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Browse our anti-FAK (PTK2) Antibodies

Full name:
anti-PTK2 Protein tyrosine Kinase 2 Antibodies (PTK2)
On are 679 PTK2 Protein tyrosine Kinase 2 (PTK2) Antibodies from 30 different suppliers available. Additionally we are shipping FAK Kits (31) and FAK Proteins (16) and many more products for this protein. A total of 753 FAK products are currently listed.
Fadk, FAK, FAK1, FRNK, mKIAA4203, p125FAK, pp125FAK, PPP1R71

All available anti-FAK Antibodies

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Top referenced anti-FAK Antibodies

  1. Chicken Monoclonal FAK Primary Antibody for BI, IP - ABIN967736 : Clancy, Rediske, Tang, Nijher, Frenkel, Philips, Abramson: Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. in The Journal of clinical investigation 1997 (PubMed)
    Show all 7 references for ABIN967736

  2. Human Polyclonal FAK Primary Antibody for EIA, WB - ABIN453801 : Calalb, Polte, Hanks: Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. in Molecular and cellular biology 1995 (PubMed)
    Show all 3 references for ABIN453801

  3. Human Polyclonal FAK Primary Antibody for IHC, ELISA - ABIN1533049 : Lee, Strunk, Spritz: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. in Oncogene 1993 (PubMed)

  4. Human Polyclonal FAK Primary Antibody for FACS, IF - ABIN652554 : Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression. in The Journal of biological chemistry 2012 (PubMed)

  5. Human Polyclonal FAK Primary Antibody for IF, IHC - ABIN1532612 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006 (PubMed)

More Antibodies against FAK Interaction Partners

Human PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. Mono treatment with lexatumumab was not sufficient to induce apoptosis in pancreatic cancer cells, whereas focal adhesion kinase inhibitor PF573228 significantly sensitized lexatumumab-induced apoptosis. Western blotting analysis revealed that lexatumumab and PF573228 combination treatment increased death receptor 5 (show TNFRSF10B Antibodies) but decreased Bcl-xL (show BCL2L1 Antibodies) expression. sed the ins (show INS Antibodies)

  2. NF2 (show NF2 Antibodies) regulates the interaction of FAK-p53 (show TP53 Antibodies) and MDM2 (show MDM2 Antibodies)-p53 (show TP53 Antibodies).

  3. These data provide insight into the mechanisms guiding PRL (show PRL Antibodies)-mediated breast cancer cell motility and invasion and highlight a significant role for phosphoTyr-PAK1 (show PAK1 Antibodies) in breast cancer metastasis.

  4. Taken together, our findings suggested that HMGB1 (show HMGB1 Antibodies) enhances tumor cell migration ability by activating alphavbeta3/FAK through TLR4 (show TLR4 Antibodies)/NF-kappaB (show NFKB1 Antibodies) signaling, leading to metastasis of NSCLC.

  5. The main significance of this work is the discovery of EPO (show EPO Antibodies) as a novel ligand for the HER2 (show ERBB2 Antibodies) receptor. Following HER2 (show ERBB2 Antibodies) activation, EPO (show EPO Antibodies) induces activation of FAK and subsequent activation of beta1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 (show MAPK1/3 Antibodies) and a sustained up regulation of both MUC4 (show MUC4 Antibodies) and the HER2 (show ERBB2 Antibodies) receptor

  6. The beta-arrestin1.STAM1 complex is necessary for promoting autophosphorylation of focal adhesion kinase (FAK). FAK is necessary for CXCL12-induced chemotaxis and associates with and localizes with beta-arrestin1 and STAM1 in a CXCL12-dependent manner.

  7. data suggest that activation of FAK by the interaction between CD133 and Src promotes cell migration, providing clues to understand the migratory mechanism of CD133(+) tumor cells.

  8. Focal adhesion kinase (FAK) is over-expressed in a variety of tumours, including hepatocellular carcinoma (HCC).

  9. data indicate that the beta4 integrin/FAK complex and subsequent FAK activation are essential regulators during the tumorigenicity of colon cancer

  10. monocytes infected with T. gondii can disrupt outer blood-retinal barrier, which is mediated by paracrinely activated FAK signaling.

