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Human JAG1 ELISA Kit for Sandwich ELISA - ABIN417745
Zeng, Jin, Ao, Cleveland, Song, Xu, Fullerton, Meng: Cross-talk between the Toll-like receptor 4 and Notch1 pathways augments the inflammatory response in the interstitial cells of stenotic human aortic valves. in Circulation 2012
Show all 6 references for ABIN417745
Our data revealed that MALAT1 inhibited tongue cancer cell growth and metastasis through miR-124-dependent JAG1 regulation. In conclusion, we revealed that MALAT1 may play an oncogenic role by increasing proliferation and metastasis of tongue cancer and is a potential therapeutic target in human tongue cancer.
Positive Jagged1 and DLL4 (show DLL4 ELISA Kits) expression is closely correlated with severe clinicopathological characteristics and poor prognosis in patients with pancreatic ductal carcinoma.
miR (show MLXIP ELISA Kits)-199a-3p targets YAP1 (show YAP1 ELISA Kits), downregulates Jagged1 and suppresses the Notch (show NOTCH1 ELISA Kits) signaling to inhibit hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) cell proliferation and promote apoptosis. These findings provide new insights into the mechanism by which miR (show MLXIP ELISA Kits)-199a-3p suppresses HCC (show FAM126A ELISA Kits) cell proliferation and induces apoptosis.
Jagged1 activation of Notch3 (show NOTCH3 ELISA Kits) resulted in a significant decrease in cell proliferation while concomitantly promoting Hemangioma-pericyte maturation.
expression of JAG1 is regulated by various pathways and is associated with poor prognosis through promoting the epithelial to mesenchymal transition and cell proliferation or maintaining cell survival in colorectal cancer
AGS is caused by mutations in one of two genes, namely, JAG1 or NOTCH2 (show NOTCH2 ELISA Kits). These genes are part of the Notch (show NOTCH1 ELISA Kits) signaling pathway, which is involved in cell fate determination. JAG1 mutations have been identified in 70-94% of individuals with clinically diagnosed AGS
On complete gene sequencing of JAG1 gene as described before, the patient was shown to be heterozygous for a known pathogenic mutationc.270delG (p.C92AfsX69) in exon 2
JAG1 protein expression was significant positive correlation with lymph node metastasis, pathological grades invasive ductal carcinoma of breast.JAG1 gene methylation level in breast cancer.
these findings demonstrate that 50 microM EGCG protects against ox-LDL-induced endothelial dysfunction through the Jagged-1/Notch (show NOTCH1 ELISA Kits) signaling pathway.
PKCalpha (show PKCa ELISA Kits) Attenuates Jagged-1-Mediated Notch (show NOTCH1 ELISA Kits) Signaling in ErbB-2 (show ERBB2 ELISA Kits)-Positive Breast Cancer to Reverse Trastuzumab Resistance
A Jagged1-Hey1 (show HEY1 ELISA Kits) signal might mediate the impairment of angiogenesis induced by Ang II (show AGT ELISA Kits) during cardiac hypertrophy.
Data show that Rac1 induced nuclear import of STAT3 (show STAT3 ELISA Kits) by physical binding, and nuclear STAT3 (show STAT3 ELISA Kits) directly activated the transcription of essential oocyte-specific genes, including Jagged1, GDF9 (show GDF9 ELISA Kits) and BMP15 (show BMP15 ELISA Kits).
Diabetes mellitus induces Jagged1 overexpression and suppresses Notch signaling in endothelial cells. Blocking Jagged1 prevented diabetes-induced microvasculopathy and could reverse it even after 4 weeks.
Jagged1 intracellular domain-mediated inhibition of Notch1 (show NOTCH1 ELISA Kits) signalling regulates cardiac homeostasis in the postnatal heart.
endothelial Jagged1 has a role in promoting solid tumor development
Jag1 expression in pulmonary capillary endothelial cells is upregulated after repeated lung injury and contributes to lung fibrosis.
On a C57BL/6 background, Jag1 haploinsufficiency results in bile duct paucity in mice
Jag1-induced Notch (show NOTCH1 ELISA Kits) activity and the subsequent (or concomitant) downregulation of the Dll4 (show DLL4 ELISA Kits)-mediated signalling are both required for generating haematopoietic stem cells in the embryo.
miR (show MLXIP ELISA Kits)-34c overexpression inhibits the Notch (show NOTCH1 ELISA Kits) signaling pathway by targeting Notch1 (show NOTCH1 ELISA Kits) and Jaggged1 in high glucose-treated podocytes.
miR-199b targeted the Notch ligand JAG1, resulting in vascular endothelial growth factor (VEGF) transcriptional activation and secretion through the transcription factor STAT3.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
jagged 1 (Alagille syndrome)
, jagged 1
, protein jagged-1-like
, protein jagged-1