Browse our SH2 Domain Containing 1A Proteins (SH2D1A)

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SH2 Domain Containing 1A Proteins (SH2D1A)
On are 19 SH2 Domain Containing 1A (SH2D1A) Proteins from 10 different suppliers available. Additionally we are shipping SH2 Domain Containing 1A Antibodies (120) and SH2 Domain Containing 1A Kits (1) and many more products for this protein. A total of 149 SH2 Domain Containing 1A products are currently listed.
list all proteins Gene Name GeneID UniProt
SH2D1A 4068 O60880
SH2D1A 501502 B2RZ59
SH2D1A 20400 O88890

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Top referenced SH2 Domain Containing 1A Proteins

  1. Human SH2D1A Protein expressed in Escherichia coli (E. coli) - ABIN667264 : Snow, Marsh, Krummey, Roehrs, Young, Zhang, van Hoff, Dhar, Nichols, Filipovich, Su, Bleesing, Lenardo: Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. in The Journal of clinical investigation 2009 (PubMed)
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More Proteins for SH2 Domain Containing 1A Interaction Partners

Human SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. study concludes that systemic lupus erythematosus (SLE) T cells display reduced levels of the adaptor protein SAP (show APCS Proteins), probably as a result of continuous T cell activation and degradation by caspase-3 (show CASP3 Proteins). Restoration of SAP (show APCS Proteins) levels in SLE T cells corrects the overexcitable lupus T cell phenotype.

  2. High LAT1 (show LAT Proteins) expression correlated with significantly shorter prostate specific antigen (show KLK3 Proteins) recurrence-free survival in patients receiving androgen deprivation therapy

  3. We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (show SLAMF1 Proteins))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.

  4. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  5. The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation

  6. Study of SAP (show APCS Proteins) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (show CD244 Proteins) functional assay allows identification of all cases

  7. Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (show APCS Proteins) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (show SLAMF1 Proteins) peptide.

  8. Signaling lymphocytic activation molecule (SLAM)/SLAM (show SLAMF1 Proteins)-associated protein pathway regulates human B-cell tolerance.

  9. In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (show APCS Proteins) is nonfunctional, not only abolishing the activating function of 2B4 (show CD244 Proteins), but rendering this receptor inhibitory.

  10. our data reveal how SAP (show APCS Proteins) nucleates a previously unknown signaling complex involving NTB-A (show SLAMF6 Proteins) and LCK (show LCK Proteins) to potentiate restimulation-induced cell death of activated human T cells.

Mouse (Murine) SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. SAP (show APCS Proteins)-dependent activating SFR signaling is essential for NKT (show CTSL1 Proteins) cell selection.

  2. SAP (show APCS Proteins) differentially regulates the late-stage lineage decisions of iNKT cell subsets. These results also provide evidence that iNKT1, iNKT2, and iNKT17 cells are differentially regulated by SAP (show APCS Proteins). SAP (show APCS Proteins)-dependent signals are essential for the fate decisions that drive the differentiation of iNKT2 but not iNKT1 and NKT17 cells.

  3. SAP (show APCS Proteins) is an essential molecule for autoimmune antibody production.

  4. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  5. SLAM (show SLAMF1 Proteins)-SAP (show APCS Proteins) signaling promotes differentiation of IL-17 (show IL17A Proteins)-producing T cells and progression of experimental autoimmune encephalomyelitis.

  6. these data suggest that SAP (show APCS Proteins) is critical for regulating type II NKT (show CTSL1 Proteins) cell responses.

  7. functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability

  8. Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (show APCS Proteins)-/- mice and in Rag-/- mice into which B cells derived from SAP (show APCS Proteins)-/- mice together with wt CD4 (show CD4 Proteins)+ T cells had been transferred.

  9. SAP (show APCS Proteins) plays an essential role in CIA (show NCOA5 Proteins) because of Fyn (show FYN Proteins)-independent and Fyn (show FYN Proteins)-dependent effects on TFH cells and, possibly, other T cell types.

  10. SAP (show APCS Proteins) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.

SH2 Domain Containing 1A (SH2D1A) Protein Profile

Protein Summary

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SH2 Domain Containing 1A (SH2D1A)

  • SH2 domain containing 1A (SH2D1A)
  • SH2 domain containing 1A (Sh2d1a)
  • SH2 domain protein 1A (Sh2d1a)
  • SH21A (LOC780420)
  • DSHP protein
  • EBVS protein
  • Gm686 protein
  • IMD5 protein
  • LYP protein
  • MTCP1 protein
  • RGD1562408 protein
  • SAP protein
  • SAP/SH2D1A protein
  • SH2D1A protein
  • XLP protein
  • XLPD protein

Protein level used designations for SH2D1A

Duncan disease SH2-protein , SH2 domain-containing protein 1A , SLAM associated protein/SH2 domain protein 1A , SLAM-associated protein , T cell signal transduction molecule SAP , T-cell signal transduction molecule SAP , signaling lymphocyte activation molecule-associated protein , signaling lymphocytic activation molecule-associated protein , SH2 domain protein 1A , SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) , Signaling lymphocytic activation molecule-associated protein , Duncan disease homolog

4068 Homo sapiens
501502 Rattus norvegicus
613356 Bos taurus
574156 Macaca mulatta
20400 Mus musculus
780420 Sus scrofa
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