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Browse our AKT2 Proteins (AKT2)

Full name:
V-Akt Murine Thymoma Viral Oncogene Homolog 2 Proteins (AKT2)
On are 24 V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) Proteins from 12 different suppliers available. Additionally we are shipping AKT2 Antibodies (423) and AKT2 Kits (19) and many more products for this protein. A total of 482 AKT2 products are currently listed.
2410016A19Rik, AKT2, akt2-a, AW554154, cb945, HIHGHH, PKB, PKBB, PKBBETA, pkbss, PRKBB, RAC-BETA, v-akt2
list all proteins Gene Name GeneID UniProt
AKT2 11652 Q60823
AKT2 208 P31751
AKT2 25233 P47197

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AKT2 Proteins (AKT2) by Origin

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Mouse (Murine) V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

  1. BAY 1125976 is a potent and highly selective allosteric AKT1 (show AKT1 Proteins)/2 inhibitor.

  2. AKT2 inhibition induces a unique mitochondrial-dependent DNA degradation pathway by activating nucleus translocation of AIF (show AIFM1 Proteins) and EndoG (show ENDOG Proteins) during cardiac ischemia.

  3. Akt2 ablation may protect against paraquat toxicity-induced cardiac contractile defect and apoptosis possibly via regulation of Nrf2 (show NFE2L2 Proteins) activation and mitochondrial homeostasis.

  4. Loss of Akt2 enhanced lung tumor development.

  5. Akt2(-/-) mice survive hepatic Akt1 (show AKT1 Proteins) deletion but all develop spontaneous hepatocellular carcinoma. They are insulin (show INS Proteins) resistant. Akt2(-/-) mice are not resistant to diethylnitrosamine hepatocarcinogenesis. They have a high incidence of lung metastasis.

  6. rescued the hepatic regenerative capability in Akt1 (show AKT1 Proteins)-deficient and Akt2-deficient mice

  7. Sustained endothelial Akt1/2 (show JAG1 Proteins) signalling is critical in main (show NOTCH1 Proteins)taining vascular stability and homeostasis, thereby preserving tissue and organ function.

  8. Akt2 upregulates dendritic cell migration at least in part by ETS1 (show ETS1 Proteins)-dependent stimulation of IP3R2 (show ITPR2 Proteins) transcription.

  9. In viable Akt (show AKT1 Proteins) three-isoforms conditional knockout mice, total Akt (show AKT1 Proteins) levels were reduced in the adult brain. They had increased levels of phosphorylated tau, GSK3alpha and PKA substrates. No significant changes in p-tau levels were found in Akt2(-/-)mice.

  10. results suggest that short-term coadministration of HU and Akti XII has immediate benefits for acute vaso-occlusive events and survival in SCD (show SCD Proteins) mice exceeding those seen for single therapy.

Human V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

  1. Quinoline-type inhibitors bind in the Akt2 PH domain.

  2. TGF-beta (show TGFB1 Proteins) signaling through Akt2 induces phosphorylation of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1 (show PCBP1 Proteins)) at serine-43 (p-hnRNP E1 (show PCBP1 Proteins)), driving epithelial to mesenchymal transition and metastasis.

  3. miR (show MLXIP Proteins)-29b plays an important role in TGF-beta1 (show TGFB1 Proteins)-mediated epithelial-mesenchymal transition in ARPE-19 cells by targeting Akt2.

  4. miR (show MLXIP Proteins)-148a functions as tumor suppressor in Renal cell carcinoma (show MOK Proteins) by targeting AKT2.

  5. This was further verified in gene expression analyses, showing downregulation of genes involved in glucose metabolism. Additionally, both AKT1 (show AKT1 Proteins) KO and AKT2 KO demonstrated an impaired fatty acid metabolism. However, genes were upregulated in the Wnt (show WNT2 Proteins) and cell proliferation pathways, which could oppose this effect. AKT (show AKT1 Proteins) inhibition should therefore be combined with other effectors to attain the best effect.

  6. Data indicate that proto-oncogene (show RAB1A Proteins) protein c-akt (Akt (show AKT1 Proteins)) phosphorylates distinct sites than SRPK1 (show SRPK1 Proteins) protein within the arginine-serine (RS) domain of Lamin B Receptor (LBR (show LBR Proteins)).

  7. MiR (show MLXIP Proteins)-650 could inhibit the proliferation, migration and invasion of rheumatoid arthritis synovial fibroblasts through targeted regulation of AKT2 expression.

  8. High AKT2 expression is associated with gallbladder cancer.

  9. miR (show MLXIP Proteins)-302b inhibits SMMC-7721 cell invasion and metastasis by targeting AKT2

  10. No association has been found between AKT2 polymorphisms and oesophageal squamous cell carcinoma risk.

Zebrafish V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

  1. Study reports that Appl1 (show APPL1 Proteins) regulates the activity of Akt (show AKT1 Proteins) and, importantly, its downstream signaling specificity from an endosomal compartment, with profound implications for development.

  2. EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.

  3. akt2 has a role in an integrative pathway directly linking glucose, Glut1 (show SLC2A1 Proteins) expression, and activation of apoptosis

Cow (Bovine) V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

  1. Profilin (show PFN1 Proteins)-dependent dissociation of G-actin (show ACTB Proteins)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK (show ILK Proteins)) in the lamellipodia.

AKT2 Protein Profile

Protein Summary

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.

Alternative names and synonyms associated with AKT2

  • v-akt murine thymoma viral oncogene homolog 2 (AKT2)
  • v-akt murine thymoma viral oncogene homolog 2 (akt2)
  • thymoma viral proto-oncogene 2 (Akt2)
  • v-akt murine thymoma viral oncogene homolog 2 (Akt2)
  • 2410016A19Rik protein
  • AKT2 protein
  • akt2-a protein
  • AW554154 protein
  • cb945 protein
  • HIHGHH protein
  • PKB protein
  • PKBB protein
  • PKBBETA protein
  • pkbss protein
  • PRKBB protein
  • RAC-BETA protein
  • v-akt2 protein

Protein level used designations for AKT2

v-akt murine thymoma viral oncogene homolog 2 , RAC-beta serine/threonine-protein kinase , AKT2 kinase , RAC-beta serine/threonine-protein kinase-like , serine/threonine protein kinase , PKB beta , RAC-PK-beta , RAC-beta serine/threonine protein kinase , protein kinase Akt-2 , protein kinase B beta , protein kinase B, beta , murine thymoma viral (v-akt) homolog-2 , rac protein kinase beta , RAC protein kinase beta RAC-PK beta , murine thymoma viral (v-akt) oncogene homolog 2 , thymoma viral proto-oncogene 2 , PKB beta-A , RAC-PK-beta-A , RAC-beta serine/threonine-protein kinase A , protein kinase Akt-2-A , protein kinase B, beta-A , protein kinase B

456035 Pan troglodytes
700591 Macaca mulatta
100144709 Xenopus (Silurana) tropicalis
100388080 Callithrix jacchus
100454279 Pongo abelii
100499544 Felis catus
100468763 Ailuropoda melanoleuca
11652 Mus musculus
208 Homo sapiens
25233 Rattus norvegicus
378972 Danio rerio
379783 Xenopus laevis
373973 Gallus gallus
449021 Canis lupus familiaris
100127478 Sus scrofa
534923 Bos taurus
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