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LRRK2 antibody (Leucine-Rich Repeat Kinase 2) (AA 2171-2207) Primary Antibody

LRRK2 Reactivity: Human FACS, IHC, WB Host: Rabbit Polyclonal RB50924 unconjugated
Catalog No. ABIN6243251
$541.79
Plus shipping costs $45.00
400 μL ABIN6243251
400 μL ABIN6243251
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Delivery in 10 to 11 Business Days
  • Target
    LRRK2
    Binding Specificity
    • 4
    • 2
    • 2
    • 2
    AA 2171-2207, C-Term
    Reactivity
    • 10
    • 7
    Human
    Host
    • 7
    • 3
    Rabbit
    Clonality
    • 7
    • 3
    Polyclonal
    Application
    • 9
    • 5
    • 2
    • 2
    • 2
    Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This LRRK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2171-2207 amino acids from the C-terminal region of human LRRK2.
    Clone
    RB50924
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. IHC: 1:25. FC: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Target
    LRRK2
    Alternative Name
    LRRK2 (LRRK2 Antibody Abstract)
    Synonyms
    LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, 4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, cI-46, leucine-rich repeat kinase 2, leucine rich repeat kinase 2, lrrk2, LRRK2, Lrrk2
    Background
    Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH , and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (,CNS),. Phosphorylates PRDX3. May also have GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
    Molecular Weight
    286103
    UniProt
    Q5S007
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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