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Browse our NDST1 Proteins (NDST1)

Full name:
N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 Proteins (NDST1)
On are 11 N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1) Proteins from 4 different suppliers available. Additionally we are shipping NDST1 Antibodies (48) and NDST1 Kits (4) and many more products for this protein. A total of 64 NDST1 products are currently listed.
1200015G06Rik, fj47c03, Hsst, NDST-1, NDST1, NST1, wu:fj47c03
list all proteins Gene Name GeneID UniProt
NDST1 3340 P52848
NDST1 15531 Q3UHN9
Rat NDST1 NDST1 29633 Q02353

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Human N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1) interaction partners

  1. Our data confirm NDST1 mutations as a cause of autosomal recessive intellectual disability with a distinctive phenotype, and support an important function of NDST1 in human development.

  2. demonstrate the essential role of domain cooperation within NDST-1 in producing HS with specific domain structures

  3. Upregulation of NDST1 is associated with chemoresistance in breast cancer.

  4. These findings establish NDST1 as a target of miR (show MLXIP Proteins)-24 and demonstrate how such NDST1 suppression in endothelial cells results in reduced responsiveness to VEGFA (show VEGFA Proteins)

  5. MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803

  6. Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.

  7. Altered expression of NDST-1 mRNA in glomerular basement membrane in puromycin aminonucleoside nephrosis.

  8. effect of targeted inactivation of the Ndst1 gene on the inflammatory response associated with allergic inflammation

  9. the expression of the NDST-1 isoform was approximately equal at all stages of mast cell maturation

Mouse (Murine) N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1) interaction partners

  1. Although the renal phenotype of the Ndst1(-/-) mouse is mild, the data show that heparan chain N-sulfation plays a key role in podocyte organization.

  2. Targeted ablation of Ndst1 in smooth muscle cells results in altered biomechanical properties of aorta.

  3. Loss of NDST1 causes defective diaphragm vascular development and congenital diaphragmatic hernia.

  4. The results of this study suggested that while Chst14 (show CHST14 Proteins) and its enzymatic products might be of limited importance for neural development, they may contribute to the regeneration-restricting environment in the adult mammalian nervous system

  5. embryonic stem cells lacking both NDST1 and NDST2 (show NDST2 Proteins), expressing a very low sulfated (show SULF1 Proteins) heparan sulfate, can take the initial step toward differentiation into all three germ layers

  6. Deletion of N-deacetylase-N-sulfotransferase1 in smooth muscle did not influence any of the blood pressure parameters measured despite significant decrease in aorta and thoracodorsal artery luminal area.

  7. Lowered expression of NDST1 also results in a higher sulfate content of the heparin synthesized and is accompanied by increased levels of stored MC proteases.

  8. Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.

  9. These data provide new evidence that modification of heparan sulfate fine structure through deletion of Ndst1 is sufficient to decrease vascular smooth muscle cell proliferation and alter vascular remodeling.

  10. These findings demonstrate a selective, highly penetrant, cell autonomous effect of Ndst1-mediated sulfation on lobuloalveolar development.

NDST1 Protein Profile

Protein Summary

Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (By similarity).

Alternative names and synonyms associated with NDST1

  • N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1b (ndst1b)
  • N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (NDST1)
  • N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 (NDST2)
  • N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (ndst1)
  • N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (Ndst1)
  • 1200015G06Rik protein
  • fj47c03 protein
  • Hsst protein
  • NDST-1 protein
  • NDST1 protein
  • NST1 protein
  • wu:fj47c03 protein

Protein level used designations for NDST1

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 , N-deacetylase/N-sulfotransferase 1 , NDST-1 , bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 , glucosaminyl N-deacetylase/N-sulfotransferase 1 , HSNST 1 , N-HSST 1 , N-heparan sulfate sulfotransferase 1 , [Heparan sulfate]-glucosamine N-sulfotransferase 1 , heparan sulfate-N-deacetylase/N-sulfotransferase , N-deacetylase/N-sulfotransferase-1

336078 Danio rerio
416274 Gallus gallus
423738 Gallus gallus
462194 Pan troglodytes
489185 Canis lupus familiaris
496577 Xenopus (Silurana) tropicalis
514172 Bos taurus
712425 Macaca mulatta
100060315 Equus caballus
100078694 Ornithorhynchus anatinus
100344304 Oryctolagus cuniculus
100392379 Callithrix jacchus
100436625 Pongo abelii
100470681 Ailuropoda melanoleuca
3340 Homo sapiens
15531 Mus musculus
29633 Rattus norvegicus
443855 Xenopus laevis
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