Browse our Lipoprotein-Associated phospholipase A2 Proteins (Lp-PLA2)

Full name:
Lipoprotein-Associated phospholipase A2 Proteins (Lp-PLA2)
On www.antibodies-online.com are 33 Lipoprotein-Associated phospholipase A2 (Lp-PLA2) Proteins from 11 different suppliers available. Additionally we are shipping Lipoprotein-Associated phospholipase A2 Antibodies (110) and Lipoprotein-Associated phospholipase A2 Kits (70) and many more products for this protein. A total of 218 Lipoprotein-Associated phospholipase A2 products are currently listed.
Synonyms:
LDL-PLA2, Lp-PLA2, PAF-AH, PAFAD, PAFAH, R75400
list all proteins Gene Name GeneID UniProt
Lp-PLA2 7941 Q13093
Rat Lp-PLA2 Lp-PLA2 301265  
Lp-PLA2 27226 Q60963

Show all synonyms

Lipoprotein-Associated phospholipase A2 Proteins (Lp-PLA2) by Origin

Select your origin of interest

Top referenced Lipoprotein-Associated phospholipase A2 Proteins

  1. Human Lp-PLA2 Protein expressed in Human Cells - ABIN2003487 : Yamada, Ichihara, Fujimura, Yokota: Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men. in Metabolism: clinical and experimental 1998 (PubMed)
    Show all 4 references for 2003487

More Proteins for Lipoprotein-Associated phospholipase A2 Interaction Partners

Human Lipoprotein-Associated phospholipase A2 (Lp-PLA2) interaction partners

  1. LpPLA2 is found in both LDL and HDL (show HSD11B1 Proteins) and is distributed differently in men with T1D without any relationship to CAC (show CA2 Proteins) score progression

  2. In a multi-ethnic cohort without baseline cardiovascular disease, higher Lp-PLA2 mass and activity were not significantly associated with an increased risk for incident peripheral arterial disease.

  3. The simultaneous presence of the PLA2G7 279VV genotype and persistence of overweight synergistically increases the risk for hypertension.

  4. Elevated mass and activity of Lp-PLA2 related to inflammation and atherosclerosis may take part in the development of kidney injury and atherosclerosis in patients with chronic kidney disease.

  5. Taken together, these results revealed that Lp-PLA2 silencing protected against ox-LDL-induced oxidative stress and cell apoptosis via Akt/mTOR signaling pathway in human THP1 macrophages.

  6. Plasma Lp-PLA2 concentration was independently associated with coronary heart disease in Chinese patients.

  7. The distribution of V279F-AA+AC genotype and R92H-AA+AG genotype in the AP group was higher than that in the control group, whereas the Severity of Acute Pancreatitis (SAP (show APCS Proteins)) group and SAP (show APCS Proteins) with multiple organ dysfunction syndrome group distributions were higher than those in the MAP group and SAP (show APCS Proteins) without MODS group.G-C-A, G-A-G, and G-C-G haploids formed by A379V, V279F, and R92H may be associated with AP susceptibility

  8. results do not support added value of Lp-PLA2 for predicting cardiovascular events or mortality among CHD (show CHDH Proteins) patients beyond traditional risk factor

  9. High Lp-PLA2 expression is associated with type 1 diabetes.

  10. This presentation aims at clarifying the involvement of Lp-PLA2 in the pathophysiology of atherosclerosis, and at assessing its interest both as a biomarker for the onset of CV events and as a therapeutic target--{REVIEW}

Mouse (Murine) Lipoprotein-Associated phospholipase A2 (Lp-PLA2) interaction partners

  1. Lp-PLA2 augments the inflammatory response after MI and antagonizes healing by disrupting the balance between inflammation and repair.

  2. Plg (show PLG Proteins) from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2), suggesting that linkage to Plg (show PLG Proteins) protects oxPtdPCs from metabolism during their transport in the plasma.

  3. SAA (show SAA1 Proteins) up-regulates Lp-PLA2 production significantly via a FPRL1 (show FPR2 Proteins)/MAPKs./PPAR-gamma (show PPARG Proteins) signaling pathway.

  4. Deletion of Pla2g7 decreases small intestinal polyp and colon tumor incidence in ApcMin/+ mice.

  5. Macrophage VLDL receptor (show VLDLR Proteins) promotes PAFAH (show PAFAH1B1 Proteins) secretion in mother's milk and suppresses systemic inflammation in nursing neonates.

  6. Pla2g7 and Tnfrsf21 (show TNFRSF21 Proteins) have been identified as genetic susceptibility to influenza genes in mice.

  7. Pla2g7 plays a crucial physiological role in smooth muscle cell differentiation from stem cells, and interactions between Nrf3 (show NFE2L3 Proteins) and Pla2g7 are essential.

  8. The effects of a specific lp-PLA2 inhibitor on atherosclerosis in ApoE (show APOE Proteins)-deficient mice and its associated mechanisms, are reported.

  9. Studies designed to evaluate the ability of precursor forms of PAF-AH to mature to fully active proteins indicated that the N-terminal end of human and mouse PAF-AH played important and opposite roles in this process.

  10. PAF acetylhydrolase activity in the uterus in early pregnancy was not produced locally but probably resulted from the influx of the plasma form of the enzyme

Pig (Porcine) Lipoprotein-Associated phospholipase A2 (Lp-PLA2) interaction partners

  1. The results demonstrated that Lp-PLA2 is associated with triglycerides which may be helpful for understanding the relationship of this protein with cardiovascular disease.

  2. Effect of splenectomy and autologous spleen transplantation on the serum PAF-AH activity and acute-phase response in a porcine model are reported.

  3. observations support a proatherogenic role for Lp-PLA2

  4. Variable gene expression (eg, matrix metalloproteinase-9 (show MMP9 Proteins), CCL2 (show CCL2 Proteins) and Lp-PLA(2) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.

  5. The significant correlation between PLA2G7 RNA expression in plaque macrophages and plasma PAFAH activity suggests that the latter is a consequence, rather than a cause of macrophage accumulation.

Lipoprotein-Associated phospholipase A2 (Lp-PLA2) Protein Profile

Protein Summary

The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Lipoprotein-Associated phospholipase A2 (Lp-PLA2)

  • phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (PLA2G7)
  • phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (Pla2g7)
  • LDL-PLA2 protein
  • Lp-PLA2 protein
  • PAF-AH protein
  • PAFAD protein
  • PAFAH protein
  • R75400 protein

Protein level used designations for Lp-PLA2

1-alkyl-2-acetylglycerophosphocholine esterase , 2-acetyl-1-alkylglycerophosphocholine esterase , LDL-PLA(2) , LDL-associated phospholipase A2 , PAF 2-acylhydrolase , PAF acetylhydrolase , gVIIA-PLA2 , group-VIIA phospholipase A2 , lipoprotein-associated phospholipase A2 , platelet-activating factor acetylhydrolase , Paf-acetylhydrolase , group VII phospholipase A2 , plasma PAF acetylhydrolase

GENE ID SPECIES
7941 Homo sapiens
301265 Rattus norvegicus
27226 Mus musculus
100135600 Cavia porcellus
396593 Sus scrofa
403848 Canis lupus familiaris
282311 Bos taurus
395816 Gallus gallus
Selected quality suppliers for Lipoprotein-Associated phospholipase A2 Proteins (Lp-PLA2)
Did you look for something else?