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PLA2G7 Protein

Lp-PLA2 Origin: Human Host: HEK-293T Cells Recombinant > 95 % pure Active
Catalog No. ABIN935738
  • Target See all PLA2G7 (Lp-PLA2) Proteins
    PLA2G7 (Lp-PLA2) (Lipoprotein-Associated phospholipase A2 (Lp-PLA2))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 10
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human
    Source
    • 10
    • 6
    • 4
    • 1
    • 1
    HEK-293T Cells
    Sequence
    FDWQYINPVA HMKSSAWVNK IQVLMAAASF GQTKIPRGNG PYSVGCTDLM FDHTNKGTFL RLYYPSQDND RLDTLWIPNK EYFWGLSKFL GTHWLMGNIL RLLFGSMTTP ANWNSPLRPG EKYPLVVFSH GLGAFRTLYS AIGIDLASHG FIVAAVEHRD RSASATYYFK DQSAAEIGDK SWLYLRTLKQ EEETHIRNEQ VRQRAKECSQ ALSLILDIDH GKPVKNALDL KFDMEQLKDS IDREKIAVIG HSFGGATVIQ TLSEDQRFRC GIALDAWMFP LGDEVYSRIP QPLFFINSEY FQYPANIIKM KKCYSPDKER KMITIRGSVH QNFADFTFAT GKIIGHMLKL KGDIDSNVAI DLSNKASLAF LQKHLGLHKD FDQWDCLIEG DDENLIPGTN INTTNQHIML QNSSGIEKYN
    Characteristics
    Purified recombinant Human PAFAH protein
    Expression System: 293 cells
    Bioactivity: Measured by its ability to cleave a PAF analog in a chromogenic substrate linked assay. At a PAF-AH concentration of 10.0 µg/mL, 50 % cleavage was achieved at an incubation time of approximately 2 minutes.
    Purity
    > 95 % pure
    Endotoxin Level
    < 0.1 ng per µg (1 EU/µg).
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    Discover our top product Lp-PLA2 Protein
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Supplied as a lyophilized powder.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
  • Target
    PLA2G7 (Lp-PLA2) (Lipoprotein-Associated phospholipase A2 (Lp-PLA2))
    Alternative Name
    PAFAH (Lp-PLA2 Products)
    Synonyms
    LDL-PLA2 Protein, LP-PLA2 Protein, PAFAD Protein, PAFAH Protein, Lp-PLA2 Protein, PAF-AH Protein, R75400 Protein, zgc:77563 Protein, phospholipase A2 group VII Protein, phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Protein, PLA2G7 Protein, Pla2g7 Protein, pla2g7 Protein
    Background
    Platelet Activating Factor (PAF) is a biologically active phospholipid, which exerts primarily proinflammatory activities by specifically signaling through G-protein-coupled receptors on platelets, neutrophils, and monocytes. Platelet Activating Factor Acetylhydrolase (PAF-AH) is a secreted protein that mediates PAF activity by specifically catalyzing hydrolysis of the "sn2" ester bond, resulting in the conversion of PAF to the biologically inactive lyso-PAF. PAF-AH can also interact with LDL particles to induce the hydrolysis of LDL associated, oxidized phospholipids, generating lysophosphatidylcholine (lyso-PC) and other lysophospholipids.
    Alternative Names: PAF 2-acylhydrolase protein, PAF acetylhydrolase protein, LDL-associated phospholipase A2 protein, LDL-PLA2 protein, 2-acetyl-1-alkylglycerophosphocholine esterase protein, 1-alkyl-2-acetylglycerophosphocholine esterase protein
    Molecular Weight
    47-55 kDa
    Pathways
    Peptide Hormone Metabolism
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