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Browse our TNFRSF10B Proteins (TNFRSF10B)

Full name:
Tumor Necrosis Factor Receptor Superfamily, Member 10b Proteins (TNFRSF10B)
On are 43 Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Proteins from 13 different suppliers available. Additionally we are shipping TNFRSF10B Antibodies (374) and TNFRSF10B Kits (10) and many more products for this protein. A total of 447 TNFRSF10B products are currently listed.
list all proteins Gene Name GeneID UniProt
Rat TNFRSF10B TNFRSF10B 364420  
TNFRSF10B 8795 O14763
TNFRSF10B 21933 Q9QZM4

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TNFRSF10B Proteins (TNFRSF10B) by Origin

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Top referenced TNFRSF10B Proteins

  1. Human TNFRSF10B Protein expressed in HEK293 - ABIN925132 : Schneider, Bodmer, Thome, Hofmann, Holler, Tschopp: Characterization of two receptors for TRAIL. in FEBS letters 1997 (PubMed)
    Show all 2 references for ABIN925132

  2. Human TNFRSF10B Protein expressed in HEK-293 Cells - ABIN2181868 : Yamaguchi, Wang: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. in The Journal of biological chemistry 2004 (PubMed)

  3. Mouse (Murine) TNFRSF10B Protein expressed in Human Cells - ABIN2007768 : Pan, Ni, Wei, Yu, Gentz, Dixit: An antagonist decoy receptor and a death domain-containing receptor for TRAIL. in Science (New York, N.Y.) 1997 (PubMed)

More Proteins for TNFRSF10B Interaction Partners

Human Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) interaction partners

  1. we found that CQ decreased the expression of Cbl (show CBL Proteins), an E3 ligase of DR5, and knock-down of Cbl (show CBL Proteins) markedly enhanced DR5 up-regulation. Other lysosomal inhibitors, including monensin and nigericin, also up-regulated DR5 and sensitized TRAIL-mediated apoptosis

  2. MG132 possesses anti-gallbladder cancer potential that correlate with regulation of DR5-dependent pathway.

  3. Edelfosine also activated p38MAPK (MAPK14 (show MAPK14 Proteins)), and edelfosine-mediated rhTRAIL sensitization was partially regulated by a p38 (show CRK Proteins)-mediated decrease in mitochondrial membrane potential. This study suggests a novel therapeutic strategy targeting gastric cancer cells by using the combination of edelfosine and TRAIL.

  4. Pro-survival effects by NF-kappaB (show NFKB1 Proteins), Akt (show AKT1 Proteins) and ERK(1 (show MAPK3 Proteins)/2) and anti-apoptosis actions by Six1 (show SIX1 Proteins) disrupt apoptotic functions of TRAIL-Dr4 (show HLADRB4 Proteins)/5 pathway in ovarian cancer, which may explain why up-regulated DR4 (show HLADRB4 Proteins) and DR5 in ovarian cancer are associated with poor prognosis and low survival ratio of the patients.

  5. CAPE/TRAIL stimulated apoptosis through the binding of TRAIL to DR5. Moreover, expression of transcription factor C/EBP homologous protein (CHOP (show DDIT3 Proteins)) markedly increased in response to CAPE and transient knockdown of CHOP (show DDIT3 Proteins) abolished CAPE/TRAIL-mediated apoptosis.

  6. Decreased level of placental TRAIl-R2 and previous C-section were found to be significantly correlated to placenta accreta.

  7. Structural analysis for the roles of DR5 death domain mutations on oligomerization of DR5 death domain-FADD complex in the death-inducing signaling complex formation has been presented.

  8. Results show that calmodulin (CaM (show CALM1 Proteins)) directly binds to death receptor-5 (DR5) in a calcium dependent manner in breast cancer cells.

  9. Bee venom inhibits colon cancer cell growth, and these anti-proliferative effects may be related to the induction of apoptosis by activation of DR4 (show HLADRB4 Proteins) and DR5 and inhibition of NF-kappaB (show NFKB1 Proteins) activity.

  10. study involving a relatively large sample size showed that TNFRSF10 eQTL (show EQTN Proteins) SNPs within lncRNAs might influence both hepatocellular carcinoma development and HBV infection

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) interaction partners

  1. Authors demonstrate, for the first time, expression of TNF-related apoptosis-inducing ligand (TRAIL (show TNFSF10 Proteins)) and its signaling death receptor 5 (DR5) in the murine inner ear.

  2. Malignant transformation in the endometrium is related to reduction of membrane DR4 (show HLADRB4 Proteins) and DR5 expression.

  3. TRAIL expression by osteoclast-like cells is increased in the presence of RANKL (show TNFSF11 Proteins) and after scraping; DcR2 (show TNFRSF10D Proteins) expression peaks at 24 hours, and and decreases at 5 days; DR5 expression peaks at 5 days

  4. Induction of death receptor 5 expression in tumor vasculature by perifosine restores the vascular disruption activity of TRAIL-expressing CD34 (show CD34 Proteins)(+) cells.

  5. TRAIL-DR5 interaction promoted malignant behaviors of B16F10 cells.

  6. results suggest that the transmembrane domains together with their adjacent stalk regions can play a major role in control of death receptor activation thereby contributing to cell type specific differences in TRAILR1 and TRAILR2 signaling

  7. DR5 is selectively expressed by neuroprogenitor cells and newborn neurons.

  8. Results suggest that excessive iodine could induce TRAIL and DR5 abnormal expression in thyroid. TRAIL band with DR5 to promote follicular cells apoptosis thus mediate thyroid destruction in EAT.

  9. NK cells inhibit dendritic cell cross-priming, but not direct priming, in a TRAIL/DR5-dependent manner.

  10. Antibody-based therapy targeting DR5 is an efficient strategy not only to eliminate TRAIL-sensitive tumor cells.

TNFRSF10B Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Alternative names and synonyms associated with TNFRSF10B

  • tumor necrosis factor receptor superfamily, member 10b (Tnfrsf10b)
  • tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B)
  • tumor necrosis factor receptor superfamily, member 10b (tnfrsf10b-b)
  • tumor necrosis factor receptor superfamily, member 10b (tnfrsf10b)
  • CD262 protein
  • DR5 protein
  • KILLER protein
  • KILLER/DR5 protein
  • Ly98 protein
  • MK protein
  • TNFRSF10B protein
  • TRAIL-R2 protein
  • TRAILR2 protein
  • TRICK2 protein
  • TRICK2A protein
  • TRICK2B protein
  • TRICKB protein
  • xDR-M1 protein
  • xDR-M2 protein
  • ZTNFR9 protein

Protein level used designations for TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b , death receptor-M2 , death receptor-M1 , Fas-like protein , TNF-related apoptosis-inducing ligand receptor 2 , apoptosis inducing protein TRICK2A/2B , apoptosis inducing receptor TRAIL-R2 , cytotoxic TRAIL receptor-2 , death domain containing receptor for TRAIL/Apo-2L , death receptor 5 , p53-regulated DNA damage-inducible cell death receptor(killer) , tumor necrosis factor receptor superfamily member 10B , tumor necrosis factor receptor-like protein ZTNFR9 , KILLER/DR5 TRAIL death-inducing receptor

364420 Rattus norvegicus
282533 Bos taurus
404687 Xenopus laevis
404688 Xenopus laevis
448240 Xenopus (Silurana) tropicalis
742898 Pan troglodytes
8795 Homo sapiens
21933 Mus musculus
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