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PRKACA Products

(Protein Kinase A, alpha (PRKACA))

Categories

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

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Featured PRKACA Categories

PRKACA Antibodies

High quality antibodies with extensive validation data.

PRKACA ELISA Kits

Reliable ELISA kits for a wide range of species.

PRKACA Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PRKACA Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application ICC, IF, IHC (p), WB
Validations
  • (4)
Cat. No. ABIN2855997
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN7146598
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN7138793
Quantity 100 μL
Datasheet Datasheet

Recommended PRKACA ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965371
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965370
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965372
Quantity 96 tests
Datasheet Datasheet

Recommended PRKACA Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1316219
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3093207
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3132509
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PRKACA products

Brunyanszki, Olah, Coletta, Szczesny, Szabo: "Regulation of mitochondrial poly(ADP-Ribose) polymerase activation by the β-adrenoceptor/cAMP/protein kinase A axis during oxidative stress." in: Molecular pharmacology, Vol. 86, Issue 4, pp. 450-62, (2014) (PubMed).

Beuschlein, Fassnacht, Assié, Calebiro, Stratakis, Osswald, Ronchi, Wieland, Sbiera, Faucz, Schaak, Schmittfull, Schwarzmayr, Barreau, Vezzosi, Rizk-Rabin, Zabel, Szarek, Salpea, Forlino, Vetro et al.: "Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. ..." in: The New England journal of medicine, Vol. 370, Issue 11, pp. 1019-28, (2014) (PubMed).

Loilome, Yooyuen, Namwat, Sithithaworn, Puapairoj, Kano, Noguchi, Miwa, Yongvanit: "PRKAR1A overexpression is associated with increased ECPKA autoantibody in liver fluke-associated cholangiocarcinoma: application for assessment of the risk group." in: Tumour biology, Vol. 33, Issue 6, pp. 2289-98, (2012) (PubMed).

Zhu, Wang, Kontrogianni-Konstantopoulos, Konstantopoulos: "Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases." in: Cell death and differentiation, Vol. 17, Issue 8, pp. 1325-34, (2010) (PubMed).

Barnitz, Wan, Tripuraneni, Bolton, Lenardo: "Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection." in: Journal of virology, Vol. 84, Issue 13, pp. 6410-24, (2010) (PubMed).

Adachi, Kano, Saido, Murata: "Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 14, Issue 3, pp. 355-69, (2009) (PubMed).

Enns, Morton, Mangalindan, McKnight, Schwartz, Kaeberlein, Kennedy, Rabinovitch, Ladiges: "Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A." in: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 64, Issue 12, pp. 1221-31, (2009) (PubMed).

Wilbur, Hwang, Brodsky: "New faces of the familiar clathrin lattice." in: Traffic (Copenhagen, Denmark), Vol. 6, Issue 4, pp. 346-50, (2005) (PubMed).

Mac?rek, Zíková, Dráberová, Dráber: "Monoclonal antibody BF-06 against the heavy chain of clathrin." in: Folia biologica, Vol. 49, Issue 6, pp. 238-40, (2004) (PubMed).

Szymkiewicz, Shupliakov, Dikic: "Cargo- and compartment-selective endocytic scaffold proteins." in: The Biochemical journal, Vol. 383, Issue Pt 1, pp. 1-11, (2004) (PubMed).

Synonyms and alternative names related to PRKACA

protein kinase cAMP-activated catalytic subunit alpha (PRKACA), protein kinase cAMP-activated catalytic subunit alpha (Prkaca), protein kinase, cAMP dependent, catalytic, alpha (Prkaca), cAMP-dependent protein kinase catalytic subunit (kin-1), protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a (prkacaa), Calpha, Cs-PKA, PKA, PKACA, Pkaca, PKCA1, PKCD, zgc:158799

Protein level used designations for PRKACA

  • PKA C-alpha
  • cAMP-dependent protein kinase catalytic subunit alpha
  • protein kinase A catalytic subunit
  • cAMP-dependent protein kinase catalytic subunit C alpha
  • protein kinase A
  • protein kinase, cAMP-dependent, catalytic, alpha
  • C-alpha subunit
  • sperm cAMP-dependent protein kinase catalytic subunit
  • protein kinase A alpha
  • prkaca
  • PKA catalytic subunit alpha
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