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Browse our Lipoprotein-Associated phospholipase A2 Proteins (Lp-PLA2)

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Lipoprotein-Associated phospholipase A2 Proteins (Lp-PLA2)
On are 20 Lipoprotein-Associated phospholipase A2 (Lp-PLA2) Proteins from 8 different suppliers available. Additionally we are shipping Lipoprotein-Associated phospholipase A2 Antibodies (90) and Lipoprotein-Associated phospholipase A2 Kits (48) and many more products for this protein. A total of 162 Lipoprotein-Associated phospholipase A2 products are currently listed.
list all proteins Gene Name GeneID UniProt
Lp-PLA2 7941 Q13093
Rat Lp-PLA2 Lp-PLA2 301265  
Lp-PLA2 27226 Q60963

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Lipoprotein-Associated phospholipase A2 Proteins (Lp-PLA2) by Origin

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Top referenced Lipoprotein-Associated phospholipase A2 Proteins

  1. Human Lp-PLA2 Protein expressed in Human Cells - ABIN2003487 : Yamada, Ichihara, Fujimura, Yokota: Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men. in Metabolism: clinical and experimental 1998 (PubMed)
    Show all 4 references for ABIN2003487

More Proteins for Lipoprotein-Associated phospholipase A2 Interaction Partners

Human Lipoprotein-Associated phospholipase A2 (Lp-PLA2) interaction partners

  1. This presentation aims at clarifying the involvement of Lp-PLA2 in the pathophysiology of atherosclerosis, and at assessing its interest both as a biomarker for the onset of CV events and as a therapeutic target--{REVIEW}

  2. The collected data showed a correlation between the occurrence of superimposed thrombosis in respiratory infection patients, and the intensity of the inflammatory process, reflected by the increased MPO activity, and the dynamics of LpPLA2 and VEGF.

  3. PLA2G7 expression is significantly upregulated in human masticatory mucosa during wound healing

  4. A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (show TBXA2R Proteins) (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms.

  5. Uremic environment but not inflammation per se increases plasma Lp-PLA2 activity and upregulates monocytic Lp-PLA2 mRNA expression. The highest Lp-PLA2 levels were found in the classical and not in the inflammatory subsets. Atherosclerosis also contributes to a subset-specific increase in Lp-PLA2 mRNA expression.

  6. Lp-PLA2 levels in human plasma were positively associated with the severity of coronary heart disease.

  7. Greater Lp-PLA2 activity or mass was independently associated with cardiovascular events in patients with coronary heart disease, particularly in patients with stable coronary heart disease who were not receiving therapies for inhibiting Lp-PLA2.[review]

  8. PLA2G7 gene expression was co-regulated by 17-beta-estradiol and promoter methylation.

  9. Lp-PLA2 activity in Japanese men aged 50-79 years was associated significantly and positively with IMT and plaque in the carotid artery but Mendelian randomization did not support that Lp-PLA2 is a causative factor for subclinical atherosclerosis.

  10. 279Val-->Phe Polymorphism of Lp-PLA2 may lead to decrease the enzymatic activity via changes of folding kinetics and recognition to its substrate.

Mouse (Murine) Lipoprotein-Associated phospholipase A2 (Lp-PLA2) interaction partners

  1. Lp-PLA2 augments the inflammatory response after MI and antagonizes healing by disrupting the balance between inflammation and repair.

  2. Plg (show PLG Proteins) from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2), suggesting that linkage to Plg (show PLG Proteins) protects oxPtdPCs from metabolism during their transport in the plasma.

  3. SAA (show SAA1 Proteins) up-regulates Lp-PLA2 production significantly via a FPRL1 (show FPR2 Proteins)/MAPKs./PPAR-gamma (show PPARG Proteins) signaling pathway.

  4. Deletion of Pla2g7 decreases small intestinal polyp and colon tumor incidence in ApcMin/+ mice.

  5. Macrophage VLDL receptor (show VLDLR Proteins) promotes PAFAH (show PAFAH1B1 Proteins) secretion in mother's milk and suppresses systemic inflammation in nursing neonates.

  6. Pla2g7 and Tnfrsf21 (show TNFRSF21 Proteins) have been identified as genetic susceptibility to influenza genes in mice.

  7. Pla2g7 plays a crucial physiological role in smooth muscle cell differentiation from stem cells, and interactions between Nrf3 (show NFE2L3 Proteins) and Pla2g7 are essential.

  8. The effects of a specific lp-PLA2 inhibitor on atherosclerosis in ApoE (show APOE Proteins)-deficient mice and its associated mechanisms, are reported.

  9. Studies designed to evaluate the ability of precursor forms of PAF-AH to mature to fully active proteins indicated that the N-terminal end of human and mouse PAF-AH played important and opposite roles in this process.

  10. PAF acetylhydrolase activity in the uterus in early pregnancy was not produced locally but probably resulted from the influx of the plasma form of the enzyme

Pig (Porcine) Lipoprotein-Associated phospholipase A2 (Lp-PLA2) interaction partners

  1. The results demonstrated that Lp-PLA2 is associated with triglycerides which may be helpful for understanding the relationship of this protein with cardiovascular disease.

  2. Effect of splenectomy and autologous spleen transplantation on the serum PAF-AH activity and acute-phase response in a porcine model are reported.

  3. observations support a proatherogenic role for Lp-PLA2

  4. Variable gene expression (eg, matrix metalloproteinase-9 (show MMP9 Proteins), CCL2 (show CCL2 Proteins) and Lp-PLA(2) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.

  5. The significant correlation between PLA2G7 RNA expression in plaque macrophages and plasma PAFAH activity suggests that the latter is a consequence, rather than a cause of macrophage accumulation.

Lipoprotein-Associated phospholipase A2 (Lp-PLA2) Protein Profile

Protein Summary

The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Lipoprotein-Associated phospholipase A2 (Lp-PLA2)

  • phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (PLA2G7)
  • phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (Pla2g7)
  • LDL-PLA2 protein
  • Lp-PLA2 protein
  • PAF-AH protein
  • PAFAD protein
  • PAFAH protein
  • R75400 protein

Protein level used designations for Lp-PLA2

1-alkyl-2-acetylglycerophosphocholine esterase , 2-acetyl-1-alkylglycerophosphocholine esterase , LDL-PLA(2) , LDL-associated phospholipase A2 , PAF 2-acylhydrolase , PAF acetylhydrolase , gVIIA-PLA2 , group-VIIA phospholipase A2 , lipoprotein-associated phospholipase A2 , platelet-activating factor acetylhydrolase , Paf-acetylhydrolase , group VII phospholipase A2 , plasma PAF acetylhydrolase

7941 Homo sapiens
301265 Rattus norvegicus
27226 Mus musculus
100135600 Cavia porcellus
396593 Sus scrofa
403848 Canis lupus familiaris
282311 Bos taurus
395816 Gallus gallus
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