Browse our CHUK Proteins (CHUK)

Full name:
conserved Helix-Loop-Helix Ubiquitous Kinase Proteins (CHUK)
On are 5 conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) Proteins from 4 different suppliers available. Additionally we are shipping CHUK Antibodies (358) and CHUK Kits (10) and many more products for this protein. A total of 387 CHUK products are currently listed.
AI256658, CHUK, Chuk1, Fbx24, Fbxo24, IKBKA, ikk, IKK-alpha, IKK1, Ikka, ikkalpha, NFKBIKA, TCF16, zgc:56539
list all proteins Gene Name GeneID UniProt
CHUK 1147 O15111
CHUK 12675  
Rat CHUK CHUK 309361  

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CHUK Proteins (CHUK) by Origin

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More Proteins for CHUK Interaction Partners

Human conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) interaction partners

  1. IKKalpha promotes migration through dynamic interactions with the EGF (show EGF Proteins) promoter depending on the redox state within cells.

  2. the dual regulation of STAT1 (show STAT1 Proteins) by IKKalpha in antiviral signaling suggests a role for IKKalpha in the fine-tuning of antiviral signaling in response to non-self RNA.

  3. In epithelial ovarian cancer cells, miR (show MLXIP Proteins)-23a enhances the expression of IKKalpha. The proliferation, migration, and invasion of EOC cells are increased by IKKalpha.

  4. TLR signaling led to lower expression of LRRC14 (show LRRC14 Proteins).

  5. IKKalpha is an important determinant of poor outcome in patients with ER-positive invasive ductal breast cancer and thus may represent a potential therapeutic target

  6. The molecular mechanisms involved in IKKalpha-related tumors. [review]

  7. this study shows that miR (show MLXIP Proteins)-23a regulated IL-17 (show IL17A Proteins)-mediated proinflammatory mediators expression in rheumatoid arthritis by directly targeting IKKalpha

  8. W346 effectively inhibited tumor necrosis factor (TNF-a (show TNF Proteins))-induced NF-kappaB (show NFKB1 Proteins) activation by suppressing IKK phosphorylation, inhibiting IkB (show NFKBIB Proteins)-a degradation, and restraining the accumulation of NF-kappaB (show NFKB1 Proteins) subunit p65 (show GORASP1 Proteins) nuclear translocation. W346 also affected NF-kappaB (show NFKB1 Proteins)-regulated downstream products involved in cycle arrest and apoptosis.

  9. Data indicate a significantly higher quantity of mesenchymal stromal cells (MSCs)was produced from human embryonic stem cells (hESCs) with IkappaB kinase (IKK)/nuclear factor kappa B (NF-kappaB (show NFKB1 Proteins)) suppression.

  10. Findings indicate that IkappaB kinase inhibitor ACHP (show LMBR1 Proteins) can slowdown the accumulation of collagen type I (COL1A1 (show COL1A1 Proteins)).

Mouse (Murine) conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) interaction partners

  1. IKKalpha as a central mediator sensing both cytokine and microbial stimulation to suppress endoplasmic reticulum stress, thereby assuring antiinflammatory function during acute intestinal inflammation.

  2. The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB (show NFKB1 Proteins) by phosphorylating the regulatory molecule TAX1BP1 (show TAX1BP1 Proteins).

  3. Data indicate that the inflammation and proliferation-related functions of I kappa B kinase (IKKbeta (show IKBKB Proteins)) can be uncoupled by quinoxaline urea analog 13-197.

  4. Hematopoietic IKKalpha deficiency in mouse suppresses Akt (show AKT1 Proteins) signaling, compromising monocyte/macrophage survival and this decreases early atherosclerosis.

  5. Anatomy of a negative feedback loop: the case of IkappaBalpha (show NFKBIA Proteins).

  6. Epithelial-intrinsic IKK-alpha expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.

  7. IKKalpha mediated the repair of the kidney via infiltrated regulatory T (Treg) cells, which can produce anti-inflammatory cytokine IL10 (show IL10 Proteins)

  8. phosphorylation of DBC1 (show DBC1 Proteins) at its C terminus by IKKalpha facilitates its interaction with RelB (show RELB Proteins) and IKKalpha, indicating that DBC1 (show DBC1 Proteins)-mediated suppression of alternative NF-kappaB (show NFKB1 Proteins) is regulated by IKKalpha.

  9. IKKalpha controls the inflammasome at the level of the adaptor molecule ASC (show STS Proteins), which interacts with IKKalpha in the nucleus of resting macrophages in an IKKalpha kinase-dependent manner.

  10. Stimulated BTK (show BTK Proteins)-deficient dendritic cells are defective in the induction of IKK alpha/beta phosphorylation and IRF-1 (show IRF1 Proteins) activation.

Zebrafish conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) interaction partners

  1. These findings reveal a molecular mechanism regulating migration and invasion of epithelial cells and establish a key direct link between IKKbeta (show IKBKB Proteins) and cell motility controlled by Rap (show LRPAP1 Proteins)-integrin signaling.

  2. poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis

  3. Ikk1 negatively regulates NF-kappaB (show NFKB1 Proteins) by sequestering NEMO (show IKBKG Proteins) from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB (show NFKB1 Proteins).

CHUK Protein Profile

Protein Summary

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.

Alternative names and synonyms associated with CHUK

  • conserved helix-loop-helix ubiquitous kinase (chuk)
  • conserved helix-loop-helix ubiquitous kinase (CHUK)
  • conserved helix-loop-helix ubiquitous kinase (Chuk)
  • AI256658 protein
  • CHUK protein
  • Chuk1 protein
  • Fbx24 protein
  • Fbxo24 protein
  • IKBKA protein
  • ikk protein
  • IKK-alpha protein
  • IKK1 protein
  • Ikka protein
  • ikkalpha protein
  • NFKBIKA protein
  • TCF16 protein
  • zgc:56539 protein

Protein level used designations for CHUK

IKK-A , IKK-alpha , NFKBIKA , i kappa-B kinase alpha , ikBKA , inhibitor of nuclear factor kappa-B kinase subunit alpha , nuclear factor NF-kappa-B inhibitor kinase alpha , SPFH domain-containing protein 1 , conserved helix-loop-helix ubiquitous kinase , I-kappa-B kinase 1 , I-kappa-B kinase-alpha , IKK-a kinase , IkB kinase alpha subunit , Nuclear factor NFkappaB inhibitor kinase alpha , TCF-16 , transcription factor 16 , I kappa B kinase 1 , I-kappa-B kinase alpha , IKK alpha , IkappaB kinase alpha , ikappaB kinase , IkB kinase-a , IKK1 , IKKa , pky

444556 Xenopus laevis
450673 Pan troglodytes
477796 Canis lupus familiaris
709511 Macaca mulatta
100174735 Pongo abelii
1147 Homo sapiens
12675 Mus musculus
309361 Rattus norvegicus
423669 Gallus gallus
100135662 Sus scrofa
281073 Bos taurus
393287 Danio rerio
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