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Browse our PRDM6 Proteins (PRDM6)

Full name:
PR Domain Containing 6 Proteins (PRDM6)
On www.antibodies-online.com are 2 PR Domain Containing 6 (PRDM6) Proteins from 1 different suppliers available. Additionally we are shipping PRDM6 Antibodies (30) and many more products for this protein. A total of 34 PRDM6 products are currently listed.
Synonyms:
Gm92, PRDM6, PRISM, RGD1559594
list all proteins Gene Name GeneID UniProt
Rat PRDM6 PRDM6 307305  
PRDM6 93166 Q9NQX0
PRDM6 225518 Q3UZD5

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PRDM6 Proteins (PRDM6) by Origin

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More Proteins for PRDM6 Interaction Partners

Human PR Domain Containing 6 (PRDM6) interaction partners

  1. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus.

  2. Three novel loci were identified in East Asians with cardiac arrhythmias: rs2483280 (PRDM16 (show PRDM16 Proteins) locus) and rs335206 (PRDM6 locus) were associated with QRS (show QARS Proteins) duration; and rs17026156 (SLC8A1 (show SLC8A1 Proteins) locus) correlated with PR interval.

Mouse (Murine) PR Domain Containing 6 (PRDM6) interaction partners

  1. identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development

  2. PRISM acts as a novel epigenetic regulator of Smooth Muscle Cells (SMC (show DYM Proteins)) phenotypic plasticity by suppressing differentiation and maintaining the proliferative potential of vascular SMCs.

  3. These data indicate that PRDM6 is expressed by vascular precursors, has differential effects in endothelial cells and smooth muscle cells, and may play a role in vascular precursor differentiation and survival.

PRDM6 Protein Profile

Protein Summary

Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).

Alternative names and synonyms associated with PRDM6

  • PR domain containing 6 (Prdm6)
  • PR domain containing 6 (PRDM6)
  • PR domain containing 6 (prdm6)
  • PR domain containing 6 (LOC100354345)
  • Gm92 protein
  • PRDM6 protein
  • PRISM protein
  • RGD1559594 protein

Protein level used designations for PR Domain Containing 6 Proteins (PRDM6)

PR domain containing 6 , PR domain zinc finger protein 6 , PR domain-containing protein 6 , PR-domain zinc finger protein 6 , putative histone-lysine N-methyltransferase PRDM6 , PR domain-containing protein in smooth muscle

GENE ID SPECIES
307305 Rattus norvegicus
426800 Gallus gallus
742318 Pan troglodytes
100169948 Danio rerio
100354345 Oryctolagus cuniculus
100579681 Nomascus leucogenys
93166 Homo sapiens
225518 Mus musculus
519857 Bos taurus
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