RANKL antibody

Catalog No. ABIN1169326

This Rabbit Polyclonal antibody specifically detects RANKL in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for RANKL antibody (ABIN1169326)

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RANKL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-RANKL Antibody

Purpose: anti-RANKL (human), pAb

Specificity: Recognizes human RANKL. Detects a band of ~35 kDa band by Western blot.

Characteristics: Polyclonal Antibody. Recognizes human RANKL. Detects a band of ~35 kDa band by Western blot. Source: Rabbit. Applications: ELISA, FACS, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. Important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. Plays an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human RANKL.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

Target Details for RANKL

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Alternative Name: RANKL

Background:

Alternate Names/Synonyms: TRANCE, ODF, OPGL, TNFSF11, CD254

Product Description: RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. Important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. Plays an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

UniProt: O14788

Pathways: NF-kappaB Signaling