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Study shows that TXNIP expression is down-regulated in new Multiple Sclerosis (MS) patients compared to controls and might be implicated in pathogenesis of the disease.
TXNIP Single nucleotide polymorphisms may individually and cumulatively affect CAD risk through a possible mechanism for regulating TXNIP expression and gene-environment interactions.
Taken together, our results firstly reveal that TMAO induces inflammation and endothelial dysfunction via activating ROS (show ROS1 Proteins)-TXNIP-NLRP3 (show NLRP3 Proteins) inflammasome, suggest a likely mechanism for TMAO-dependent enhancement in atherosclerosis and cardiovascular risks.
results suggest that TXNIP is required early in the apoptotic-inducing pathway resulting from r-Moj-DM binding to the alphav integrin (show ITGAV Proteins) subunit
Hypoxia suppresses thioredoxin binding protein-2 gene expression, which may ultimately alter placental development.
Heme oxygenase (show HMOX1 Proteins) rs2071749 polymorphism was positively associated with obesity in Mexicans.
These data identify novel Txnip protein interactions.
Glucose exerts strong stimulatory effects on activation histone marks while having inhibitory effects on repression marks in the promoter of the TXNIP gene, and this was associated with a marked increase in expression of the proinflammatory gene in kidney.
No evidence that SNPS in TXNIP has effect, but the rs4485648 polymorphism of the TrxR2 (show TXNRD2 Proteins) gene might exert an independent effect on the development of Diabetic retinopathy.
An association has been found between the TXNIP gene methylation pattern and type 2 diabetes mellitus in ischemic stroke patients through epigenetic mechanisms, related to sustained hyperglycemia levels with HbA1c >/= 7%.
The molecular characterization of porcine TXNIP gene, is described.
single-marker and haplotype analyses revealed significant effects of TXNIP on hot carcass weight, test daily gain, and lifetime daily gain
Foam cell-released 4-hydroxnonenal activates PPARdelta (show PPARD Proteins) in Vascular endothelial cells, leading to increased TXNIP expression and consequently to senescence.
TXNIP-NFYA (show NFYA Proteins)-SREBP2 (show SREBF2 Proteins)/miR (show MLXIP Proteins)-33a-AMPKalpha (show GRK4 Proteins)/CROT (show CROT Proteins)/CPT1 (show CPT1A Proteins)/HADHB (show HADHB Proteins) pathway is conserved in mouse, rat, and human cardiomyocytes and regulates myocardial beta-oxidation.
results suggest that melatonin confers protection against Cd-induced liver inflammation and hepatocyte death via inhibition of the TXNIP-NLRP3 (show NLRP3 Proteins) inflammasome pathway.
proteomic and functional analyses demonstrated that Txnip inhibits glucose transport through direct binding to glucose transporter 1 (GLUT1 (show SLC2A1 Proteins)). An ex vivo analysis of perfused hearts further demonstrated that the enhanced functional reserve afforded by deletion of Txnip was associated with myocardial glucose utilization during beta-adrenergic stimulation.
Thrombin (show F2 Proteins) activates reactive oxygen species (ROS (show ROS1 Proteins))/thioredoxin (show TXN Proteins) binding protein (TXNIP)/NLRP3 (show NLRP3 Proteins) signaling in BV2 microglia cells, which may indicate a mechanism that pro-inflammatory and pro-apoptotic contributes to the development of intracerebral hemorrhage (ICH (show ACE Proteins)).
TxNIP appears to be an important factor in FFA-induced ROS (show ROS1 Proteins) generation and insulin (show INS Proteins) resistance in skeletal muscle cells
Diabetes induces TXNIP expressions at mRNA levels, but shows the opposite effect on GS.
ITCH targets TXNIP for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (show TXN Proteins) system.
These findings thereby provide new mechanistic insight into the regulation of TXNIP and beta-cell biology and reveal novel links between proinflammatory cytokines, carbohydrate response element binding protein (show MLXIPL Proteins)-mediated transcription, and microRNA signaling.
Txnip plays an important role in oxidative inflammatory response and atherosclerotic lesion development in ApoE (show APOE Proteins) knockout mice.
regulates thioredoxin to play an important role in the preservation of cellular viability
thioredoxin interacting protein
, Thioredoxin-interacting protein
, thioredoxin binding protein 2
, thioredoxin-binding protein 2
, thioredoxin-interacting protein
, upregulated by 1,25-dihydroxyvitamin D-3
, vitamin D3 up-regulated protein 1
, hyperlipidemia 1
, thioredoxin binding protein-2