatal morbidity in preterm birth

  2. study found that IL-18 (show IL18 Proteins) and IL-1beta are differentially regulated. Despite being constitutively expressed, IL-18 (show IL18 Proteins) expression was increased and sustained after stimulation of TLRs. In contrast, IL-1beta was induced but not sustained after chronic treatment.

  3. These findings provide new evidence that IL-27 (show IL27 Proteins) plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta secretion levels triggered by dual LPS (show TLR4 Proteins)-ATP stimulation.

  4. inhibiting or silencing multiple cathepsins in macrophages, several key proinflammatory events induced by sterile particles are blocked, including cell death, pro-IL-1beta production, and IL-1beta secretion.

  5. recombinant macrophage migration inhibitory factor (show MIF Proteins) is important for the synthesis of il1beta mRNA in vivo and in isolated macrophages.

  6. the data suggest that UA promotes macrophage autophagy and, thereby, suppresses IL-1beta secretion, promotes cholesterol efflux, and attenuates atherosclerosis in mice.

  7. the transient upregulation of IL-1beta and PTPRC/CD45 (show PTPRC Proteins) during the early phase as well as the increased expression of collagen type I at later stages of repair and validate the differential expression of miR (show MLXIP Proteins)-204, miR (show MLXIP Proteins)-205, and miR (show MLXIP Proteins)-31 in skin wounds.

  8. Irradiation targeting a D2A1 tumor and its microenvironment increased the level of the inflammatory cytokine IL-1beta and was associated with the promotion of cancer cell invasion and lung metastasis development

  9. results indicate that dental calculus stimulates IL-1beta secretion via NLRP3 (show NLRP3 Proteins) inflammasome in human and mouse phagocytes, and that the crystalline structure has a partial role in the activation of NLRP3 (show NLRP3 Proteins) inflammasome

  10. NLRP3 inflammasome is decreased and IL-1beta secretion is inhibited in macrophages by hydroxysafflor yellow A and xanthine oxidase

Human Interleukin 1, beta (IL1B) interaction partners

  1. The presence of IL1B-31*C allele plus the presence of S. aureus and/or H. influenzae could be related to the development of tonsillitis in this particular Mexican population. Patients with at least one copy of the IL1B-31*C allele had a higher risk of recurrent tonsillitis (OR = 4.03; 95% CI = 1.27-14.27; P = 0.013).

  2. p38 (show CRK Proteins), c-jun (show JUN Proteins), and NFkappaB (show NFKB1 Proteins) pathways activated during intervertebral disc degeneration by IL-1beta but not GDF-5 (show GDF5 Proteins)

  3. Study showed that alterations in CRHR1 (show CRHR1 Proteins) gene were associated with higher levels of IL-1beta, and increased risk for suicide, reinforcing the importance of multifactorial interactions of biological markers for psychiatric disorders.

  4. These findings provide new evidence that IL-27 (show IL27 Proteins) plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta secretion levels triggered by dual LPS (show IRF6 Proteins)-ATP stimulation.

  5. Cystatin C significantly decreased the lipopolysaccharide-stimulated release and expression of interleukin-1beta in monocyte and peripheral blood mononuclear cultures from healthy donors and Crohn's patients.

  6. IL-1beta Induces NF2 (show NF2 Proteins) Promoter Methylation in Meningioma/Leptomeningeal Cells.

  7. The results of this study showed that Depression during the acute ACS (show PLA2G15 Proteins) was significantly associated with the IL-1beta levels and the -511T allele

  8. Our data indicate sustained activation of IL-1 (show IL1A Proteins) and IL-36 in generalized pustular psoriasis (GPP), inducing neutrophil chemokine (show CCL1 Proteins) expression, infiltration, and pustule formation, suggesting that the IL-1 (show IL1A Proteins)/IL-36 inflammatory axis is a potent driver of disease pathology in GPP

  9. Proteases caspase-1 (show CASP1 Proteins) and caspase-8 (show CASP8 Proteins) have redundant roles in cleaving IL-1beta and promoting osteomyelitis. [review]

  10. Inhibition of the inflammatory signaling intermediate p38 MAPK (show MAPK14 Proteins) reduced tissue factor (show F3 Proteins) (TF) mRNA by one third but increased tumor necrosis factor (TNF (show TNF Proteins)) and interleukin-1 beta (IL-1beta) mRNA.

Pig (Porcine) Interleukin 1, beta (IL1B) interaction partners

  1. This study showed that classical swine fever virus and p7 protein induced IL-1beta secretion and that p7 protein was a short-lived protein degraded by the proteasome.

