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Browse our CHUK Proteins (CHUK)

Full name:
conserved Helix-Loop-Helix Ubiquitous Kinase Proteins (CHUK)
On www.antibodies-online.com are 4 conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) Proteins from 3 different suppliers available. Additionally we are shipping CHUK Antibodies (357) and CHUK Kits (10) and many more products for this protein. A total of 384 CHUK products are currently listed.
Synonyms:
AI256658, CHUK, Chuk1, Fbx24, Fbxo24, IKBKA, ikk, IKK-alpha, IKK1, Ikka, ikkalpha, NFKBIKA, TCF16, zgc:56539
list all proteins Gene Name GeneID UniProt
CHUK 1147 O15111
CHUK 12675  
Rat CHUK CHUK 309361  

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CHUK Proteins (CHUK) by Origin

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More Proteins for CHUK Interaction Partners

Human conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) interaction partners

  1. TRIM22 (show TRIM22 Proteins) could interact with IkappaB kinase (IKK)alpha but not IKKbeta (show IKBKB Proteins) and could increase the level and phosphorylation of IKKalpha through its really interesting new gene (RING) and spla-ryanodine receptor (SPRY) domains.

  2. IKKalpha is diversely expressed in keratinizing and non-keratinizing carcinomas in the same type of cancer.

  3. results indicate that nuclear active IKK is a robust biomarker to predict cutaneous squamous cell carcinoma outcome, and suggest the possibility of targeting IKK activity as a future therapy for treating metastatic cutaneous squamous cell carcinomas

  4. BRAF (show BRAF Proteins)-induced tumorigenesis is IKKalpha-dependent but NF-kappaB (show NFKB1 Proteins)-independent

  5. We also report that the extra-genomic effects elicited by both ligands, leading to recruitment of active Akt (show AKT1 Proteins) to chromatin, are essential for phosphorylation of serine 10 in histone H3 (show HIST3H3 Proteins) by IKKa

  6. Upon infection, the HCV 3'UTR redistributes DDX3X (show DDX3X Proteins) and IKK-alpha to speckle-like cytoplasmic structures shown to be stress granules.

  7. Suppression of PKK (show RIPK4 Proteins) expression by RNA interference inhibits phosphorylation of IKKalpha and IKKbeta (show IKBKB Proteins) as well as activation of NF-kappaB (show NFKB1 Proteins) in human cancer cell lines; thus, PKK (show RIPK4 Proteins) regulates NF-kappaB (show NFKB1 Proteins) activation by modulating activation of IKKalpha and IKKbeta (show IKBKB Proteins).

  8. Silencing of IKKa in E2-challenged cells resulted into an increased presence of either 8-oxo-Gs as well as of the base excision repair enzyme 8-oxo-guanine-DNA glycosylase 1.

  9. Findings indicated that IKKalpha plays a crucial role as a tumor suppressor that suppresses the invasion, metastasis, and angiogenesis of nasopharyngeal carcinoma (NPC (show NPC1 Proteins)) cells in vitro and correlates with the survival in NPC (show NPC1 Proteins) patients.

  10. Authors show that activation of NF-kappaB (show NFKB1 Proteins) by Kaposi's sarcoma-associated herpesvirus K15 (show KRT15 Proteins) protein involves the recruitment of NF-kappaB (show NFKB1 Proteins)-inducing kinase (NIK (show MAP3K14 Proteins)) and IKK alpha/beta to result in the phosphorylation of p65/RelA (show NFkBP65 Proteins) on Ser536.

Mouse (Murine) conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) interaction partners

  1. Data indicate that the inflammation and proliferation-related functions of I kappa B kinase (IKKbeta (show IKBKB Proteins)) can be uncoupled by quinoxaline urea analog 13-197.

  2. Hematopoietic IKKalpha deficiency in mouse suppresses Akt (show AKT1 Proteins) signaling, compromising monocyte/macrophage survival and this decreases early atherosclerosis.

  3. Anatomy of a negative feedback loop: the case of IkappaBalpha (show NFKBIA Proteins).

  4. Epithelial-intrinsic IKK-alpha expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.

  5. IKKalpha mediated the repair of the kidney via infiltrated regulatory T (Treg) cells, which can produce anti-inflammatory cytokine IL10 (show IL10 Proteins)

  6. phosphorylation of DBC1 (show DBC1 Proteins) at its C terminus by IKKalpha facilitates its interaction with RelB (show RELB Proteins) and IKKalpha, indicating that DBC1 (show DBC1 Proteins)-mediated suppression of alternative NF-kappaB (show NFKB1 Proteins) is regulated by IKKalpha.

  7. IKKalpha controls the inflammasome at the level of the adaptor molecule ASC (show STS Proteins), which interacts with IKKalpha in the nucleus of resting macrophages in an IKKalpha kinase-dependent manner.

  8. Stimulated BTK (show BTK Proteins)-deficient dendritic cells are defective in the induction of IKK alpha/beta phosphorylation and IRF-1 (show IRF1 Proteins) activation.

  9. IKKalpha has a role in the maintenance of a normal Treg population and in the control of expansion of CD4 (show CD4 Proteins) T cells

  10. TCR-stimulated activation of NF-kappaB requires the assembly of cytosolic p62-Bcl10-Malt1-IKK signalosomes, which may ensure highly regulated activation of NF-kappaB in response to TCR engagement.

Zebrafish conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) interaction partners

  1. These findings reveal a molecular mechanism regulating migration and invasion of epithelial cells and establish a key direct link between IKKbeta (show IKBKB Proteins) and cell motility controlled by Rap (show LRPAP1 Proteins)-integrin signaling.

  2. poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis

  3. Ikk1 negatively regulates NF-kappaB (show NFKB1 Proteins) by sequestering NEMO (show IKBKG Proteins) from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB (show NFKB1 Proteins).

CHUK Protein Profile

Protein Summary

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.

Alternative names and synonyms associated with CHUK

  • conserved helix-loop-helix ubiquitous kinase (chuk)
  • conserved helix-loop-helix ubiquitous kinase (CHUK)
  • conserved helix-loop-helix ubiquitous kinase (Chuk)
  • AI256658 protein
  • CHUK protein
  • Chuk1 protein
  • Fbx24 protein
  • Fbxo24 protein
  • IKBKA protein
  • ikk protein
  • IKK-alpha protein
  • IKK1 protein
  • Ikka protein
  • ikkalpha protein
  • NFKBIKA protein
  • TCF16 protein
  • zgc:56539 protein

Protein level used designations for CHUK

IKK-A , IKK-alpha , NFKBIKA , i kappa-B kinase alpha , ikBKA , inhibitor of nuclear factor kappa-B kinase subunit alpha , nuclear factor NF-kappa-B inhibitor kinase alpha , SPFH domain-containing protein 1 , conserved helix-loop-helix ubiquitous kinase , I-kappa-B kinase 1 , I-kappa-B kinase-alpha , IKK-a kinase , IkB kinase alpha subunit , Nuclear factor NFkappaB inhibitor kinase alpha , TCF-16 , transcription factor 16 , I kappa B kinase 1 , I-kappa-B kinase alpha , IKK alpha , IkappaB kinase alpha , ikappaB kinase , IkB kinase-a , IKK1 , IKKa , pky

GENE ID SPECIES
444556 Xenopus laevis
450673 Pan troglodytes
477796 Canis lupus familiaris
709511 Macaca mulatta
100174735 Pongo abelii
1147 Homo sapiens
12675 Mus musculus
309361 Rattus norvegicus
423669 Gallus gallus
100135662 Sus scrofa
281073 Bos taurus
393287 Danio rerio
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