Browse our PRKACA Proteins (PRKACA)

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Protein Kinase A, alpha Proteins (PRKACA)
On are 18 Protein Kinase A, alpha (PRKACA) Proteins from 7 different suppliers available. Additionally we are shipping PRKACA Antibodies (113) and PRKACA Kits (12) and many more products for this protein. A total of 150 PRKACA products are currently listed.
list all proteins Gene Name GeneID UniProt
PRKACA 18747 P05132
PRKACA 5566 P17612
PRKACA 25636  

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PRKACA Proteins (PRKACA) by Origin

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Top referenced PRKACA Proteins

  1. Human PRKACA Protein expressed in Baculovirus infected Insect Cells - ABIN411950 : Taskén, Solberg, Zhao, Hansson, Jahnsen, Siciliano: The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1. in Genomics 1997 (PubMed)
    Show all 3 references for 411950

  2. Human PRKACA Protein expressed in Wheat germ - ABIN1316219 : Loilome, Yooyuen, Namwat, Sithithaworn, Puapairoj, Kano, Noguchi, Miwa, Yongvanit: PRKAR1A overexpression is associated with increased ECPKA autoantibody in liver fluke-associated cholangiocarcinoma: application for assessment of the risk group. in Tumour biology 2012 (PubMed)

More Proteins for PRKACA Interaction Partners

Mouse (Murine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. study identifies a new role of Dual-AKAP1 (show AKAP1 Proteins) in regulating mitochondrial trafficking through Miro-2 (show RHOT2 Proteins), and supports a model in which PINK1 (show PINK1 Proteins) and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity

  2. Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)

  3. cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH (show SHH Proteins) signaling through regulation of GLI3 (show GLI3 Proteins) processing.

  4. this study shows illustrates for the first time the ability of protein kinase A to increase colony-stimulating factor 1 receptor (show CSF1R Proteins) DNA methylation (show HELLS Proteins) resulting in macrophage maturation

  5. these results suggest that the activation of 5-HT1D receptors selectively enhanced IA via the Gbetagamma of the Go-protein, PKA, and the sequential B-Raf (show SNRPE Proteins)-dependent p38 MAPK (show MAPK14 Proteins) signaling cascade.

  6. These data indicate that LPA increases CCN2 (show CTGF Proteins) expression through the activation of PKC and PKA. Thus, the regulatory functions of the PKC and PKA pathways are implicated in the LPA-induced increase in CCN2 (show CTGF Proteins) expression

  7. PKA phosphorylates the ATPase inhibitory factor 1 (show ATPIF1 Proteins) and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.

  8. Data suggest PRKAR1A (show PRKAR1A Proteins) contains two structurally homologous cAMP-binding domains that exhibit marked differences in dynamic profiles in activation/inhibition of Prkaca; conservation of structure does not necessarily imply conservation of dynamics.

  9. Data (including data from studies in transgenic mice) suggest that constitutive activation of Prkaca in osteoblasts is sufficient to increase bone mass, favorably modify bone architecture, and improve mechanical properties of bone.

  10. Lin28a (show LIN28A Proteins) protects against DCM through PKA/ROCK2 (show ROCK2 Proteins) dependent pathway.

Human Protein Kinase A, alpha (PRKACA) interaction partners

  1. PRKACA mutations are present in cortisol-producing adenomas and bilateral adrenal macronodular hyperplasia. PRKACA mutation is associated with more severe autonomous cortisol secretion.

  2. Dual co-expression of human fetal Tau with PKA in Escherichia coli results in multisite Tau phosphorylation including also naturally occurring sites which were not previously considered in the context of 14-3-3 (show YWHAQ Proteins) binding. Tau protein co-expressed with PKA displays tight functional interaction with 14-3-3 (show YWHAQ Proteins) isoforms of a different type.

  3. This review will discuss the effects of PKA phosphorylation on wild-type CFTR (show CFTR Proteins), the consequences of cystic fibrosis (show S100A8 Proteins) mutations on PKA phosphorylation, and the development of therapies that target PKA-mediated signaling. [review]

  4. This interaction is promoted by EPAC1 (show RAPGEF3 Proteins) activation, triggering its translocation to the plasma membrane and binding to NHERF1 (show SLC9A3R1 Proteins). Our findings identify a new CFTR (show CFTR Proteins)-interacting protein and demonstrate that cAMP activates CFTR (show CFTR Proteins) through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1 (show RAPGEF3 Proteins).

  5. The inhibitory effects of BMP4 (show BMP4 Proteins) on PDGF (show PDGFA Proteins)-induced cell proliferation, collagen synthesis, and calpain-2 (show CAPN2 Proteins) activation are impaired in pulmonary artery smooth muscle cells from pulmonary arterial hypertension patient.

  6. description of PRKACA mutations in 2 cases of primary aldosteronism (PA) patients: a novel variant (p.His88Asp) in a case of sudden onset of PA and a mutation (p.Leu206Arg) in context of hypokalemic aggravation of long-term hypertension; these genetic alterations were not found in a subsequent series of 120 aldosterone-producing adenomas and thereby appear to be very rare events

  7. PKA signaling is pivotal in pigmentation process itself in cultured melanoma cells, while the importance of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling should be emphasized in the context of development and differentiation

  8. Studies indicate a functional interaction between leucine-rich repeat kinase 2 (LRRK2 (show LRRK2 Proteins)) and protein kinase A (PKA) cross-talk in neuron and microglia.

  9. Studies indicate the importance of the AKAP79 (show AKAP5 Proteins)/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 (show CA1 Proteins) region of the hippocampus.

  10. GPER enhances melanogenesis via PKA by upregulating microphthalmia-related transcription factor-tyrosinase (show TYR Proteins) in melanoma

Pig (Porcine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. ceramide as a potent physiological modulator of the Na(+)-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta (show PRKCZ Proteins)

  2. we demonstrate that PKA, PKC (show FYN Proteins) and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A (show GSK3a Proteins) phosphorylation which subsequently controls cell motility.

Cow (Bovine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1

  2. Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.

  3. structural basis of selectivity for protein kinase A in complex with Rho-kinase (show ROCK1 Proteins) inhibitors by x-ray crystallography

  4. Purification and characterisation of protein kinase catalytic subunit (PKAcat) from bovine lens.

PRKACA Protein Profile

Protein Summary

Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.

Alternative names and synonyms associated with PRKACA

  • protein kinase, cAMP dependent, catalytic, alpha (Prkaca)
  • protein kinase, cAMP-dependent, catalytic, alpha (PRKACA)
  • protein kinase, cAMP-dependent, catalytic, alpha (Prkaca)
  • protein kinase, cAMP-dependent, regulatory, type I, beta (PRKAR1B)
  • Calpha protein
  • Cs-PKA protein
  • PKA protein
  • PKACA protein
  • PKCA1 protein
  • PKCD protein
  • PRKAR1 protein

Protein level used designations for PRKACA

PKA C-alpha , cAMP-dependent protein kinase catalytic subunit alpha , sperm cAMP-dependent protein kinase catalytic subunit , protein kinase A catalytic subunit , protein kinase, cAMP-dependent, catalytic, alpha , C-alpha subunit , protein kinase A , cAMP-dependent protein kinase catalytic subunit C alpha , protein kinase A alpha , cAMP-dependent protein kinase type I-beta regulatory subunit

18747 Mus musculus
5566 Homo sapiens
397652 Sus scrofa
282322 Bos taurus
443094 Ovis aries
25636 Rattus norvegicus
403556 Canis lupus familiaris
5575 Homo sapiens
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