Browse our anti-LRRK2 (LRRK2) Antibodies

Full name:
anti-Leucine-Rich Repeat Kinase 2 Antibodies (LRRK2)
On www.antibodies-online.com are 0 Leucine-Rich Repeat Kinase 2 (LRRK2) Antibodies from different suppliers available. A total of 0 LRRK2 products are currently listed.
Synonyms:
4921513O20Rik, 9330188B09Rik, AURA17, AW561911, cI-46, D630001M17Rik, DARDARIN, Gm927, LRRK2, PARK8, RIPK7, ROCO2
list all antibodies Gene Name GeneID UniProt
Anti-Human LRRK2 LRRK2 120892 Q5S007
Anti-Mouse LRRK2 LRRK2 66725 Q5S006
Anti-Rat LRRK2 LRRK2 300160  

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More Antibodies against LRRK2 Interaction Partners

Zebrafish Leucine-Rich Repeat Kinase 2 (LRRK2) interaction partners

  1. our similar early study and recent confirming experiments using the same reagents reported by Sheng et al. failed to reproduce the phenotype of the loss of dopaminergic neurons, although the mRNA of LRRK2 was molecularly disrupted

  2. results demonstrate that zLRRK2 is an ortholog of hLRRK2 and that the deletion of WD40 domain (show DCAF12L2 Antibodies) of zLRRK2 provides a disease model for PD

Human Leucine-Rich Repeat Kinase 2 (LRRK2) interaction partners

  1. There was no significant difference between nonmanifesting family members with and without a LRRK2 mutation in any of the 5 HRV parameters investigated.

  2. These results indicate that LRRK2 and alpha-synuclein (show SNCA Antibodies) participate in the dysregulation of CADPS2 (show CADPS2 Antibodies) by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease.

  3. each mutation in LRRK2 and ARHGEF7 (show ARHGEF7 Antibodies) demonstrated its unique functional property, which may contribute to the pathogenesis of Parkinson disease

  4. the important contribution of LRRK2 G2019S mutations to parkinsonism in Brazilian families.

  5. propose that the interplay between LRRK2 and p62 (show GTF2H1 Antibodies) may contribute to the pathophysiological function and homeostasis of LRRK2 protein

  6. Mutation in the PARK8 locus encoding for the leucine-rich repeated kinase 2 protein (LRRK2 also named dardarin) is the most frequent cause of autosomal-dominant forms of Parkinson's disease.

  7. Semiquantitative DaT (show SLC6A3 Antibodies)-SPECT could be used to predict early conversion to Parkinson disease (PD) in asymptomatic carriers of the LRRK2 G2019S mutation. Rate of conversion to PD at 4 years in this cohort aged approximately 64 years was 12%. The slope of DaT (show SLC6A3 Antibodies) binding decline on DaT (show SLC6A3 Antibodies)-SPECT imaging seems to be similar across different stages of the premotor period.

  8. In addition to disease modeling, leucine-rich repeat kinase 2 (LRRK2) konckin (KI) mice represent a valuable resource for pharmacological studies.

  9. Studies indicate that overexpression of pathogenic mutant leucine-rich repeat kinase 2 (LRRK2) is sufficient to induce an apoptotic-like cell death in isolated neurons.

  10. Studies indicate that Innate immunity involves macrophages and microglia, in which endogenous leucine-rich repeat kinase 2 (LRRK2) expression is precisely regulated and expression is strongly up-regulated upon cell activation.

Mouse (Murine) Leucine-Rich Repeat Kinase 2 (LRRK2) interaction partners

  1. LRRK2 negatively regulates the clearance of alphaSYN accompanied by down-regulation of the endocytosis pathway; LRRK2 in microglia may function as the offending molecule responsible for neurodegeneration, in terms of down-regulation of alphaSYN clearance.

  2. In addition to disease modeling, leucine-rich repeat kinase 2 (LRRK2) konckin (KI) mice represent a valuable resource for pharmacological studies.

  3. These results of this study demonstrate that alpha-synuclein (show SNCA Antibodies) inclusion formation in neurons can be blocked and that novel therapeutic compounds targeting this process by inhibiting LRRK2 kinase activity may slow progression of PD-associated pathology.

  4. The findings of this study indicated that the G2019S mutation of LRRK2 imparts a gain-of-abnormal function to striatal spiny projection neurons activity and morphology during a stage of development when activity can permanently modify circuit structure and function.

  5. LRRK2 is expressed in enteric neurons and related to alterations of neuronal peptides and IgA.

  6. our findings reveal a previously unknown regulatory role for LRRK2 in CX3CR1 (show CX3CR1 Antibodies) signalling and suggest that an increase of CX3CR1 (show CX3CR1 Antibodies) activity contributes to the attenuated inflammatory responses in Lrrk2-null microglia

  7. this study reveals that LRRK2 is a new positive regulator of Rip2 (show ARHGDIG Antibodies) and promotes inflammatory cytokine induction through the Nod1 (show NOD1 Antibodies)/2-Rip2 (show ARHGDIG Antibodies) pathway.

  8. LRRK2 kinase activity in microglia can contribute to neuroinflammation in Parkinson's disease via phosphorylating p53 (show TP53 Antibodies) at T304 and T377 site

  9. an altered sphingolipid composition in Lrrk2(-/-) mouse brains, is reported.

  10. findings reveal a novel function of LRRK2 in regulating EPO (show EPO Antibodies) expression and imply a potentially novel relationship between PD genes and hematopoiesis.

Pig (Porcine) Leucine-Rich Repeat Kinase 2 (LRRK2) interaction partners

  1. show that the LRRK2 sequence and expression patterns are conserved between pig and human

LRRK2 Antigen Profile

Antigen Summary

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

Alternative names and synonyms associated with LRRK2

  • leucine-rich repeat kinase 2 (lrrk2) antibody
  • leucine-rich repeat kinase 2 (LRRK2) antibody
  • leucine-rich repeat kinase 2 (Lrrk2) antibody
  • 4921513O20Rik antibody
  • 9330188B09Rik antibody
  • AURA17 antibody
  • AW561911 antibody
  • cI-46 antibody
  • D630001M17Rik antibody
  • DARDARIN antibody
  • Gm927 antibody
  • LRRK2 antibody
  • PARK8 antibody
  • RIPK7 antibody
  • ROCO2 antibody

Protein level used designations for LRRK2

leucine-rich repeat serine/threonine-protein kinase 2 , leucine-rich repeat kinase 2 , leucine-rich repeat serine/threonine-protein kinase 2-like , augmented in rheumatoid arthritis 17

GENE ID SPECIES
559366 Danio rerio
745893 Pan troglodytes
100137384 Papio anubis
100145062 Xenopus (Silurana) tropicalis
100440374 Pongo abelii
100548936 Meleagris gallopavo
120892 Homo sapiens
66725 Mus musculus
300160 Rattus norvegicus
486608 Canis lupus familiaris
535652 Bos taurus
780403 Sus scrofa
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