Browse our HTRA2 Proteins (HTRA2)

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HtrA Serine Peptidase 2 Proteins (HTRA2)
On are 13 HtrA Serine Peptidase 2 (HTRA2) Proteins from 7 different suppliers available. Additionally we are shipping HTRA2 Antibodies (206) and HTRA2 Kits (7) and many more products for this protein. A total of 233 HTRA2 products are currently listed.
AI481710, CG8464, Dmel\\CG8464, DmHtrA2, domi, HTRA2, HtrA2/Omi, mnd2, OMI, PARK13, Prss25
list all proteins Gene Name GeneID UniProt
HTRA2 27429 O43464
HTRA2 64704 Q9JIY5
Rat HTRA2 HTRA2 297376  

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HTRA2 Proteins (HTRA2) by Origin

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Top referenced HTRA2 Proteins

  1. Human HTRA2 Protein expressed in Escherichia coli (E. coli) - ABIN2003150 : Faccio, Fusco, Chen, Martinotti, Bonventre, Zervos: Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia. in The Journal of biological chemistry 2000 (PubMed)
    Show all 3 references for 2003150

More Proteins for HTRA2 Interaction Partners

Fruit Fly (Drosophila melanogaster) HtrA Serine Peptidase 2 (HTRA2) interaction partners

  1. Mitochondrial serine protease HtrA2 (show F2 Proteins)/Omi is an important mediator of germ cell death.

  2. Data show the presence of apoptosis at the cellular level in both ade2 (show PAICS Proteins) and Prat (show PPAT Proteins) mutants, and the upregulated gene HtrA2, which encodes an apoptosis effector and is thus a candidate for initiating apoptosis in response to purine depletion.

  3. Drosophila Omi (dOmi), a fly homologue of the serine protease Omi/HtrA2, alleviates th/DIAP1 (show DIAPH1 Proteins) inhibition of all caspases by proteolytically degrading th/DIAP1 (show DIAPH1 Proteins) and induces apoptosis both in cultured cells and in the developing fly eye.

  4. The binding of DIAP1 (show DIAPH1 Proteins) to dOmi resulted in DIAP1 (show DIAPH1 Proteins)-mediated polyubiquitination of dOmi, suggesting that DIAP1 (show DIAPH1 Proteins) could target dOmi for proteasomal degradation.

  5. found that Rhomboid-7, a mitochondrial protease not previously implicated in PD, acts as an upstream component of this pathway, and showed that it is required to cleave the precursor forms of both Pink1 (show PINK1 Proteins) and Omi

  6. HtrA2 was shown to be phosphorylated in a PINK1 (show PINK1 Proteins)-dependent manner, suggesting it might act in the PINK1 (show PINK1 Proteins) pathway.

Human HtrA Serine Peptidase 2 (HTRA2) interaction partners

  1. The first report of recessive deleterious mutations in HTRA2 in human. Absence of HTRA2/Omi is associated with severe neurodegenerative disorder of infancy, abnormal mitochondria, 3-methylglutaconic aciduria and increased sensitivity to apoptosis.

  2. HTRA2 and ANO3 (show ANO3 Proteins) mutations are not common causes of essential tremor

  3. HtrA2 under stress conditions induces vimentin (show VIM Proteins) cleavage in wild-type and SH-SY5Y cells transfected with ABP (show ABP1 Proteins) with the Alzheimer disease-associated Swedish mutation. Interplay between Omi/HtrA2 and vimentin (show VIM Proteins) affects mitochondrial distribution in neurons.

  4. The a5 helix of PDZ was involved in both, the intra- and intersubunit changes of interactions and thus seems to play an important role in HtrA2 activation.

  5. study examined the association of HTRA2 p.G399S mutation with essential tremor(ET) and Parkinson disease (PD) in Asians and found that HTRA2 p.G399S is rare and does not appear to play a major role in subjects with coexistent ET and PD nor in those with pure ET or PD phenotype

  6. The NG2 (show MCSP Proteins) proteoglycan (show Vcan Proteins) protects oligodendrocyte precursor cells against oxidative stress via interaction with OMI/HtrA2.

