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Study results provide new insights into the molecular mechanisms of maspin (show SERPINB5 Proteins) suppression in response to HBx, and revealed nuclear IKKalpha as a prognostic biomarker and a potential therapeutic target to improve the clinical outcome of HBV-associated HCC (show FAM126A Proteins) patients.
Data show that IKKalpha directly bind to the promoters of LGR5 (show LGR5 Proteins), in turn, upregulating LGR5 (show LGR5 Proteins) expression through activation of STAT3 (show STAT3 Proteins) signaling pathway during cancer progression.
single-particle cryoelectron microscopy (cryo-EM) and X-ray crystal structures of human IKK1 in dimeric ( approximately 150 kDa) and hexameric ( approximately 450 kDa) forms, are reported.
results suggest that changes in the relative concentrations of RelB (show RELB Proteins), NIK:IKK1, and p100 (show CUX1 Proteins) during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100 (show CUX1 Proteins).
IKKalpha-dependent phosphorylation of S376 stimulated whereas IKKalpha-independent phosphorylation of S484 inhibited RORgammat function in Th17 differentiation.
Akt2 (show AKT2 Proteins), Erk2 (show MAPK1 Proteins), and IKK1/2 phosphorylate Bcl3 (show BCL3 Proteins), converting Bcl3 (show BCL3 Proteins) into a transcriptional coregulator by facilitating its recruitment to DNA.
IKKalpha promotes migration through dynamic interactions with the EGF (show EGF Proteins) promoter depending on the redox state within cells.
the dual regulation of STAT1 (show STAT1 Proteins) by IKKalpha in antiviral signaling suggests a role for IKKalpha in the fine-tuning of antiviral signaling in response to non-self RNA.
In epithelial ovarian cancer cells, miR (show MLXIP Proteins)-23a enhances the expression of IKKalpha. The proliferation, migration, and invasion of EOC cells are increased by IKKalpha.
TLR signaling led to lower expression of LRRC14 (show LRRC14 Proteins).
Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkalpha and Irf6 (show IRF6 Proteins).
results suggest that changes in the relative concentrations of RelB (show RELB Proteins), NIK:IKK1, and p100 (show PATL2 Proteins) during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100 (show PATL2 Proteins).
IKKalpha as a central mediator sensing both cytokine and microbial stimulation to suppress endoplasmic reticulum stress, thereby assuring antiinflammatory function during acute intestinal inflammation.
The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB (show NFKB1 Proteins) by phosphorylating the regulatory molecule TAX1BP1 (show TAX1BP1 Proteins).
Data indicate that the inflammation and proliferation-related functions of I kappa B kinase (IKKbeta (show IKBKB Proteins)) can be uncoupled by quinoxaline urea analog 13-197.
Hematopoietic IKKalpha deficiency in mouse suppresses Akt (show AKT1 Proteins) signaling, compromising monocyte/macrophage survival and this decreases early atherosclerosis.
Anatomy of a negative feedback loop: the case of IkappaBalpha (show NFKBIA Proteins).
Epithelial-intrinsic IKK-alpha expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.
IKKalpha mediated the repair of the kidney via infiltrated regulatory T (Treg) cells, which can produce anti-inflammatory cytokine IL10 (show IL10 Proteins)
These findings reveal a molecular mechanism regulating migration and invasion of epithelial cells and establish a key direct link between IKKbeta (show IKBKB Proteins) and cell motility controlled by Rap (show LRPAP1 Proteins)-integrin signaling.
poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis
Ikk1 negatively regulates NF-kappaB (show NFKB1 Proteins) by sequestering NEMO (show IKBKG Proteins) from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB (show NFKB1 Proteins).
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
, i kappa-B kinase alpha
, inhibitor of nuclear factor kappa-B kinase subunit alpha
, nuclear factor NF-kappa-B inhibitor kinase alpha
, SPFH domain-containing protein 1
, conserved helix-loop-helix ubiquitous kinase
, I-kappa-B kinase 1
, I-kappa-B kinase-alpha
, IKK-a kinase
, IkB kinase alpha subunit
, Nuclear factor NFkappaB inhibitor kinase alpha
, transcription factor 16
, I kappa B kinase 1
, I-kappa-B kinase alpha
, IKK alpha
, IkappaB kinase alpha
, ikappaB kinase
, IkB kinase-a