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We found that neither S6K-dependent cell growth nor S6K-Thr-398 phosphorylation was affected in rictor-null mutants.
In this study we began by validating the expression of four main mTOR (show FRAP1 Proteins) pathway components, mTOR (show FRAP1 Proteins), DEPTOR (show DEPTOR Proteins), rictor and raptor, at gene and protein level in in vitro models of endometrioid (MDAH2774) and clear cell (SKOV3) ovarian cancer
Our results demonstrate for the first time that the expression quantitative trait loci of RPTOR, rs7502563, is susceptible to glioma
The positive regulation of mTORC1 activity by NPRL2 (show NPRL2 Proteins) is mediated through NPRL2 (show NPRL2 Proteins) interaction with Raptor.
Propose regulation of placental SNAT2 (show SLC38A2 Proteins)/LAT1 (show LAT Proteins) ubiquitination by mTORC1 and Nedd4-2 (show NEDD4L Proteins).
RPTOR was not associated with bipolar disorder or schizophrenia.
microRNA-210 and raptor are involved in mithramycin-mediated erythroid differentiation of K562 cells and participate to the fine-tuning and control of gamma-globin gene expression in erythroid precursor cells.
the expressions of Beclin1, Raptor, and Rictor are related to the development and progression of colorectal carcinoma and multidrug resistance.
Common genetic variation in RPTOR is associated with overweight/obesity but does not discernibly contribute to either essential hypertension or isolated systolic hypertension in the Hawaiian population studied.
Studied the impact of SNPs in/near UCP3 and RPTOR on obesity-related traits.
phosphorylating the T-loop Akt (show AKT1 Proteins) residue Thr (show TRH Proteins)(308) by PDK1 (show PDK1 Proteins) requires Raptor of the mTORC1 complex as a platform or scaffold protein (show HOMER1 Proteins).
Raptor knockout mice are lean and insulin (show INS Proteins) resistant with increased energy expenditure, and they are resistant to a high-fat diet.
The findings reveal HDAC5 (show HDAC5 Proteins)-mTORC1 signaling as a novel mechanism in the differential regulation of gastric ghrelin (show GHRL Proteins) and nesfatin-1 (show NUCB2 Proteins).
data suggest that EtOH-induced decreases in protein synthesis in fasted mice may be independent of mTORC1 and MAPK (show MAPK1 Proteins) signaling.
Raptor negatively regulates hepatic Akt (show AKT1 Proteins) activity and lipogenesis via PHLPP2 (show PHLPP2 Proteins) stabilization.
mTOR (show FRAP1 Proteins) kinase-dependent, but raptor-independent regulation of downstream signaling is important for myogenic differentiation.
conditional gene ablation of raptor causes delayed myelination initiation as well as hypomyelination, together with abnormal lipid composition and decreased nerve conduction velocity.
Rptor deficiency/mTORC1 Signaling in oocytes are dispensable for the survival of primordial follicles and for female fertility.
Raptor ablation in skeletal muscle decreases Cav1.1 (show CACNA1S Proteins) expression and affects the function of the excitation-contraction coupling supramolecular complex.
This study demonistrated that developmental co-expression and functional redundancy of tyrosine phosphatases with neurotrophin (show BDNF Proteins) receptors in developing sensory neurons.
Changes in the phosphorylation of Raptor play an important role in the pathway through which mechanical stimuli activate mTOR (show FRAP1 Proteins) signaling.
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.
, target of rapamycin (TOR)-associated protein
, Raptor family protein
, WD40 repeat-containing protein
, armadillo-like helical domain-containing protein
, p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
, regulatory-associated protein of mTOR
, p150 target of rapamycin (TOR)-scaffold protein