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Human NGFB Protein expressed in CHO Cells - ABIN2003789
Ullrich, Gray, Berman, Dull: Human beta-nerve growth factor gene sequence highly homologous to that of mouse. in Nature 1983
Show all 6 Pubmed References
Mouse (Murine) NGFB Protein expressed in Mouse - ABIN804474
Varon, Raiborn: Dissociation, fractionation and culture of chick embryo sympathetic ganglionic cells. in Journal of neurocytology 1996
nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA (show NTRK1 Proteins)) directs innervation of the developing mouse femur to promote vascularization and osteoprogenitor lineage progression.
These data support a role for islet NGF in fine-tuning insulin (show INS Proteins) secretion.
Mechanical stress-induced upregulation of NGF in colon SMC (show DYM Proteins) underlies the visceral hypersensitivity in bowel obstruction through increased gene expression and activity of tetrodotoxin-resistant Na channels in sensory neurons.
results suggest that perivascular nerves innervate neovessels as neovasculatures mature and that NGF accelerates the innervation of perivascular nerves in neovessels.
These findings reveal a non-neuronal role for neurotrophins and identify a new regulatory pathway in insulin (show INS Proteins) secretion that can be targeted to ameliorate beta cell dysfunction.
NGF signalling directly controls basal APP (show APP Proteins) phosphorylation, subcellular localization and BACE (show BACE Proteins) cleavage.
NGF facilitates OVA with lowLPS-induced maturation of mouse BMDCs through LPS-up-regulated p75 NTR via activation of NF-kappaB pathways, providing another mechanism for the involvement of NGF in the Th2 response
NGF-OE mice exhibit age-dependent increases in Substance P (show TAC1 Proteins) and CGRP (show CALCA Proteins) in the urothelium and hyperinnervation of the bladder.
TNF-alpha upregulated Nerve Growth Factor [NGF] expression in synovial fibroblasts and macrophages and IL-1beta upregulated NGF expression in synovial fibroblasts. IL-1beta and TNF-alpha may regulate NGF signaling in Osteoarthritic joints and be suitable therapeutic targets for treating Osteoarthritis pain
functional PAP (show ASAP1 Proteins)(thorn) neurons are essential for the analgesic effect, which is mediated by NGF-trkA (show NTRK1 Proteins) signaling.
the effect and underlying mechanisms of NGF/BDNF on the production of NPW in PC12 cells and hypothalamus, is reported.
Findings suggest that IL-1beta (show IL1B Proteins) and TNF-alpha (show TNF Proteins) regulate Nerve Growth Factor expression and production in synovial macrophages and fibroblasts in osteoarthritic joints.
These results advance our knowledge of the conformational properties of proNGF and NGF and help provide a rationale for the diverse biological effects of NGF and proNGF at the molecular level.
The results of this study suggest that proNGF protein levels may augment the diagnostic accuracy of currently used CSF (show CSF2 Proteins) biomarker panels.
Neuroimmune-endocrine events may lead to overactivity of sympathetic nervous system that triggers cascade of pathologic conditions in ovary in polycystic ovary syndrome (PCOS). Data suggest women with PCOS exhibit reduction of CRH (show CRH Proteins) and NGF; reduction of CRH (show CRH Proteins)/NGF may be under influence of sympathetic nervous system and may reflect deficit of neuronal stress-adaptation in PCOS patients. (CRH (show CRH Proteins) = corticotropin releasing hormone (show CRH Proteins))
The rare nerve growth factor-beta (NGFB) mutation R221W causes a selective loss of thinly myelinated fibers and especially unmyelinated C-fibers. Carriers of this mutation show altered pain sensation.
NGF expression was positively correlated with disease severity and visceral hypersensitivity in irritable bowel syndrome patients.
a stage-related modulation of beta-NGF and its receptors in the inflammatory process of OA
BDNF and NGF serum levels are reduced in the early and moderate glaucoma stages, suggesting the possibility that both factors could be further investigated as potential circulating biomarkers for the early detection of glaucoma.
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.
beta-nerve growth factor
, nerve growth factor beta
, nerve growth factor, beta polypeptide
, nerve growth factor
, beta-Nerve growth factor
, nerve growth factor beta subunit
, nerve growth factor, beta
, nerve growth factor, beta subunit
, Beta-nerve growth factor
, nerve growth factor B
, beta-beta-nerve growth factor