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anti-Human JAG1 Antibodies:
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Human Monoclonal JAG1 Primary Antibody for CyTOF, FACS - ABIN4900205
Kibbie, Teles, Wang, Hong, Montoya, Krutzik, Lee, Kwon, Modlin, Cruz: Jagged1 Instructs Macrophage Differentiation in Leprosy. in PLoS pathogens 2016
Show all 5 Pubmed References
Human Monoclonal JAG1 Primary Antibody for CyTOF, FACS - ABIN4900206
Le Friec, Sheppard, Whiteman, Karsten, Shamoun, Laing, Bugeon, Dallman, Melchionna, Chillakuri, Smith, Drouet, Couzi, Fremeaux-Bacchi, Köhl, Waddington, McDonnell, Baker, Handford, Lea, Kemper: The CD46-Jagged1 interaction is critical for human TH1 immunity. in Nature immunology 2012
Show all 5 Pubmed References
Dog (Canine) Monoclonal JAG1 Primary Antibody for IF, WB - ABIN968827
Berezovska, Xia, Hyman: Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease. in Journal of neuropathology and experimental neurology 1998
Show all 4 Pubmed References
Mouse (Murine) Monoclonal JAG1 Primary Antibody for IHC (fro), FACS - ABIN2480076
McKusick: The Human Genome Project and clinical medicine. in Hospital practice (Office ed.) 1991
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Rat (Rattus) Polyclonal JAG1 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900585
Stahl, Uemura, Ge, Shi, Tashima, Stanley: Roles of Pofut1 and O-fucose in mammalian Notch signaling. in The Journal of biological chemistry 2008
Show all 2 Pubmed References
Human Polyclonal JAG1 Primary Antibody for ICC, IF - ABIN269362
Okamoto, Matsuda, Joetham, Lucas, Domenico, Yasutomo, Takeda, Gelfand: Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production. in Journal of immunology (Baltimore, Md. : 1950) 2009
Human Polyclonal JAG1 Primary Antibody for ICC, IF - ABIN337168
Siar, Ha, Aung, Nakano, Tsujigiwa, Nagatsuka, Ng, Kawakami: Immunolocalization of notch signaling protein molecules in a maxillary chondrosarcoma and its recurrent tumor. in European journal of medical research 2010
Human Polyclonal JAG1 Primary Antibody for FM, IHC - ABIN1043767
Yabe, Matsumoto, Tsurumoto, Shindo: Immunohistological localization of Notch receptors and their ligands Delta and Jagged in synovial tissues of rheumatoid arthritis. in Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2005
Human Polyclonal JAG1 Primary Antibody for IHC, IHC (p) - ABIN4327850
Gunin, Petrov, Golubtzova, Vasilieva, Kornilova: Age-related changes in angiogenesis in human dermis. in Experimental gerontology 2014
Bruceine D inhibits hepatocellular carcinoma growth by targeting beta-catenin/jagged1 signaling pathways.
Results showed that JAG1 was significantly downregulated in miR (show MLXIP Antibodies)-26a-overexpressing osteosarcoma cells and is a direct target of miR (show MLXIP Antibodies)-26a.
the effects of two Notch (show NOTCH1 Antibodies) ligands, i.e., Jagged1 and DLL1 (show DLL1 Antibodies), on murine and human hematopoiesis in vitro. Our observations indicate that the stromal expression of Notch (show NOTCH1 Antibodies) ligands increases the production of both the total and phenotypically early murine and human hematopoietic cells in the co-culture.
Specific Notch3 (show NOTCH3 Antibodies) and Jag1 subcellular localization patterns may provide clues for the behavior of the corresponding tumors and could potentially be applied in the clinic for Jag1 targeting in triple-negative breast cancer patients.
there is a cross-talk between Jagged1/Notch3 (show NOTCH3 Antibodies) and VEGF (show VEGFA Antibodies) in TNBC angiogenesis. Jagged1/Notch3 (show NOTCH3 Antibodies) is expected to be an important signaling pathway for TNBC progression and a potential target for TNBC neovascularization therapy.
Low levels of Notch pathway genes Notch1, Notch2, Notch4 and Jagged1 correlated with poor prognostic factors such as larger tumor size, positive lymph-node status, tumor phenotype and infiltrating tumor Treg cells.
Human Jagged-1 induced the proliferation and differentiation of CD133+ cord blood progenitors compared with hDll-1. Thus, hJagged-1 signaling in the bone marrow niche may be used to expand EPCs for therapeutic angiogenesis
By studying leprosy as a model, we provide evidence that upregulation of JAG1 on endothelium instructs monocytes to differentiate into M1 macrophages with antimicrobial activity.
High Jag1 expression is associated with metastasis in colorectal cancer.
amplification of Jagged1 contributed to mRNA expression that activates the Jagged1-Notch (show NOTCH1 Antibodies) signaling pathway in liver cancer and led to poor outcome.
JAG1 is the main activator of NOTCH signaling and GDNF expression in Sertoli cells.
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
A Jagged1-Hey1 (show HEY1 Antibodies) signal might mediate the impairment of angiogenesis induced by Ang II (show AGT Antibodies) during cardiac hypertrophy.
Data show that Rac1 induced nuclear import of STAT3 (show STAT3 Antibodies) by physical binding, and nuclear STAT3 (show STAT3 Antibodies) directly activated the transcription of essential oocyte-specific genes, including Jagged1, GDF9 (show GDF9 Antibodies) and BMP15 (show BMP15 Antibodies).
Diabetes mellitus induces Jagged1 overexpression and suppresses Notch signaling in endothelial cells. Blocking Jagged1 prevented diabetes-induced microvasculopathy and could reverse it even after 4 weeks.
Jagged1 intracellular domain-mediated inhibition of Notch1 (show NOTCH1 Antibodies) signalling regulates cardiac homeostasis in the postnatal heart.
endothelial Jagged1 has a role in promoting solid tumor development
Jag1 expression in pulmonary capillary endothelial cells is upregulated after repeated lung injury and contributes to lung fibrosis.
On a C57BL/6 background, Jag1 haploinsufficiency results in bile duct paucity in mice
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
jagged 1 (Alagille syndrome)
, jagged 1
, protein jagged-1-like
, protein jagged-1