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Browse our PRKACA Proteins (PRKACA)

Full name:
Protein Kinase A, alpha Proteins (PRKACA)
On are 17 Protein Kinase A, alpha (PRKACA) Proteins from 7 different suppliers available. Additionally we are shipping PRKACA Antibodies (73) and PRKACA Kits (6) and many more products for this protein. A total of 100 PRKACA products are currently listed.
list all proteins Gene Name GeneID UniProt
PRKACA 18747 P05132
PRKACA 5566 P17612
PRKACA 25636  

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PRKACA Proteins (PRKACA) by Origin

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Top referenced PRKACA Proteins

  1. Human PRKACA Protein expressed in Baculovirus infected Insect Cells - ABIN411950 : Taskén, Solberg, Zhao, Hansson, Jahnsen, Siciliano: The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1. in Genomics 1997 (PubMed)
    Show all 3 references for ABIN411950

  2. Human PRKACA Protein expressed in Wheat germ - ABIN1316219 : Loilome, Yooyuen, Namwat, Sithithaworn, Puapairoj, Kano, Noguchi, Miwa, Yongvanit: PRKAR1A overexpression is associated with increased ECPKA autoantibody in liver fluke-associated cholangiocarcinoma: application for assessment of the risk group. in Tumour biology 2012 (PubMed)

More Proteins for PRKACA Interaction Partners

Mouse (Murine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. PKA phosphorylates the ATPase inhibitory factor 1 (show ATPIF1 Proteins) and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.

  2. Data suggest PRKAR1A (show PRKAR1A Proteins) contains two structurally homologous cAMP-binding domains that exhibit marked differences in dynamic profiles in activation/inhibition of Prkaca; conservation of structure does not necessarily imply conservation of dynamics.

  3. Data (including data from studies in transgenic mice) suggest that constitutive activation of Prkaca in osteoblasts is sufficient to increase bone mass, favorably modify bone architecture, and improve mechanical properties of bone.

  4. Lin28a (show LIN28A Proteins) protects against DCM through PKA/ROCK2 (show ROCK2 Proteins) dependent pathway.

  5. We postulate that this novel interaction linking MVI with the PKA pathway could be important for targeting AKAP9-PKA complex within cells and/or providing PKA to phosphorylate MVI tail domain.

  6. acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.

  7. Data suggest that investigation of cAMP-dependent protein kinase A (PKA) and its signaling in D2 receptor (show DRD2 Proteins)-expressing indirect pathway medium-sized spiny neurons (iMSNs) would better understand the mechanisms underlying psychiatric disorders.

  8. This study investigates the affinity between the protein kinase PKA and peptide substrates derived from kemptide using molecular dynamics simulations.

  9. Our results provide evidence that cSrc is activated downstream of PKA and that inhibition of its activity blocks the capacitation-induced hyperpolarization of the sperm plasma membrane .

  10. Collectively, our studies highlighted that the CuB-induced actin aggregation and cofilin (show CFL1 Proteins)-actin rod formation was mediated via the Ga13/RhoA (show RHOA Proteins)/PKA/VASP (show VASP Proteins) pathway.

Human Protein Kinase A, alpha (PRKACA) interaction partners

  1. Data show that activated PKA phosphorylates the 19S subunit, Rpn6/PSMD11 (show PSMD11 Proteins) (regulatory particle non-ATPase 6/proteasome subunit D11) at Ser14.

  2. PKA phosphorylates the ATPase inhibitory factor 1 (show ATPIF1 Proteins) and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.

  3. DNAJB1 (show DNAJB1 Proteins)-PRKACA was evaluated as a key driver of fibrolamellar carcinoma and as a candidate therapeutic target

  4. No somatic mutations were observed in PRKACA in a cohort of GH-secreting pituitary adenomas.

  5. Kapbeta2 interacts with ULK2 (show ULK2 Proteins) through ULK2 (show ULK2 Proteins)'s putative PY-NLS (show ALDH1A2 Proteins) motif, and facilitates transport from the cytoplasm to the nucleus, depending on its Ser1027 residue phosphorylation by PKA, thereby reducing autophagic activity.

  6. ITM2A expression is positively regulated by PKA-CREB signaling and ITM2A expression interferes with autophagic flux by interacting with vacuolar ATPase.

  7. Akt (show AKT1 Proteins) and PKA phosphorylated KLHL3 (show KLHL3 Proteins) at S433, and phosphorylation of KLHL3 (show KLHL3 Proteins) by PKA inhibited WNK4 (show WNK4 Proteins) degradation.

  8. Data indicate that protein kinase A (PKA) phosphorylates only serine-253 amino acid on activator of G-protein signaling 1 (show RASD1 Proteins) protein Dexras1 (RASD1 (show RASD1 Proteins)).

  9. PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation.

  10. Leu206Arg and Leu199_Cys200insTrp mutations in PRKACA impair its association with PRKAR2B (show PRKAR2B Proteins) and PRKAR1A (show PRKAR1A Proteins).

Pig (Porcine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. ceramide as a potent physiological modulator of the Na(+)-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta (show PRKCZ Proteins)

  2. we demonstrate that PKA, PKC (show FYN Proteins) and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A (show GSK3a Proteins) phosphorylation which subsequently controls cell motility.

Cow (Bovine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.

  2. structural basis of selectivity for protein kinase A in complex with Rho-kinase (show ROCK1 Proteins) inhibitors by x-ray crystallography

  3. Purification and characterisation of protein kinase catalytic subunit (PKAcat) from bovine lens.

PRKACA Protein Profile

Protein Summary

Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.

Alternative names and synonyms associated with PRKACA

  • protein kinase, cAMP dependent, catalytic, alpha (Prkaca)
  • protein kinase, cAMP-dependent, catalytic, alpha (PRKACA)
  • protein kinase, cAMP-dependent, catalytic, alpha (Prkaca)
  • protein kinase, cAMP-dependent, regulatory, type I, beta (PRKAR1B)
  • Calpha protein
  • Cs-PKA protein
  • PKA protein
  • PKACA protein
  • PKCA1 protein
  • PKCD protein
  • PRKAR1 protein

Protein level used designations for PRKACA

PKA C-alpha , cAMP-dependent protein kinase catalytic subunit alpha , sperm cAMP-dependent protein kinase catalytic subunit , protein kinase A catalytic subunit , protein kinase, cAMP-dependent, catalytic, alpha , C-alpha subunit , protein kinase A , cAMP-dependent protein kinase catalytic subunit C alpha , protein kinase A alpha , cAMP-dependent protein kinase type I-beta regulatory subunit

18747 Mus musculus
5566 Homo sapiens
397652 Sus scrofa
282322 Bos taurus
443094 Ovis aries
25636 Rattus norvegicus
403556 Canis lupus familiaris
5575 Homo sapiens
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