Browse our anti-TNFSF11 (TNFSF11) Antibodies

On are 324 Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Antibodies from 34 different suppliers available. Additionally we are shipping TNFSF11 Kits (118) and TNFSF11 Proteins (75) and many more products for this protein. A total of 534 TNFSF11 products are currently listed.
BTF3L1, CD254, hRANKL2, HUMBTFB, Ly109l, OCIF, ODF, Opg, OPGL, OPTB2, RANKL, sOdf, TNFRSF11B, TNFSF11, Trance
list all antibodies Gene Name GeneID UniProt
TNFSF11 690  
TNFSF11 21943 O35235
TNFSF11 117516 Q9ESE2

Most Popular Reactivities for anti-TNFSF11 (TNFSF11) Antibodies

anti-Human TNFSF11 Antibodies:

anti-Mouse (Murine) TNFSF11 Antibodies:

anti-Rat (Rattus) TNFSF11 Antibodies:

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More Antibodies against TNFSF11 Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. Correlations between sRANKL and IL-18 (show IL18 Antibodies) in BALF.

  2. RANK/RANKL signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin (show TNFRSF11B Antibodies) to prevent bone metastasis.

  3. This study suggested that RANKL could be a marker to differentiate between pagetoid squamous cell carcinoma in situ and extramammary Paget disease .

  4. TNF-alpha-converting enzyme (show ADAM17 Antibodies) -mediated cleavage of soluble RANKL from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.

  5. RANKL is required for progesterone-mediated cell proliferation in BRCA1mut/+ breast tissue.

  6. MAOA (show MAOA Antibodies) provides tumor cell growth advantages in the bone microenvironment by stimulating interleukin-6 (IL6 (show IL6 Antibodies)) release from osteoblasts, and triggers skeletal colonization by activating osteoclastogenesis through osteoblast production of RANKL and IL6 (show IL6 Antibodies).

  7. In this review, we will provide a summary of the biological functions of RANK signaling pathway (receptor activator of nuclear factor kappaB ligand RANKL and its receptor RANK ) and downstream pathways in bone remodeling, immunity and epithelial homeostasis, with a particular emphasis on cancer

  8. The results showed that AG490 inhibited (p)-JAK2 (show JAK2 Antibodies) and RANKL expression.

  9. Review: OPG (show TNFRSF11B Antibodies), RANKL and TRAIL are involved in vascular calcification.

  10. Our results suggest that the polymorphism of the RANKL, RANK, and OPG (show TNFRSF11B Antibodies) genes does not make a significant genetic contribution to heel ultrasound measurements in a population of young Caucasian adults. Further studies replicating the results in independent populations are needed to support these initial findings.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. Data suggest that mutations at position I248 in DE-loop of murine RANKL have effects on interaction of RANKL with RANK and on subsequent activation of osteoclastogenesis by this hetero-multimer. (RANKL = osteoclast differentiation factor; RANK = tumor necrosis factor (show TNF Antibodies) receptor superfamily, member 11a protein)

  2. sRANKL increased macrophage glucose uptake at normal glucose concentrations, which was impaired by hyperglycemia pretreatment through the inhibition of Glut1 (show SLC2A1 Antibodies) membrane translocation and the insulin receptor (show INSR Antibodies) and IRS-1 (show IRS1 Antibodies) gene transcription.

  3. Our findings show that anti-RANKL antibody administration during pregnancy results in not only an undesirable increase in bone mass, but also has harmful effects on newborn survival.

  4. RANKL represses the transcription of the E3 ubiquitin ligase (show MUL1 Antibodies) RNF146 (show RNF146 Antibodies) through an NF-kappaB (show NFKB1 Antibodies)-related inhibitory element in the RNF146 (show RNF146 Antibodies) promoter.

  5. This study showed that RANKL favors osteoclastogenesis via attenuation of Nrf2 (show NFE2L2 Antibodies)-mediated antioxidant enzyme expression by competing with Bach1 (show BACH1 Antibodies) nuclear accumulation.

  6. Membrane-bound RANKL induces M cell differentiation and CCL20 (show CCL20 Antibodies) expression in the follicle associated epithelium of gut (show GUSB Antibodies)-associated lymphoid tissues.

  7. The data show that S. aureus enhances bone resorption and periosteal osteoclast formation by increasing osteoblast RANKL production through TLR2 (show TLR2 Antibodies).

  8. Data (including data from studies using knockout mice) suggest that RANKL enhances TNF (show TNF Antibodies)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 (show TRAF6 Antibodies) by degrading Traf3 (show TRAF3 Antibodies), a known inhibitor of osteoclastogenesis. (RANKL = osteoclast differentiation factor; TNF (show TNF Antibodies) = tumor necrosis factor (show TNF Antibodies); Traf (show TRAF1 Antibodies) = TNF (show TNF Antibodies) receptor-associated factor)

  9. Results suggest that MAPK (show MAPK1 Antibodies) signaling pathway is necessary for receptor activator of nuclear factor kappa-B ligand (RANKL) expression in bone marrow stromal cell.

  10. endocortical resorption is driven by reduced osteoprotegerin (show TNFRSF11B Antibodies) rather than elevated RANKL expression

TNFSF11 Antigen Profile

Antigen Summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Alternative names and synonyms associated with TNFSF11

  • tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11) antibody
  • basic transcription factor 3 pseudogene 11 (BTF3P11) antibody
  • tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11) antibody
  • tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b) antibody
  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B) antibody
  • BTF3L1 antibody
  • CD254 antibody
  • hRANKL2 antibody
  • HUMBTFB antibody
  • Ly109l antibody
  • OCIF antibody
  • ODF antibody
  • Opg antibody
  • OPGL antibody
  • OPTB2 antibody
  • RANKL antibody
  • sOdf antibody
  • TNFRSF11B antibody
  • TNFSF11 antibody
  • Trance antibody

Protein level used designations for TNFSF11

tumor necrosis factor (ligand) superfamily, member 11 , tumor necrosis factor ligand superfamily member 11 , Receptor activator of nuclear factor kappa-B ligand , TNF-related activation-induced cytokine , osteoclast differentiation factor , osteoprotegerin ligand , receptor activator of nuclear factor kappa B ligand , receptor activator of nuclear factor kappa-B ligand , OPG ligand , receptor activator of NF-kappaB ligand , tumor necrosis factor-related activation-induced cytokine , ODF , OPGL , TRANCE , Osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

467353 Pan troglodytes
513836 Bos taurus
609418 Canis lupus familiaris
699955 Macaca mulatta
100599838 Nomascus leucogenys
690 Homo sapiens
8600 Homo sapiens
21943 Mus musculus
117516 Rattus norvegicus
25341 Rattus norvegicus
378803 Gallus gallus
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