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LRRK2 antibody (AA 878-909)

LRRK2 Reactivity: Human, Mouse IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031607
$578.58
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  • Target See all LRRK2 Antibodies
    LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
    Binding Specificity
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 878-909
    Reactivity
    • 18
    • 7
    • 1
    Human, Mouse
    Host
    • 15
    • 3
    Rabbit
    Clonality
    • 14
    • 4
    Polyclonal
    Conjugate
    • 15
    • 1
    • 1
    • 1
    This LRRK2 antibody is un-conjugated
    Application
    • 10
    • 10
    • 7
    • 4
    • 2
    • 1
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 878-909 from the human protein was used as the immunogen for this LRRK2 antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the LRRK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the LRRK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
    Alternative Name
    LRRK2 (LRRK2 Products)
    Synonyms
    LRRK2 antibody, AURA17 antibody, DARDARIN antibody, PARK8 antibody, RIPK7 antibody, ROCO2 antibody, 4921513O20Rik antibody, 9330188B09Rik antibody, AW561911 antibody, D630001M17Rik antibody, Gm927 antibody, cI-46 antibody, leucine-rich repeat kinase 2 antibody, leucine rich repeat kinase 2 antibody, lrrk2 antibody, LRRK2 antibody, Lrrk2 antibody
    Background
    Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.
    UniProt
    Q5S007
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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