HTRA2 Protein (His tag)
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- Target See all HTRA2 Proteins
- HTRA2 (HtrA Serine Peptidase 2 (HTRA2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This HTRA2 protein is labelled with His tag.
- Purpose
- Recombinant Human HtrA2/Omi Protein (His Tag)
- Sequence
- Ala134-Glu458
- Characteristics
- Recombinant Human High Temperature Requirement Protein-2 is produced by our Mammalian expression system and the target gene encoding Ala134-Glu458 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product HTRA2 Protein
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HtrA Serine Peptidase 2 (HTRA2) (AA 134-458) protein (His tag)
HTRA2 Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS
HtrA Serine Peptidase 2 (HTRA2) (AA 133-358) protein (His tag)HTRA2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
HtrA Serine Peptidase 2 (HTRA2) (full length) protein (His tag)HTRA2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS - PAGE SDS
HtrA Serine Peptidase 2 (HTRA2) (AA 359-458) protein (GST tag)HTRA2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
HtrA Serine Peptidase 2 (HTRA2) (AA 134-458) protein (rho-1D4 tag)Crystallography grade HTRA2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
HtrA Serine Peptidase 2 (HTRA2) (AA 134-458) protein (rho-1D4 tag)Crystallography grade HTRA2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 7.5.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- HTRA2 (HtrA Serine Peptidase 2 (HTRA2))
- Alternative Name
- HtrA2/Omi (HTRA2 Products)
- Synonyms
- CG8464 Protein, DmHtrA2 Protein, Dmel\\CG8464 Protein, HtrA2/Omi Protein, Omi Protein, dOmi Protein, domi Protein, htrA2 Protein, omi Protein, HTRA2 Protein, PRSS25 Protein, OMI Protein, PARK13 Protein, AI481710 Protein, Prss25 Protein, mnd2 Protein, HTRA2-related serine protease Protein, HtrA serine peptidase 2 Protein, HtrA2 Protein, HTRA2 Protein, htra2 Protein, Htra2 Protein
- Background
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Background: High temperature requirement protein A2(HTRA2) is a single-pass membrane protein .It contains 1 PDZ (DHR) domain and belongs to the peptidase S1C family. HtrA2 can be released from the mitochondria during apoptosis and uses its four most N-terminal amino acids to mimic a caspase and be recruited by IAP caspase inhibitors such as XIAP and CIAP1/2. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. The protein cleaves THAP5 and promotes its degradation during apoptosis.
Synonym: Serine protease HTRA2, mitochondrial,High temperature requirement protein A2,HtrA2,Omi stress-regulated endoprotease,Serine protease 25,Serine proteinase OMI,HTRA2,OMI, PRSS25
- Molecular Weight
- 36.0 kDa
- UniProt
- O43464
- Pathways
- Positive Regulation of Endopeptidase Activity
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