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Browse our anti-TNFSF11 (TNFSF11) Antibodies

Full name:
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Antibodies (TNFSF11)
On www.antibodies-online.com are 248 Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Antibodies from 29 different suppliers available. Additionally we are shipping TNFSF11 Kits (105) and TNFSF11 Proteins (53) and many more products for this protein. A total of 419 TNFSF11 products are currently listed.
Synonyms:
BTF3L1, CD254, hRANKL2, HUMBTFB, Ly109l, OCIF, ODF, Opg, OPGL, OPTB2, RANKL, sOdf, TNFRSF11B, TNFSF11, Trance
list all antibodies Gene Name GeneID UniProt
TNFSF11 690  
TNFSF11 21943 O35235
TNFSF11 117516 Q9ESE2

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Top referenced anti-TNFSF11 Antibodies

  1. Human Polyclonal TNFSF11 Primary Antibody for IF (p), IHC (p) - ABIN672696 : Yang, Li, Yang, Shen, Zou, Zhu, Zhang, Yang, Li: Efficacy and safety of echinacoside in a rat osteopenia model. in Evidence-based complementary and alternative medicine : eCAM 2013 (PubMed)
    Show all 7 references for ABIN672696

  2. Human Polyclonal TNFSF11 Primary Antibody for IF (p), IHC (p) - ABIN668556 : Zhang, Liu, Li, Bai: Mycobacterium tuberculosis 10-kDa co-chaperonin regulates the expression levels of receptor activator of nuclear factor-?B ligand and osteoprotegerin in human osteoblasts. in Experimental and therapeutic medicine 2015 (PubMed)
    Show all 5 references for ABIN668556

  3. Human Polyclonal TNFSF11 Primary Antibody for EIA, IHC (p) - ABIN500805 : Kong, Yoshida, Sarosi, Tan, Timms, Capparelli, Morony, Oliveira-dos-Santos, Van, Itie, Khoo, Wakeham, Dunstan, Lacey, Mak, Boyle, Penninger: OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. in Nature 1999 (PubMed)
    Show all 4 references for ABIN500805

  4. Human Polyclonal TNFSF11 Primary Antibody for IF, ELISA - ABIN1533487 : Anderson, Maraskovsky, Billingsley, Dougall, Tometsko, Roux, Teepe, DuBose, Cosman, Galibert: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. in Nature 1997 (PubMed)
    Show all 2 references for ABIN1533487

  5. Human Monoclonal TNFSF11 Primary Antibody for ELISA (Detection), FACS - ABIN281395 : Kanamaru, Iwai, Ikeda, Nakajima, Ishikawa, Azuma: Expression of membrane-bound and soluble receptor activator of NF-kappaB ligand (RANKL) in human T cells. in Immunology letters 2004 (PubMed)

  6. Human Polyclonal TNFSF11 Primary Antibody for EIA, WB - ABIN116279 : Grimaud, Soubigou, Couillaud, Coipeau, Moreau, Passuti, Gouin, Redini, Heymann: Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis. in The American journal of pathology 2003 (PubMed)

  7. Human Monoclonal TNFSF11 Primary Antibody for WB - ABIN2668631 : Hikita, Yana, Wakeyama, Nakamura, Kadono, Oshima, Nakamura, Seiki, Tanaka: Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand. in The Journal of biological chemistry 2006 (PubMed)

More Antibodies against TNFSF11 Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. Switched memory B cells from RA patients expressed significantly more RANKL compared to healthy controls. B cells supported osteoclast differentiation in vitro in a RANKL-dependent manner.

  2. high level of mRANKL/RANK expression in cervical cancer lesions plays an important role in the rapid growth of cervical cancer cells possibly through strengthening the dialogue between cervical cancer cells and regulation of IL-8 (show IL8 Antibodies) secretion

  3. Transglutaminase 2 (show TGM2 Antibodies) up-regulation is associated with RANKL/OPG pathway

  4. The plasma OPG (show TNFRSF11B Antibodies) level is negatively associated with nonalcoholic fatty liver disease independent of potential cofounders

  5. Mast cell density and expression of MMP-9 (show MMP9 Antibodies), RANKL and Ntx correlated positively with of bone disease severity in multiple myeloma patients.

  6. Th17 cytokines have a dual effect on osteoclastogenesis in rheumatoid arthritis (RA): direct induction of osteoclastogenesis from monocytes and up-regulation of RANKL production in RA fibroblast-like synoviocytes (FLSs).