  2. local expression of IL-1beta and IL-8 (show IL8 Proteins) in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls

  3. IL1B regulates expression of IL1R1 (show IL1RN Proteins) and IL1RAP (show IL1RAP Proteins) and stimulates expression of PTGS1 (show PTGS1 Proteins) and PTGS2 (show PTGS2 Proteins) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (show PLIN1 Proteins)-implantation period of pregnancy in pigs.

  4. the results presented here strongly suggest IL-1beta as a key molecule guiding tissue remodelling events after myocardial infarction.

Cow (Bovine) Interleukin 1, beta (IL1B) interaction partners

  1. The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 (show IL1RN Proteins) protein and IL1B and IL1R1 (show IL1RN Proteins) mRNA were detected.

  2. For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor (show P2RX7 Proteins).

  3. Role of TGF-beta1 (show TGFB1 Proteins) and TNF-alpha (show TNF Proteins) in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

  4. Testicular IL-1 alpha (show IL1A Proteins) and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Proteins) bioactivity and IL-6 (show IL6 Proteins) concentrations were greatest in the immediate pre-pubertal period.

  5. Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.

  6. Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF (show PGF Proteins)(2alpha) and PGE (show LIPF Proteins)(2) production during luteal phase.

  7. non-metalloproteinase mechanisms participate in IL-1 (show IL1A Proteins)-induced matrix degradation and loss of tissue material properties

  8. dynamic compression stimulates cell proliferation and proteoglycan (show Vcan Proteins) synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 (show JUN Proteins) signalling pathways

  9. These results indicate that activation of the intrinsic antistaphylococcal response in bovine endothelial cells (BEC), enhanced by TNF-alpha (show TNF Proteins) and IL-1beta, is effective to eliminate S. aureus and S. epidermidis.

  10. the low friction of articular cartilage can be modified by TGF-beta1 (show TGFB1 Proteins) and IL-1beta treatment and that the friction coefficient depends on multiple factors, including superficial zone protein localization and surface roughness

Rabbit Interleukin 1, beta (IL1B) interaction partners

  1. Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 (show IL6 Proteins) in rabbit cornea cells.

  2. IL-1beta and TNF-alpha (show TNF Proteins) expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha (show TNF Proteins).

  3. IL-1beta induced a significant reduction in the relative intrinsic activity of GLUT5 and in this decrease are involved NO signal pathways; blockage of D-fructose intestinal uptake by IL-1beta may play an essential role in the pathophysiology of septic shock.

  4. The inhibitory effect of IL-1beta on D-galactose absorption across mucosal side of enterocyte could be mediated by the activation of several kinases and nuclear factor kappa B.

  5. Glucosamine hydrochloride treatment can can partially decrease the expression levels of IL-1 beta and increase the expression levels of TGF-beta 1 (show TGFB1 Proteins), which delays the development of osteoarthritis.

  6. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of IL1B transcripts depending on luteal stage.

  7. results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta,COX-2, and TGFbeta1 (show TGFB1 Proteins)

Horse (Equine) Interleukin 1, beta (IL1B) interaction partners

  1. Increased PGE2 production led to reduction in 5-LO (show ALOX5 Proteins) products in LPS (show IRF6 Proteins)-treated equine whole blood via IL-1b.

  2. Results suggested that chemokine (show CCL1 Proteins) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.

  3. IL-1beta-induced up-regulation of matrix metalloproteinase 13 (show MMP13 Proteins) mRNA was blocked by all concentrations of geldanamycin tested

  4. This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Proteins) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

IL1B Protein Profile

Protein Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Alternative names and synonyms associated with IL1B

  • interleukin 1, beta (il1b)
  • interleukin 1 beta (Il1b)
  • interleukin 1 beta (IL-1B)
  • interleukin 1, beta (IL1B)
  • IL-1 protein
  • IL-1B protein
  • IL-1BETA protein
  • il1-b protein
  • IL1-BETA protein
  • IL1B protein
  • IL1beta protein
  • IL1F2 protein
  • zgc:111873 protein

Protein level used designations for Interleukin 1, beta Proteins (IL1B)

interlukin-1 beta , IL-1 beta , interleukin-1 beta , catabolin , preinterleukin 1 beta , pro-interleukin-1-beta , prointerleukin-1 beta , Interleukin-1 beta , precursor interleukin-1beta , interleukin-1 beta proprotein , interleukin 1 beta , lymphocyte proliferation-potentiating factor , interleukin-beta

GENE ID SPECIES
405770 Danio rerio
16176 Mus musculus
24494 Rattus norvegicus
443539 Ovis aries
100135556 Cavia porcellus
3553 Homo sapiens
397122 Sus scrofa
281251 Bos taurus
100860816 Capra hircus
395196 Gallus gallus
403974 Canis lupus familiaris
100008990 Oryctolagus cuniculus
100034237 Equus caballus
768274 Felis catus
704701 Macaca mulatta
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