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Browse our PRKACA Proteins (PRKACA)

Full name:
Protein Kinase A, alpha Proteins (PRKACA)
On are 17 Protein Kinase A, alpha (PRKACA) Proteins from 7 different suppliers available. Additionally we are shipping PRKACA Antibodies (94) and PRKACA Kits (9) and many more products for this protein. A total of 125 PRKACA products are currently listed.
list all proteins Gene Name GeneID UniProt
PRKACA 18747 P05132
PRKACA 5566 P17612
PRKACA 25636  

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PRKACA Proteins (PRKACA) by Origin

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Top referenced PRKACA Proteins

  1. Human PRKACA Protein expressed in Baculovirus infected Insect Cells - ABIN411950 : Taskén, Solberg, Zhao, Hansson, Jahnsen, Siciliano: The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1. in Genomics 1997 (PubMed)
    Show all 3 references for ABIN411950

  2. Human PRKACA Protein expressed in Wheat germ - ABIN1316219 : Loilome, Yooyuen, Namwat, Sithithaworn, Puapairoj, Kano, Noguchi, Miwa, Yongvanit: PRKAR1A overexpression is associated with increased ECPKA autoantibody in liver fluke-associated cholangiocarcinoma: application for assessment of the risk group. in Tumour biology 2012 (PubMed)

More Proteins for PRKACA Interaction Partners

Mouse (Murine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH (show SHH Proteins) signaling through regulation of GLI3 (show GLI3 Proteins) processing.

  2. this study shows illustrates for the first time the ability of protein kinase A to increase colony-stimulating factor 1 receptor (show CSF1R Proteins) DNA methylation (show HELLS Proteins) resulting in macrophage maturation

  3. these results suggest that the activation of 5-HT1D receptors selectively enhanced IA via the Gbetagamma of the Go-protein, PKA, and the sequential B-Raf (show SNRPE Proteins)-dependent p38 MAPK (show MAPK14 Proteins) signaling cascade.

  4. These data indicate that LPA increases CCN2 (show CTGF Proteins) expression through the activation of PKC and PKA. Thus, the regulatory functions of the PKC and PKA pathways are implicated in the LPA-induced increase in CCN2 (show CTGF Proteins) expression

  5. PKA phosphorylates the ATPase inhibitory factor 1 (show ATPIF1 Proteins) and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.

  6. Data suggest PRKAR1A (show PRKAR1A Proteins) contains two structurally homologous cAMP-binding domains that exhibit marked differences in dynamic profiles in activation/inhibition of Prkaca; conservation of structure does not necessarily imply conservation of dynamics.

  7. Data (including data from studies in transgenic mice) suggest that constitutive activation of Prkaca in osteoblasts is sufficient to increase bone mass, favorably modify bone architecture, and improve mechanical properties of bone.

  8. Lin28a (show LIN28A Proteins) protects against DCM through PKA/ROCK2 (show ROCK2 Proteins) dependent pathway.

  9. We postulate that this novel interaction linking MVI with the PKA pathway could be important for targeting AKAP9-PKA complex within cells and/or providing PKA to phosphorylate MVI tail domain.

  10. acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.

Human Protein Kinase A, alpha (PRKACA) interaction partners

  1. PRKACA mutation is associated with Adrenocortical Adenomas.

  2. Differentiation of mesenchymal stem cells into beige/brown adipocytes can be related via PKA modulation.

  3. FL-HCCs (show HCCS Proteins) in children and young adults uniquely overexpress DNAJB1 (show DNAJB1 Proteins)-PRKACA, which results in elevated cAMP-dependent PKA activity

  4. CFTR (show CFTR Proteins) inhibition also affected cAMP/PKA-downstream events such as the increase in tyrosine phosphorylation, hyperactivated motility, and acrosome reaction.

  5. Results suggest that G protein alpha (show GNAO1 Proteins) S subunit (Galphas (show GNAS Proteins)) plays a tumor-promoting role in renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) and possibly acts through a protein kinase A (PKA)-dependent pathway.

  6. Phosphorylation of ezrin together with its binding to phosphatidylinositol-4,5-bisphosphate tethers the F508del CFTR to the actin cytoskeleton, stabilizing it on the apical membrane and rescuing the sub-membrane compartmentalization of cAMP and activated PKA.

  7. Data show that activated PKA phosphorylates the 19S subunit, Rpn6/PSMD11 (show PSMD11 Proteins) (regulatory particle non-ATPase 6/proteasome subunit D11) at Ser14.

  8. PKA phosphorylates the ATPase inhibitory factor 1 (show ATPIF1 Proteins) and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.

  9. DNAJB1 (show DNAJB1 Proteins)-PRKACA was evaluated as a key driver of fibrolamellar carcinoma and as a candidate therapeutic target

  10. No somatic mutations were observed in PRKACA in a cohort of GH-secreting pituitary adenomas.

Pig (Porcine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. ceramide as a potent physiological modulator of the Na(+)-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta (show PRKCZ Proteins)

  2. we demonstrate that PKA, PKC (show FYN Proteins) and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A (show GSK3a Proteins) phosphorylation which subsequently controls cell motility.

Cow (Bovine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1

  2. Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.

  3. structural basis of selectivity for protein kinase A in complex with Rho-kinase (show ROCK1 Proteins) inhibitors by x-ray crystallography

  4. Purification and characterisation of protein kinase catalytic subunit (PKAcat) from bovine lens.

PRKACA Protein Profile

Protein Summary

Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.

Alternative names and synonyms associated with PRKACA

  • protein kinase, cAMP dependent, catalytic, alpha (Prkaca)
  • protein kinase, cAMP-dependent, catalytic, alpha (PRKACA)
  • protein kinase, cAMP-dependent, catalytic, alpha (Prkaca)
  • protein kinase, cAMP-dependent, regulatory, type I, beta (PRKAR1B)
  • Calpha protein
  • Cs-PKA protein
  • PKA protein
  • PKACA protein
  • PKCA1 protein
  • PKCD protein
  • PRKAR1 protein

Protein level used designations for PRKACA

PKA C-alpha , cAMP-dependent protein kinase catalytic subunit alpha , sperm cAMP-dependent protein kinase catalytic subunit , protein kinase A catalytic subunit , protein kinase, cAMP-dependent, catalytic, alpha , C-alpha subunit , protein kinase A , cAMP-dependent protein kinase catalytic subunit C alpha , protein kinase A alpha , cAMP-dependent protein kinase type I-beta regulatory subunit

18747 Mus musculus
5566 Homo sapiens
397652 Sus scrofa
282322 Bos taurus
443094 Ovis aries
25636 Rattus norvegicus
403556 Canis lupus familiaris
5575 Homo sapiens
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