Xenopus laevis PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. evidence that despite the fact that FAK is in the active, open conformation at CAs (show CSE1L Antibodies), its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells.

  2. FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.

  3. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.

  4. work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development

  5. These data suggest an important role for the FERM domain in the activation of FAK.

  6. FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (show BDNF Antibodies), while phosphorylation at Y925 controls the rate of point contact turnover.

  7. Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.

  8. FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.

Mouse (Murine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.

  2. FAK promotes nascent integrin adhesions (NA) assembly and timely turnover to couple lamellipodial protrusion to adhesions for efficient advance of the leading edge. Phosphorylation on Y397 of FAK promotes dense NA formation but is dispensable for transient NA stabilization and leading edge advance.

  3. this manuscript shows that endothelial cell FAK activity induces VCAM-1 (show VCAM1 Antibodies) expression and contributes to atherosclerosis

  4. FAK activation is necessary for the promotion of osteogenesis induced by extracorporeal shockwave.

  5. Data show that the essential oil (EO) decreased focal adhesion and invadopodia formation which was accompanied by a drastic downregulation of focal adhesion kinase (FAK) and proto-oncogene protein Src.

  6. results suggest that LPS (show TLR4 Antibodies)-stimulated macrophage mediators attenuate both FAK and Src (show SRC Antibodies) activations in osteoblast, suggesting a novel role for TNFalpha (show TNF Antibodies) on osteoblast performance

  7. Report phosphorylation sites in focal adhesion kinase and putative new binding partners.

  8. data indicate that PTPalpha (show PTPRA Antibodies) and FAK, which are enriched in FAs (show FAS Antibodies), interact with IP3R1 (show ITPR1 Antibodies) at adjacent ER sites to spatially sequester IL-1 (show IL1A Antibodies)-induced Ca(2 (show CA2 Antibodies)+) signalling

  9. FAK-regulated signalling module PDK1 (show PDPK1 Antibodies)-Akt (show AKT1 Antibodies)-p70S6K (show RPS6KB1 Antibodies) that controls Src's intracellular trafficking operates at Src (show SRC Antibodies)-containing autophagosomes.

  10. Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes.

Cow (Bovine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. RhoA (show RHOA Antibodies) and membrane fluidity mediates the spatially polarized Src (show SRC Antibodies)/FAK activation in response to shear stress.

  2. XIAP (show XIAP Antibodies) plays an essential role in shear stress-stimulated FAK phosphorylation.

  3. mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C (show PKC Antibodies)

  4. These results suggest that TGF-beta1 (show TGFB1 Antibodies)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (show SRC Antibodies)-dependent and -independent pathways.

  5. Results suggest focal adhesion kinase is involved in thrombospondin-1 (show THBS1 Antibodies)-induced vascular smooth muscle cell migration.

FAK (PTK2) Antigen Profile

Antigen Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Alternative names and synonyms associated with FAK (PTK2)

  • PTK2 protein tyrosine kinase 2 (PTK2) antibody
  • protein tyrosine kinase 2 (PTK2) antibody
  • protein tyrosine kinase 2 (Ptk2) antibody
  • protein tyrosine kinase 2 (ptk2) antibody
  • PTK2 protein tyrosine kinase 2 (Ptk2) antibody
  • Fadk antibody
  • FAK antibody
  • FAK1 antibody
  • FRNK antibody
  • mKIAA4203 antibody
  • p125FAK antibody
  • pp125FAK antibody
  • PPP1R71 antibody

Protein level used designations for PTK2

FADK 1 , FAK-related non-kinase polypeptide , PTK2 protein tyrosine kinase 2 , focal adhesion kinase 1 , focal adhesion kinase-related nonkinase , protein phosphatase 1 regulatory subunit 71 , protein phosphatase 1, regulatory subunit 71 , pp125FAK , protein-tyrosine kinase 2 , focal adhesion kinase pp125FAK , focal ashension kinase 1 , p41/p43FRNK , focal adhesion kinase

100058245 Equus caballus
5747 Homo sapiens
25614 Rattus norvegicus
399286 Xenopus laevis
14083 Mus musculus
396416 Gallus gallus
475108 Canis lupus familiaris
506270 Bos taurus
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