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HTRA2 Products

(HtrA Serine Peptidase 2 (HTRA2))
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008].

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Featured HTRA2 Categories

HTRA2 Antibodies

High quality antibodies with extensive validation data.

HTRA2 ELISA Kits

Reliable ELISA kits for a wide range of species.

HTRA2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HTRA2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IP, WB
Validations
  • (5)
Cat. No. ABIN7168921
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC (p), IP, WB
Validations
  • (1)
  • (3)
Cat. No. ABIN1107619
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application IF, ELISA, WB
Validations
  • (4)
Cat. No. ABIN565385
Quantity 100 μg
Datasheet Datasheet

Recommended HTRA2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN625463
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5592170
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5592169
Quantity 96 tests
Datasheet Datasheet

Recommended HTRA2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3110065
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3130101
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN666802
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our HTRA2 products

Chung, Islam, Rahman, Hong: "Neuroprotective function of Omi to α-synuclein-induced neurotoxicity." in: Neurobiology of disease, Vol. 136, pp. 104706, (2021) (PubMed).

Papa, Germain: "SirT3 regulates the mitochondrial unfolded protein response." in: Molecular and cellular biology, Vol. 34, Issue 4, pp. 699-710, (2014) (PubMed).

Papa, Germain: "Estrogen receptor mediates a distinct mitochondrial unfolded protein response." in: Journal of cell science, Vol. 124, Issue Pt 9, pp. 1396-402, (2011) (PubMed).

Griparic, Kanazawa, van der Bliek: "Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage." in: The Journal of cell biology, Vol. 178, Issue 5, pp. 757-64, (2007) (PubMed).

Laforge, Bidère, Carmona, Devocelle, Charpentier, Senik: "Apoptotic death concurrent with CD3 stimulation in primary human CD8+ T lymphocytes: a role for endogenous granzyme B." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 7, pp. 3966-77, (2006) (PubMed).

Heiser, Labi, Erlacher, Villunger: "The Bcl-2 protein family and its role in the development of neoplastic disease." in: Experimental gerontology, Vol. 39, Issue 8, pp. 1125-35, (2004) (PubMed).

Hatziioannou, Perez-Caballero, Yang, Cowan, Bieniasz: "Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10774-9, (2004) (PubMed).

Stremlau, Owens, Perron, Kiessling, Autissier, Sodroski: "The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys." in: Nature, Vol. 427, Issue 6977, pp. 848-53, (2004) (PubMed).

Wang, Zhu, Wang, Hagberg, Korhonen, Sandberg, Lindholm, Blomgren: "X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia." in: Neurobiology of disease, Vol. 16, Issue 1, pp. 179-89, (2004) (PubMed).

Xu, Yang, Moitra, Hashimoto, Rallabhandi, Kaul, Meroni, Jensen, Weissman, DArpa: "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta." in: Experimental cell research, Vol. 288, Issue 1, pp. 84-93, (2003) (PubMed).

Synonyms and alternative names related to HTRA2

HTRA2-related serine protease (HtrA2), HtrA serine peptidase 2 (HTRA2), HtrA serine peptidase 2 (htra2), HtrA serine peptidase 2 (Htra2), AI481710, CG8464, Dmel\\CG8464, DmHtrA2, dOmi, domi, htrA2, HTRA2, HtrA2/Omi, mnd2, Omi, omi, OMI, PARK13, PRSS25, Prss25

Protein level used designations for HTRA2

  • CG8464-PA
  • CG8464-PB
  • HtrA2-PA
  • HtrA2-PB
  • HtrA serine peptidase 2
  • protease, serine, 25
  • serine protease HTRA2, mitochondrial-like
  • HtrA-like serine protease
  • Omi stress-regulated endoprotease
  • high temperature requirement protein A2
  • serine protease 25
  • serine protease HTRA2, mitochondrial
  • serine proteinase OMI
  • motor neuron degeneration 2
  • omi stress-regulated endoprotease
  • serine protease OMI
  • protease serine 25
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