  7. these findings suggest a possible mechanism underlying the RANKL expression induced by wear particles in fibroblasts, and downregulating ER stress and the XBP1s expression of fibroblasts

  8. Taken together, these results suggested that the expression of RANKL induced by TiPs was mediated by ER stress in fibroblasts.

  9. Data show that receptor activator of nuclear factor kappa B ligand (RANKL) was elevated in anti-citrullinated protein antibodies (ACPA (show PRTN3 Antibodies))-positive and in anti-cit (show CIT Antibodies)-vimentin (show VIM Antibodies)-positive patients with early untreated rheumatoid arthritis (RA).

  10. qPCR and in silico hybridization revealed that miR (show MLXIP Antibodies)-124 and miR (show MLXIP Antibodies)-155 can be directly involved in the transcriptional regulation of Runt-related transcription factor 2 (RUNX2 (show RUNX2 Antibodies)) and receptor activator of nuclear factor kappa-B ligand (RANKL) genes.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. OPG inhibits osteoclast differentiation via the MAPK (show MAPK1 Antibodies) signaling pathway.

  2. Stromal reticular cells activate lymphatic endothelial cells via RANKL and support the action of hematopoietic cell-derived lymphotoxin (show LTB Antibodies).

  3. SAA (show SAA1 Antibodies) inhibits osteoclast formation from mouse macrophages. SAA (show SAA1 Antibodies) blocks RANKL-induced osteoclastogenesis.

  4. Adseverin (show SCIN Antibodies) knockdown also suppressed the RANKL-mediated induction of nuclear factor of activated T-cell (show NFATC3 Antibodies) c1 (NFATc1 (show NFATC1 Antibodies)), which is a key transcription factor in osteoclastogenesis.

  5. Expression of RANKL is related to sex differences in collagen-induced arthritis

  6. Study reports that loss of the Opg gene results in deterioration of abdominal aortic aneurysms (AAA (show AAAS Antibodies)), possibly through involvement of TRAIL in smooth muscle actin (SMA (show SMN1 Antibodies))-positive cells and myofibroblasts.

  7. Data (including data from studies in transgenic mice) suggest RANKL induces incomplete cytokinesis (as well as cell fusion) as myeloid precursors commit to becoming polyploid osteoclasts; Akt (show AKT1 Antibodies) activation via phosphorylation appears to be involved.

  8. Results show that moderate increases in affinity for RANK lead to a substantial augmentation of osteoclast formation, signaling, and bone resorption suggesting a biphasic relationship between RANKL/RANK affinity and osteoclastogenic capacity.

  9. OPG induces osteoclasts and osteoclast progenitor cells apoptosis partly by the Fas (show FAS Antibodies)/FasL (show FASL Antibodies) signaling pathway.

  10. Although RL-D5 (enhancer) mediates RANKL expression in multiple lineages, other cell type- or factor-specific enhancers are required for its appropriate control, demonstrating the cell type-specific and complex regulation of RANKL expression.

TNFSF11 Antigen Profile

Antigen Summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Alternative names and synonyms associated with TNFSF11

  • tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11) antibody
  • basic transcription factor 3 pseudogene 11 (BTF3P11) antibody
  • tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11) antibody
  • tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b) antibody
  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B) antibody
  • BTF3L1 antibody
  • CD254 antibody
  • hRANKL2 antibody
  • HUMBTFB antibody
  • Ly109l antibody
  • OCIF antibody
  • ODF antibody
  • Opg antibody
  • OPGL antibody
  • OPTB2 antibody
  • RANKL antibody
  • sOdf antibody
  • TNFRSF11B antibody
  • TNFSF11 antibody
  • Trance antibody

Protein level used designations for TNFSF11

tumor necrosis factor (ligand) superfamily, member 11 , tumor necrosis factor ligand superfamily member 11 , Receptor activator of nuclear factor kappa-B ligand , TNF-related activation-induced cytokine , osteoclast differentiation factor , osteoprotegerin ligand , receptor activator of nuclear factor kappa B ligand , receptor activator of nuclear factor kappa-B ligand , OPG ligand , receptor activator of NF-kappaB ligand , tumor necrosis factor-related activation-induced cytokine , ODF , OPGL , TRANCE , Osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

GENE ID SPECIES
467353 Pan troglodytes
513836 Bos taurus
609418 Canis lupus familiaris
699955 Macaca mulatta
100599838 Nomascus leucogenys
690 Homo sapiens
8600 Homo sapiens
21943 Mus musculus
117516 Rattus norvegicus
25341 Rattus norvegicus
378803 Gallus gallus
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