  7. Omi/HtrA2 overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 pro-apoptotic marker in the various hepatocellular carcinoma cell lines

  8. HtrA2 might promote the apoptosis of non-small cell lung cancer cells, and serve as a target for NSCLC's treatment.

  9. HtrA2 expression was a predictor for sensitivity to chemotherapy, and could be a candidate of molecular target in the treatment of high-grade serous ovarian cancers.

  10. results suggest that in some families, HTRA2 p.G399S is responsible for hereditary essential tremor and that homozygotes for this allele develop Parkinson disease

Mouse (Murine) HtrA Serine Peptidase 2 (HTRA2) interaction partners

  1. Mice overexpressing wild-type or G399S mutant HtrA2 have mitochondrial defects resulting in neurodegeneration.

  2. Protease Omi facilitates neurite outgrowth by cleaving the transcription factor E2F1 (show E2F1 Proteins) in differentiated neuroblastoma (show ARHGEF16 Proteins) cells; E2F1 (show E2F1 Proteins) is a substrate of Omi.

  3. Protease Omi impairs mitochondrial function by cleaving Hax-1 (show HAX1 Proteins), which induces apoptosis in oxygen-glucose deprivation and reoxygenation -treated N2a cells and causes reperfusion injury in middle cerebral artery occlusion mice.

  4. The NG2 (show Vcan Proteins) proteoglycan (show Vcan Proteins) protects oligodendrocyte precursor cells against oxidative stress via interaction with OMI/HtrA2.

  5. Loss of Omi protease activity results in an abnormal increase of GSK3b, leading to the degradation of PGC (show PGC Proteins)-1a, which causes an impairment of mitochondrial biogenesis and induces neurodegeneration.

  6. Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.

  7. Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase (show MUL1 Proteins) and increased mitophagy.

  8. Phosphorylated HtrA2/Omi cleaves beta-actin and decreases the amount of filamentous actin (F-actin) in the cytosol.

  9. The proteases HtrA2/Omi and UCH-L1 (show UCHL1 Proteins) regulate TNF (show TNF Proteins)-induced necroptosis.

  10. Downregulation of PARL (show PARL Proteins) after ischemia is a key step in ischemic neuronal injury, and that it decreases HtrA2 processing and increases neuronal vulnerability.

HTRA2 Protein Profile

Protein Summary

This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.

Alternative names and synonyms associated with HTRA2

  • CG8464 gene product from transcript CG8464-RB (HtrA2)
  • HtrA serine peptidase 2 (HTRA2)
  • HtrA serine peptidase 2 (htra2)
  • HtrA serine peptidase 2 (Htra2)
  • AI481710 protein
  • CG8464 protein
  • Dmel\\CG8464 protein
  • DmHtrA2 protein
  • domi protein
  • HTRA2 protein
  • HtrA2/Omi protein
  • mnd2 protein
  • OMI protein
  • PARK13 protein
  • Prss25 protein

Protein level used designations for HTRA2

CG8464-PA , CG8464-PB , HtrA2-PA , HtrA2-PB , HtrA serine peptidase 2 , protease, serine, 25 , serine protease HTRA2, mitochondrial-like , HtrA-like serine protease , Omi stress-regulated endoprotease , high temperature requirement protein A2 , serine protease 25 , serine protease HTRA2, mitochondrial , serine proteinase OMI , motor neuron degeneration 2 , omi stress-regulated endoprotease , serine protease OMI , protease serine 25

41756 Drosophila melanogaster
709938 Macaca mulatta
768259 Felis catus
100135286 Xenopus (Silurana) tropicalis
100461940 Pongo abelii
100591213 Nomascus leucogenys
27429 Homo sapiens
64704 Mus musculus
297376 Rattus norvegicus
523039 Bos taurus
475782 Canis lupus familiaris
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